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  1. Book ; Online: The Perspectives of Plant Natural Products for Mitigation of Obesity

    Chen, Fang

    2023  

    Keywords Research & information: general ; Biology, life sciences ; dietary supplement ; obesity ; botanicals ; nutrients ; weight loss
    Language English
    Size 1 electronic resource (172 pages)
    Publisher MDPI - Multidisciplinary Digital Publishing Institute
    Publishing place Basel
    Document type Book ; Online
    Note English
    HBZ-ID HT030376743
    ISBN 9783036569710 ; 3036569715
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Article ; Online: Inhibiting Pink1/Parkin-mediated mitophagy enhances the anticancer effects of quercetin in hepatocellular carcinomaf.

    Chen, Fang

    Biochemical and biophysical research communications

    2024  Volume 712-713, Page(s) 149899

    Abstract: Quercetin, a naturally occurring flavonoid, has been investigated for its potential anti-cancer effects in various types of cancer, including hepatocellular carcinoma (HCC). However, its suppressing effect on reactive oxygen species (ROS) production ... ...

    Abstract Quercetin, a naturally occurring flavonoid, has been investigated for its potential anti-cancer effects in various types of cancer, including hepatocellular carcinoma (HCC). However, its suppressing effect on reactive oxygen species (ROS) production might limited its anti-cancer effects. In this study, we aimed to explore the interplay among quercetin, mitochondrial dynamics and mitophagy and whether mitophagy-inhibition synergistically enhances the anti-tumor effects of quercetin. Huh7 and Hep3B cells were utilized for in vitro and in vivo studies. Results showed that quercetin treatment significantly increased the expression of mitochondrial fusion genes (MFN1 and MFN2) and decreased the expression of fission genes (DRP1 and FIS1) in Huh7 and Hep3B cells, leading to a more fused and elongated mitochondrial network. Quercetin upregulated the expression of key mitophagy regulators, PINK1 and PARK2, and enhanced the colocalization of mitochondria with lysosomes, indicating increased mitophagy. Knockdown of PINK1, PARK2, or SIRT1 attenuated quercetin-induced mitophagy and reduction of intracellular ROS levels. Quercetin treatment upregulates SIRT1 expression, which subsequently enhances PINK1 and PARK2 expression in Huh7 and Hep3B cells. In vivo experiments using Hep3B xenograft models revealed that the combination of quercetin with the mitophagy inhibitor hydroxychloroquine or SIRT1 knockdown significantly enhanced the anticancer effects of quercetin, as evidenced by reduced tumor size and weight, increased necrosis and apoptosis, and decreased proliferation in tumor tissues. These findings suggest that quercetin-induced mitochondrial fusion and Pink1/Parkin-dependent mitophagy may negatively influence its anti-cancer effects in HCC. Targeting mitophagy may enhance the therapeutic potential of quercetin in HCC treatment.
    Language English
    Publishing date 2024-04-05
    Publishing country United States
    Document type Journal Article
    ZDB-ID 205723-2
    ISSN 1090-2104 ; 0006-291X ; 0006-291X
    ISSN (online) 1090-2104 ; 0006-291X
    ISSN 0006-291X
    DOI 10.1016/j.bbrc.2024.149899
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 116: Show issues Location:
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  3. Article ; Online: SPONTANEOUS CLOSURE OF MYOPIC MACULAR HOLE TWICE WITHOUT POSTERIOR VITREOUS DETACHMENT.

    Chen, Fang-Ting

    Retinal cases & brief reports

    2022  Volume 17, Issue 5, Page(s) 554–556

    Abstract: Purpose: To present a case of a myopic macular hole that spontaneously closed twice in the presence of a broadly adherent posterior hyaloid membrane.: Methods: Case report.: Results: A 49-year-old man with high myopia and pseudophakia had a full- ... ...

    Abstract Purpose: To present a case of a myopic macular hole that spontaneously closed twice in the presence of a broadly adherent posterior hyaloid membrane.
    Methods: Case report.
    Results: A 49-year-old man with high myopia and pseudophakia had a full-thickness macular hole in the left eye. The hole spontaneously closed in all retinal layers before the elective surgery, but the macular hole recurred one month later. The hole started sealing again spontaneously after one month, leaving a defect in the outer retinal layers. Four months later, the outer layer defect sealed and a lamellar macular hole developed. Throughout the course, the posterior hyaloid membrane remained parallel to the macular surface. The macular morphology and the patient's vision remained stationary at the 2-year follow-up.
    Conclusion: This case demonstrated that myopic macular holes can form and seal repeatedly with a broadly adherent posterior hyaloid membrane. Although bridging phenomenon was the common sign indicating the initiation of the two hole closures, different patterns of tissue regeneration ensued.
    MeSH term(s) Male ; Humans ; Middle Aged ; Retinal Perforations/diagnosis ; Retinal Perforations/etiology ; Vitreous Detachment/complications ; Vitreous Detachment/diagnosis ; Myopia/complications ; Retina ; Pseudophakia
    Language English
    Publishing date 2022-01-13
    Publishing country United States
    Document type Case Reports ; Journal Article
    ISSN 1937-1578
    ISSN (online) 1937-1578
    DOI 10.1097/ICB.0000000000001235
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Disinfection and hand hygiene knowledge, attitude, and practices among childcare facilities staff during the COVID-19 pandemic in Anhui, China: a cross-sectional study.

    Chen, Fang / Xu, Qing Hua

    Frontiers in public health

    2024  Volume 12, Page(s) 1335560

    Abstract: Objective: This study aimed to investigate the knowledge, attitude, and practice (KAP) regarding disinfection and hand hygiene, along with associated influencing factors among childcare facilities staff during the COVID-19 pandemic in Anhui, and to ... ...

    Abstract Objective: This study aimed to investigate the knowledge, attitude, and practice (KAP) regarding disinfection and hand hygiene, along with associated influencing factors among childcare facilities staff during the COVID-19 pandemic in Anhui, and to provide information for developing disinfection and hand hygiene strategies for childcare facilities.
    Methods: A web-based cross-sectional study was conducted among Anhui Province residents in China in September 2020. In this study, 60 childcare facilities in two cities of Anhui Province were selected using the convenient sampling method for questionnaires. The questionnaires were distributed through a web-based platform. The disinfection and hand hygiene KAP scores among childcare facilities staff were calculated, and their influencing factors were analyzed. The accuracy rates of knowledge, attitude, and practice of behavior were calculated and analyzed.
    Results: A total of 1,029 participants were included in the study. The disinfection and hand hygiene knowledge, attitude and practice ranged from approximately 5 to 23, 1 to 5, 3 to 13, respectively. The score of urban areas was higher than that of rural areas. Higher education levels and more years of working were associated with higher scores. Additionally, staff who received training or supervision had higher scores than those without. The categories with the lowest knowledge accuracy rate (46.3%), lowest attitude accuracy rate (4.2%), and "always" practice rate (5.3%) among childcare facility staff were all related to the question categories concerning the appropriate range of disinfectants for use. The accuracy rates of hand hygiene knowledge and attitude among the childcare facility staff were high (83.7%-99.6%), but the "always" practice rate was in the middle range (63.0%).
    Conclusion: The disinfection and hand hygiene knowledge among childcare facilities staff was inadequate during the COVID-19 pandemic in Anhui. Continuous implementation of education and training, particularly in rural areas, is essential. Establishing a monitoring system to assess usage effectiveness and adverse reactions in China is critical. Interventions should focus on increasing compliance with hand hygiene practices. Further research should explore the training and intervention of disinfection and hand hygiene, the safety of disinfection measures, and more operational hand hygiene methods in childcare facilities.
    MeSH term(s) Child ; Humans ; Hand Hygiene/methods ; COVID-19/epidemiology ; COVID-19/prevention & control ; Cross-Sectional Studies ; Child Care ; Disinfection ; Health Knowledge, Attitudes, Practice ; Pandemics/prevention & control
    Language English
    Publishing date 2024-04-04
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2711781-9
    ISSN 2296-2565 ; 2296-2565
    ISSN (online) 2296-2565
    ISSN 2296-2565
    DOI 10.3389/fpubh.2024.1335560
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Selective and efficient H2 evolution upon NH3BH3 hydrolysis at subzero temperatures

    Qing Zhang / Chen Fang / Yanlan Wang / Xiang Liu

    iScience, Vol 27, Iss 1, Pp 108774- (2024)

    2024  

    Abstract: Summary: In the winter months, the temperature in most of the Earth stays below 0°C; the average temperature in winter at the South Pole is about −60°C. Therefore, it is urgent to develop efficient catalytic systems for selective and efficient H2 ... ...

    Abstract Summary: In the winter months, the temperature in most of the Earth stays below 0°C; the average temperature in winter at the South Pole is about −60°C. Therefore, it is urgent to develop efficient catalytic systems for selective and efficient H2 evolution upon NH3BH3 hydrolysis at subzero temperatures. For solving the freezing issue of water at below 0°C, herein, we have employed a facile and surfactant-free approach to synthesize M-Pt/C nanocomposites (M = Pd, Rh, Ru, Ni, Cu, or Fe), by the alloying of commercial Pt/C with Pd, Rh, Ru, Cu, Ni, or Fe for selective and efficient H2 evolution upon NH3BH3 hydrolysis in saline solution at below 0°C, even at −15°C. In addition, NH3BH3 hydrolysis over Pd-Pt/C in the saturated NaCl solution is utilized not only for safe hydrogen production but also for its in situ hydrogenation reduction in organic chemistry, which could avoid using dangerous hydrogen cylinders.
    Keywords Electrochemistry ; Applied sciences ; Science ; Q
    Subject code 540
    Language English
    Publishing date 2024-01-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Book: Reductions in mortality among medicare beneficiaries following the implementation of medicare part D

    Semilla, April P. / Chen, Fang / Dall, Timothy M.

    (The American journal of managed care ; 21,9, Suppl.)

    2015  

    Author's details April P. Semilla ; Fang Chen ; Timothy M. Dall
    Series title The American journal of managed care ; 21,9, Suppl.
    Collection
    Language English
    Size S. [S165] - S171 : graph. Darst.
    Publisher Managed Care & Healthcare Communications
    Publishing place S.l.
    Publishing country United States
    Document type Book
    HBZ-ID HT018802804
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    Zs A 5353 -21,9,Suppl.- not available for loan Zeitschriften-Lesesaal

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  7. Article: The ACE2/Ang-(1-7)/MasR axis alleviates brain injury after cardiopulmonary resuscitation in rabbits by activating PI3K/Akt signaling.

    Cheng, Jing / Yang, Hong / Chen, Fang / Qiu, Li / Chen, Fang / Du, Yanhua / Meng, Xiangping

    Translational neuroscience

    2024  Volume 15, Issue 1, Page(s) 20220334

    Abstract: Background: Death among resuscitated patients is mainly caused by brain injury after cardiac arrest/cardiopulmonary resuscitation (CA/CPR). The angiotensin converting enzyme 2 (ACE2)/angiotensin (Ang)-(1-7)/Mas receptor (MasR) axis has beneficial ... ...

    Abstract Background: Death among resuscitated patients is mainly caused by brain injury after cardiac arrest/cardiopulmonary resuscitation (CA/CPR). The angiotensin converting enzyme 2 (ACE2)/angiotensin (Ang)-(1-7)/Mas receptor (MasR) axis has beneficial effects on brain injury. Therefore, we examined the roles of the ACE2/Ang-(1-7)/MasR axis in brain injury after CA/CPR.
    Method: We used a total of 76 male New Zealand rabbits, among which 10 rabbits underwent sham operation and 66 rabbits received CA/CPR. Neurological functions were determined by assessing serum levels of neuron-specific enolase and S100 calcium-binding protein B and neurological deficit scores. Brain water content was estimated. Neuronal apoptosis in the hippocampus was assessed by terminal deoxynucleotidyl transferase dUTP nick end labeling assays. The expression levels of various genes were measured by enzyme-linked immunosorbent assay and western blotting.
    Results: Ang-(1-7) (MasR activator) alleviated CA/CPR-induced neurological deficits, brain edema, and neuronal damage, and A779 (MasR antagonist) had the opposite functions. The stimulation of ACE2/Ang-(1-7)/MasR inactivated the ACE/Ang II/AT1R axis and activated PI3K/Akt signaling. Inhibiting PI3K/Akt signaling inhibited Ang-(1-7)-mediated protection against brain damage after CA/CPR.
    Conclusion: Collectively, the ACE2/Ang-(1-7)/MasR axis alleviates CA/CPR-induced brain injury through attenuating hippocampal neuronal apoptosis by activating PI3K/Akt signaling.
    Language English
    Publishing date 2024-04-11
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2581219-1
    ISSN 2081-6936 ; 2081-3856
    ISSN (online) 2081-6936
    ISSN 2081-3856
    DOI 10.1515/tnsci-2022-0334
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Functional Enhancement of Guar Gum-Based Hydrogel by Polydopamine and Nanocellulose.

    Pak, SolJu / Chen, Fang

    Foods (Basel, Switzerland)

    2023  Volume 12, Issue 6

    Abstract: The development of green, biomedical hydrogels using natural polymers is of great significance. From this viewpoint, guar gum (GG) has been widely used for hydrogel preparation; however, its mechanical strength and adhesion often cannot satisfy the ... ...

    Abstract The development of green, biomedical hydrogels using natural polymers is of great significance. From this viewpoint, guar gum (GG) has been widely used for hydrogel preparation; however, its mechanical strength and adhesion often cannot satisfy the biomedical application. Therefore, in the present study, gelatin and a cellulose nanocrystal (CNC) were first applied to overcome the defects of guar gum hydrogel. Dopamine was self-polymerized into polydopamine (PDA) on the gelatin chain at alkaline condition, and gelatin-polydopamine (Gel-PDA) further cross-linked with guar gum and CNC via the borate-didiol bond, intramolecular Schiff base reaction, and Michael addition. CNC not only interacted with guar gum using borate chemistry but also acted as a mechanical reinforcer. The obtained Gel-PDA+GG+CNC hydrogel had an excellent self-healing capacity, injectability, and adhesion due to the catechol groups of PDA. Moreover, dopamine introduction caused a significant increase in the anti-oxidant activity. This hydrogel was cyto- and hemo-compatible, which implies a potential usage in the medical field.
    Language English
    Publishing date 2023-03-18
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2704223-6
    ISSN 2304-8158
    ISSN 2304-8158
    DOI 10.3390/foods12061304
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Prenatal diagnosis of X-linked hydrocephalus: The "hydrocephalus" is the focus.

    Chen, Fang / Li, Dong-Zhi

    Taiwanese journal of obstetrics & gynecology

    2023  Volume 62, Issue 2, Page(s) 380–381

    MeSH term(s) Pregnancy ; Female ; Humans ; Prenatal Diagnosis ; Hydrocephalus/diagnostic imaging ; Hydrocephalus/genetics ; Genetic Diseases, X-Linked/diagnosis ; Cerebral Aqueduct ; Pedigree
    Language English
    Publishing date 2023-03-25
    Publishing country China (Republic : 1949- )
    Document type Letter
    ZDB-ID 2202946-1
    ISSN 1875-6263 ; 1875-6263
    ISSN (online) 1875-6263
    ISSN 1875-6263
    DOI 10.1016/j.tjog.2022.08.019
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Re: Letter to the editor for the article 'One-stage repair of proximal hypospadias by in situ tubularization of the transverse preputial island flap'.

    Lyu, Yiqing / Chen, Fang

    World journal of urology

    2023  Volume 41, Issue 6, Page(s) 1705–1706

    MeSH term(s) Male ; Humans ; Infant ; Hypospadias/surgery ; Surgical Flaps ; Urethra ; Urologic Surgical Procedures, Male
    Language English
    Publishing date 2023-04-15
    Publishing country Germany
    Document type Letter ; Comment
    ZDB-ID 380333-8
    ISSN 1433-8726 ; 0724-4983
    ISSN (online) 1433-8726
    ISSN 0724-4983
    DOI 10.1007/s00345-023-04400-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1832: Show issues Location:
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