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  1. Article: High lactic acid levels in the brain contribute to the generation of focal slowing on the electroencephalogram.

    Chegodaev, Dmitry Alexandrovich / Pavlova, Polina Alekseevna

    Frontiers in neurology

    2024  Volume 15, Page(s) 1393274

    Abstract: Focal slowing on the EEG is often associated with structural pathology of the brain. Despite the clinical significance of focal slowing, the actual electrochemical mechanisms underlying this EEG phenomenon are still poorly understood. This paper briefly ... ...

    Abstract Focal slowing on the EEG is often associated with structural pathology of the brain. Despite the clinical significance of focal slowing, the actual electrochemical mechanisms underlying this EEG phenomenon are still poorly understood. This paper briefly reviews the role of lactate in the pathogenesis of brain disorders that are primarily related to focal EEG slowing. An attempt is made to trace the hypothetical link between this EEG pattern and focal cerebral tissue lactacidosis.
    Language English
    Publishing date 2024-04-17
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2564214-5
    ISSN 1664-2295
    ISSN 1664-2295
    DOI 10.3389/fneur.2024.1393274
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: A psychometric study of the Russian-language version of the "Bayley Scales of Infant and Toddler Development-third edition": An assessment of reliability and validity.

    Pavlova, Polina / Maksimov, Dmitry / Chegodaev, Dmitry / Kiselev, Sergey

    Frontiers in psychology

    2022  Volume 13, Page(s) 961567

    Abstract: Introduction: The Bayley Scales of Infant and Toddler Development-third edition (Bayley-III) is one of the most widely used tools for assessing child development, and adapted versions of this instrument have been successfully used in many countries. No ... ...

    Abstract Introduction: The Bayley Scales of Infant and Toddler Development-third edition (Bayley-III) is one of the most widely used tools for assessing child development, and adapted versions of this instrument have been successfully used in many countries. No comprehensive psychometric studies of the Bayley-III have yet been performed in Russia.
    Materials and methods: This psychometric study was part of the longitudinal study conducted by the Ural Federal University in 2016-2020. Within the project, the original Bayley-III manual was translated into Russian and then used in a cohort of 333 infants to assess cognition, expressive/receptive communication, and fine/gross motor skills. For the purpose of psychometric analysis, we selected the data for four age groups of children from the longitudinal study database: 4-6 months (
    Results: The average scaled scores of the examined children were generally comparable with the original (US) Bayley-III norms, with the exception of those older than 1 year, who demonstrated 1.2-1.9 points better performance in cognitive development and gross motor skills and 0.9-2.6 points lower performance in expressive communication. The correlation of both raw and scaled scores between different scales was low to moderate in all age groups (Spearman's ρ mostly within the range of 0.3-0.6;
    Conclusion: The Russian version of the Bayley-III proved to be a psychometrically valid and reliable tool for assessing child development, at least in a research context. The development of the examined children was close to the original US norms, with some deviation in cognitive, gross motor, and expressive communication scores mostly in older children, which could be attributed to the biased sample.
    Language English
    Publishing date 2022-09-02
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2563826-9
    ISSN 1664-1078
    ISSN 1664-1078
    DOI 10.3389/fpsyg.2022.961567
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: More than just immaturity: evidence supporting the hypothesis that sleep spindle characteristics reflect GABAergic depolarization in infancy.

    Chegodaev, Dmitry / Pavlova, Polina / Kiselev, Sergey

    Sleep science (Sao Paulo, Brazil)

    2022  Volume 15, Issue 4, Page(s) 459–462

    Abstract: Sleep spindles are thalamocortical oscillations with waxing-waning morphology, which comprise the key electroencephalographic (EEG) hallmark of stage 2 non-rapid eye movement sleep. The functional role of sleep spindles is not sufficiently clear, but ... ...

    Abstract Sleep spindles are thalamocortical oscillations with waxing-waning morphology, which comprise the key electroencephalographic (EEG) hallmark of stage 2 non-rapid eye movement sleep. The functional role of sleep spindles is not sufficiently clear, but there is a large body of literature that indicates the relationship between spindle activity and neural plasticity. Many of the spindle parameters (frequency, configuration, duration, density, and topography) vary significantly throughout life. However, the long duration, asynchrony and sharp morphology are the most distinctive characteristics of sleep spindles in infants. This unique infantile phenotype of sleep spindles typically changes after approximately one year of postnatal life in humans. Considering that EEG reflects brain electrochemical activity, there is evidence to suggest that substantial neurochemical events underlie these changes. In this paper, we hypothesize that the GABA (gamma-aminobutyric acid) shift is a key event influencing the sleep spindle phenotype during infancy. We briefly review evidence for the relation between infantile sleep spindles and depolarizing GABA transmission occurring in the developing brain.
    Language English
    Publishing date 2022-11-07
    Publishing country Brazil
    Document type Journal Article
    ZDB-ID 2697016-8
    ISSN 1984-0063 ; 1984-0659
    ISSN (online) 1984-0063
    ISSN 1984-0659
    DOI 10.5935/1984-0063.20220079
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: More than just immaturity: evidence supporting the hypothesis that sleep spindle characteristics reflect GABAergic depolarization in infancy

    Chegodaev, Dmitry / Pavlova, Polina / Kiselev, Sergey

    Sleep Science

    2022  Volume 15, Issue 04, Page(s) 459–462

    Abstract: Sleep spindles are thalamocortical oscillations with waxing-waning morphology, which comprise the key electroencephalographic (EEG) hallmark of stage 2 non-rapid eye movement sleep. The functional role of sleep spindles is not sufficiently clear, but ... ...

    Abstract Sleep spindles are thalamocortical oscillations with waxing-waning morphology, which comprise the key electroencephalographic (EEG) hallmark of stage 2 non-rapid eye movement sleep. The functional role of sleep spindles is not sufficiently clear, but there is a large body of literature that indicates the relationship between spindle activity and neural plasticity. Many of the spindle parameters (frequency, configuration, duration, density, and topography) vary significantly throughout life. However, the long duration, asynchrony and sharp morphology are the most distinctive characteristics of sleep spindles in infants. This unique infantile phenotype of sleep spindles typically changes after approximately one year of postnatal life in humans. Considering that EEG reflects brain electrochemical activity, there is evidence to suggest that substantial neurochemical events underlie these changes. In this paper, we hypothesize that the GABA (gamma-aminobutyric acid) shift is a key event influencing the sleep spindle phenotype during infancy. We briefly review evidence for the relation between infantile sleep spindles and depolarizing GABA transmission occurring in the developing brain.
    Keywords Electroencephalography ; Sleep ; Infant ; GABA-A Receptor Agonists
    Language English
    Publishing date 2022-12-01
    Publisher Thieme Revinter Publicações Ltda.
    Publishing place Stuttgart ; New York
    Document type Article
    ZDB-ID 2697016-8
    ISSN 1984-0063 ; 1984-0659 ; 1984-0063
    ISSN (online) 1984-0063
    ISSN 1984-0659 ; 1984-0063
    DOI 10.5935/1984-0063.20220079
    Database Thieme publisher's database

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  5. Article ; Online: LPDs - «Linked to penumbra» discharges or EEG correlate of excitotoxicity: A review based hypothesis.

    Chegodaev, Dmitry / Pavlova, Nadezhda V / Pavlova, Polina / Lvova, Olga

    Epilepsy research

    2020  Volume 166, Page(s) 106429

    Abstract: Periodic lateralized epileptiform discharges (PLEDs) or lateralized periodic discharges (LPDs) are a well-known variant of pathological EEG activity. However, the mechanisms underpinning the appearance of this pattern are not completely understood. The ... ...

    Abstract Periodic lateralized epileptiform discharges (PLEDs) or lateralized periodic discharges (LPDs) are a well-known variant of pathological EEG activity. However, the mechanisms underpinning the appearance of this pattern are not completely understood. The heterogeneity of the features derived from LPDs patterns, and the wide range of pathological conditions in which they occur, raise a question about the unifying mechanisms underlying these phenomena. This paper reassesses the current opinion surrounding LPDs which considers glutamate excitotoxicity to be the primary pathophysiological basis, and the penumbral region to be the main morphological substrate. Arguments in favour of this hypothesis are presented, with interpretations supported by evidence from recent literature involving clinical and experimental data. Presently, no single hypothesis places considerable emphasis on the pathochemical properties of LPDs, which are implicitly meaningful towards better understanding of the clinical significance of this pattern.
    MeSH term(s) Animals ; Brain/physiopathology ; Electroencephalography/methods ; Electroencephalography/trends ; Epilepsy/diagnosis ; Epilepsy/physiopathology ; Functional Laterality/physiology ; Humans ; Periodicity
    Language English
    Publishing date 2020-07-15
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 632939-1
    ISSN 1872-6844 ; 0920-1211
    ISSN (online) 1872-6844
    ISSN 0920-1211
    DOI 10.1016/j.eplepsyres.2020.106429
    Database MEDical Literature Analysis and Retrieval System OnLINE

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