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  1. Article: Adjuvant therapy for rare rectal gastrointestinal stromal tumors: A case report.

    Chu, Ting-Yi / Pu, Ta-Wei / Chen, Chao-Yang

    Clinical case reports

    2024  Volume 12, Issue 4, Page(s) e8774

    Abstract: Key clinical message: Anorectal gastrointestinal stromal tumors are extremely rare, constituting less than 0.1% of rectal tumors. Surgical resection using a transanal wide excision followed by adjuvant therapy with tyrosine kinase inhibitors can be a ... ...

    Abstract Key clinical message: Anorectal gastrointestinal stromal tumors are extremely rare, constituting less than 0.1% of rectal tumors. Surgical resection using a transanal wide excision followed by adjuvant therapy with tyrosine kinase inhibitors can be a successful treatment combination to remove the mass and prevent recurrence while preserving the integrity of the anal sphincter.
    Abstract: Gastrointestinal stromal tumors (GISTs) are a rare subset of neoplasms, accounting for about 1%-2% of primary gastrointestinal malignancies. The stomach is the most common site for GISTs, with anorectal GISTs being exceptionally rare, representing only 0.1% of all rectal tumors. The standard approach for managing localized GIST involves complete surgical excision to achieve negative microscopic margins (R0) while preserving the tumor capsule and maintaining anal sphincter function. Surgical resection with transanal wide excision followed by adjuvant therapy using tyrosine kinase inhibitors can successfully remove the mass, prevent recurrence, and preserve the anal sphincter's integrity. Adjuvant therapy with imatinib is the recommended treatment for all localized GISTs assessed to have an intermediate or high risk of relapse. Here, we report a case of a 63-year-old male with a rectal GIST who underwent transanal wide excision followed by adjuvant therapy with tyrosine kinase inhibitors.
    Language English
    Publishing date 2024-04-16
    Publishing country England
    Document type Case Reports
    ZDB-ID 2740234-4
    ISSN 2050-0904
    ISSN 2050-0904
    DOI 10.1002/ccr3.8774
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Atrial Fibrillation After mRNA-1273 SARS-CoV-2 Vaccination: Case Report with Literature Review.

    Chen, Chao-Yang / Hsieh, Ming-Ta / Wei, Chen-Ting / Lin, Chi-Wei

    Risk management and healthcare policy

    2023  Volume 16, Page(s) 209–214

    Abstract: Importance: COVID-19 vaccination has been associated with various adverse outcomes. Although studies have reported cases of arrhythmia after COVID-19 vaccination, the precise underlying mechanism remains to be elucidated.: Objective: Here, we report ... ...

    Abstract Importance: COVID-19 vaccination has been associated with various adverse outcomes. Although studies have reported cases of arrhythmia after COVID-19 vaccination, the precise underlying mechanism remains to be elucidated.
    Objective: Here, we report the case of a patient who developed atrial fibrillation after receiving the mRNA-1273 vaccine and describe our findings in light of relevant cases in the literature.
    Design setting and participants: This is a case report and a review of the relevant literature. A 55-year-old woman presented to our clinic with a history of paroxysmal atrial fibrillation, hypertension, and mild mitral valve prolapse. The patient developed atrial fibrillation 3 days after receiving a COVID-19 vaccine. She was diagnosed with moderate-to-severe tricuspid regurgitation and severe mitral regurgitation, and underwent valve repair surgery. To obtain relevant articles (December 2020 through August 2022), we searched the following key words on PubMed: atrial fibrillation and COVID-19 vaccination.
    Results: A total of 5 relevant case reports were identified. COVID-19 vaccination led to arrhythmia, including atrial fibrillation, within 14 days.
    Conclusions and relevance: Cases of patients developing arrhythmia after COVID-19 vaccination have been increasingly reported. Although the underlying mechanism remains unclear, we hypothesize that mRNA vaccination may lead to arrhythmia and associated valve diseases. Thus, before administering mRNA-1273 vaccines to patients with a history of valvular heart disease or atrial fibrillation, the patients' cardiologists must be consulted.
    Language English
    Publishing date 2023-02-10
    Publishing country England
    Document type Case Reports
    ZDB-ID 2495128-6
    ISSN 1179-1594
    ISSN 1179-1594
    DOI 10.2147/RMHP.S402007
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: An influential node identification method considering multi-attribute decision fusion and dependency.

    Chen, Chao-Yang / Tan, Dingrong / Meng, Xiangyi / Gao, Jianxi

    Scientific reports

    2022  Volume 12, Issue 1, Page(s) 19465

    Abstract: It is essential to study the robustness and centrality of interdependent networks for building reliable interdependent systems. Here, we consider a nonlinear load-capacity cascading failure model on interdependent networks, where the initial load ... ...

    Abstract It is essential to study the robustness and centrality of interdependent networks for building reliable interdependent systems. Here, we consider a nonlinear load-capacity cascading failure model on interdependent networks, where the initial load distribution is not random, as usually assumed, but determined by the influence of each node in the interdependent network. The node influence is measured by an automated entropy-weighted multi-attribute algorithm that takes into account both different centrality measures of nodes and the interdependence of node pairs, then averaging for not only the node itself but also its nearest neighbors and next-nearest neighbors. The resilience of interdependent networks under such a more practical and accurate setting is thoroughly investigated for various network parameters, as well as how nodes from different layers are coupled and the corresponding coupling strength. The results thereby can help better monitoring interdependent systems.
    Language English
    Publishing date 2022-11-14
    Publishing country England
    Document type Journal Article
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-022-23430-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Treatment of benign rectal stricture caused by repeated anal insertion by endoscopy and balloon dilation: A case report.

    Liu, Shih-Hung / Kang, Jung-Cheng / Hu, Je-Ming / Chen, Chao-Yang / Lin, Kuan-Hsun / Pu, Ta-Wei

    World journal of gastrointestinal endoscopy

    2024  Volume 16, Issue 2, Page(s) 91–97

    Abstract: Background: Benign rectal strictures can be categorized as primary (disease-related) and secondary (surgical anastomosis-related). Secondary strictures arise from surgical complications, whereas primary strictures have diverse etiologies, including ... ...

    Abstract Background: Benign rectal strictures can be categorized as primary (disease-related) and secondary (surgical anastomosis-related). Secondary strictures arise from surgical complications, whereas primary strictures have diverse etiologies, including various inflammatory conditions. Benign strictures are usually managed by surgery and endoscopy. We present an unusual etiology of benign rectal stricture caused by the repeated insertion of foreign objects into the rectum for sexual purposes, resulting in rectal injury and subsequent chronic inflammation.
    Case summary: A 53-year-old man presented to the outpatient clinic of the Colorectal Surgery Department with symptoms of chronic constipation and bloody stools. The patient previously experienced rectal injury due to foreign object insertion for sexual purposes. Colonoscopy revealed benign circumferential narrowing of the rectum. He underwent treatment by endoscopic argon plasma coagulation and balloon dilation and follow-up as an outpatient for 4 months. A colonoscopy at the end of the follow-up period revealed no evidence of rectal stricture relapse.
    Conclusion: A history of rectal injury, followed by chronic inflammation, should be considered in patients with benign rectal strictures. Management with endoscopic argon plasma coagulation and balloon dilation can prevent the need for surgical resection of benign rectal strictures.
    Language English
    Publishing date 2024-03-16
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2573698-X
    ISSN 1948-5190
    ISSN 1948-5190
    DOI 10.4253/wjge.v16.i2.91
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Stercoral perforation of the cecum: A case report.

    Yu, Hung-Chun / Pu, Ta-Wei / Kang, Jung-Cheng / Chen, Chao-Yang / Hu, Je-Ming / Su, Ruei-Yu

    World journal of gastrointestinal surgery

    2024  Volume 16, Issue 4, Page(s) 1189–1194

    Abstract: Background: With less than 90 reported cases to date, stercoral perforation of the colon is a rare occurrence. Stercoral ulceration is thought to occur due to ischemic pressure necrosis of the bowel wall, which is caused by the presence of a ... ...

    Abstract Background: With less than 90 reported cases to date, stercoral perforation of the colon is a rare occurrence. Stercoral ulceration is thought to occur due to ischemic pressure necrosis of the bowel wall, which is caused by the presence of a stercoraceous mass. To underscore this urgent surgical situation concerning clinical presentation, surgical treatment, and results, we present the case of a 66-year-old man with a stercoral perforation.
    Case summary: A 66-year-old man with a history of hypertension, hyperlipidemia, and gout presented at the emergency department with lower abdominal pain and a low-grade fever lasting for a few hours. Abdominal computed tomography indicated a suspected bezoar (approximately 7.6 cm) in the dilated cecum, accompanied by pericolic fat stranding, mild proximal dilatation of the ileum, pneumoperitoneum, and minimal ascites. Intraoperatively, feculent peritonitis with isolated cecal perforation were observed. Consequently, a right hemicolectomy with peritoneal lavage was performed. A histopathological examination supported the intraoperative findings.
    Conclusion: In stercoral perforations, a diagnosis should be diligently pursued, especially in older adults, and prompt surgical intervention should be implemented.
    Language English
    Publishing date 2024-04-25
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2573700-4
    ISSN 1948-9366
    ISSN 1948-9366
    DOI 10.4240/wjgs.v16.i4.1189
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Deafness enhances perceptual span size in Chinese reading: Evidence from a gaze-contingent moving-window paradigm.

    Liu, Zhi Fang / Chen, Chao Yang / Tong, Wen / Su, Yong Qiang

    PsyCh journal

    2021  Volume 10, Issue 4, Page(s) 508–520

    Abstract: Using a gaze-contingent moving-window paradigm, we investigated whether/how deafness affects perceptual processing in Chinese reading. Besides the manipulation of window size, word length of sentences used in the experiment was also manipulated to check ... ...

    Abstract Using a gaze-contingent moving-window paradigm, we investigated whether/how deafness affects perceptual processing in Chinese reading. Besides the manipulation of window size, word length of sentences used in the experiment was also manipulated to check whether deafness enhanced the word length effect on perceptual span. Significant interactions of window constraints and deafness and a three-way interaction were observed on reading rate. Smaller effects of window constraints for deaf Chinese readers and nonreliable three-way interactions were observed on forward saccade length. This suggests that deaf Chinese readers exhibit a larger perceptual span, and word length affected the span from which information was acquired for comprehension whereas both deafness and word length might have little impact on the span from which information is acquired for oculomotor targeting during natural reading of Chinese.
    MeSH term(s) China ; Deafness ; Eye Movements ; Humans ; Language ; Reading
    Language English
    Publishing date 2021-04-25
    Publishing country Australia
    Document type Journal Article
    ZDB-ID 2717141-3
    ISSN 2046-0260 ; 2046-0252
    ISSN (online) 2046-0260
    ISSN 2046-0252
    DOI 10.1002/pchj.442
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 6992: Show issues Location:
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  7. Article ; Online: N-glycosylation on Asn-57 is required for the correct HAI-2 protein folding and protease inhibitory activity.

    Huang, Nanxi / Wang, Qiaochu / Chen, Chao-Yang / Hu, Je-Ming / Wang, Jehng-Kang / Chang, Ping-Ying / Johnson, Michael D / Lin, Chen-Yong

    Glycobiology

    2023  Volume 33, Issue 3, Page(s) 203–214

    Abstract: Hepatocyte growth factor activator inhibitor (HAI)-2 is an integral membrane Kunitz-type serine protease inhibitor that regulates the proteolysis of matriptase and prostasin in a cell-type selective manner. The cell-type selective nature of HAI-2 ... ...

    Abstract Hepatocyte growth factor activator inhibitor (HAI)-2 is an integral membrane Kunitz-type serine protease inhibitor that regulates the proteolysis of matriptase and prostasin in a cell-type selective manner. The cell-type selective nature of HAI-2 function depends largely on whether the inhibitor and potential target enzymes are targeted to locations in close proximity. The N-glycan moiety of HAI-2 can function as a subcellular targeting signal. HAI-2 is synthesized with 1 of 2 different N-glycan modifications: one of oligomannose-type, which largely remains in the endoplasmic reticulum/GA, and another of complex-type, which is targeted toward the apical surface in vesicle-like structures, and could function as an inhibitor of matriptase and prostasin. HAI-2 contains 2 putative N-glycosylation sites, Asn-57 and Asn-94, point mutations of which were generated and characterized in this study. The protein expression profile of the HAI-2 mutants indicates that Asn-57, and not Asn-94, is responsible for the N-glycosylation of both HAI-2 species, suggesting that the form with oligomannose-type N-glycan is the precursor of the form with complex-type N-glycan. Unexpectedly, the vast majority of non-glycosylated HAI-2 is synthesized into multiple disulfide-linked oligomers, which lack protease inhibitory function, likely due to distorted conformations caused by the disarrayed disulfide linkages. Although forced expression of HAI-2 in HAI-2 knockout cells artificially enhances HAI-2 oligomerization, disulfide-linked HAI-2 oligomers can also be observed in unmodified cells. These results suggest that N-glycosylation on Asn-57 is required for folding into a functional HAI-2 with full protease suppressive activity and correct subcellular targeting signal.
    MeSH term(s) Membrane Glycoproteins/chemistry ; Proteolysis ; Glycosylation ; Endoplasmic Reticulum/metabolism ; Polysaccharides/metabolism
    Chemical Substances Membrane Glycoproteins ; Polysaccharides
    Language English
    Publishing date 2023-01-13
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 1067689-2
    ISSN 1460-2423 ; 0959-6658
    ISSN (online) 1460-2423
    ISSN 0959-6658
    DOI 10.1093/glycob/cwad002
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    Zs.A 3150: Show issues Location:
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  8. Article: Mucinous neoplasm of the appendix: A case report and review of literature.

    Chang, Hao-Cheng / Kang, Jung-Cheng / Pu, Ta-Wei / Su, Ruei-Yu / Chen, Chao-Yang / Hu, Je-Ming

    World journal of gastrointestinal surgery

    2023  Volume 16, Issue 3, Page(s) 944–954

    Abstract: Background: Appendiceal mucinous neoplasms (AMNs), although not classified as rare, are relatively uncommon tumors most often discovered incidentally during colorectal surgery. Accurate identification of AMNs is difficult due to non-specific symptoms, ... ...

    Abstract Background: Appendiceal mucinous neoplasms (AMNs), although not classified as rare, are relatively uncommon tumors most often discovered incidentally during colorectal surgery. Accurate identification of AMNs is difficult due to non-specific symptoms, overlapping tumor markers with other conditions, and the potential for misdiagnosis. This underscores the urgent need for precision in diagnosis to prevent severe complications.
    Case summary: This case report describes the unexpected discovery and treatment of a low-grade AMN (LAMN) in a 74-year-old man undergoing laparoscopic hemicolectomy for transverse colon adenocarcinoma (AC). Preoperatively, non-specific gastrointestinal symptoms and elevated tumor markers masked the presence of AMN. The tumor, presumed to be an AMN peritoneal cyst intraoperatively, was confirmed as LAMN through histopathological examination. The neoplasm exhibited mucin accumulation and a distinct immunohistochemical profile: Positive for Homeobox protein
    Conclusion: This case highlights the diagnostic complexity of AMNs, emphasizing the need for vigilant identification to avert potential complications, such as pseudomyxoma peritonei.
    Language English
    Publishing date 2023-12-15
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2573700-4
    ISSN 1948-9366
    ISSN 1948-9366
    DOI 10.4240/wjgs.v16.i3.944
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Risk factors predict microscopic extranodal tumor deposits in advanced stage III colon cancer patients.

    Jhuang, Yi-Han / Chou, Yu-Ching / Lin, Yu-Chun / Hu, Je-Ming / Pu, Ta-Wei / Chen, Chao-Yang

    World journal of gastroenterology

    2023  Volume 29, Issue 11, Page(s) 1735–1744

    Abstract: Background: Colorectal cancer is a frequent cause of cancer-related mortality in patients with lymph node or distant metastases. Pericolonic tumor deposits (TDs) are considered prognostically distinct from lymph node metastases.: Aim: To investigate ... ...

    Abstract Background: Colorectal cancer is a frequent cause of cancer-related mortality in patients with lymph node or distant metastases. Pericolonic tumor deposits (TDs) are considered prognostically distinct from lymph node metastases.
    Aim: To investigate risk factors for extranodal TDs in stage III colon cancer.
    Methods: This was a retrospective cohort study. We selected 155 individuals diagnosed with stage III colon cancer from the database of the Cancer Registry of the Tri-Service General Hospital. The patients were allocated into the groups with/without N1c. Multivariate Cox regression analysis and Kaplan-Meier method were done. The primary outcomes investigate the association between the covariates and extranodal TDs, and prognostic significance of the covariates regarding the survival.
    Results: There were 136 individuals in the non-N1c group and 19 individuals in the N1c group. Patients with lymphovascular invasion (LVI) had a higher risk of TDs. Overall survival rates of patients with and without LVI were 6.64 years and 8.61 years, respectively (
    Conclusion: Patients having stage III colon cancer with LVI have a higher probability of having TDs than those with stage III colon cancer without LVI. Stage III colon cancer patients with TDs and LVI could have poor prognosis and outcome.
    MeSH term(s) Humans ; Extranodal Extension/pathology ; Neoplasm Staging ; Retrospective Studies ; Colonic Neoplasms/pathology ; Prognosis ; Risk Factors ; Neoplasm Invasiveness/pathology
    Language English
    Publishing date 2023-04-10
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2185929-2
    ISSN 2219-2840 ; 1007-9327
    ISSN (online) 2219-2840
    ISSN 1007-9327
    DOI 10.3748/wjg.v29.i11.1735
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    Zs.A 6039: Show issues Location:
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  10. Article ; Online: The Auricular Injection Technique: A New Treatment for Lying Ear.

    Chen, Chao-Yang / Zhou, Yu-Hao / Fang, Jun-Ren / Luo, Cheng-En / Tan, Lin-Lin / Wang, Hai-Bin

    Plastic and reconstructive surgery

    2023  Volume 153, Issue 1, Page(s) 74e–78e

    Abstract: Summary: Lying-ear deformity refers to an auricle that bends backward excessively, is excessively folded against the head, and has a very prominent antihelix. It usually requires experienced surgeons to perform surgical treatment and a prolonged ... ...

    Abstract Summary: Lying-ear deformity refers to an auricle that bends backward excessively, is excessively folded against the head, and has a very prominent antihelix. It usually requires experienced surgeons to perform surgical treatment and a prolonged postoperative recovery process. This article proposes a simple and effective hyaluronic acid injection technique that significantly improves the shape of the outer ear and enhances perceived facial aesthetics. Twenty patients underwent treatment with multiple injections. Measure-related parameters were used to evaluate the postoperative effect, and the results were graded using a visual analog scale. Interrater reliability among graders was evaluated using intraclass correlation coefficients. After treatment, no serious complications, such as infection or embolism, occurred. Six months after the procedure, the average auriculocephalic angle increased from 25.11 ± 9.46 to 32.72 ± 8.29 degrees, the average conchoscaphal angle increased from 87.69 ± 9.06 to 95.94 ± 7.11 degrees, and patients' average visual analog scale score increased from 4.40 ± 1.14 to 8.57 ± 0.68. Interrater reliability was fair to good for visual analog scale before injection and 6 months after injection (intraclass correlation coefficients, 0.49 and 0.45, respectively; both P < 0.001). The patients were satisfied with the injection process and results. This injection protocol improved the shape of the outer ear, resulting in excellent postoperative outcomes.
    MeSH term(s) Humans ; Plastic Surgery Procedures ; Reproducibility of Results ; Ear, External/surgery ; Ear Auricle/surgery ; Skin Transplantation ; Treatment Outcome
    Language English
    Publishing date 2023-03-27
    Publishing country United States
    Document type Journal Article
    ZDB-ID 208012-6
    ISSN 1529-4242 ; 0032-1052 ; 0096-8501
    ISSN (online) 1529-4242
    ISSN 0032-1052 ; 0096-8501
    DOI 10.1097/PRS.0000000000010484
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