Article ; Online: IL-10 promoter genetic polymorphisms and risk of Kawasaki disease in Taiwan.
2011 Volume 30, Issue 1, Page(s) 51–59
Abstract: Kawasaki disease (KD) is the most common cause of pediatric acquired heart disease. KD patients have spontaneously high plasma/serum levels of IL-10 during the acute phase. Therefore, two independent studies were carried out to investigate the ... ...
| Abstract | Kawasaki disease (KD) is the most common cause of pediatric acquired heart disease. KD patients have spontaneously high plasma/serum levels of IL-10 during the acute phase. Therefore, two independent studies were carried out to investigate the association between genetic variants in IL-10 promoter (-1082, -819, and -592) and risk of KD. A total of 134 trios were included for the family-based association study. A significantly preferential transmission of the C allele at loci -819 T > C and -592 A > C for KD cases was observed (P permutation = 0.029 and P permutation = 0.034, respectively). There was a significant increase in the transmission of haplotype CC (p = 0.016) at the above two loci (OR, 1.632; 95% CI, 1.090-2.443; P permutation = 0.019). We also carried out a follow-up case-control study that included 146 KD cases and 315 unrelated healthy children. The haplotype CC (-819, -592) showed an increased risk of KD (but statistically non-significant; OR, 1.332; 95% CI, 0.987-1.797; p = 0.061). In diplotype analysis, a trend was found between number of CC haplotype and risk of KD (but non-significant, p =0.061). In conclusion, CC genotype and CC/CC diplotype at IL-10-819T > C and -592A > C were significantly associated with risk of KD in case-parent trio study, which were replicated partially in our follow-up case-control study. |
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| MeSH term(s) | Case-Control Studies ; Child, Preschool ; Female ; Genetic Association Studies ; Haplotypes ; Heredity ; Humans ; Infant ; Interleukin-10/genetics ; Male ; Mucocutaneous Lymph Node Syndrome/genetics ; Polymorphism, Single Nucleotide ; Promoter Regions, Genetic ; Taiwan |
| Chemical Substances | IL10 protein, human ; Interleukin-10 (130068-27-8) |
| Language | English |
| Publishing date | 2011-04-21 |
| Publishing country | United States |
| Document type | Journal Article ; Research Support, Non-U.S. Gov't |
| ZDB-ID | 604951-5 |
| ISSN | 1875-8630 ; 0278-0240 |
| ISSN (online) | 1875-8630 |
| ISSN | 0278-0240 |
| DOI | 10.3233/DMA-2011-0765 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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