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  1. Book ; Online ; E-Book: Capillary electrophoresis -- mass spectrometry for proteomics and metabolomics

    Ramautar, Rawi / Chen, David D. Y.

    principles and applications

    2023  

    Author's details edited by Rawi Ramautar and David D. Y. Chen
    Keywords Capillary electrophoresis
    Subject code 541.372
    Language English
    Size 1 online resource (403 pages)
    Publisher John Wiley & Sons
    Publishing place Hoboken, New Jersey
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    ISBN 3-527-83309-9 ; 3-527-83308-0 ; 9783527349210 ; 978-3-527-83309-2 ; 978-3-527-83308-5 ; 3527349219
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Book: Stress management and prevention

    Chen, David D.

    applications to daily life

    2017  

    Author's details David D. Chen
    Keywords Stress, Psychological / therapy ; Life Style
    Subject code 616.9/8
    Language English
    Size xvii, 422 Seiten, Illustrationen
    Edition Third edition
    Publisher Routledge
    Publishing place New York, NY
    Publishing country United States
    Document type Book
    Note Previous edition: Stress management and prevention : applications to everyday life / Jeffrey A. Kottler and David D. Chen ; Includes bibliographical references and index
    HBZ-ID HT020584550
    ISBN 9781138906280 ; 113890628X
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2020 A 1362 available for loan (reading room) Lesesaal EG

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  3. Article ; Online: Firearm Violence in Wilmington, DE:: An Update on 2020.

    Chen, David D / Bolaji, Toba

    Delaware journal of public health

    2022  Volume 8, Issue 4, Page(s) 62–63

    Abstract: Firearm violence within Delaware has been concentrated in the City of Wilmington and rates disproportionately affect populations, with the highest disparity and inequity in mortality among young Black men. This commentary provides an update to a prior ... ...

    Abstract Firearm violence within Delaware has been concentrated in the City of Wilmington and rates disproportionately affect populations, with the highest disparity and inequity in mortality among young Black men. This commentary provides an update to a prior review from 2018 with an analysis of the factors contributing to a surge in 2020 and the years beyond.
    Language English
    Publishing date 2022-10-28
    Publishing country United States
    Document type Journal Article
    ISSN 2639-6378
    ISSN (online) 2639-6378
    DOI 10.32481/djph.2022.10.012
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Book: Stress management and prevention

    Chen, David D

    applications to daily life

    2017  

    Author's details David D. Chen
    MeSH term(s) Stress, Psychological/therapy ; Life Style
    Language English
    Size xvii, 422 pages :, illustrations, portraits
    Edition Third edition.
    Document type Book
    Note Previous edition: Stress management and prevention : applications to everyday life / Jeffrey A. Kottler and David D. Chen.
    ISBN 9781138906280 ; 113890628X ; 9781315695594 ; 1315695596 ; 9781315695594
    Database Catalogue of the US National Library of Medicine (NLM)

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  5. Article: Capillary electrophoresis–mass spectrometry analysis of bisphenol A and its analogues in bottled tea beverages with dynamic pH focusing

    Yahaya, Noorfatimah / Huang, Zi-ao / Yan, Binjun / Chen, David D.Y.

    Food chemistry. 2022 Mar. 15, v. 372

    2022  

    Abstract: A simple and sensitive method for the determination of bisphenol A and its analogues at the ng/mL level in bottled tea beverages is presented. This method utilized a dynamic pH junction to focus the analyte into a more concentrated zone, based on the ... ...

    Abstract A simple and sensitive method for the determination of bisphenol A and its analogues at the ng/mL level in bottled tea beverages is presented. This method utilized a dynamic pH junction to focus the analyte into a more concentrated zone, based on the electrophoretic mobility difference of analytes in the sample matrix and background electrolytes in capillary electrophoresis coupled to mass spectrometry (CE-MS). The optimised analyte focusing led to enhanced signal detection with average peak heights for five bisphenols of 53–170 folds higher than conventional injections. Under optimised conditions, the method showed good linearity in the range of 0.1–100 ng/mL, excellent limits of detection (0.03–0.04 ng/mL), good analyte recovery (80.3–118.1%) with acceptable relative standard deviations (<12%). The limits of quantifications were below the maximum permissible content of bisphenol A set by the European Commission for this product. This method was used to quantitatively analyse bisphenols in six different kinds of bottled tea beverages, making it a promising tool for practical applications.
    Keywords bisphenol A ; capillary electrophoresis ; chemical species ; food chemistry ; mass spectrometry ; pH ; tea
    Language English
    Dates of publication 2022-0315
    Publishing place Elsevier Ltd
    Document type Article
    ZDB-ID 243123-3
    ISSN 1873-7072 ; 0308-8146
    ISSN (online) 1873-7072
    ISSN 0308-8146
    DOI 10.1016/j.foodchem.2021.131220
    Database NAL-Catalogue (AGRICOLA)

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    In stock of ZB MED Bonn / Germany

    Z 3634: Show issues

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  6. Article ; Online: Bottom-up proteomics of envelope proteins extracted from spinach chloroplast via high organic content CE-MS.

    Cheng, Jianhui / Morin, Gregg B / Chen, David D Y

    Electrophoresis

    2020  Volume 41, Issue 5-6, Page(s) 370–378

    Abstract: A high organic content CE-MS/MS (HOCE-MS/MS) method was developed for the proteomic analysis of envelope proteins extracted from spinach leaves. Separation was performed in a 1-m long hydroxypropyl cellulose coated capillary, using 8% (v/v) formic acid ... ...

    Abstract A high organic content CE-MS/MS (HOCE-MS/MS) method was developed for the proteomic analysis of envelope proteins extracted from spinach leaves. Separation was performed in a 1-m long hydroxypropyl cellulose coated capillary, using 8% (v/v) formic acid in 70% (v/v) methanol and 22% water as the BGE. A flow-through microvial interface was used to couple the CE system with an Orbitrap Fusion Lumos mass spectrometer, and field-amplified sample stacking was used to improve the concentration sensitivity. Using this optimized method, 3579 peptides and 1141 proteins were identified using the Proteome Discoverer software with a 1% false discovery rate at the protein level. Relative to conventional aqueous CE, HOCE-MS did a better job of discovering hydrophobic peptides and provided more peptide and protein identifications. Relative to nano-LC-MS, it achieved comparable peptide and protein identification performance and detected peptides not identified by LC-MS: of the full set of peptides identified using the two techniques, 19% were identified only using HOCE-MS. It also outperformed nano-LC-MS with respect to the detection of low molecular weight peptides.
    MeSH term(s) Chloroplast Proteins/analysis ; Chloroplast Proteins/chemistry ; Chloroplast Proteins/isolation & purification ; Chloroplasts/chemistry ; Electrophoresis, Capillary/methods ; Hydrophobic and Hydrophilic Interactions ; Plant Leaves/chemistry ; Proteome/analysis ; Proteome/chemistry ; Proteomics/methods ; Spinacia oleracea/chemistry ; Tandem Mass Spectrometry/methods
    Chemical Substances Chloroplast Proteins ; Proteome
    Language English
    Publishing date 2020-02-19
    Publishing country Germany
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 619001-7
    ISSN 1522-2683 ; 0173-0835
    ISSN (online) 1522-2683
    ISSN 0173-0835
    DOI 10.1002/elps.201900452
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1868: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  7. Article ; Online: Rapid fingerprint analysis for herbal polysaccharides using direct analysis in real-time ionization mass spectrometry.

    Wang, Xing / Jiang, Qing / Li, Hongli / Chen, David D Y

    Rapid communications in mass spectrometry : RCM

    2021  Volume 35, Issue 16, Page(s) e9139

    Abstract: Rationale: Herbal polysaccharides have various potential medicinal values. Development of reliable analytical method for the fingerprint analysis of polysaccharides is critical for their quality assessment, origin identification, and authenticity ... ...

    Abstract Rationale: Herbal polysaccharides have various potential medicinal values. Development of reliable analytical method for the fingerprint analysis of polysaccharides is critical for their quality assessment, origin identification, and authenticity evaluation.
    Methods: Mechanochemical extraction (MCE) was used to extract polysaccharide components from different herbal species. Intact polysaccharides were then directly analyzed by direct analysis in real-time mass spectrometry (DART-MS). Standard addition method with isotope-labeled internal standard was used to quantify polysaccharide amounts directly from liquid extract. Multivariate data analysis was further conducted for species classification.
    Results: The intact and large polysaccharides were decomposed into small fragment ions less than m/z 350 instantaneously using DART ion source. Different polysaccharides showed distinguished fingerprint DART-MS spectra using both individual and mixed herbal species. The liquid supernatant from MCE was validated to be used as direct sample for DART-MS analysis. Quantitation was successfully achieved for polysaccharide contents in Dendrobium officinale from different locations.
    Conclusions: A rapid fingerprint protocol in combination of MCE and DART-MS for herbal polysaccharides was developed. The whole process could be accomplished within a few minutes, from raw materials to final spectra, without requirements of pre-digestion and additional sample purification.
    MeSH term(s) Drugs, Chinese Herbal/chemistry ; Mass Spectrometry/methods ; Plant Preparations/chemistry ; Polysaccharides/analysis ; Polysaccharides/chemistry
    Chemical Substances Drugs, Chinese Herbal ; Plant Preparations ; Polysaccharides
    Language English
    Publishing date 2021-06-04
    Publishing country England
    Document type Journal Article
    ZDB-ID 58731-x
    ISSN 1097-0231 ; 0951-4198
    ISSN (online) 1097-0231
    ISSN 0951-4198
    DOI 10.1002/rcm.9139
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3461: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  8. Article ; Online: Capillary electrophoresis-mass spectrometry analysis of bisphenol A and its analogues in bottled tea beverages with dynamic pH focusing.

    Yahaya, Noorfatimah / Huang, Zi-Ao / Yan, Binjun / Chen, David D Y

    Food chemistry

    2021  Volume 372, Page(s) 131220

    Abstract: A simple and sensitive method for the determination of bisphenol A and its analogues at the ng/mL level in bottled tea beverages is presented. This method utilized a dynamic pH junction to focus the analyte into a more concentrated zone, based on the ... ...

    Abstract A simple and sensitive method for the determination of bisphenol A and its analogues at the ng/mL level in bottled tea beverages is presented. This method utilized a dynamic pH junction to focus the analyte into a more concentrated zone, based on the electrophoretic mobility difference of analytes in the sample matrix and background electrolytes in capillary electrophoresis coupled to mass spectrometry (CE-MS). The optimised analyte focusing led to enhanced signal detection with average peak heights for five bisphenols of 53-170 folds higher than conventional injections. Under optimised conditions, the method showed good linearity in the range of 0.1-100 ng/mL, excellent limits of detection (0.03-0.04 ng/mL), good analyte recovery (80.3-118.1%) with acceptable relative standard deviations (<12%). The limits of quantifications were below the maximum permissible content of bisphenol A set by the European Commission for this product. This method was used to quantitatively analyse bisphenols in six different kinds of bottled tea beverages, making it a promising tool for practical applications.
    MeSH term(s) Benzhydryl Compounds ; Beverages ; Electrophoresis, Capillary ; Hydrogen-Ion Concentration ; Mass Spectrometry ; Phenols ; Tea
    Chemical Substances Benzhydryl Compounds ; Phenols ; Tea ; bisphenol A (MLT3645I99)
    Language English
    Publishing date 2021-09-24
    Publishing country England
    Document type Journal Article
    ZDB-ID 243123-3
    ISSN 1873-7072 ; 0308-8146
    ISSN (online) 1873-7072
    ISSN 0308-8146
    DOI 10.1016/j.foodchem.2021.131220
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Bonn / Germany

    Z 3634: Show issues

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  9. Article ; Online: Electroosmotic Flow Dispersion of Large Molecules in Electrokinetic Migration.

    Khodabandehloo, Akram / Chen, David D Y

    Analytical chemistry

    2017  Volume 89, Issue 15, Page(s) 7823–7827

    Abstract: It is a common knowledge that large molecules have small diffusion coefficients. Therefore, it was thought that these molecules should generate very narrow peaks in electropherograms, because longitudinal diffusion was thought to be the only factor that ... ...

    Abstract It is a common knowledge that large molecules have small diffusion coefficients. Therefore, it was thought that these molecules should generate very narrow peaks in electropherograms, because longitudinal diffusion was thought to be the only factor that contributes to band broadening in electrophoretic separation systems in capillaries and microfluidics. However, it is also common to observe that large molecules such as proteins and polymers often produce wider peaks than most small molecules. It is demonstrated in this work that dispersion of analytes during electrokinetic migration is also the results of Taylor dispersion. Similar to conventional Taylor dispersion, peak broadening is more pronounced for particles with smaller diffusion coefficients. The theoretical description of band broadening caused by electroosmotic flow dispersion (EOFD) and the experimental verification of this phenomenon are presented in this paper. The dispersion of various sized molecules, from small peptides to large proteins, in capillary electrophoresis is used as examples in this study.
    Language English
    Publishing date 2017-07-17
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1508-8
    ISSN 1520-6882 ; 0003-2700
    ISSN (online) 1520-6882
    ISSN 0003-2700
    DOI 10.1021/acs.analchem.7b01592
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4033: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  10. Article ; Online: Nonaqueous capillary electrophoresis mass spectrometry method for determining highly hydrophobic peptides.

    Cheng, Jianhui / Chen, David D Y

    Electrophoresis

    2017  Volume 39, Issue 9-10, Page(s) 1216–1221

    Abstract: A nonaqueous capillary electrophoresis mass spectrometry (NACE-MS) method was developed to separate and determine highly hydrophobic temporin peptides. The nonaqueous background electrolyte solution was a mixture of 20% acetonitrile, 78% methanol and 2% ... ...

    Abstract A nonaqueous capillary electrophoresis mass spectrometry (NACE-MS) method was developed to separate and determine highly hydrophobic temporin peptides. The nonaqueous background electrolyte solution was a mixture of 20% acetonitrile, 78% methanol and 2% formic acid, with 20 mM ammonium formate. The separation of six peptides was completed within 12 min. The CE system was connected to a triple quadrupole mass spectrometer operating in MRM mode using a chemical modifier solution of 2 mM ammonium formate in ethanol with the flow through microvial interface. The mass spectrometer offered a second dimension of separation for peptides having identical migration times but different structures. The new method represents the first system capable of reliably determining hydrophobic peptides without using reversed phase liquid chromatography mass spectrometry.
    MeSH term(s) Electrophoresis, Capillary/methods ; Hydrogen-Ion Concentration ; Hydrophobic and Hydrophilic Interactions ; Peptides/analysis ; Peptides/isolation & purification ; Spectrometry, Mass, Electrospray Ionization/methods
    Chemical Substances Peptides
    Language English
    Publishing date 2017-10-31
    Publishing country Germany
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 619001-7
    ISSN 1522-2683 ; 0173-0835
    ISSN (online) 1522-2683
    ISSN 0173-0835
    DOI 10.1002/elps.201700364
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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