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  1. Article ; Online: ASO Author Reflections: Objective Outcome Measure of Upper Limb Function Following Axillary Lymph Node Dissection and Sentinel Lymph Node Biopsy.

    Che Bakri, Nur Amalina / Kwasnicki, Richard M / Giannas, Emmanuel / Tenang, Luqman / Khan, Naairah / Moenig, Catharina / Imam, Zoha / Dhillon, Kieran / Ashrafian, Hutan / Darzi, Ara / Leff, Daniel R

    Annals of surgical oncology

    2023  Volume 30, Issue 12, Page(s) 7133–7134

    MeSH term(s) Humans ; Female ; Sentinel Lymph Node Biopsy ; Lymph Node Excision ; Lymph Nodes/pathology ; Upper Extremity/surgery ; Outcome Assessment, Health Care ; Breast Neoplasms/surgery ; Breast Neoplasms/pathology ; Axilla/pathology ; Sentinel Lymph Node
    Language English
    Publishing date 2023-07-23
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1200469-8
    ISSN 1534-4681 ; 1068-9265
    ISSN (online) 1534-4681
    ISSN 1068-9265
    DOI 10.1245/s10434-023-13984-5
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4042: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: The Use of Wearable Activity Monitors to Measure Upper Limb Physical Activity After Axillary Lymph Node Dissection and Sentinel Lymph Node Biopsy.

    Che Bakri, Nur Amalina / Kwasnicki, Richard M / Giannas, Emmanuel / Tenang, Luqman / Khan, Naairah / Moenig, Catharina / Imam, Zoha / Dhillon, Kieran / Ashrafian, Hutan / Darzi, Ara / Leff, Daniel R

    Annals of surgical oncology

    2023  Volume 30, Issue 12, Page(s) 7036–7045

    Abstract: Background: We suspect that morbidity from both sentinel lymph node biopsy (SLNB) and axillary lymph node dissection (ALND) has been inadequately evaluated to date. Current methodologies are subjective and susceptible to bias. Objective assessment using ...

    Abstract Background: We suspect that morbidity from both sentinel lymph node biopsy (SLNB) and axillary lymph node dissection (ALND) has been inadequately evaluated to date. Current methodologies are subjective and susceptible to bias. Objective assessment using wearable activity monitors (WAMs) would allow quantitative analysis of recovery by measuring physical activity (PA) and could provide evidence for axillary de-escalation.
    Patients and methods: A prospective, single center, observational study was conducted from February 2020 to May 2022. Consecutive patients undergoing breast and/or reconstructive surgery and axillary surgeries were identified from the operating schedules. Patients wore WAMs for an average of 3 days prior to surgery and up to 2 weeks following surgery. In total, 56 patients with breast cancer were recruited, of whom 35 underwent SLNB and 21 ALND.
    Results: Patients who underwent ALND experienced significantly worse PA compared with those who underwent SLNB in week 2 (median 66.4% versus 72.7%, p = 0.015). Subgroup analysis revealed significantly lower PA in simple mastectomy (Mx)-ALND versus Mx-SLNB (median 90.3% versus 70.5%, p = 0.015) in week 2. The PA for SLNB did not return to baseline at 2 weeks after surgery.
    Conclusions: Compared with SLNB, ALND results in a lower PA level in week 2. The findings also indicate that SLNB has a protracted effect on PA levels, which extend to 2 weeks postoperatively. Monitoring recovery objectively following breast cancer surgery provides patients and surgeons with more information regarding the predicted outcomes of their surgery, which can drive the development of a personalized rehabilitation program.
    MeSH term(s) Humans ; Female ; Sentinel Lymph Node Biopsy/methods ; Breast Neoplasms/surgery ; Breast Neoplasms/pathology ; Prospective Studies ; Mastectomy ; Lymphatic Metastasis ; Lymph Node Excision/methods ; Axilla/pathology ; Wearable Electronic Devices ; Sentinel Lymph Node/pathology
    Language English
    Publishing date 2023-07-28
    Publishing country United States
    Document type Observational Study ; Journal Article
    ZDB-ID 1200469-8
    ISSN 1534-4681 ; 1068-9265
    ISSN (online) 1534-4681
    ISSN 1068-9265
    DOI 10.1245/s10434-023-13966-7
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    Zs.A 4042: Show issues Location:
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    ab Jg. 2022: Lesesaal (EG)

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  3. Article ; Online: Identifying variation in the cost of abdominally based breast reconstruction in the UK.

    Kwasnicki, Richard M / Irukulla, Meghna / Che Bakri, Nur Amalina / Whiteman, Elena / Gardiner, Matthew / Dunne, Jonathan / Henry, Francis P / Gokani, Vimal / Hunter, Judith E / Williams, Georgina / Wood, Simon H

    Journal of plastic, reconstructive & aesthetic surgery : JPRAS

    2023  Volume 88, Page(s) 466–472

    Abstract: Aims: To understand variation in the cost of autologous breast reconstruction in the UK, including identifying key areas of cost variability, differences between and within units and the impact of enhanced recovery protocols (ERAS).: Methods: A micro- ...

    Abstract Aims: To understand variation in the cost of autologous breast reconstruction in the UK, including identifying key areas of cost variability, differences between and within units and the impact of enhanced recovery protocols (ERAS).
    Methods: A micro-costing study was designed based on the responses to a national survey of clinical preferences completed by the majority of plastic surgeons and anaesthetists involved in the UK. Detailed costs were estimated from macro elements such as ward and theatre running costs, down to that of surgical meshes, anaesthetic drugs and flap monitoring devices.
    Results: The largest variation in cost arose from postoperative location and length of stay, preoperative imaging and flap monitoring strategies. Plastic surgeon costs varied from £1282 to £3141, whereas anaesthetic costs were between £32 and £151 (not including salary). Estimated cost variation within units was up to £893 per case. Units with ERAS had significantly lower total costs than those without (p < 0.05).
    Conclusion: This study reveals significant cost variation in breast reconstruction in the UK based on clinician preferences. Many areas of practice driving this variation lack strong evidence of any clinical advantage. The total cost of a deep inferior epigastric perforator in the majority, if not all units, likely surpasses the national tariff for reimbursement, particularly when considering additional resource demand for immediate and bilateral breast reconstruction, as well as future symmetrisation procedures. Whilst units should look to streamline costs through ERAS, there should also be a realistic tariff that promotes excellent care.
    MeSH term(s) Humans ; Female ; Mammaplasty/methods ; Surgical Flaps/surgery ; United Kingdom ; Perforator Flap/surgery ; Breast Neoplasms/surgery ; Epigastric Arteries/surgery ; Retrospective Studies
    Language English
    Publishing date 2023-11-22
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2217750-4
    ISSN 1878-0539 ; 1748-6815 ; 0007-1226
    ISSN (online) 1878-0539
    ISSN 1748-6815 ; 0007-1226
    DOI 10.1016/j.bjps.2023.11.025
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  4. Article ; Online: Objective Assessment of Postoperative Morbidity After Breast Cancer Treatments with Wearable Activity Monitors: The "BRACELET" Study.

    Che Bakri, Nur Amalina / Kwasnicki, Richard M / Dhillon, Kieran / Khan, Naairah / Ghandour, Omar / Cairns, Alexander / Darzi, Ara / Leff, Daniel R

    Annals of surgical oncology

    2021  Volume 28, Issue 10, Page(s) 5597–5609

    Abstract: Background: Current validated tools to measure upper limb dysfunction after breast cancer treatment, such as questionnaires, are prone to recall bias and do not enable comparisons between patients. This study aimed to test the feasibility of wearable ... ...

    Abstract Background: Current validated tools to measure upper limb dysfunction after breast cancer treatment, such as questionnaires, are prone to recall bias and do not enable comparisons between patients. This study aimed to test the feasibility of wearable activity monitors (WAMs) for achieving a continuous, objective assessment of functional recovery by measuring peri-operative physical activity (PA).
    Methods: A prospective, single-center, non-randomized, observational study was conducted. Patients undergoing breast and axillary surgery were invited to wear WAMs on both wrists in the peri-operative period and then complete upper limb function (DASH) and quality-of-life (EQ-5D-5L) questionnaires. Statistical analyses were performed to determine the construct validity and concurrent validity of WAMs.
    Results: The analysis included 39 patients with a mean age of 55 ± 13.2 years. Regain of function on the surgically treated side was observed to be an increase of arm activity as a percentage of preoperative levels, with the greatest increase observed between the postoperative days 1 and 2. The PA was significantly greater on the side not treated by surgery than on the surgically treated side after week 1 (mean PA, 75.8% vs. 62.3%; p < 0.0005) and week 2 (mean PA, 91.6% vs. 77.4%; p < 0.005). Subgroup analyses showed differences in recovery trends between different surgical procedures. Concurrent validity was demonstrated by a significant negative moderate correlation between the PA and DASH questionnaires (R = -0.506; p < 0.05).
    Conclusion: This study demonstrated the feasibility and validity of WAMs to objectively measure postoperative recovery of upper limb function after breast surgery, providing a starting point for personalized rehabilitation through early detection of upper limb physical morbidity.
    MeSH term(s) Adult ; Aged ; Breast Neoplasms/surgery ; Female ; Humans ; Mastectomy ; Middle Aged ; Morbidity ; Prospective Studies ; Quality of Life ; Surveys and Questionnaires ; Wearable Electronic Devices
    Language English
    Publishing date 2021-07-26
    Publishing country United States
    Document type Journal Article ; Observational Study
    ZDB-ID 1200469-8
    ISSN 1534-4681 ; 1068-9265
    ISSN (online) 1534-4681
    ISSN 1068-9265
    DOI 10.1245/s10434-021-10458-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4042: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  5. Article ; Online: ASO Author Reflections: Improving Management of Upper Limb Complications after Breast Cancer Treatments.

    Che Bakri, Nur Amalina / Kwasnicki, Richard M / Dhillon, Kieran / Khan, Naairah / Ghandour, Omar / Cairns, Alexander / Darzi, Ara / Leff, Daniel R

    Annals of surgical oncology

    2021  Volume 29, Issue Suppl 3, Page(s) 566–567

    MeSH term(s) Humans ; Female ; Breast Neoplasms/therapy ; Breast ; Upper Extremity
    Language English
    Publishing date 2021-08-24
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 1200469-8
    ISSN 1534-4681 ; 1068-9265
    ISSN (online) 1534-4681
    ISSN 1068-9265
    DOI 10.1245/s10434-021-10603-z
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4042: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  6. Article ; Online: Impact of Axillary Lymph Node Dissection and Sentinel Lymph Node Biopsy on Upper Limb Morbidity in Breast Cancer Patients: A Systematic Review and Meta-Analysis.

    Che Bakri, Nur Amalina / Kwasnicki, Richard M / Khan, Naairah / Ghandour, Omar / Lee, Alice / Grant, Yasmin / Dawidziuk, Aleksander / Darzi, Ara / Ashrafian, Hutan / Leff, Daniel R

    Annals of surgery

    2022  Volume 277, Issue 4, Page(s) 572–580

    Abstract: Objective: To evaluate the impact of axillary lymph node dissection (ALND) and sentinel lymph node biopsy (SLNB) on upper limb (UL) morbidity in breast cancer patients.: Background: Axillary de-escalation is motivated by a desire to reduce harm of ... ...

    Abstract Objective: To evaluate the impact of axillary lymph node dissection (ALND) and sentinel lymph node biopsy (SLNB) on upper limb (UL) morbidity in breast cancer patients.
    Background: Axillary de-escalation is motivated by a desire to reduce harm of ALND. Understanding the impact of axillary surgery and disparities in operative procedures on postoperative arm morbidity would better direct resources to the point of need and cement the need for de-escalation strategies.
    Methods: Embase, MEDLINE, CINAHL, and PsychINFO were searched from 1990 until March 2020. Included studies were randomized-controlled and observational studies focusing on UL morbidities, in breast surgery patients. The study followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. The prevalence of UL morbidity comparing SLNB and ALND at <12 months, 12 to 24 months, and beyond 24 months were analyzed.
    Results: Sixty-seven studies were included. All studies reported a higher rate of lymphedema and pain after ALND compared with SLNB. The difference in lymphedema and pain prevalence between SLNB and ALND was 13.7% (95% confidence interval: 10.5-16.8, P <0.005) and 24.2% (95% confidence interval: 12.1-36.3, P <0.005), respectively. Pooled estimates for prevalence of reduced strength and range of motion after SLNB and ALND were 15.2% versus 30.9% and 17.1% versus 29.8%, respectively. Type of axillary surgery, greater body mass index, and radiotherapy were some of the predictors for UL morbidities.
    Conclusions: Prevalence of lymphedema after ALND was higher than previously estimated. ALND patients experienced greater rates of lymphedema, pain, reduced strength, and range of motion compared with SLNB. The findings support the continued drive to de-escalate axillary surgery.
    MeSH term(s) Humans ; Female ; Sentinel Lymph Node Biopsy/adverse effects ; Sentinel Lymph Node Biopsy/methods ; Breast Neoplasms/surgery ; Breast Neoplasms/pathology ; Lymph Node Excision/adverse effects ; Lymph Node Excision/methods ; Morbidity ; Lymphedema/epidemiology ; Lymphedema/etiology ; Axilla ; Pain ; Lymph Nodes/pathology ; Sentinel Lymph Node/pathology ; Randomized Controlled Trials as Topic
    Language English
    Publishing date 2022-08-10
    Publishing country United States
    Document type Meta-Analysis ; Systematic Review ; Journal Article
    ZDB-ID 340-2
    ISSN 1528-1140 ; 0003-4932
    ISSN (online) 1528-1140
    ISSN 0003-4932
    DOI 10.1097/SLA.0000000000005671
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Uk I Zs.35/1: Show issues Location:
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  7. Article ; Online: The effect of TRV027 on coagulation in COVID-19: A pilot randomized, placebo-controlled trial.

    Robbins, Alexander J / Che Bakri, Nur Amalina / Toke-Bjolgerud, Edward / Edwards, Aaron / Vikraman, Asha / Michalsky, Cathy / Fossler, Michael / Lemm, Nana-Marie / Medhipour, Savviz / Budd, William / Gravani, Athanasia / Hurley, Lisa / Kapil, Vikas / Jackson, Aimee / Lonsdale, Dagan / Latham, Victoria / Laffan, Michael / Chapman, Neil / Cooper, Nichola /
    Szydlo, Richard / Boyle, Joseph / Pollock, Katrina M / Owen, David

    British journal of clinical pharmacology

    2022  Volume 89, Issue 4, Page(s) 1495–1501

    Abstract: COVID-19 causes significant thrombosis and coagulopathy, with elevated D-dimer a predictor of adverse outcome. The precise mechanism of this coagulopathy remains unclear; one hypothesis is that loss of angiotensin-converting enzyme 2 activity during ... ...

    Abstract COVID-19 causes significant thrombosis and coagulopathy, with elevated D-dimer a predictor of adverse outcome. The precise mechanism of this coagulopathy remains unclear; one hypothesis is that loss of angiotensin-converting enzyme 2 activity during viral endocytosis leads to pro-inflammatory angiotensin-II accumulation, loss of angiotensin-1-7 and subsequent vascular endothelial activation. We undertook a double-blind randomized, placebo-controlled experimental medicine study to assess the effect of TRV027, a synthetic angiotensin-1-7 analogue on D-dimer in 30 patients admitted to hospital with COVID-19. The study showed a similar rate of adverse events in TRV027 and control groups. There was a numerical decrease in D-dimer in the TRV027 group and increase in D-dimer in the placebo group; however, this did not reach statistical significance (P = .15). A Bayesian analysis demonstrated that there was a 92% probability that this change represented a true drug effect.
    MeSH term(s) Humans ; COVID-19 ; Bayes Theorem ; Pilot Projects ; Blood Coagulation Disorders ; Angiotensins ; Double-Blind Method ; Treatment Outcome
    Chemical Substances Sar-Arg-Val-Tyr-Ile-His-Pro-Ala-OH (J1J4P3PQZD) ; Angiotensins
    Language English
    Publishing date 2022-12-14
    Publishing country England
    Document type Randomized Controlled Trial ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 188974-6
    ISSN 1365-2125 ; 0306-5251 ; 0264-3774
    ISSN (online) 1365-2125
    ISSN 0306-5251 ; 0264-3774
    DOI 10.1111/bcp.15618
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