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  1. Article ; Online: Iron metabolism in human body and its regulatory factors

    CHEN Chun-mei, GE Pin, GUO Chong

    Jichu yixue yu linchuang, Vol 42, Iss 5, Pp 818-

    2022  Volume 823

    Abstract: This article reviews the molecular mechanism of iron metabolism covering iron absorption,transportation,utilization and storage with focus on the key proteins involved in iron metabolism and elaborate regulation factors. Based on these results of ... ...

    Abstract This article reviews the molecular mechanism of iron metabolism covering iron absorption,transportation,utilization and storage with focus on the key proteins involved in iron metabolism and elaborate regulation factors. Based on these results of research it might be able to provide some new strategies to find potential biomarkers of iron metabolism to support early and correct diagnosis. What's more, a clear mechanism may also provide a breakthrough point for the targeted treatment of iron metabolism disorders in future.
    Keywords iron metabolism|divalent metal transporter (dmt1)|ferroportin 1(fpn1)|hepcidin ; Medicine ; R
    Language Chinese
    Publishing date 2022-05-01T00:00:00Z
    Publisher Institute of Basic Medical Sciences and Peking Union Medical College Hospital, Chinese Academy of Medical Sciences / Peking Union Medical College.
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article: Public health messages about COVID-19 prevention in multilingual Taiwan

    Chen, Chun-Mei

    Multilingua-Journal of Cross-Cultural and Interlanguage Communication

    Abstract: In this paper, I explore multilingual preventative public health messages against the spread of COVID-19 in Taiwan between January and April 2020 Based on empirical data, the symbolic and substantive content of multilingual top-down and bottom-up public ... ...

    Abstract In this paper, I explore multilingual preventative public health messages against the spread of COVID-19 in Taiwan between January and April 2020 Based on empirical data, the symbolic and substantive content of multilingual top-down and bottom-up public health strategies was analyzed and discussed Findings suggest that the voices of indigenous people have largely been excluded from top-down efforts and strategies in public health communications Top-down communication did not address the actual concerns of indigenous populations who relied on tourism to bolster their economy Bottom-up efforts emerged from social exclusion and the inaccessibility of public health information to indigenous populations;such efforts were over-communicated, and the problems of indigenous populations remained unaddressed I conclude by relating multilingualism and the needs of minority groups, and suggest an inclusive approach to social challenges and solutions for future pandemic preparedness
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #781694
    Database COVID19

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  3. Article ; Online: Public health messages about COVID-19 prevention in multilingual Taiwan

    Chen, Chun-Mei

    Multilingua

    2020  Volume 39, Issue 5, Page(s) 597–606

    Abstract: Abstract In this paper, I explore multilingual preventative public health messages against the spread of COVID-19 in Taiwan between January and April 2020. Based on empirical data, the symbolic and substantive content of multilingual top-down and bottom- ... ...

    Abstract Abstract In this paper, I explore multilingual preventative public health messages against the spread of COVID-19 in Taiwan between January and April 2020. Based on empirical data, the symbolic and substantive content of multilingual top-down and bottom-up public health strategies was analyzed and discussed. Findings suggest that the voices of indigenous people have largely been excluded from top-down efforts and strategies in public health communications. Top-down communication did not address the actual concerns of indigenous populations who relied on tourism to bolster their economy. Bottom-up efforts emerged from social exclusion and the inaccessibility of public health information to indigenous populations; such efforts were over-communicated, and the problems of indigenous populations remained unaddressed. I conclude by relating multilingualism and the needs of minority groups, and suggest an inclusive approach to social challenges and solutions for future pandemic preparedness.
    Keywords Linguistics and Language ; Communication ; Language and Linguistics ; covid19
    Publisher Walter de Gruyter GmbH
    Publishing country de
    Document type Article ; Online
    ZDB-ID 2049683-7
    ISSN 1613-3684 ; 0167-8507
    ISSN (online) 1613-3684
    ISSN 0167-8507
    DOI 10.1515/multi-2020-0092
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  4. Article: Efficacy of non-enhanced computer tomography-based radiomics for predicting hematoma expansion: A meta-analysis.

    Jiang, Yan-Wei / Xu, Xiong-Jei / Wang, Rui / Chen, Chun-Mei

    Frontiers in oncology

    2023  Volume 12, Page(s) 973104

    Abstract: Background: This meta-analysis aimed to assess the efficacy of radiomics using non-enhanced computed tomography (NCCT) for predicting hematoma expansion in patients with spontaneous intracerebral hemorrhage.: Methods: Throughout the inception of the ... ...

    Abstract Background: This meta-analysis aimed to assess the efficacy of radiomics using non-enhanced computed tomography (NCCT) for predicting hematoma expansion in patients with spontaneous intracerebral hemorrhage.
    Methods: Throughout the inception of the project to April 11, 2022, a comprehensive search was conducted on PubMed, Embase, and Cochrane Central Register of Controlled Trials. The methodological quality of studies in this analysis was assessed by the radiomics quality scoring system (RQS). A meta-analysis of radiomic studies based on NCCT for predicting hematoma expansion in patients with intracerebral hemorrhage was performed. The efficacy of the radiomics approach and non-contrast CT markers was compared using network meta-analysis (NMA).
    Results: Ten articles comprising a total of 1525 patients were quantitatively analyzed for hematoma expansion after cerebral hemorrhage using radiomics. Based on the included studies, the mean RQS was 14.4. The AUC value (95% confidence interval) of the radiomics model was 0.80 (0.76-0.83). Five articles comprising 846 patients were included in the NMA. The results synthesized according to Bayesian NMA revealed that the predictive ability of the radiomics model outperformed most of the NCCT biomarkers.
    Conclusions: The NCCT-based radiomics approach has the potential to predict hematoma expansion. Compared to NCCT biomarkers, we recommend a radiomics approach. Standardization of the radiomics approach is required for further clinical implementation.
    Systematic review registration: https://www.crd.york.ac.uk/PROSPERO/display_record.php?RecordID=324034, identifier [CRD42022324034].
    Language English
    Publishing date 2023-01-10
    Publishing country Switzerland
    Document type Systematic Review
    ZDB-ID 2649216-7
    ISSN 2234-943X
    ISSN 2234-943X
    DOI 10.3389/fonc.2022.973104
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  5. Article: Clinical evaluation of paraspinal mini-tubular technique vs. laminoplasty for spinal intradural extramedullary tumors: Study protocol for a multicenter, randomized controlled trial.

    Wang, Rui / Liang, Ze-Yan / Chen, Yan / Chen, Chun-Mei

    Frontiers in surgery

    2023  Volume 9, Page(s) 1053885

    Abstract: The development of minimally invasive surgery has promoted the use of the paraspinal mini-tubular technique (PMTT) for spinal tumors. The similarity of the efficacy of PMTT to that of traditional surgery remains unclear; randomized controlled trials ( ... ...

    Abstract The development of minimally invasive surgery has promoted the use of the paraspinal mini-tubular technique (PMTT) for spinal tumors. The similarity of the efficacy of PMTT to that of traditional surgery remains unclear; randomized controlled trials (RCTs) have not been conducted to investigate this technique for spinal tumors. The conventional surgery used for such tumors is laminoplasty (LP). To compare the differences between the two surgical techniques, an RCT is significantly required. Therefore, a prospective, multi-center, non-inferiority RCT was designed to compare the safety and effectiveness of LP and PMTT for treating spinal intradural extramedullary (IDEM) tumors. Moreover, the availability of PMTT, including its advantages and disadvantages, surgical indications, procedures, complications, and prognosis, would be explored. Overall, 280 patients will be randomly allocated to the PMTT and LP groups in a 1:1 ratio. The trial hypothesis is that PMTT has superior or equivalent efficacy and cost-effectiveness to LP. The primary outcome is the Japanese Orthopedic Association score. The non-inferiority margin for the primary outcome is five. The Ethics Committee of Fujian Medical University Union Hospital, Fuzhou, China, has approved this study (project number: FJMUUH05). Any results of the trial will be published in international peer-reviewed journals and disseminated through presentations at scientific conferences.
    Trial registration number: ChiCTR2100047582.
    Language English
    Publishing date 2023-01-05
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2773823-1
    ISSN 2296-875X
    ISSN 2296-875X
    DOI 10.3389/fsurg.2022.1053885
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  6. Article: Comparison of the Clinical Efficacy of Transforaminal Endoscopy and Microtubular Technology for the Treatment of Lumbar Dumbbell-Shaped Tumors.

    Wang, Rui / Liang, Ze Yan / Chen, Yan / Chen, Chun Mei

    Neurospine

    2022  Volume 19, Issue 3, Page(s) 513–523

    Abstract: Objective: To analyze differences in feasibility and efficacy between the paravertebral approach and microtubular tumorectomy (PAMT) or percutaneous transforaminal endoscopic tumorectomy (PTET) for the treatment of lumbar dumbbell-shaped tumors.: ... ...

    Abstract Objective: To analyze differences in feasibility and efficacy between the paravertebral approach and microtubular tumorectomy (PAMT) or percutaneous transforaminal endoscopic tumorectomy (PTET) for the treatment of lumbar dumbbell-shaped tumors.
    Methods: Clinical data of dumbbell-shaped lumbar tumors in patients treated with PAMT or PTET in our hospital between June 2015 and November 2020 were retrospectively analyzed. The gross total resection (GTR) rate, operation time, estimated blood loss, postoperative hospital stay (PHS), postoperative neurological function, and spinal stability were compared between the 2 surgical methods. Neurological improvement was assessed using the pain visual analogue scale (VAS) and the Japanese Orthopaedic Association (JOA) score.
    Results: Fifteen cases of GTR (93.8%) and 1 case of subtotal resection were included in the PTET group, whilst all 18 patients in the PAMT group achieved GTR. There was no significant difference in the GTR rate, operation time, and PHS between the PAMT and PTET groups. The estimated blood loss was significantly lower in the PTET group than in the PAMT group. At the last follow-up, there was no significant difference in the VAS or JOA scores between PTET and PAMT. No tumor recurrence or spinal instability was observed in either group during the follow-up period.
    Conclusion: Both PAMT and PTET can achieve Eden type III-IV lumbar 1-stage tumor resection without additional spinal internal fixation due to reduced muscle, ligament, and facet joint damage. No lumbar instability and tumor recurrence occurred, and neurological function was improved.
    Language English
    Publishing date 2022-05-16
    Publishing country Korea (South)
    Document type Journal Article
    ZDB-ID 3031654-6
    ISSN 2586-6591 ; 2586-6583
    ISSN (online) 2586-6591
    ISSN 2586-6583
    DOI 10.14245/ns.2244152.076
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  7. Article ; Online: Identification and validation of potential novel prognostic biomarkers for patients with glioma based on a gene co-expression network.

    Jiang, Yan-Wei / Wang, Rui / Zhuang, Yuan-Dong / Chen, Chun-Mei

    Translational cancer research

    2022  Volume 9, Issue 10, Page(s) 6444–6454

    Abstract: Background: Glioma is widely regarded as one of most lethal and challenging diseases of the nervous system. The aim of this study was to identify novel biomarkers that offer better prognosis prediction for Chinese patients with glioma.: Methods: By ... ...

    Abstract Background: Glioma is widely regarded as one of most lethal and challenging diseases of the nervous system. The aim of this study was to identify novel biomarkers that offer better prognosis prediction for Chinese patients with glioma.
    Methods: By using systematic approaches, the co-expression modules were identified from the Chinese Glioma Genome Atlas (CGGA) database through weighted gene co-expression network analysis and functional enrichment of essential modules of Kyoto Encyclopedia of Genes and Genomes terms. The co-expression modules were validated using The Cancer Genome Atlas database and the protein-protein interaction (PPI) network.
    Results: For network construction, 5,374 among 21,494 genes were selected, and an increasing genetic variance was associated with the prognosis of glioma. By using functional enrichment analysis, the involvement of multiple vital processes, including metabolism of fatty acids, was correlated with the patient prognosis. Notably, five hub genes (KCNB1, UST, SOX8, KLHL42, and HDAC4) were identified for these processes. Accordingly, using the Kaplan-Meier method, there was enhanced expression of these genes in patients with significantly lower overall survival rates, especially those from the CGGA database.
    Conclusions: This study not only revealed the essential co-expression gene modules in patients with glioma, but it also unraveled the potential signaling pathways underlying these functional processes.
    Language English
    Publishing date 2022-01-15
    Publishing country China
    Document type Journal Article
    ZDB-ID 2901601-0
    ISSN 2219-6803 ; 2218-676X
    ISSN (online) 2219-6803
    ISSN 2218-676X
    DOI 10.21037/tcr-20-492
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  8. Article ; Online: Radiomics analysis based on lumbar spine CT to detect osteoporosis.

    Jiang, Yan-Wei / Xu, Xiong-Jie / Wang, Rui / Chen, Chun-Mei

    European radiology

    2022  Volume 32, Issue 11, Page(s) 8019–8026

    Abstract: Objectives: Undiagnosed osteoporosis may lead to severe complications after spinal surgery. This study aimed to construct and validate a radiomic signature based on CT scans to screen for lumbar spine osteoporosis.: Methods: Using a stratified random ...

    Abstract Objectives: Undiagnosed osteoporosis may lead to severe complications after spinal surgery. This study aimed to construct and validate a radiomic signature based on CT scans to screen for lumbar spine osteoporosis.
    Methods: Using a stratified random sample method, 386 vertebral bodies were randomly divided into a training set (n = 270) and a test set (n = 116). A total of 1040 radiomics features were automatically retracted from lumbar spine CT scans using the 3D slicer pyradiomics module, and a radiomic signature was created. The sensitivity, specificity, accuracy, and area under the receiver operating characteristic curve (AUC) of the Hounsfield and radiomics signature models were calculated. The AUCs of the two models were compared using the DeLong test. Their clinical usefulness was assessed using a decision curve analysis.
    Results: Twelve features were chosen to establish the radiomic signature. The AUCs of the radiomics signature and Hounsfield models were 0.96 and 0.88 in the training set and 0.92 and 0.84 in the test set, respectively. According to the DeLong test, the AUCs of the two models were significantly different (p < 0.05). The radiomics signature model indicated a higher overall net benefit than the Hounsfield model, as determined by decision curve analysis.
    Conclusions: The CT-based radiomic signature can differentiate patients with/without osteoporosis prior to lumbar spinal surgery. Without additional medical cost and radiation exposure, the radiomics method may provide valuable information facilitating surgical decision-making.
    Key points: • The goal of the study was to evaluate the efficacy of a radiomics signature model based on routine preoperative lumbar spine CT scans in screening osteoporosis. • The radiomics signature model demonstrated excellent prediction performance in both the training and test sets. • This radiomics method may provide valuable information and facilitate surgical decision-making without additional medical costs and radiation exposure.
    MeSH term(s) Humans ; Area Under Curve ; Osteoporosis/diagnostic imaging ; ROC Curve ; Tomography, X-Ray Computed/methods
    Language English
    Publishing date 2022-04-30
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1085366-2
    ISSN 1432-1084 ; 0938-7994 ; 1613-3749
    ISSN (online) 1432-1084
    ISSN 0938-7994 ; 1613-3749
    DOI 10.1007/s00330-022-08805-4
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  9. Article ; Online: Tubular minimally invasive resection of McCormick type II paraspinal schwannoma: preliminary experience.

    Jiang, Yan-Wei / Xu, Xiong-Jie / Wang, Rui / Chen, Chun-Mei

    British journal of neurosurgery

    2022  Volume 37, Issue 2, Page(s) 193–198

    Abstract: Purpose: Complete removal of paraspinal schwannomas is generally required for full patient recovery. However, traditional open approaches to surgery are often extensive and may lead to more postoperative complications. Herein, we present our preliminary ...

    Abstract Purpose: Complete removal of paraspinal schwannomas is generally required for full patient recovery. However, traditional open approaches to surgery are often extensive and may lead to more postoperative complications. Herein, we present our preliminary experience with tubular minimally invasive resection of McCormick type II paraspinal schwannomas and describe the technique by specifically reviewing two patient cases.
    Materials and methods: Type of study: Retrospective: Level of evidence: Level III: A total of 15 patients (six men; nine women; median age, 45 years) who underwent minimally invasive resection of McCormick type II paraspinal schwannomas were retrospectively analysed. Preoperative characteristics, including age, location of tumour, Visual Analog Scale score, Modified McCormick Scale score, and intraoperative findings and complications were analysed. Furthermore, postoperative outcomes using imaging, such as magnetic resonance imaging (MRI) and thin-slice computed tomography, and postoperative neural status using the Modified McCormick and Visual Analog Scales were also assessed.
    Results: The mean operation time was 134.72 ± 34.21 min. The estimated mean blood loss and mean hospital stay were 25.33 ± 17.27 ml and 7.67 ± 1.88 days, respectively. Regarding complications, one of the patients had a local wound infection, which improved after antibiotic treatment. The total resection in all cases was verified using postoperative MRI.
    Conclusion: The tubular minimally invasive approach is a feasible technique for the total resection of McCormick type II paraspinal schwannomas. Using this technique, surgeons can resect paraspinal schwannomas while maintaining spinal stability.
    MeSH term(s) Male ; Humans ; Female ; Middle Aged ; Retrospective Studies ; Magnetic Resonance Imaging ; Laminectomy/methods ; Minimally Invasive Surgical Procedures/methods ; Neurilemmoma/diagnostic imaging ; Neurilemmoma/surgery ; Treatment Outcome
    Language English
    Publishing date 2022-04-05
    Publishing country England
    Document type Journal Article
    ZDB-ID 639029-8
    ISSN 1360-046X ; 0268-8697
    ISSN (online) 1360-046X
    ISSN 0268-8697
    DOI 10.1080/02688697.2022.2057433
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    Zs.A 2210: Show issues Location:
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  10. Article: Computer-modified paramedian approach technique reduces failures and alleviates pain in lumbar puncture: a prospective comparative study.

    Zhuang, Yuan-Dong / Xie, Hai-Shu / Chen, Jing / Wu, Guo-Hua / Wu, Jian-Feng / Chen, Chun-Mei

    Frontiers in medicine

    2024  Volume 10, Page(s) 1293689

    Abstract: Background: The conventional midline approach for lumbar puncture (MAT-LP) has a relatively low success rate of 70%. The paramedian approach can increase the effective puncture area and success rate but lacks standardized guidelines. This study ... ...

    Abstract Background: The conventional midline approach for lumbar puncture (MAT-LP) has a relatively low success rate of 70%. The paramedian approach can increase the effective puncture area and success rate but lacks standardized guidelines. This study evaluated a computer-modified paramedian approach technique (CMPAT) to optimize lumbar puncture using computational techniques.
    Methods: In this prospective study, 120 patients underwent CMPAT-LP (
    Results: No significant demographic differences existed between groups. Failure rates were 3.3% for CMPAT vs. 13.3% for MAT. Puncture attempts averaged 2.0 vs. 3.5 and pain scores were 2.7 vs. 4.1 for CMPAT and MAT, respectively. All outcomes were significantly improved with CMPAT, especially in elderly patients. No significant difference in complications was observed.
    Conclusion: Compared to MAT, CMPAT-LP demonstrated lower failure rates, fewer puncture attempts, and less pain, without compromising safety. CMPAT may be superior and should be more widely implemented in clinical practice.
    Language English
    Publishing date 2024-01-22
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2775999-4
    ISSN 2296-858X
    ISSN 2296-858X
    DOI 10.3389/fmed.2023.1293689
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