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  1. Article ; Online: Inhibiting degradation of 2-arachidonoylglycerol as a therapeutic strategy for neurodegenerative diseases.

    Chen, Chu

    Pharmacology & therapeutics

    2023  Volume 244, Page(s) 108394

    Abstract: Endocannabinoids are endogenous lipid signaling mediators that participate in a variety of physiological and pathological processes. 2-Arachidonoylglycerol (2-AG) is the most abundant endocannabinoid and is a full agonist of G-protein-coupled cannabinoid ...

    Abstract Endocannabinoids are endogenous lipid signaling mediators that participate in a variety of physiological and pathological processes. 2-Arachidonoylglycerol (2-AG) is the most abundant endocannabinoid and is a full agonist of G-protein-coupled cannabinoid receptors (CB1R and CB2R), which are targets of Δ
    MeSH term(s) Animals ; Endocannabinoids/metabolism ; Neurodegenerative Diseases/drug therapy ; Neuroinflammatory Diseases ; Neuroprotective Agents/pharmacology ; Neuroprotective Agents/therapeutic use
    Chemical Substances glyceryl 2-arachidonate (8D239QDW64) ; Endocannabinoids ; Neuroprotective Agents
    Language English
    Publishing date 2023-03-24
    Publishing country England
    Document type Journal Article ; Review ; Research Support, N.I.H., Extramural
    ZDB-ID 194735-7
    ISSN 1879-016X ; 0163-7258
    ISSN (online) 1879-016X
    ISSN 0163-7258
    DOI 10.1016/j.pharmthera.2023.108394
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: TDP-43 is a key molecule accelerating development of Alzheimer's disease following traumatic brain injury.

    Chen, Chu

    Neural regeneration research

    2023  Volume 19, Issue 5, Page(s) 955–956

    Language English
    Publishing date 2023-10-20
    Publishing country India
    Document type Journal Article
    ZDB-ID 2388460-5
    ISSN 1876-7958 ; 1673-5374
    ISSN (online) 1876-7958
    ISSN 1673-5374
    DOI 10.4103/1673-5374.385301
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Endocannabinoid metabolism and Alzheimer's disease.

    Chen, Chu

    Neural regeneration research

    2022  Volume 17, Issue 9, Page(s) 1987–1988

    Language English
    Publishing date 2022-02-10
    Publishing country India
    Document type Journal Article
    ZDB-ID 2388460-5
    ISSN 1876-7958 ; 1673-5374
    ISSN (online) 1876-7958
    ISSN 1673-5374
    DOI 10.4103/1673-5374.335153
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  4. Article: Endocannabinoid control of neuroinflammation in traumatic brain injury by monoacylglycerol lipase in astrocytes.

    Chen, Chu

    Neural regeneration research

    2022  Volume 18, Issue 5, Page(s) 1023–1024

    Language English
    Publishing date 2022-08-11
    Publishing country India
    Document type Journal Article
    ZDB-ID 2388460-5
    ISSN 1876-7958 ; 1673-5374
    ISSN (online) 1876-7958
    ISSN 1673-5374
    DOI 10.4103/1673-5374.355755
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  5. Article ; Online: Chagos in ‘Blue’:

    Chen Chu

    Cidades, Comunidades e Território, Vol

    2021  Volume 43

    Abstract: Around 1500 Chagos Islanders were expelled from the Chagos Archipelago and moved to Mauritius and Seychelles between 1965 and 1973. Diego Garcia, the largest island of the Chagos, became a US military base. The Chagos Marine Protected Area (MPA) was ... ...

    Abstract Around 1500 Chagos Islanders were expelled from the Chagos Archipelago and moved to Mauritius and Seychelles between 1965 and 1973. Diego Garcia, the largest island of the Chagos, became a US military base. The Chagos Marine Protected Area (MPA) was established in 2010 and currently acts as legal ammunition against Chagossians’ claims for their rights of return and abode. This article uncovers the multi-layered impacts of the Chagos MPA as fortress conservation by conducting a multiscale spatial analysis and addresses the epistemic system(s) of power. It pays particular attention to colonial and imperial legacies in the construction of environmental science, a planetary-scale archipelagic network, and the rhetoric of ecological (in)security. The politics of coconut manifested in the Barton Point restoration project substantiates claims of spatial and epistemic violence. This article further describes Chagossian strategies of resistance using the works of Clement Siatous and Shenaz Patel. It concludes by arguing against the coupling of military occupation with an environmental fortress that conceals and perpetuates historical injustice. Chagos ecology is storied, layered and laminated through human–land interactions. Chagossians’ imaginative accounts of a shared homeland are inspirational manifestos.
    Keywords Chagos ; ecology ; Marine Protected Areas ; militarization ; territoriality ; Aesthetics of cities. City planning and beautifying ; NA9000-9428 ; Urban groups. The city. Urban sociology ; HT101-395 ; Urbanization. City and country ; HT361-384
    Subject code 333
    Language English
    Publishing date 2021-12-01T00:00:00Z
    Publisher DINÂMIA’CET – IUL, Centre for Socioeconomic and Territorial Studies
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article ; Online: Better survival was found in patients treated with breast-conserving surgery compared with mastectomy in malignant phyllodes tumor of the breast.

    Chen, Chu-Ying / Ya-Chen

    Updates in surgery

    2023  Volume 76, Issue 1, Page(s) 265–270

    Abstract: Malignant phyllodes tumor of the breast (MPTB) is a rare type of breast cancer. The prognosis between breast-conserving surgery (BCS) and mastectomy remains unclear in MPTB. Therefore, long-term survival was investigated between BCS and mastectomy in ... ...

    Abstract Malignant phyllodes tumor of the breast (MPTB) is a rare type of breast cancer. The prognosis between breast-conserving surgery (BCS) and mastectomy remains unclear in MPTB. Therefore, long-term survival was investigated between BCS and mastectomy in MPTB via the Surveillance, Epidemiology, and End Results (SEER) database. MPTB patients with T1-2/N0 stage between 2000 and 2015 from SEER database were retrospectively reviewed. Prognosis between different surgical approaches was assessed by Kaplan-Meier curves and Cox proportional hazards analysis. A total of 795 patients were enrolled with a median follow-up of 126 months. BCS was associated with significantly increased 10-year overall survival (OS) (89.2% vs. 81.1%, p = 0.002) and breast cancer-specific survival (BCSS) (95.2% vs. 90%, p = 0.004) compared with mastectomy. Multivariate analysis showed better OS (HR = 0.587, 95% CI 0.406-0.850, p = 0.005) and BCSS (HR = 0.463, 95%CI 0.267-0.804, p = 0.006) in the BCS group than the mastectomy group. After 1:1 propensity score matching (PSM), improved 10-year OS (89.2% vs.81%, p = 0.023) and BCSS (95.8% vs. 90.1%, p = 0.033) were observed in BCS compared with mastectomy. This study found the survival benefit of BCS over mastectomy in patients with early-stage MPTB. BCS should be recommended as a priority in MPTB patients when both surgical approaches are feasible.
    MeSH term(s) Humans ; Female ; Mastectomy/methods ; Mastectomy, Segmental/methods ; Breast Neoplasms/surgery ; Breast Neoplasms/pathology ; Retrospective Studies ; Breast
    Language English
    Publishing date 2023-06-08
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 2572692-4
    ISSN 2038-3312 ; 2038-131X
    ISSN (online) 2038-3312
    ISSN 2038-131X
    DOI 10.1007/s13304-023-01547-y
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  7. Article ; Online: Reducing universal health coverage regional disparities in China.

    Pan, Jay / Chen, Chu

    The Lancet. Public health

    2022  Volume 7, Issue 12, Page(s) e985–e986

    MeSH term(s) Humans ; Universal Health Insurance ; China/epidemiology
    Language English
    Publishing date 2022-11-18
    Publishing country England
    Document type Journal Article
    ISSN 2468-2667
    ISSN (online) 2468-2667
    DOI 10.1016/S2468-2667(22)00256-0
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  8. Article: [Effect of Health Poverty Alleviation Project on the Economic Burden of Disease Among Poor Households: Empirical Evidence from Sichuan Province].

    Chen, Chu / Chen, Ting / Pan, Jie

    Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition

    2023  Volume 54, Issue 2, Page(s) 393–399

    Abstract: Objective: To evaluate the effect of Health Poverty Alleviation Project on the economic burden of disease among poor families and to provide references for further improvement of the Health Poverty Alleviation Project.: Methods: The difference-in- ... ...

    Abstract Objective: To evaluate the effect of Health Poverty Alleviation Project on the economic burden of disease among poor families and to provide references for further improvement of the Health Poverty Alleviation Project.
    Methods: The difference-in-differences with propensity score matching method was used to analyze 48 counties in Sichuan Province. Propensity score matching was first carried out with data from the Sichuan Provincial Information System for Medical Care for Low-Income Population and the New Rural Cooperative Medical Insurance data to identify the non-poor population closest to the poor population. Then, difference-in-difference method was used to determine the effect of the Health Poverty Alleviation Project.
    Results: Health Poverty Alleviation Project reduced the total annual out-of-pocket (OOP) payments by 13.1% on average, the outpatient OOP payments by an average 2.4%, inpatient OOP payments by an average 19.5%, and the probability of incurring catastrophic health care expenditures by an average of 3.9% for low-income households. In addition, the program had a more significant effect in poverty-stricken counties than it did in non-poverty-stricken counties. Despite the significant effectiveness of the project, 12.1% of the low-income families still incurred catastrophic health expenditures after the program was implemented.
    Conclusion: Health Poverty Alleviation Project reduces the economic burden of disease for poor households, and it has a better effect on reducing the economic burden of poor households in poverty-stricken counties. However, a certain number of households still incurred catastrophic health expenditures. When consolidating and expanding the effects of Health Poverty Alleviation Project and monitoring medical expenses for poverty prevention, policymakers should focus on the households with catastrophic medical expenditures to prevent them from sinking back into poverty.
    MeSH term(s) Humans ; Financial Stress ; Financing, Personal ; Family Characteristics ; Cost of Illness ; China
    Language Chinese
    Publishing date 2023-03-22
    Publishing country China
    Document type English Abstract ; Journal Article
    ZDB-ID 2106840-9
    ISSN 1672-173X
    ISSN 1672-173X
    DOI 10.12182/20230360105
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  9. Article ; Online: Financial development, technological innovation and urban-rural income gap

    Li-Min Wang / Xiang-Li Wu / Nan-Chen Chu

    PLoS ONE, Vol 18, Iss 2, p e

    Time series evidence from China.

    2023  Volume 0279246

    Abstract: The main purpose of the paper is to investigate the relationship between technological innovation and income inequality for China based on the financial Kuznets curve (FKC) hypothesis. The study uses time-series data from 1985 to 2019. We employ the ... ...

    Abstract The main purpose of the paper is to investigate the relationship between technological innovation and income inequality for China based on the financial Kuznets curve (FKC) hypothesis. The study uses time-series data from 1985 to 2019. We employ the Johansen cointegration, ARDL model and VECM Granger causality techniques to analyze the links between the variables. We also use the DOLS, FMOLS and CCR mechanisms to estimate the long-run parameters. The paper finds that the FKC is valid for China's economy in the long run. Technological innovation positively affects the urban-rural income gap, while there is an inverted-U shaped between financial development and the urban-rural income gap. The relationship between financial development and the urban-rural income gap is bi-directional causality. Technological innovation and the urban-rural income gap cause each other. Empirical results suggest a twofold policy meaning: i) to further the financial system and ii) to eliminate the adverse impacts of technological innovations on income distribution.
    Keywords Medicine ; R ; Science ; Q
    Subject code 339
    Language English
    Publishing date 2023-01-01T00:00:00Z
    Publisher Public Library of Science (PLoS)
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article ; Online: Outlier Reconstruction of NDVI for Vegetation-Cover Dynamic Analyses

    Zhengbao Sun / Lizhen Wang / Chen Chu / Yu Zhang

    Applied Sciences, Vol 12, Iss 4412, p

    2022  Volume 4412

    Abstract: The normalized difference vegetation index (NDVI) contains important data for providing vegetation-cover information and supporting environmental analyses. However, understanding long-term vegetation cover dynamics remains challenging due to data ... ...

    Abstract The normalized difference vegetation index (NDVI) contains important data for providing vegetation-cover information and supporting environmental analyses. However, understanding long-term vegetation cover dynamics remains challenging due to data outliers that are found in cloudy regions. In this article, we propose a sliding-window-based tensor stream analysis algorithm (SWTSA) for reconstructing outliers in NDVI from multitemporal optical remote-sensing images. First, we constructed a tensor stream of NDVI that was calculated from clear-sky optical remote-sensing images corresponding to seasons on the basis of the acquired date. Second, we conducted tensor decomposition and reconstruction by SWTSA. Landsat series remote-sensing images were used in experiments to demonstrate the applicability of the SWTSA. Experiments were carried out successfully on the basis of data from the estuary area of Salween River in Southeast Asia. Compared with random forest regression (RFR), SWTSA has higher accuracy and better reconstruction capabilities. Results show that SWTSA is reliable and suitable for reconstructing outliers of NDVI from multitemporal optical remote-sensing images.
    Keywords outlier reconstruction ; tensor decomposition ; tensor stream analysis ; normalized difference vegetation index (NDVI) ; Salween River estuary ; Technology ; T ; Engineering (General). Civil engineering (General) ; TA1-2040 ; Biology (General) ; QH301-705.5 ; Physics ; QC1-999 ; Chemistry ; QD1-999
    Subject code 333
    Language English
    Publishing date 2022-04-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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