Article ; Online: Prognostic value of pretreatment procalcitonin and neutrophil-lymphocyte ratio in extensive-stage small-cell lung cancer.
2024 Volume 25, Issue 1, Page(s) 2331273
Abstract: Background: To investigate the influence of pretreatment neutrophil-to-lymphocyte ratio (NLR) and procalcitonin (PCT) on progression-free survival (PFS) in extensive-stage small-cell lung cancer (SCLC) patients.: Method: A total of 100 extensive- ... ...
Abstract | Background: To investigate the influence of pretreatment neutrophil-to-lymphocyte ratio (NLR) and procalcitonin (PCT) on progression-free survival (PFS) in extensive-stage small-cell lung cancer (SCLC) patients. Method: A total of 100 extensive-stage SCLC patients were enrolled in our study. Patients were stratified according to the median values of pretreatment NLR and PCT levels: low NLR group (NLR ≤3.17), high NLR group (NLR>3.17), low PCT group (PCT ≤0.06; ng/ml), high PCT group (PCT>0.06; ng/ml). The Kaplan-Meier method and multivariable Cox regression model were used to reveal the prognostic effects of pretreatment NLR and PCT on PFS. Results: The median PFS of the total extensive-stage SCLC patients was 6.0 months. The median PFS of low pretreatment NLR group (NLR ≤3.17) was not significantly different from that of high pretreatment NLR group (6.2 months vs 5.8 months; Conclusion: Pretreatment PCT is an independent factor associated with PFS in extensive-stage SCLC patients treated with first-line chemotherapy, but pretreatment NLR reflects no significant prognostic value in our study. |
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MeSH term(s) | Humans ; Lung Neoplasms/drug therapy ; Prognosis ; Neutrophils ; Procalcitonin/therapeutic use ; Lymphocyte Count ; Retrospective Studies ; Small Cell Lung Carcinoma/drug therapy ; Lymphocytes |
Chemical Substances | Procalcitonin |
Language | English |
Publishing date | 2024-03-27 |
Publishing country | United States |
Document type | Journal Article |
ZDB-ID | 2146305-0 |
ISSN | 1555-8576 ; 1538-4047 |
ISSN (online) | 1555-8576 |
ISSN | 1538-4047 |
DOI | 10.1080/15384047.2024.2331273 |
Database | MEDical Literature Analysis and Retrieval System OnLINE |
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