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  1. Article ; Online: L

    Chen, Cheng-Neng / Wang, Mao-Hsien / Soung, Hung-Sheng / Chen, Shu-Mei / Fang, Chih-Hsiang / Lin, Yi-Wen / Tseng, Hsiang-Chien

    Neurotoxicity research

    2022  Volume 40, Issue 1, Page(s) 241–258

    Abstract: Rotenone (RO)-induced neurotoxicity exhibits pathophysiological features similar to those reported in patients with Parkinson's disease (PD), such as nitrosative and oxidative stress, mitochondrial dysfunction, and neural cytoarchitecture alterations in ... ...

    Abstract Rotenone (RO)-induced neurotoxicity exhibits pathophysiological features similar to those reported in patients with Parkinson's disease (PD), such as nitrosative and oxidative stress, mitochondrial dysfunction, and neural cytoarchitecture alterations in the substantia nigra pars compacta (SNpc)/striatum (ST), which has been used for decades as an animal model of PD in humans.
    MeSH term(s) Animals ; Disease Models, Animal ; Glutamates/therapeutic use ; Humans ; Neuroprotective Agents/pharmacology ; Neuroprotective Agents/therapeutic use ; Parkinsonian Disorders/metabolism ; Rats ; Rotenone/toxicity
    Chemical Substances Glutamates ; Neuroprotective Agents ; Rotenone (03L9OT429T) ; theanine (8021PR16QO)
    Language English
    Publishing date 2022-01-06
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2036826-4
    ISSN 1476-3524 ; 1029-8428
    ISSN (online) 1476-3524
    ISSN 1029-8428
    DOI 10.1007/s12640-021-00451-w
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5749: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Article: Protective Effect of L-Theanine on Haloperidol-Induced Orofacial.

    Chen, Cheng-Neng / Chang, Kuo-Chi / Wang, Mao-Hsien / Tseng, Hsiang-Chien / Soung, Hung-Sheng

    The Chinese journal of physiology

    2018  Volume 61, Issue 1, Page(s) 35–41

    MeSH term(s) Animals ; Corpus Striatum/drug effects ; Corpus Striatum/metabolism ; Disease Models, Animal ; Dyskinesias/prevention & control ; Glutamates/pharmacology ; Haloperidol/toxicity ; Lipid Peroxidation/drug effects ; Male ; Rats ; Rats, Wistar ; Tardive Dyskinesia/chemically induced ; Tardive Dyskinesia/prevention & control
    Chemical Substances Glutamates ; theanine (8021PR16QO) ; Haloperidol (J6292F8L3D)
    Language English
    Publishing date 2018-01-26
    Publishing country India
    Document type Journal Article
    ZDB-ID 966112-8
    ISSN 0304-4920 ; 0300-8525
    ISSN 0304-4920 ; 0300-8525
    DOI 10.4077/CJP.2018.BAG529
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 309: Show issues Location:
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  3. Article ; Online: L

    Soung, Hung-Sheng / Wang, Mao-Hsien / Chang, Kuo-Chi / Chen, Cheng-Neng / Chang, Yi / Yang, Chih-Chuan / Tseng, Hsiang-Chien

    Neurotoxicity research

    2018  Volume 34, Issue 3, Page(s) 375–387

    Abstract: Reserpine (RES)-induced orofacial dyskinesia (OD) has been used as an animal model for human tardive dyskinesia (TD) for decades, due to its strong pathophysiological association with striatal oxidative stress and neural cytoarchitecture alteration. ...

    Abstract Reserpine (RES)-induced orofacial dyskinesia (OD) has been used as an animal model for human tardive dyskinesia (TD) for decades, due to its strong pathophysiological association with striatal oxidative stress and neural cytoarchitecture alteration.
    MeSH term(s) Analysis of Variance ; Animals ; Antipsychotic Agents/toxicity ; Caspase 3/metabolism ; Cytokines/metabolism ; Disease Models, Animal ; Dose-Response Relationship, Drug ; Dyskinesias/drug therapy ; Dyskinesias/etiology ; Glutamates/therapeutic use ; Glutathione/metabolism ; Lipid Peroxidation/drug effects ; Male ; Neurotransmitter Agents/metabolism ; Rats ; Rats, Wistar ; Reserpine/toxicity ; Superoxide Dismutase/metabolism
    Chemical Substances Antipsychotic Agents ; Cytokines ; Glutamates ; Neurotransmitter Agents ; theanine (8021PR16QO) ; Reserpine (8B1QWR724A) ; Superoxide Dismutase (EC 1.15.1.1) ; Caspase 3 (EC 3.4.22.-) ; Glutathione (GAN16C9B8O)
    Language English
    Publishing date 2018-04-09
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2036826-4
    ISSN 1476-3524 ; 1029-8428
    ISSN (online) 1476-3524
    ISSN 1029-8428
    DOI 10.1007/s12640-018-9897-z
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5749: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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  4. Article ; Online: Nitric oxide pathway activity modulation alters the protective effects of (-)Epigallocatechin-3-gallate on reserpine-induced impairment in rats.

    Chen, Cheng-Neng / Chang, Kuo-Chi / Lin, Rui-Feng / Wang, Mao-Hsien / Shih, Ruoh-Lan / Tseng, Hsiang-Chien / Soung, Hung-Sheng / Tsai, Cheng-Chia

    Behavioural brain research

    2016  Volume 305, Page(s) 198–211

    Abstract: Reserpine (RES) has been reported to increase the brain's neural oxidative stress and cause cognitive dysfunction. Having powerful antioxidative properties, green tea catechins, especially (-)epigallocatechin-3-gallate (EGCG), are able to protect against ...

    Abstract Reserpine (RES) has been reported to increase the brain's neural oxidative stress and cause cognitive dysfunction. Having powerful antioxidative properties, green tea catechins, especially (-)epigallocatechin-3-gallate (EGCG), are able to protect against many oxidative injuries. In this study, we examined the protecting properties of EGCG on RES-induced impairment of short-term memory in three-month-old male Wistar rats. RES (1mg/kg i.p.) induced memory impairment (p<0.001) as evaluated by the social recognition task. EGCG treatment (100mg/kg i.p. for 7days, starting 6days before RES injection) was able to improve the impaired memory caused by RES. RES treatment increased the nitric oxide (NO) level and lipid peroxidation (LPO) production, and decreased the antioxidation power in hippocampi. EGCG treatment was able to counteract the RES-induced NO level and LPO production, as well as enhanced the hippocampal antioxidation power in RES-treated rats. In order to examine the implication of NO pathway activity in RES treatment, either NO precursor (L-arginine; L-A) or NO synthase inhibitor (L-NAME; L-N) was co-pretreated with EGCG; NO precursor treatment eliminated the protective effect of EGCG, in contrast to that NO synthase inhibitor treatment significantly increased the EGCG effects on cognitive and biochemical protection in RES-treated rats. These results suggested that the NO pathway was implicated, at least in part, in the RES-induced impairment, as well as in the protective effect of EGCG in treating RES-induced impairment of memory. The above evidence provides a clinically relevant value for EGCG in preventing RES-induced cognitive dysfunction.
    MeSH term(s) Animals ; Arginine/pharmacology ; Catechin/analogs & derivatives ; Catechin/pharmacology ; Catechin/therapeutic use ; Discrimination (Psychology)/drug effects ; Disease Models, Animal ; Dose-Response Relationship, Drug ; Enzyme Inhibitors/pharmacology ; Exploratory Behavior/drug effects ; Glutathione/metabolism ; Hippocampus/drug effects ; Hippocampus/metabolism ; Lipid Peroxidation/drug effects ; Male ; Memory Disorders/chemically induced ; Memory Disorders/drug therapy ; NG-Nitroarginine Methyl Ester/pharmacology ; Neuroprotective Agents/pharmacology ; Neuroprotective Agents/therapeutic use ; Nitric Oxide/metabolism ; Rats ; Rats, Wistar ; Reserpine/toxicity ; Signal Transduction/drug effects ; Smell/drug effects ; Superoxide Dismutase/metabolism
    Chemical Substances Enzyme Inhibitors ; Neuroprotective Agents ; Nitric Oxide (31C4KY9ESH) ; Reserpine (8B1QWR724A) ; Catechin (8R1V1STN48) ; Arginine (94ZLA3W45F) ; epigallocatechin gallate (BQM438CTEL) ; Superoxide Dismutase (EC 1.15.1.1) ; Glutathione (GAN16C9B8O) ; NG-Nitroarginine Methyl Ester (V55S2QJN2X)
    Language English
    Publishing date 2016-05-15
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 449927-x
    ISSN 1872-7549 ; 0166-4328
    ISSN (online) 1872-7549
    ISSN 0166-4328
    DOI 10.1016/j.bbr.2016.02.038
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1599: Show issues Location:
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  5. Article ; Online: Gender Gap and Risk Factors for Poor Stroke Outcomes: A Single Hospital-Based Prospective Cohort Study.

    Hung, Kuo-Hua / Lai, Jerry Cheng-Yen / Hsu, Kuang-Nan / Hu, Chihmin / Chang, Hung-Chang / Chen, Cheng-Neng / Ku, He-Shu / Yang, Ming-Shiang / Chen, Pei-Hao

    Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association

    2018  Volume 27, Issue 8, Page(s) 2250–2258

    Abstract: Background: This study intended to investigate whether etiological stroke subtypes and their corresponding major risk factors have differential effects on outcomes between genders.: Patients and methods: We enrolled 403 consecutive patients with ... ...

    Abstract Background: This study intended to investigate whether etiological stroke subtypes and their corresponding major risk factors have differential effects on outcomes between genders.
    Patients and methods: We enrolled 403 consecutive patients with first-ever acute ischemic stroke (170 women, 233 men), from a referral hospital in Taiwan over a 2-year period. Gender differences in demographics, vascular risk factors, access to health care, etiological stroke subtypes, stroke severity, and outcomes were examined. The primary outcome variable of the study was any unfavorable outcome due to acute ischemic stroke, defined as a modified Rankin Scale score of 3 or higher at 90 days after stroke. Multivariable logistic regression models were used to identify predictors of poor outcomes.
    Results: There were no gender disparities in baseline severity, stroke subtypes, access to health care, and medical comorbidities. Although women had poorer outcomes, female gender was not a predictor of unfavorable outcomes. Important predictors included age of 75years or older (odds ratio [OR] = 2.67; 95% confidence interval [CI], 1.46-4.90), National Institutes of Health Stroke Scale greater than or equal to 8 (OR = 8.38; 95% CI, 4.61-15.2), lack of cohabitation (OR = 2.13; 95% CI, 1.26-3.61), subtypes of cardioembolism (OR = 2.76; 95% CI, 1.29-5.93), and large-artery atherosclerosis (OR = 2.93; 95% CI, 1.47-5.85). In subgroup analyses, the gender-specific independent predictors were cardioembolism (OR = 7.42; 95% CI, 2.21-24.9) or atrial fibrillation (OR = 3.57; 95% CI, 1.31-9.74) in women, and large-artery atherosclerosis (OR = 3.35; 95% CI, 1.30-8.64) or symptomatic large-artery stenosis (OR = 3.42; 95% CI, 1.69-6.96) in men. The differential effects of these predictors according to gender were revealed by interaction tests.
    Conclusion: Atrial fibrillation and symptomatic large-artery stenosis are predictors of poor stroke outcomes in women and men, respectively.
    MeSH term(s) Age Factors ; Aged ; Atherosclerosis/complications ; Atherosclerosis/epidemiology ; Atrial Fibrillation/complications ; Atrial Fibrillation/epidemiology ; Brain Ischemia/complications ; Brain Ischemia/epidemiology ; Brain Ischemia/therapy ; Comorbidity ; Female ; Humans ; Male ; Odds Ratio ; Prospective Studies ; Risk Factors ; Severity of Illness Index ; Sex Factors ; Stroke/complications ; Stroke/epidemiology ; Stroke/therapy ; Treatment Outcome
    Language English
    Publishing date 2018-05-18
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1131675-5
    ISSN 1532-8511 ; 1052-3057
    ISSN (online) 1532-8511
    ISSN 1052-3057
    DOI 10.1016/j.jstrokecerebrovasdis.2018.04.014
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 3519: Show issues Location:
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