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  1. Article: Headache: contrast between childhood and adult pain.

    Chen, Andrew C N

    International journal of adolescent medicine and health

    2011  Volume 6, Issue 2, Page(s) 75–94

    Language English
    Publishing date 2011-05-18
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 639287-8
    ISSN 2191-0278 ; 0334-0139
    ISSN (online) 2191-0278
    ISSN 0334-0139
    DOI 10.1515/IJAMH.1993.6.2.75
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    Zs.B 3178: Show issues Location:
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  2. Article ; Online: Nicotinamide and the skin.

    Chen, Andrew C / Damian, Diona L

    The Australasian journal of dermatology

    2014  Volume 55, Issue 3, Page(s) 169–175

    Abstract: Nicotinamide, an amide form of vitamin B3, boosts cellular energy and regulates poly-ADP-ribose-polymerase 1, an enzyme with important roles in DNA repair and the expression of inflammatory cytokines. Nicotinamide shows promise for the treatment of a ... ...

    Abstract Nicotinamide, an amide form of vitamin B3, boosts cellular energy and regulates poly-ADP-ribose-polymerase 1, an enzyme with important roles in DNA repair and the expression of inflammatory cytokines. Nicotinamide shows promise for the treatment of a wide range of dermatological conditions, including autoimmune blistering disorders, acne, rosacea, ageing skin and atopic dermatitis. In particular, recent studies have also shown it to be a potential agent for reducing actinic keratoses and preventing skin cancers.
    MeSH term(s) Acne Vulgaris/drug therapy ; Animals ; Autoimmune Diseases/drug therapy ; Carcinogenesis/drug effects ; Carcinogenesis/radiation effects ; Dermatitis, Atopic/drug therapy ; Humans ; Keratosis, Actinic/drug therapy ; Niacinamide/therapeutic use ; Rosacea/drug therapy ; Skin Aging/drug effects ; Skin Diseases, Vesiculobullous/drug therapy ; Skin Neoplasms/prevention & control ; Ultraviolet Rays/adverse effects ; Vitamin B Complex/therapeutic use
    Chemical Substances Vitamin B Complex (12001-76-2) ; Niacinamide (25X51I8RD4)
    Language English
    Publishing date 2014-08
    Publishing country Australia
    Document type Journal Article ; Review
    ZDB-ID 138052-7
    ISSN 1440-0960 ; 0004-8380
    ISSN (online) 1440-0960
    ISSN 0004-8380
    DOI 10.1111/ajd.12163
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    Zs.A 236: Show issues Location:
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  3. Article ; Online: Adhesion Molecules as Potential Novel Biomarkers for Opioid Dependence.

    Liu, Yu-Li / Kuo, Hsiang-Wei / Fang, Chiu-Ping / Tsung, Jieh-Hen / Chen, Andrew C H

    Current pharmaceutical design

    2020  Volume 26, Issue 2, Page(s) 253–259

    Abstract: Background: Cell-cell adhesion is essential in maintaining the structure and function of an organ. Several adhesion molecules have recently been identified as associated with heroin dependence in both genetic and peripheral plasma studies.: Methods ... ...

    Abstract Background: Cell-cell adhesion is essential in maintaining the structure and function of an organ. Several adhesion molecules have recently been identified as associated with heroin dependence in both genetic and peripheral plasma studies.
    Methods and results: We reviewed literature concerning studies on adhesion molecules in opioid addictions in rodents and human, including human genetic associations in different ethnic groups, and treatment responses to methadone maintenance treatment in heroin-dependent patients.
    Conclusion: Some important and novel findings were summarized and discussed. Adhesion molecules in the peripheral plasma, e.g., cadherin-2 (CDH2), may be biomarkers for both methadone treatment outcome and nectin 4 may be an indicator for continued opioid use. Neural cell adhesion molecule (NCAM) in the central nervous system may regulate opioid withdrawal and analgesic responses. Future studies to uncover the mechanisms underlying the involvement of adhesion molecules in the pathological process of addictions will be an important research direction in the field.
    MeSH term(s) Biomarkers/blood ; Cadherins/blood ; Humans ; Methadone/therapeutic use ; Neural Cell Adhesion Molecules/blood ; Opioid-Related Disorders/diagnosis ; Opioid-Related Disorders/drug therapy
    Chemical Substances Biomarkers ; Cadherins ; Neural Cell Adhesion Molecules ; Methadone (UC6VBE7V1Z)
    Language English
    Publishing date 2020-01-31
    Publishing country United Arab Emirates
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 1304236-1
    ISSN 1873-4286 ; 1381-6128
    ISSN (online) 1873-4286
    ISSN 1381-6128
    DOI 10.2174/1381612826666200116144147
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    Zs.A 4714: Show issues Location:
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  4. Article ; Online: Auricular neural stimulation as a new non-invasive treatment for opioid detoxification.

    Qureshi, Imran S / Datta-Chaudhuri, Timir / Tracey, Kevin J / Pavlov, Valentin A / Chen, Andrew C H

    Bioelectronic medicine

    2020  Volume 6, Page(s) 7

    Abstract: The recent opioid crisis is one of the rising challenges in the history of modern health care. New and effective treatment modalities with less adverse effects to alleviate and manage this modern epidemic are critically needed. The FDA has recently ... ...

    Abstract The recent opioid crisis is one of the rising challenges in the history of modern health care. New and effective treatment modalities with less adverse effects to alleviate and manage this modern epidemic are critically needed. The FDA has recently approved two non-invasive electrical nerve stimulators for the adjunct treatment of symptoms of acute opioid withdrawal. These devices, placed behind the ear, stimulate certain cranial nerves with auricular projections. This neural stimulation reportedly generates a prompt effect in terms of alleviation of withdrawal symptoms resulting from acute discontinuation of opioid use. Current experimental evidence indicates that this type of non-invasive neural stimulation has excellent potential to supplement medication assisted treatment in opioid detoxification with lower side effects and increased adherence to treatment. Here, we review current findings supporting the use of non-invasive neural stimulation in detoxification from opioid use. We briefly outline the neurophysiology underlying this approach of auricular electrical neural stimulation and its role in enhancing medication assisted treatment in treating symptoms of opioid withdrawal. Considering the growing deleterious impact of addictive disorders on our society, further studies on this emerging treatment modality are warranted.
    Language English
    Publishing date 2020-03-30
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2929561-0
    ISSN 2332-8886 ; 2332-8886
    ISSN (online) 2332-8886
    ISSN 2332-8886
    DOI 10.1186/s42234-020-00044-6
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  5. Article ; Online: Nicotinamide for Skin-Cancer Chemoprevention.

    Chen, Andrew C / Martin, Andrew J / Damian, Diona L

    The New England journal of medicine

    2016  Volume 374, Issue 8, Page(s) 790

    MeSH term(s) Carcinoma, Basal Cell/prevention & control ; Carcinoma, Squamous Cell/prevention & control ; Female ; Humans ; Keratosis, Actinic/prevention & control ; Male ; Niacinamide/therapeutic use ; Skin Neoplasms/prevention & control ; Vitamin B Complex/therapeutic use
    Chemical Substances Vitamin B Complex (12001-76-2) ; Niacinamide (25X51I8RD4)
    Language English
    Publishing date 2016-02-25
    Publishing country United States
    Document type Comment ; Letter
    ZDB-ID 207154-x
    ISSN 1533-4406 ; 0028-4793
    ISSN (online) 1533-4406
    ISSN 0028-4793
    DOI 10.1056/NEJMc1514791
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  6. Article ; Online: Acetylcholinesterase of Stomoxys calcitrans (L.) (Diptera: Muscidae): cDNA sequence, baculovirus expression, and biochemical properties.

    Temeyer, Kevin B / Chen, Andrew C

    Veterinary parasitology

    2012  Volume 184, Issue 1, Page(s) 92–95

    Abstract: A 2193-nucleotide cDNA encoding acetylcholinesterase (AChE) of the stable fly, Stomoxys calcitrans (L.) was sequenced and expressed in the baculovirus system. The open reading frame encoded a 91 amino acid secretion signal peptide and a 613 amino acid ... ...

    Abstract A 2193-nucleotide cDNA encoding acetylcholinesterase (AChE) of the stable fly, Stomoxys calcitrans (L.) was sequenced and expressed in the baculovirus system. The open reading frame encoded a 91 amino acid secretion signal peptide and a 613 amino acid mature protein with 96% and 94% identity to the AChEs of Haematobia irritans (L.) and Musca domestica (L.), respectively. Structural characteristics of M. domestica, H. irritans, and Drosophila melanogaster AChEs were conserved in the S. calcitrans AChE. The recombinant enzyme was inhibited by eserine, coroxon, and paraoxon and exhibited K(m) values of 63.9μM for acetylthiocholine and 96.7μM for butyrylthiocholine, confirming its biochemical identity as an acetylcholinesterase (EC 3.1.1.7). These data will enable rapid identification and assay for mutations that reduce AChE sensitivity to organophosphate (OP) pesticides, potentially aiding resistance management efforts to prevent fixation of the mutations in pest populations.
    MeSH term(s) Acetylcholinesterase/genetics ; Acetylcholinesterase/metabolism ; Amino Acid Sequence ; Animals ; Baculoviridae/genetics ; Base Sequence ; Enzyme Activation/drug effects ; Enzyme Inhibitors/pharmacology ; Molecular Sequence Data ; Muscidae/enzymology ; Muscidae/genetics ; Recombinant Proteins/metabolism ; Sequence Homology, Amino Acid
    Chemical Substances Enzyme Inhibitors ; Recombinant Proteins ; Acetylcholinesterase (EC 3.1.1.7)
    Language English
    Publishing date 2012-02-28
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 196831-2
    ISSN 1873-2550 ; 0304-4017
    ISSN (online) 1873-2550
    ISSN 0304-4017
    DOI 10.1016/j.vetpar.2011.08.007
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    Zs.A 4380: Show issues Location:
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  7. Article ; Online: Association of the D-amino acid oxidase gene with methadone dose in heroin dependent patients under methadone maintenance treatment.

    Liu, Tung-Hsia / Tsou, Hsiao-Hui / Chung, Ren-Hua / Liu, Shu Chih / Wang, Sheng-Chang / Kuo, Hsiang-Wei / Fang, Chiu-Ping / Chen, Andrew C H / Liu, Yu-Li

    Journal of human genetics

    2022  Volume 67, Issue 5, Page(s) 273–278

    Abstract: Methadone is a synthetic opioid used for the maintenance treatment (MMT) of heroin dependence. It primarily binds to the μ-opioid receptor (MOR; with its gene, namely OPRM1). Methadone is also an N-methyl-D-aspartate (NMDA) receptor antagonist. The role ... ...

    Abstract Methadone is a synthetic opioid used for the maintenance treatment (MMT) of heroin dependence. It primarily binds to the μ-opioid receptor (MOR; with its gene, namely OPRM1). Methadone is also an N-methyl-D-aspartate (NMDA) receptor antagonist. The role of NMDA receptor in the regulatory mechanisms of methadone dosage in heroin dependent patients is so far not clear. D-amino acid oxidase (DAO) is an important enzyme that indirectly activates the NMDA receptor through its effect on the D-serine level. To test the hypothesis that genetic polymorphisms in the DAO gene are associated with methadone treatment dose and responses, we selected four single nucleotide polymorphisms (SNPs) in DAO from the literature reports of the Taiwanese population. SNPs were genotyped in 344 MMT patients. In this study, we identified a functional SNP rs55944529 in the DAO gene that reveals a modest but significant association with the methadone dosage in the recessive model of analysis (P = 0.003) and plasma concentrations (P = 0.003) in MMT patients. However, it did not show association with plasma methadone concentration in multiple linear regression analysis. It is also associated with the methadone adverse reactions of dry mouth (P = 0.002), difficulty with urination (P = 0.0003) in the dominant model, and the withdrawal symptoms of yawning (P = 0.005) and gooseflesh skin (P = 0.004) in the recessive model. Our results suggest a role of the indirect regulatory mechanisms of the NMDA reporter, possibly via the DAO genetic variants, in the methadone dose and some adverse reactions in MMT patients.
    MeSH term(s) Heroin ; Humans ; Methadone/adverse effects ; N-Methylaspartate/genetics ; Oxidoreductases/genetics ; Polymorphism, Single Nucleotide ; Receptors, N-Methyl-D-Aspartate/genetics
    Chemical Substances Receptors, N-Methyl-D-Aspartate ; N-Methylaspartate (6384-92-5) ; Heroin (70D95007SX) ; Oxidoreductases (EC 1.-) ; Methadone (UC6VBE7V1Z)
    Language English
    Publishing date 2022-01-04
    Publishing country England
    Document type Journal Article
    ZDB-ID 1425192-9
    ISSN 1435-232X ; 1434-5161
    ISSN (online) 1435-232X
    ISSN 1434-5161
    DOI 10.1038/s10038-021-01008-7
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    Zs.A 201: Show issues Location:
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  8. Article ; Online: Delayed finger tapping and cognitive responses in preterm-born male teenagers with mild spastic diplegia.

    Gao, Fei / Mei, Xi / Chen, Andrew C N

    Pediatric neurology

    2015  Volume 52, Issue 2, Page(s) 206–213

    Abstract: Background: Information on fine motor and basic cognitive functions in spastic diplegia is sparse in the literature. The aim of this study was to investigate index finger's tapping speed and cognitive functions in categorization and old/new recognition ... ...

    Abstract Background: Information on fine motor and basic cognitive functions in spastic diplegia is sparse in the literature. The aim of this study was to investigate index finger's tapping speed and cognitive functions in categorization and old/new recognition of pictures in patients with mild spastic diplegia.
    Methods: Fifteen preterm-born male teenagers with mild spastic diplegia and 15 healthy male teenagers participated in this study. Finger-tapping tests and cognitive tests were performed on all participants. Outcomes were compared between the two groups.
    Results: In the finger-tapping tests, the tapping speed was significantly slower in patients than in controls. In the tests of tapping one key persistently and tapping two keys alternately, the reaction time gaps between the left and right digits were larger in patients than in controls. In the categorization tests, the accuracies and reaction times for animal/plant and girl face pictures, but not for boy face pictures, were significantly worse in patients than in controls. In the recognition tests, the accuracies for old/new, animal/plant, and boy/girl face pictures were significantly lower in patients than in controls. The reaction times for old/new, animal/plant, and new face pictures, but not for old face pictures, were significantly longer in patients compared with controls.
    Conclusions: Our results demonstrate delayed finger tapping and cognitive responses in preterm-born male teenagers with mild spastic diplegia. Our experimental paradigm is sensitive for the study of fine motor and cognitive functions between patients and healthy controls.
    MeSH term(s) Adolescent ; Brain/pathology ; Cerebral Palsy/complications ; Child ; Cognition Disorders/etiology ; Fingers/physiopathology ; Functional Laterality ; Humans ; Magnetic Resonance Imaging ; Male ; Neuropsychological Tests ; Premature Birth/physiopathology ; Psychomotor Disorders/etiology ; Reaction Time ; Statistics, Nonparametric ; Young Adult
    Language English
    Publishing date 2015-02
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 639164-3
    ISSN 1873-5150 ; 0887-8994
    ISSN (online) 1873-5150
    ISSN 0887-8994
    DOI 10.1016/j.pediatrneurol.2014.04.012
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    Zs.A 2260: Show issues Location:
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  9. Article ; Online: Repetitive Transcranial Magnetic Stimulation for the Recovery of Stroke Patients With Disturbance of Consciousness.

    Xie, Ying / Zhang, Tong / Chen, Andrew C N

    Brain stimulation

    2015  Volume 8, Issue 3, Page(s) 674–675

    Language English
    Publishing date 2015-05
    Publishing country United States
    Document type Letter
    ZDB-ID 2394410-9
    ISSN 1876-4754 ; 1935-861X
    ISSN (online) 1876-4754
    ISSN 1935-861X
    DOI 10.1016/j.brs.2015.01.406
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  10. Article ; Online: Influence of propofol on the electroencephalogram default mode network in patients of advanced age.

    Ke, Jing-Dong / Xu, Min / Wang, Pei-Pei / Wang, Min / Tian, Ming / Chen, Andrew C N

    The Journal of international medical research

    2018  Volume 46, Issue 11, Page(s) 4660–4668

    Abstract: Objective: This study was performed to evaluate the effects of propofol on the electroencephalogram (EEG) default mode network (DMN) in patients of advanced age.: Methods: Fifteen men aged >60 years (mean, 70 years) were selected. Propofol target- ... ...

    Abstract Objective: This study was performed to evaluate the effects of propofol on the electroencephalogram (EEG) default mode network (DMN) in patients of advanced age.
    Methods: Fifteen men aged >60 years (mean, 70 years) were selected. Propofol target-controlled infusion was performed under EEG bispectral index monitoring. The propofol target effect-site concentration, blood pressure, heart rate, and distributions and powers of the EEG spectrum were recorded in an awake state and under anesthesia. The EEG included seven bands: delta (0.5-3.5 Hz), theta (4.0-7.0 Hz), alpha-1 (7.5-9.5 Hz), alpha-2 (10-12 Hz), beta-1 (13-23 Hz), beta-2 (24-34 Hz), and gamma (35-45 Hz).
    Results: From an awake state to anesthesia, the brain topographic map showed that the energies of delta, theta, alpha-1, alpha-2, and beta-1 were concentrated in the frontoparietal site, and the power increased significantly. The energy distribution of beta-2 was significantly decreased and the power significantly reduced. The energy distribution of gamma in the temporal lobe was also markedly decreased and the power significantly reduced.
    Conclusions: This study revealed the changes in the spatial distribution and regional energy of the EEG DMD in men of advanced age from the awake state to the anesthetized state.
    MeSH term(s) Aged ; Anesthesia ; Brain Mapping ; Brain Waves/drug effects ; Brain Waves/physiology ; Consciousness Monitors ; Electrodes ; Electroencephalography ; Humans ; Male ; Middle Aged ; Nerve Net/drug effects ; Nerve Net/physiology ; Propofol/pharmacology ; Wakefulness/drug effects
    Chemical Substances Propofol (YI7VU623SF)
    Language English
    Publishing date 2018-09-23
    Publishing country England
    Document type Clinical Trial ; Journal Article
    ZDB-ID 184023-x
    ISSN 1473-2300 ; 0300-0605 ; 0142-2596
    ISSN (online) 1473-2300
    ISSN 0300-0605 ; 0142-2596
    DOI 10.1177/0300060518788241
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