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  1. Book ; Online ; E-Book: Global perspectives in ocular oncology

    Chawla, Bhavna V. / Aronow, Mary E.

    2023  

    Abstract: Eye cancers vary in presentation depending upon geographic location and access to healthcare. Global Perspectives in Ocular Oncology offers an international platform for leading ocular oncologists and multidisciplinary specialists to highlight worldwide ... ...

    Author's details edited by Bhavna V. Chawla and Mary E. Aronow
    Abstract Eye cancers vary in presentation depending upon geographic location and access to healthcare. Global Perspectives in Ocular Oncology offers an international platform for leading ocular oncologists and multidisciplinary specialists to highlight worldwide strengths and solutions to the challenges in treating eye cancer. The goal of the book is to provide a universal view on the management of adult and pediatric tumors affecting the eye and ocular adnexa. A range of topics pertinent to the global community have been included. Organized into seven distinct sections, this book covers international collaborations and initiatives, technology and innovations, and novel treatment strategies. In addition, it provides a glimpse into the future of the specialty. The emphasis on sharing perspectives as well as the global and multidisciplinary framework of the book are unique to the market. This work will appeal to a variety of audiences including ocular oncologists and ophthalmic subspecialists, oncologists and other specialists, optometrists, geneticists, allied medical professionals, and trainees entering these disciplines.
    MeSH term(s) Eye Neoplasms. ; Orbital Neoplasms.
    Keywords Eye/Cancer
    Subject code 880.9
    Language English
    Dates of publication 2023-2022
    Size 1 online resource (417 pages)
    Publisher Springer
    Publishing place Cham, Switzerland
    Document type Book ; Online ; E-Book
    Note Includes index.
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    ISBN 3-031-08250-8 ; 9783031082498 ; 978-3-031-08250-4 ; 3031082494
    DOI 10.1007/978-3-031-08250-4
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Article ; Online: Disinsert, retract and rotate technique of plaque brachytherapy.

    Lomi, Neiwete / Chawla, Bhavna / Das, Deepsekhar

    Indian journal of ophthalmology

    2024  Volume 72, Issue 2, Page(s) 303

    Abstract: Background: Plaque brachytherapy is commonly used in the management of choroidal melanomas. The surgical steps usually involve creating a conjunctival peritomy, fixing the recti muscles, with or without disinserting them based on the location of the ... ...

    Abstract Background: Plaque brachytherapy is commonly used in the management of choroidal melanomas. The surgical steps usually involve creating a conjunctival peritomy, fixing the recti muscles, with or without disinserting them based on the location of the lesion, and placing the plaque. The inferior oblique muscle is attached close to the macula, and in cases of perimacular or peripapillary lesions, the muscle needs to be sacrificed.
    Purpose: The authors here demonstrate a novel technique of placing radioactive plaque without disinserting the inferior oblique muscle in cases of perimacular or peripapillary choroidal melanomas.
    Synopsis: The video demonstrates how the "disinsert, retract, and rotate technique" of brachytherapy plaque placement can be performed and what are the fundamentals behind this technique. The authors have performed this procedure multiple times and there has been no incidence of plaque tilt or migration.
    Highlights: In perimacular and peripapillary choroidal melanoma brachytherapy plaque placement, the inferior oblique muscle can be spared. The simple technique does not lead to any tilt or migration of the radioactive plaque.
    Video link: https://youtu.be/YMIg3rYyp2o.
    MeSH term(s) Humans ; Brachytherapy/methods ; Melanoma/radiotherapy ; Melanoma/pathology ; Iodine Radioisotopes ; Choroid Neoplasms/radiotherapy ; Choroid Neoplasms/pathology ; Uveal Neoplasms
    Chemical Substances Iodine Radioisotopes
    Language English
    Publishing date 2024-01-25
    Publishing country India
    Document type Journal Article
    ZDB-ID 187392-1
    ISSN 1998-3689 ; 0301-4738
    ISSN (online) 1998-3689
    ISSN 0301-4738
    DOI 10.4103/IJO.IJO_2213_23
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Post-decolonisation: Global Health and Global Surgery's Coming of Age.

    Chawla, Bhavna / Lindert, Judith / Sharma, Dhananjaya

    The Indian journal of surgery

    2022  Volume 84, Issue 2, Page(s) 259–261

    Language English
    Publishing date 2022-02-19
    Publishing country India
    Document type Editorial
    ZDB-ID 138063-1
    ISSN 0972-2068 ; 0019-5650
    ISSN 0972-2068 ; 0019-5650
    DOI 10.1007/s12262-022-03330-6
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  4. Article: 8-Hydroxy-2'-Deoxyguanosine in Sperm DNA and Increased Risk of Nonfamilial Sporadic Heritable Retinoblastoma in the Child.

    Bisht, Shilpa / Chawla, Bhavna / Dada, Rima

    Journal of pediatric genetics

    2020  Volume 9, Issue 2, Page(s) 145–148

    Language English
    Publishing date 2020-01-13
    Publishing country Germany
    Document type Journal Article
    ISSN 2146-4596
    ISSN 2146-4596
    DOI 10.1055/s-0039-1700974
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Identification of novel genes by targeted exome sequencing in Retinoblastoma.

    Bisht, Shilpa / Chawla, Bhavna / Kumar, Amit / Vijayan, Viswanathan / Kumar, Manoj / Sharma, Pradeep / Dada, Rima

    Ophthalmic genetics

    2022  Volume 43, Issue 6, Page(s) 771–788

    Abstract: Background: Retinoblastoma (RB) is initiated by mutation in both alleles of : Methodology: The current study was planned to utilize targeted exome sequencing in Indian RB patients affected with unilateral non-familial RB. 75 unilateral RB patients ... ...

    Abstract Background: Retinoblastoma (RB) is initiated by mutation in both alleles of
    Methodology: The current study was planned to utilize targeted exome sequencing in Indian RB patients affected with unilateral non-familial RB. 75 unilateral RB patients below 5 years of age were enrolled. Genomic DNA was extracted from blood and tumor tissue. From peripheral blood DNA, all coding and exon/intron regions were amplified using PCR and direct sequencing. Cases which did not harbor pathogenic variants in peripheral blood DNA were further screened for mutations in their tumor tissue DNA using targeted exome sequencing. Three pathogenicity prediction tools (Mutation Taster, SIFT, and PolyPhen-2) were used to determine the pathogenicity of non-synonymous variations. An in-house bioinformatics pipeline was devised for the mutation screening by targeted exome sequencing. Protein modeling studies were also done to predict the effect of the mutations on the protein structure and function.
    Results: Using the mentioned approach, we found two novel variants (g.69673_69674insT and g.48373314C>A) in
    Conclusion: The present study expands our current knowledge regarding the genomic landscape of RB and also highlights the importance of NGS technologies to detect genes and novel variants that may play an important role in cancer initiation, progression, and prognosis.
    MeSH term(s) Humans ; Retinoblastoma/pathology ; Exome Sequencing ; Mutation ; Genes, Retinoblastoma/genetics ; DNA Mutational Analysis ; Retinal Neoplasms/pathology ; Proteins/genetics ; ADP-Ribosylation Factors/genetics ; Tumor Suppressor Proteins/genetics ; SOX Transcription Factors/genetics
    Chemical Substances OTOR protein, human ; Proteins ; ARL11 protein, human (EC 3.6.5.2) ; ADP-Ribosylation Factors (EC 3.6.5.2) ; SOX30 protein, human ; Tumor Suppressor Proteins ; SOX Transcription Factors
    Language English
    Publishing date 2022-08-05
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1199279-7
    ISSN 1744-5094 ; 0167-6784 ; 1381-6810
    ISSN (online) 1744-5094
    ISSN 0167-6784 ; 1381-6810
    DOI 10.1080/13816810.2022.2106497
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Recent advances and challenges in the management of retinoblastoma.

    Chawla, Bhavna / Singh, Rashmi

    Indian journal of ophthalmology

    2017  Volume 65, Issue 2, Page(s) 133–139

    Abstract: The treatment of retinoblastoma (Rb) has improved significantly in recent times. Worldwide, there is an increasing trend to use conservative treatment modalities that aim to preserve the globe as well as vision with minimum morbidity. Recently, the use ... ...

    Abstract The treatment of retinoblastoma (Rb) has improved significantly in recent times. Worldwide, there is an increasing trend to use conservative treatment modalities that aim to preserve the globe as well as vision with minimum morbidity. Recently, the use of targeted delivery of chemotherapy to the eye in the form of selective intra-arterial and intravitreal chemotherapy has shown promising results. Radiotherapy is beneficial in selected cases, either in the form of plaque brachytherapy or as external beam radiotherapy. Orbital disease carries a poor prognosis for survival. However, a multimodal treatment protocol has improved survival in children with extraocular disease. Nevertheless, challenges remain, especially for the developing world. This review aims to highlight recent advances in the management of Rb that have contributed towards improving treatment outcomes and also discuss the challenges ahead, with special reference to the Indian scenario.
    MeSH term(s) Combined Modality Therapy ; Disease Management ; Humans ; Neoplasm Staging ; Retinal Neoplasms/diagnosis ; Retinal Neoplasms/therapy ; Retinoblastoma/diagnosis ; Retinoblastoma/therapy
    Language English
    Publishing date 2017-02
    Publishing country India
    Document type Journal Article ; Review
    ZDB-ID 187392-1
    ISSN 1998-3689 ; 0301-4738
    ISSN (online) 1998-3689
    ISSN 0301-4738
    DOI 10.4103/ijo.IJO_883_16
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Oxidative Stress and Polymorphism in

    Bisht, Shilpa / Chawla, Bhavna / Dada, Rima

    Journal of pediatric genetics

    2018  Volume 7, Issue 3, Page(s) 103–113

    Abstract: Sperm DNA is considered as the most vulnerable to oxidative stress-induced damage that also impairs global sperm DNA methylation leading to sperm-associated pathologies. C677T and A1298C polymorphisms of the methylene tetrahydrofolate ... ...

    Abstract Sperm DNA is considered as the most vulnerable to oxidative stress-induced damage that also impairs global sperm DNA methylation leading to sperm-associated pathologies. C677T and A1298C polymorphisms of the methylene tetrahydrofolate reductase
    Language English
    Publishing date 2018-07-11
    Publishing country Germany
    Document type Journal Article
    ISSN 2146-4596
    ISSN 2146-4596
    DOI 10.1055/s-0038-1667037
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  8. Article: Impact of yoga based lifestyle intervention on psychological stress and quality of life in the parents of children with retinoblastoma.

    Bisht, Shilpa / Chawla, Bhavna / Tolahunase, Madhuri / Mishra, Richa / Dada, Rima

    Annals of neurosciences

    2019  Volume 26, Issue 2, Page(s) 66–74

    Abstract: Background: Childhood cancers are associated with a psychological burden to the parents and hence, decline their mental and physical health and overall quality of life.: Purpose: The purpose of the present study is to investigate the impact of 12- ... ...

    Abstract Background: Childhood cancers are associated with a psychological burden to the parents and hence, decline their mental and physical health and overall quality of life.
    Purpose: The purpose of the present study is to investigate the impact of 12-weeks yoga based lifestyle intervention on psychological stress and quality of life in the parents of children affected with retinoblastoma.
    Method: Single arm prospective clinical trial conducted from October 2015 to October 2017 at the Laboratory for Molecular Reproduction and Genetics, Department of Anatomy, All India Institute of Medical Sciences, New Delhi, India. A pre-tested 12-weeks yoga based lifestyle intervention included asanas (physical postures), pranayama (breathing exercises), dhyana (meditation), relaxation techniques, lectures and films on yoga, interactive sessions and individualized advice was administered to the participants.
    Results: 12-weeks of yoga based lifestyle intervention programme leads to a significant improvement in psychological stress and overall quality of life in the parents of retinoblastoma patients. There was a significant improvement in all the domains (physical health, psychological health, social relationships, and environment) of WHOQOL-BREF from baseline (day 0) to 12-weeks of yoga based lifestyle intervention. Yoga based lifestyle intervention also led to a significant increase in the levels of brain derived neurotrophic factor, dehydroepiandrosterone sulphate, sirtuin 1 and decreased the cortisol and IL-6 levels.
    Conclusion: Yoga based lifestyle intervention reduced the severity of psychological stress and resulted in improvement in overall quality of life and upregulation in levels of systemic biomarkers of neuroplasticity. YBLI may serve as a beneficial therapy and may also act as an effective medium for better stress management to develop better coping strategies in the parents of retinoblastoma patients.
    Language English
    Publishing date 2019-04-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2576191-2
    ISSN 0976-3260 ; 0972-7531
    ISSN (online) 0976-3260
    ISSN 0972-7531
    DOI 10.5214/ans.0972.7531.260206
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: 8-Hydroxy-2'-Deoxyguanosine in Sperm DNA and Increased Risk of Nonfamilial Sporadic Heritable Retinoblastoma in the Child

    Bisht, Shilpa / Chawla, Bhavna / Dada, Rima

    Journal of Pediatric Genetics

    2020  Volume 09, Issue 02, Page(s) 145–148

    Language English
    Publishing date 2020-01-13
    Publisher Georg Thieme Verlag KG
    Publishing place Stuttgart ; New York
    Document type Article
    ISSN 2146-460X ; 2146-4596
    ISSN (online) 2146-460X
    ISSN 2146-4596
    DOI 10.1055/s-0039-1700974
    Database Thieme publisher's database

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  10. Article ; Online: Trabeculectomy in an unsuspected extramedullary iris-ciliary body plasmacytoma.

    Selvan, Harathy / Kashyap, Seema / Sen, Seema / Chawla, Bhavna / Lomi, Neiwete / Gupta, Viney

    European journal of ophthalmology

    2020  Volume 31, Issue 5, Page(s) NP5–NP8

    Abstract: Extramedullary plasmacytoma of the iris and ciliary body is extremely rare. We present a case which was misdiagnosed as granulomatous uveitis with neovascular glaucoma, and underwent a trabeculectomy with mitomycin-c along with iris biopsy. The post- ... ...

    Abstract Extramedullary plasmacytoma of the iris and ciliary body is extremely rare. We present a case which was misdiagnosed as granulomatous uveitis with neovascular glaucoma, and underwent a trabeculectomy with mitomycin-c along with iris biopsy. The post-operative period showed early bleb failure and catastrophic growth of the suspected mass. Histopathological examination revealed a diagnosis iris plasmacytoma. Subsequent ultrasound biomicroscopy showed involvement of the iris and ciliary body. A prompt systemic workup was done, and an associated systemic plasma cell dyscrasia was ruled out. The affected eye was enucleated, and the patient remains disease free at the end of 3-year follow-up.
    MeSH term(s) Ciliary Body/diagnostic imaging ; Ciliary Body/surgery ; Humans ; Iris/diagnostic imaging ; Iris/surgery ; Microscopy, Acoustic ; Plasmacytoma/diagnostic imaging ; Plasmacytoma/surgery ; Trabeculectomy
    Language English
    Publishing date 2020-04-21
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 1089461-5
    ISSN 1724-6016 ; 1120-6721
    ISSN (online) 1724-6016
    ISSN 1120-6721
    DOI 10.1177/1120672120920225
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