LIVIVO - Suchergebnisse -

Suchergebnis

Treffer 1 - 8 von insgesamt 8

Suchoptionen

Artikel ; Online: The profile of HIV-1 drug resistance in Shanghai, China: a retrospective study from 2017 to 2021.

Zhang, Min / Ma, Yingying / Wang, Gang / Wang, Zhenyan / Wang, Qianying / Li, Xin / Lin, Feng / Qiu, Jianping / Chen, Daihong / Shen, Yinzhong / Zhang, Chiyu / Lu, Hongzhou

The Journal of antimicrobial chemotherapy

2024 Band 79, Heft 3, Seite(n) 526–530

Abstract: Background: HIV-1 drug resistance is a huge challenge in the era of ART.: Objectives: To investigate the prevalence and characteristics of acquired HIV-1 drug resistance (ADR) in Shanghai, China.: Methods: An epidemiological study was performed ... ...

Abstract	Background: HIV-1 drug resistance is a huge challenge in the era of ART. Objectives: To investigate the prevalence and characteristics of acquired HIV-1 drug resistance (ADR) in Shanghai, China. Methods: An epidemiological study was performed among people living with human immunodeficiency virus (PLWH) receiving ART in Shanghai from January 2017 to December 2021. A total of 8669 PLWH were tested for drug resistance by genotypic resistance testing. Drug resistance mutations (DRMs) were identified using the Stanford University HIV Drug Resistance Database program. Results: Ten HIV-1 subtypes/circulating recombinant forms (CRFs) were identified, mainly including CRF01_AE (46.8%), CRF07_BC (35.7%), B (6.4%), CRF55_01B (2.8%) and CRF08_BC (2.4%). The prevalence of ADR was 48% (389/811). Three NRTI-associated mutations (M184V/I/L, S68G/N/R and K65R/N) and four NNRTI-associated mutations (V179D/E/T/L, K103N/R/S/T, V106M/I/A and G190A/S/T/C/D/E/Q) were the most common DRMs. These DRMs caused high-level resistance to lamivudine, emtricitabine, efavirenz and nevirapine. The DRM profiles appeared to be significantly different among different subtypes. Conclusions: We revealed HIV-1 subtype characteristics and the DRM profile in Shanghai, which provide crucial guidance for clinical treatment and management of PLWH.
Mesh-Begriff(e)	Humans ; HIV-1/genetics ; Retrospective Studies ; China/epidemiology ; HIV Seropositivity ; Alkynes
Chemische Substanzen	Alkynes
Sprache	Englisch
Erscheinungsdatum	2024-02-01
Erscheinungsland	England
Dokumenttyp	Journal Article
ZDB-ID	191709-2
ISSN	1460-2091 ; 0305-7453
ISSN (online)	1460-2091
ISSN	0305-7453
DOI	10.1093/jac/dkad370
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

Volltext online

Zugriff für angemeldete ZB MED Nutzerinnen und Nutzer

Zusatzmaterialien

Verfügbar in ZB MED Köln/Königswinter

Zs.A 1197: Hefte anzeigen			Standort: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 124: Hefte anzeigen

Über subito bestellen

Dieser Service ist kostenpflichtig (siehe Lieferbedingungen von subito). Bestellungen, die einen Artikel nebst Supplementary Material umfassen, werden grundsätzlich wie mehrfache Bestellungen bearbeitet. Gebühren fallen in diesen Fällen für jede einzelne Bestellung an.

Details ▾

Artikel: An inter-correlated cytokine network identified at the center of cytokine storm predicted COVID-19 prognosis

Liu, Yili Chen Daihong Hou Junjie Li Haicong Cao Dan Guo Mingquan Ling Yun Gao Menglu Zhou Yi Wan Yanmin Zhu Zhaoqin

Cytokine

Abstract: The hyper-inflammatory response is thought to be a major cause of acute respiratory distress syndrome (ARDS) in patients with COVID-19 Although multiple cytokines are reportedly associated with disease severity, the key mediators of SARS-CoV-2 induced ... ...

Abstract	The hyper-inflammatory response is thought to be a major cause of acute respiratory distress syndrome (ARDS) in patients with COVID-19 Although multiple cytokines are reportedly associated with disease severity, the key mediators of SARS-CoV-2 induced cytokine storm and their predictive values have not been fully elucidated The present study analyzed maximal and early (within 10 days after disease onset) concentrations of 12-plex cytokines in plasma We found consistently elevated plasma levels of IL-6, IL-8 and IL-5 in patients who were deceased compared with those who had mild/moderate or severe disease The early plasma concentrations of IFN-a and IL-2 positively correlated with the length of the disease course Moreover, correlation network analysis showed that IL-6, IL-8, and IL-5 located at the center of an inter-correlated cytokine network These findings suggested that IL-8, IL-6, IL-5 might play central roles in cytokine storms associated with COVID-19 and that the early detection of multiple plasma cytokines might help to predict the prognosis of this disease
Schlagwörter	covid19
Verlag	WHO
Dokumenttyp	Artikel
Anmerkung	WHO #Covidence: #917276
Datenquelle	COVID19

Fernleihe an ZB MED

Sie können sich den gewünschten Titel als lokale Nutzerin oder lokaler Nutzer von ZB MED direkt an den Standort Köln schicken lassen.

Details ▾

Artikel ; Online: Immunogenicity of an inactivated SARS-CoV-2 vaccine in people living with HIV-1: a non-randomized cohort study.

Feng, Yanmeng / Zhang, Yifan / He, Zhangyufan / Huang, Haojie / Tian, Xiangxiang / Wang, Gang / Chen, Daihong / Ren, Yanqin / Jia, Liqiu / Wang, Wanhai / Wu, Jing / Shao, Lingyun / Zhang, Wenhong / Tang, Heng / Wan, Yanmin

EClinicalMedicine

2021 Band 43, Seite(n) 101226

Abstract: Background: Inactivated COVID-19 vaccines are safe and effective in the general population with intact immunity. However, their safety and immunogenicity have not been demonstrated in people living with HIV (PLWH).: Methods: 42 HIV-1 infected ... ...

Abstract	Background: Inactivated COVID-19 vaccines are safe and effective in the general population with intact immunity. However, their safety and immunogenicity have not been demonstrated in people living with HIV (PLWH). Methods: 42 HIV-1 infected individuals who were stable on combination antiretroviral therapy (cART) and 28 healthy individuals were enrolled in this open-label two-arm non-randomized study at Hubei Provincial Center for Disease Control and Prevention, China. Two doses of an inactivated COVID-19 vaccine (BBIBP-CorV) were given on April 22, 2021 and May 25, 2021, respectively. The reactogenicity of the vaccine were evaluated by observing clinical adverse events and solicited local and systemic reactions. Humoral responses were measured by anti-spike IgG ELISA and surrogate neutralization assays. Cell-mediated immune responses and vaccine induced T cell activation were measured by flow cytometry. Findings: All the HIV-1 infected participants had a CD4 Interpretation: Our data demonstrated that the inactivated SARS-CoV-2 vaccine was safe, immunogenic in PLWH who are stable on cART with suppressed viral load and CD4
Sprache	Englisch
Erscheinungsdatum	2021-12-04
Erscheinungsland	England
Dokumenttyp	Journal Article
ISSN	2589-5370
ISSN (online)	2589-5370
DOI	10.1016/j.eclinm.2021.101226
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

Zusatzmaterialien

Über subito bestellen

Fernleihe an ZB MED

Sie können sich den gewünschten Titel als lokale Nutzerin oder lokaler Nutzer von ZB MED direkt an den Standort Köln schicken lassen.

Details ▾
- Kostenpflichtig bestellen

Artikel ; Online: Validation of the BD FACSPresto system for the measurement of CD4 T-lymphocytes and hemoglobin concentration in HIV-negative and HIV-positive subjects.

Lu, Xiaofan / Sun, Hanxiao / Li, Haicong / Xia, Wei / Wu, Hao / Chen, Daihong / Tan, Meiyu / Yu, Shijun / Zhang, Tong / Sheng, Huiming / Zhu, Zhaoqin

Scientific reports

2020 Band 10, Heft 1, Seite(n) 19605

Abstract: This study aimed to compare the performance of the BD FACSPresto system with the conventional standard-of-care technologies for the measurement of absolute CD4 count (AbsCD4), CD4 percentage (CD4%) and total hemoglobin concentration (Hb) in capillary and ...

Abstract	This study aimed to compare the performance of the BD FACSPresto system with the conventional standard-of-care technologies for the measurement of absolute CD4 count (AbsCD4), CD4 percentage (CD4%) and total hemoglobin concentration (Hb) in capillary and venous blood samples of HIV-negative and HIV-positive subjects. A total of 1304 participants were included in this prospective cohort study. Both venous and capillary blood samples were analyzed using the BD FACSPresto system and the results were compared against the BD FACSCalibur for enumerating AbsCD4 and CD4% and Sysmex XT-4000i hematology analyzer for determining Hb levels. Method comparison studies were performed using Deming regression and Bland-Altman plots. The Deming regression analyses comparing the accuracy of the BD FACSPresto system with the reference standard technologies demonstrated a significant linear correlation between the AbsCD4, CD4%, and Hb values generated by the two platforms. The 95% CI of the slopes for AbsCD4, CD4%, and Hb levels were 0.94-0.99, 0.99-1.01 and 0.86-0.93, respectively (P < 0.001). Bland-Altman plots for AbsCD4, CD4%, and Hb levels demonstrated close agreement between the BD FACSPresto system and the reference standards for all study participants. The performance and accuracy of BD FACSPresto system was comparable to the reference standard technologies. The BD FACSPresto system can be used interchangeably with BD FACSCalibur platform for CD4 and Sysmex XT-4000i hematology analyzer for Hb concentrations in resource-limited settings thus, improving accessibility to point-of-care testing services.
Mesh-Begriff(e)	Adult ; CD4 Lymphocyte Count ; Female ; Flow Cytometry/instrumentation ; HIV Infections/blood ; HIV Seropositivity ; Hemoglobins/analysis ; Humans ; Male ; Point-of-Care Systems ; Pregnancy ; Prospective Studies
Chemische Substanzen	Hemoglobins
Sprache	Englisch
Erscheinungsdatum	2020-11-11
Erscheinungsland	England
Dokumenttyp	Comparative Study ; Journal Article ; Multicenter Study ; Research Support, Non-U.S. Gov't ; Validation Study
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-020-76549-6
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

Zusatzmaterialien

Über subito bestellen

Details ▾
- Kostenpflichtig bestellen

Artikel ; Online: An inter-correlated cytokine network identified at the center of cytokine storm predicted COVID-19 prognosis.

Liu, Yili / Chen, Daihong / Hou, Junjie / Li, Haicong / Cao, Dan / Guo, Mingquan / Ling, Yun / Gao, Menglu / Zhou, Yi / Wan, Yanmin / Zhu, Zhaoqin

Cytokine

2020 Band 138, Seite(n) 155365

Abstract: The hyper-inflammatory response is thought to be a major cause of acute respiratory distress syndrome (ARDS) in patients with COVID-19. Although multiple cytokines are reportedly associated with disease severity, the key mediators of SARS-CoV-2 induced ... ...

Abstract	The hyper-inflammatory response is thought to be a major cause of acute respiratory distress syndrome (ARDS) in patients with COVID-19. Although multiple cytokines are reportedly associated with disease severity, the key mediators of SARS-CoV-2 induced cytokine storm and their predictive values have not been fully elucidated. The present study analyzed maximal and early (within 10 days after disease onset) concentrations of 12-plex cytokines in plasma. We found consistently elevated plasma levels of IL-6, IL-8 and IL-5 in patients who were deceased compared with those who had mild/moderate or severe disease. The early plasma concentrations of IFN-a and IL-2 positively correlated with the length of the disease course. Moreover, correlation network analysis showed that IL-6, IL-8, and IL-5 located at the center of an inter-correlated cytokine network. These findings suggested that IL-8, IL-6, IL-5 might play central roles in cytokine storms associated with COVID-19 and that the early detection of multiple plasma cytokines might help to predict the prognosis of this disease.
Mesh-Begriff(e)	Aged ; COVID-19/pathology ; Correlation of Data ; Cytokine Release Syndrome/pathology ; Cytokines/blood ; Female ; Humans ; Interferon-alpha/blood ; Interleukin-2/blood ; Interleukin-5/blood ; Interleukin-6/blood ; Interleukin-8/blood ; Male ; Middle Aged ; Prognosis ; Respiratory Distress Syndrome/pathology ; Retrospective Studies ; SARS-CoV-2/immunology ; Severity of Illness Index
Chemische Substanzen	CXCL8 protein, human ; Cytokines ; IFNA1 protein, human ; IL2 protein, human ; IL5 protein, human ; IL6 protein, human ; Interferon-alpha ; Interleukin-2 ; Interleukin-5 ; Interleukin-6 ; Interleukin-8
Sprache	Englisch
Erscheinungsdatum	2020-11-09
Erscheinungsland	England
Dokumenttyp	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1018055-2
ISSN	1096-0023 ; 1043-4666
ISSN (online)	1096-0023
ISSN	1043-4666
DOI	10.1016/j.cyto.2020.155365
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

Volltext online

Zugriff für angemeldete ZB MED Nutzerinnen und Nutzer

Zusatzmaterialien

Verfügbar in ZB MED Köln/Königswinter

Zs.A 2840: Hefte anzeigen

Standort:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

Über subito bestellen

Details ▾

Artikel ; Online: Immunogenicity and safety of an inactivated SARS-CoV-2 vaccine in people living with HIV-1

medRxiv

Abstract: It has been proven that inactivated COVID-19 vaccines are safe and effective in general population with intact immunity. However, their safety and immunogenicity have not been demonstrated in people living with HIV (PLWH). In this study, we compared the ... ...

Abstract	It has been proven that inactivated COVID-19 vaccines are safe and effective in general population with intact immunity. However, their safety and immunogenicity have not been demonstrated in people living with HIV (PLWH). In this study, we compared the immunogenicity of an inactivated COVID-19 vaccine between healthy individuals (n=28) and HIV-1 infected participants stable on cART (n=42). All the HIV-1 infected participants had a CD4+ T cell count of > 200 cells/μL both at baseline and 4 weeks after vaccination. Comparable RBD binding antibody and neutralizing antibody responses were elicited in PLWH and healthy individuals after two-dose vaccination. Further analyses showed that PLWH with low baseline CD4+/CD8+ T cell ratios (<0.6) responded poorly to vaccination compared with PLWH with medium (0.6~1.0) or high (>1.0) baseline CD4+/CD8+ T cell ratios (P<0.01). No solicited adverse incident was observed in both cohorts. The CD3+, CD4+ and CD8+ T cell counts of PLWH decreased significantly after vaccination, but it did not lead to any adverse clinical manifestation. On the contrary, we found that the general burden of HIV-1 among PLWH decreased significantly (P=0.0059) after two doses of vaccination. Collectively, our data demonstrate that the inactivated COVID-19 vaccine is safe and immunogenic in PLWH who are stale on cART with unsuppressed CD4 count .
Schlagwörter	covid19
Sprache	Englisch
Erscheinungsdatum	2021-09-22
Verlag	Cold Spring Harbor Laboratory Press
Dokumenttyp	Artikel ; Online
DOI	10.1101/2021.09.14.21263556
Datenquelle	COVID19

Volltext online

Fernleihe an ZB MED

Sie können sich den gewünschten Titel als lokale Nutzerin oder lokaler Nutzer von ZB MED direkt an den Standort Köln schicken lassen.

Artikel ; Online: An inter-correlated cytokine network identified at the center of cytokine storm predicted COVID-19 prognosis

Liu, Yili / Chen, Daihong / Hou, Junjie / Li, Haicong / Cao, Dan / Guo, Mingquan / Ling, Yun / Gao, Menglu / Zhou, Yi / Wan, Yanmin / Zhu, Zhaoqin

Cytokine

2020 , Seite(n) 155365

Schlagwörter	Immunology ; Immunology and Allergy ; Biochemistry ; Molecular Biology ; Hematology ; covid19
Sprache	Englisch
Verlag	Elsevier BV
Erscheinungsland	us
Dokumenttyp	Artikel ; Online
ZDB-ID	1018055-2
ISSN	1096-0023 ; 1043-4666
ISSN (online)	1096-0023
ISSN	1043-4666
DOI	10.1016/j.cyto.2020.155365
Datenquelle	BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

Volltext online

Zugriff für angemeldete ZB MED Nutzerinnen und Nutzer

Zusatzmaterialien

Verfügbar in ZB MED Köln/Königswinter

Zs.A 2840: Hefte anzeigen

Standort:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

Über subito bestellen

Details ▾

Artikel ; Online: Clinical Immunophenotype at Disease Onset in Previously Healthy Patients With Cryptococcal Meningitis.

Xu, Lie / Huang, Qin / Lin, Jin-Ran / Zhu, Cui-Yun / Li, Xin-Hua / Ye, Shan-Ke / Zhu, Ai-Hong / Chen, Dai-Hong / Zhang, Cheng-Feng / Chen, Liang / Ling, Yun

Medicine

2016 Band 95, Heft 6, Seite(n) e2744

Abstract: Cryptococcal meningitis (CM) is a global disease with significant morbidity and mortality. Although low peripheral blood cluster of differentiation 4 (CD4) cell counts are found to be related to a high burden of cryptococcus in HIV-infected patients, ... ...

Abstract	Cryptococcal meningitis (CM) is a global disease with significant morbidity and mortality. Although low peripheral blood cluster of differentiation 4 (CD4) cell counts are found to be related to a high burden of cryptococcus in HIV-infected patients, little is known about possible immune defects in previously healthy patients (PHPs). We performed a retrospective study of 41 CM patients treated from January 2005 to December 2014 who did not have HIV-infection. There were 33 PHPs and 8 not previously healthy patients (non-PHPs). We analyzed clinical test data pertaining to peripheral blood T cells, antibodies, inflammation markers, and cerebral spinal fluid (CSF) completed during the disease onset phase and 5 years following diagnosis. PHPs had significantly higher counts of cluster of differentiation 3 (CD3), cluster of differentiation 4 (CD4), and cluster of differentiation 45 (CD45) cells, and lower percentages of CD8 cells than non-PHPs (P < 0.05). Measurements of inflammatory markers and immunoglobulin in blood were comparable except for lower immunoglobulin A (IgA) levels in non-PHPs (P = 0.0410). Examination of CSF revealed lower white blood cell (WBC) counts in non-PHPs. Five-year mortality in PHPs was higher than in non-PHPs (22.0% vs 12.5%) but this was not statistically significant (P > 0.05). Multivariate analysis revealed that higher immunoglobulin G (IgG) levels in serum during disease onset may be an independent predictor of mortality (P = 0.015). In conclusion, PHPs demonstrate an immunophenotype that is distinct from that of non-PHPs, leading to an improved understanding of the immunology of cryptococcal meningitis.
Mesh-Begriff(e)	Adolescent ; Adult ; Aged ; Biomarkers/metabolism ; CD4-Positive T-Lymphocytes/metabolism ; CD8-Positive T-Lymphocytes/metabolism ; Child ; Child, Preschool ; Female ; Humans ; Immunoglobulin G/blood ; Lymphocyte Count ; Male ; Meningitis, Cryptococcal/immunology ; Meningitis, Cryptococcal/metabolism ; Meningitis, Cryptococcal/mortality ; Middle Aged ; Phenotype ; Retrospective Studies ; Young Adult
Chemische Substanzen	Biomarkers ; Immunoglobulin G
Sprache	Englisch
Erscheinungsdatum	2016-02-05
Erscheinungsland	United States
Dokumenttyp	Journal Article ; Observational Study ; Research Support, Non-U.S. Gov't
ZDB-ID	80184-7
ISSN	1536-5964 ; 0025-7974
ISSN (online)	1536-5964
ISSN	0025-7974
DOI	10.1097/MD.0000000000002744
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

Zusatzmaterialien

Verfügbar in ZB MED Köln/Königswinter

Ua VI Zs.171: Hefte anzeigen

Standort:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Über subito bestellen

Details ▾
- Im ZB MED-Bestand
- Kostenpflichtig bestellen

Zum Seitenanfang

Ihre letzten Suchen

Volltext online

Zusatzmaterialien

Kategorien

Verfügbar in ZB MED Köln/Königswinter

Über subito bestellen

Kategorien

Fernleihe an ZB MED

Zusatzmaterialien

Kategorien

Über subito bestellen

Fernleihe an ZB MED

Zusatzmaterialien

Kategorien

Über subito bestellen

Volltext online

Zusatzmaterialien

Kategorien

Verfügbar in ZB MED Köln/Königswinter

Über subito bestellen

Volltext online

Kategorien

Fernleihe an ZB MED

Volltext online

Zusatzmaterialien

Kategorien

Verfügbar in ZB MED Köln/Königswinter

Über subito bestellen

Zusatzmaterialien

Kategorien

Verfügbar in ZB MED Köln/Königswinter

Über subito bestellen