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  1. Book ; Conference proceedings: Abstracts from the 10th International Hong Kong Springfield Pan-Asian Symposium on Advances in Alzheimer Therapy

    Chen, Christopher

    February 28, 29 - March 1, 2008, Hong Kong

    (Neurobiology of aging ; 29,S1 = Suppl.)

    2008  

    Title variant Abstracts
    Event/congress International Pan-Asian Symposium on Advances in Alzheimer Therapy (10, 2008, Hongkong)
    Author's details organizers: Christopher Chen
    Series title Neurobiology of aging ; 29,S1 = Suppl.
    Collection
    Language English
    Size S30 S.
    Publisher Elsevier
    Publishing place New York, NY
    Publishing country Netherlands
    Document type Book ; Conference proceedings
    HBZ-ID HT015499166
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    Zs A 1685 -29,S1- not available for loan Zeitschriften-Lesesaal

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  2. Book: Reproductive medicine and surgery

    Chen, Christopher

    (International surgery ; 91,5, Suppl.)

    2006  

    Series title International surgery ; 91,5, Suppl.
    Collection
    Language English
    Size S113 S. : Ill., graph. Darst.
    Publishing place S.l.
    Document type Book
    HBZ-ID HT014928994
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    Uk I Zs 134 -91,5,Suppl.- verfügbar in Königswinter Königswinter

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  3. Article ; Online: Advances in Stroke: Brain Health in 2023.

    Rundek, Tatjana / Chen, Christopher L H

    Stroke

    2023  Volume 54, Issue 11, Page(s) 2923–2925

    MeSH term(s) Humans ; Stroke/therapy ; Brain ; Brain Edema
    Language English
    Publishing date 2023-10-06
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80381-9
    ISSN 1524-4628 ; 0039-2499 ; 0749-7954
    ISSN (online) 1524-4628
    ISSN 0039-2499 ; 0749-7954
    DOI 10.1161/STROKEAHA.123.043019
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 448: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  4. Book ; Online ; E-Book: Warlow's stroke

    Hankey, Graeme / Macleod, Malcolm / Gorelick, Philip B. / Chen, Christopher / Caprio, Fan / Mattle, Heinrich

    practical management

    2019  

    Title variant Stroke
    Author's details edited by Graeme Hankey, Malcolm Macleod, Philip B. Gorelick, Christopher Chen, Fan Caprio, Heinrich Mattle
    Keywords Stroke / therapy ; Intracranial Hemorrhages / therapy ; Ischemic Attack, Transient / therapy
    Language English
    Size 1 Online-Ressource (xv, 988 Seiten), Illustrationen, Diagramme
    Edition Fourth edition
    Publisher Wiley Blackwell
    Publishing place Hoboken, NJ
    Publishing country United States
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    HBZ-ID HT020028299
    ISBN 978-1-118-49242-0 ; 9781118492222 ; 1-118-49242-0 ; 1118492226
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

    Full text online

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  5. Article ; Online: Next-generation engineered microsystems for cell biology: a systems-level roadmap.

    Sundaram, Subramanian / Chen, Christopher S

    Trends in cell biology

    2022  Volume 32, Issue 6, Page(s) 490–500

    Abstract: Engineered microsystems for in vitro studies of cultured cells are evolving from simple 2D platforms to 3D architectures and organoid cultures. Despite advances in reproducing ever more sophisticated biology in these systems, there remain foundational ... ...

    Abstract Engineered microsystems for in vitro studies of cultured cells are evolving from simple 2D platforms to 3D architectures and organoid cultures. Despite advances in reproducing ever more sophisticated biology in these systems, there remain foundational challenges in re-creating key aspects of tissue composition, architecture, and mechanics that are critical to recapitulating in vivo processes. Against the backdrop of current progress in 3D fabrication methods, we evaluate the key requirements for the next generation of cellular platforms. We postulate that these future platforms - apart from building tissue-like structures - will need to have the ability to readily sense and autonomously modulate tissue responses over time, as occurs in natural microenvironments. Such interactive robotic platforms that report and guide cellular events will enable us to probe a previously inaccessible class of questions in cell biology.
    MeSH term(s) Cells, Cultured ; Humans ; Organoids ; Tissue Engineering
    Language English
    Publishing date 2022-01-31
    Publishing country England
    Document type Journal Article ; Review ; Research Support, U.S. Gov't, Non-P.H.S. ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 30122-x
    ISSN 1879-3088 ; 0962-8924
    ISSN (online) 1879-3088
    ISSN 0962-8924
    DOI 10.1016/j.tcb.2022.01.003
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.MG 25: Show issues
    Zs.MO 113: Show issues
    Zs.A 3410: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  6. Article ; Online: A Novel Framework for the Next Generation of Precision Oncology Targets.

    Chen, Christopher T / Ford, James M

    JAMA oncology

    2022  Volume 8, Issue 7, Page(s) 974–976

    MeSH term(s) High-Throughput Nucleotide Sequencing ; Humans ; Medical Oncology ; Neoplasms/drug therapy ; Precision Medicine
    Language English
    Publishing date 2022-05-19
    Publishing country United States
    Document type Journal Article
    ISSN 2374-2445
    ISSN (online) 2374-2445
    DOI 10.1001/jamaoncol.2022.0760
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Unlikely cause of primary upper limb venous thrombosis.

    Chen, Christopher / Baker, Luke

    Journal of medical imaging and radiation oncology

    2022  Volume 66, Issue 8, Page(s) 1087–1088

    Abstract: Primary upper limb venous thrombosis is a rare disease usually caused by external compression of the proximal deep upper limb veins from aberrant musculoskeletal anatomy such as cervical ribs, abnormal tendon insertions and hypertrophy of the anterior ... ...

    Abstract Primary upper limb venous thrombosis is a rare disease usually caused by external compression of the proximal deep upper limb veins from aberrant musculoskeletal anatomy such as cervical ribs, abnormal tendon insertions and hypertrophy of the anterior scalene or subclavius muscles. We present an unusual case of primary upper limb thrombosis caused by compression of the brachiocephalic vein from a sternoclavicular ganglion cyst. This case illustrates the importance of considering a wide differential when searching for a cause of primary upper limb venous thrombosis.
    MeSH term(s) Humans ; Thrombosis/complications ; Arm ; Venous Thrombosis/diagnostic imaging
    Language English
    Publishing date 2022-10-08
    Publishing country Australia
    Document type Case Reports ; Letter
    ZDB-ID 2389687-5
    ISSN 1754-9485 ; 1440-1673 ; 1754-9477 ; 0004-8461
    ISSN (online) 1754-9485 ; 1440-1673
    ISSN 1754-9477 ; 0004-8461
    DOI 10.1111/1754-9485.13483
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 66: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  8. Book ; Online: COVID-19

    Chen, Christopher

    private sector’s role in times of crisis

    2020  

    Abstract: While people usually rely on the state in times of crisis, the scale and significance of the COVID-19 pandemic necessitates a more inclusive global response. Can the private sector step in to fill existing gaps in the current response? ... Published ... ...

    Abstract While people usually rely on the state in times of crisis, the scale and significance of the COVID-19 pandemic necessitates a more inclusive global response. Can the private sector step in to fill existing gaps in the current response?

    Published version
    Keywords Business::General ; Country and Region Studies ; East Asia and Asia Pacific ; covid19
    Language English
    Publishing country sg
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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  9. Article: DNA-PK phosphorylation at Ser2056 during adenovirus E4 mutant infection is promoted by viral DNA replication and independent of the MRN complex

    Chen, Christopher / Bridge, Eileen

    Virology. 2022 Jan. 02, v. 565

    2022  

    Abstract: Adenovirus (Ad) early region 4 (E4) mutants activate cellular DNA damage responses (DDRs) that include non-homologous end joining (NHEJ) pathways mediated by the DNA repair kinase DNA-PK and its associated factors Ku70/Ku86. NHEJ results in concatenation ...

    Abstract Adenovirus (Ad) early region 4 (E4) mutants activate cellular DNA damage responses (DDRs) that include non-homologous end joining (NHEJ) pathways mediated by the DNA repair kinase DNA-PK and its associated factors Ku70/Ku86. NHEJ results in concatenation of the viral linear double-stranded DNA genome and inhibits a productive infection. E4 proteins normally prevent activation of cellular DDRs in wild-type Ad type 5 (Ad5) infections, thereby promoting efficient viral growth. The purpose of this study was to evaluate the factors that govern DNA-PK activation during adenovirus infection. Our data indicate that viral DNA replication promotes DNA-PK activation, which is required for genome concatenation by NHEJ. Although the Mre11/Rad50/Nbs1 (MRN) DDR sensor complex is not required for DNA-PK activation, Mre11 is important for recruitment of the NHEJ factor Ku86 to viral replication centers. Our study addresses the interplay between the DNA-PK and MRN complexes during viral genome concatenation by NHEJ.
    Keywords Adenoviridae ; Adenoviridae infections ; DNA ; DNA damage ; DNA repair ; DNA replication ; mutants ; phosphorylation ; viral genome ; viral growth ; virus replication
    Language English
    Dates of publication 2022-0102
    Size p. 82-95.
    Publishing place Elsevier Inc.
    Document type Article
    ZDB-ID 200425-2
    ISSN 1096-0341 ; 0042-6822
    ISSN (online) 1096-0341
    ISSN 0042-6822
    DOI 10.1016/j.virol.2021.10.011
    Database NAL-Catalogue (AGRICOLA)

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    In stock of ZB MED Bonn / Germany

    Z 3686: Show issues

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  10. Article ; Online: Fibroblast clearance of damaged tissue following laser ablation in engineered microtissues.

    Griebel, Megan / Vasan, Anish / Chen, Christopher / Eyckmans, Jeroen

    APL bioengineering

    2023  Volume 7, Issue 1, Page(s) 16112

    Abstract: Although the mechanisms underlying wound healing are largely preserved across wound types, the method of injury can affect the healing process. For example, burn wounds are more likely to undergo hypertrophic scarring than are lacerations, perhaps due to ...

    Abstract Although the mechanisms underlying wound healing are largely preserved across wound types, the method of injury can affect the healing process. For example, burn wounds are more likely to undergo hypertrophic scarring than are lacerations, perhaps due to the increased underlying damage that needs to be cleared. This tissue clearance is thought to be mainly managed by immune cells, but it is unclear if fibroblasts contribute to this process. Herein, we utilize a 3D
    Language English
    Publishing date 2023-03-14
    Publishing country United States
    Document type Journal Article
    ISSN 2473-2877
    ISSN (online) 2473-2877
    DOI 10.1063/5.0133478
    Database MEDical Literature Analysis and Retrieval System OnLINE

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