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Article ; Online: Nurse Life-and-Death Education From the Perspective of Chinese Traditional Culture.

Zhang, Huilin / Lv, Tingting / Li, Lezhi / Chen, Fengzhi / He, Shijia / Ding, Daoqun

2024 , Page(s) 302228241236981

Abstract: This quasi-experimental study investigated the impact of traditional Chinese culture-based life-and-death education on 38 ICU nurses. Participants underwent 14 hours of training, and data were collected before and after the intervention using various ... ...

Abstract	This quasi-experimental study investigated the impact of traditional Chinese culture-based life-and-death education on 38 ICU nurses. Participants underwent 14 hours of training, and data were collected before and after the intervention using various questionnaires. Frequency and percentage were used for categorical data; mean and standard deviation for measurement data; and paired-sample
Language	English
Publishing date	2024-03-04
Publishing country	United States
Document type	Journal Article
ZDB-ID	207363-8
ISSN	1541-3764 ; 0030-2228
ISSN (online)	1541-3764
ISSN	0030-2228
DOI	10.1177/00302228241236981
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Article: Male breast cancer differs from female breast cancer in molecular features that affect prognoses and drug responses.

Li, Yangyang / Guo, Yan / Chen, Fengzhi / Cui, Yuqing / Chen, Xuesong / Shi, Guangyue

Translational oncology

2024 Volume 45, Page(s) 101980

Abstract: Background: Male breast cancer (MBC) is a rare malignancy with a worse prognosis than female breast cancer (FBC). Current MBC treatment strategies are based on those for FBC. However, molecular differences between MBC and FBC with respect to prognosis ... ...

Abstract	Background: Male breast cancer (MBC) is a rare malignancy with a worse prognosis than female breast cancer (FBC). Current MBC treatment strategies are based on those for FBC. However, molecular differences between MBC and FBC with respect to prognosis and drug responses remain unclear. Methods: After controlling for confounding factors with propensity score matching (PSM), differences between MBC and FBC were comprehensively analyzed using many types of data: survival, immune microenvironments, sex hormone responses, drug sensitivity, transcriptomes, genomes, epigenomes, and proteomes. Results: Overall survival (OS) and cancer-specific survival (CSS) were both worse for MBC than for FBC. Differentially expressed mRNAs were enriched in numerous cancer-related functions and pathways, with SPAG16 and STOX1 being as the most important prognosis-related mRNAs for MBC. Competing endogenous RNA (ceRNA) and transcription factor (TF)-mRNA regulatory networks contain potential prognostic genes. Nine genes had higher mutation frequencies in MBC than in FBC. MBC shows a comparatively poor response to immunotherapy, with five proteins that promote breast cancer progression being highly expressed in MBC. MBC may be more responsive than FBC to estrogen. We detected six United States Food and Drug Administration (FDA)-approved therapeutic target genes as being differentially expressed between MBC and FBC. Conclusion: The poor prognosis of MBC compared to FBC is due to numerous molecular differences and resulting drug responses.
Language	English
Publishing date	2024-05-02
Publishing country	United States
Document type	Journal Article
ZDB-ID	2443840-6
ISSN	1936-5233
ISSN	1936-5233
DOI	10.1016/j.tranon.2024.101980
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Article ; Online: Renal pseudoaneurysm after holmium laser lithotripsy with flexible ureteroscopy: an unusual case report and literature review.

Yin, Cong / Chen, Fengzhi / Jiang, Jiahao / Xu, Jinming / Shi, Bentao

The Journal of international medical research

2023 Volume 51, Issue 3, Page(s) 3000605231162784

Abstract: Pseudoaneurysms of the renal arteries are caused by focal rupture or perforation of the arterial wall, resulting in local bleeding. Such pseudoaneurysms can be observed in conditions such as nodular polyarteritis, penetrating or closed renal injury, and ... ...

Abstract	Pseudoaneurysms of the renal arteries are caused by focal rupture or perforation of the arterial wall, resulting in local bleeding. Such pseudoaneurysms can be observed in conditions such as nodular polyarteritis, penetrating or closed renal injury, and medically induced injuries (such as renal puncture biopsy, percutaneous nephrostomy, or partial nephrectomy). Flexible ureteroscopy (FURS) is performed entirely through the urethra to prevent potentially severe kidney damage. Because of this, almost no renal parenchymal hemorrhage occurs after FURS laser lithotripsy. Only four cases had been documented in the literature as of December 2022. In this report, we describe a 53-year-old man with a history of recurrent kidney stones who underwent FURS laser lithotripsy for bilateral kidney stones. The procedure was smoothly performed, and no active bleeding occurred. However, the patient developed recurrent macroscopic hematuria after discharge from the hospital, and renal angiography revealed a pseudoaneurysm in the distal right kidney. The pseudoaneurysm was treated with selective arterial embolization. Serious complications of FURS surgery are rare, particularly the formation of pseudoaneurysms. We report the present case to bring this potential complication to the attention of urologists.
MeSH term(s)	Male ; Humans ; Middle Aged ; Lithotripsy, Laser/adverse effects ; Lithotripsy, Laser/methods ; Ureteroscopy/adverse effects ; Ureteroscopy/methods ; Aneurysm, False/diagnostic imaging ; Aneurysm, False/etiology ; Holmium ; Kidney Calculi/surgery ; Kidney Calculi/pathology ; Hemorrhage ; Kidney/pathology ; Treatment Outcome ; Retrospective Studies
Chemical Substances	Holmium (W1XX32SQN1)
Language	English
Publishing date	2023-02-28
Publishing country	England
Document type	Review ; Case Reports ; Journal Article
ZDB-ID	184023-x
ISSN	1473-2300 ; 0300-0605 ; 0142-2596
ISSN (online)	1473-2300
ISSN	0300-0605 ; 0142-2596
DOI	10.1177/03000605231162784
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Article: The mediating effects of attitude toward death and meaning of life on the relationship between perception of death and coping with death competence among Chinese nurses: a cross-sectional study.

He, Shijia / Zhao, Hong / Wang, Huiping / Chen, Fengzhi / Lv, Tingting / Li, Lezhi / Zhang, Huilin

BMC nursing

2023 Volume 22, Issue 1, Page(s) 87

Abstract: Background: It is important to understand how the perception of death affects the competence to cope with death.: Objectives: To explore whether the perception of death has an indirect effect on competence to cope with death through the mediation of ... ...

Abstract	Background: It is important to understand how the perception of death affects the competence to cope with death. Objectives: To explore whether the perception of death has an indirect effect on competence to cope with death through the mediation of attitude toward death and meaning of life. Methods: A total of 786 nurses from Hunan Province, China, selected by random sampling method and asked to complete an online electronic questionnaire between October and November 2021 were included in the study. Results: The nurses' scored 125.39 ± 23.88 on the competence to cope with death. There was a positive correlation among perception of death, competence to cope with death, the meaning of life, and attitude toward death. There were three mediating pathways: the separate mediating effect of natural acceptance and meaning of life, and the chain mediating effect of natural acceptance and meaning of life. Conclusion: The nurses' competence to cope with death was moderate. Perception of death could indirectly and positively predict nurses' competence to cope with death by enhancing natural acceptance or sense of meaning in life. In addition, perception of death could improve natural acceptance and then enhance the sense of meaning in life to positively predict nurses' competence to cope with death.
Language	English
Publishing date	2023-03-30
Publishing country	England
Document type	Journal Article
ZDB-ID	2091496-9
ISSN	1472-6955
ISSN	1472-6955
DOI	10.1186/s12912-023-01245-5
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Article ; Online: Relationship between Death Coping and Death Cognition and Meaning in Life among Nurses: A Cross-Sectional Study.

Lv, Tingting / Li, Lezhi / Wang, Huiping / Zhao, Hong / Chen, Fengzhi / He, Xiachan / Zhang, Huilin

Omega

2023 , Page(s) 302228231158911

Abstract: To explore nurses' ability to cope with death and its relationship with death cognition and meaning in life in the context of Chinese traditional culture. 1146 nurses from six tertiary hospitals were recruited. Participants completed the Coping with ... ...

Abstract	To explore nurses' ability to cope with death and its relationship with death cognition and meaning in life in the context of Chinese traditional culture. 1146 nurses from six tertiary hospitals were recruited. Participants completed the Coping with Death Scale, the Meaning in Life Questionnaire, and the self-made Death Cognition Questionnaire. Multiple regression analysis revealed that the search for meaning, the understanding of "good death", receiving education related to life-and-death, cultural aspect, the presence of meaning, and the number of patient deaths experienced in career explained 20.3% of the variance in the ability to cope with death. Lacking a correct understanding of death, nurses are not sufficiently prepared to deal with death and their ability to cope with death is influenced by the unique cognition of death and the sense of the meaning in life in the context of Chinese traditional culture.
Language	English
Publishing date	2023-02-20
Publishing country	United States
Document type	Journal Article
ZDB-ID	207363-8
ISSN	1541-3764 ; 0030-2228
ISSN (online)	1541-3764
ISSN	0030-2228
DOI	10.1177/00302228231158911
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Article ; Online: An antihypertensive drug-AT1 inhibitor attenuated BRCA development promoted by chronic psychological stress via Ang II/PARP1/FN1 pathway.

Cui, Yuqing / Zhuang, Ming / Huang, Zheping / Guo, Yan / Chen, Fengzhi / Li, Yangyang / Long, Yuanhui / Liu, Ying / Zeng, Guangchun / Feng, Xujing / Chen, Xuesong

Biochimica et biophysica acta. Molecular basis of disease

2024 Volume 1870, Issue 3, Page(s) 167031

Abstract: Chronic psychological stress contributes to the occurrence of cancer and activates the renin-angiotensin system (RAS). However, the mechanisms by which RAS promotes the progression of breast cancer (BRCA) under chronic psychological stress are remain ... ...

Abstract	Chronic psychological stress contributes to the occurrence of cancer and activates the renin-angiotensin system (RAS). However, the mechanisms by which RAS promotes the progression of breast cancer (BRCA) under chronic psychological stress are remain unknown. In this study, we observed elevated levels of Angiotensin II (Ang II) in both serum and BRCA tissue under chronic stress, leading to accelerated BRCA growth in a mouse model. An antihypertensive drug, candesartan (an AT1 inhibitor), effectively attenuated Ang II-induced cell proliferation and metastasis. Utilizing mass spectrometry and weighted gene co-expression network analysis (WGCNA), we identified fibronectin 1 (FN1) as the hub protein involved in chronic stress-Ang II/AT1 axis. Focal adhesion pathway was identified as a downstream signaling pathway activated during the progression of chronic stress. Depletion of FN1 significantly attenuated Ang II-induced proliferation and metastasis of BRCA cells. Poly (ADP-ribose) polymerase 1 (PARP1) was found to bind to the DNA promoter of FN1, leading to the transcription of FN1. Ang II upregulated PARP1 expression, resulting in increased FN1 levels. Recombinant FN1 partially restored the progress of BRCA malignancy induced by the Ang II/PARP1 pathway. In vivo, candesartan reversed the progressive effect of chronic psychological stress on BRCA. In clinical samples, Ang II levels in both serum and tumor tissues are higher in stressed patients compared to control patients. Serum Ang II levels were positively correlated with chronic stress indicators. In conclusion, our study demonstrated that chronic psychological stress accelerates the malignancy of BRCA, and the AT1 inhibitor candesartan counteracts these effects by suppressing the Ang II-AT1 axis and the downstream PARP1/FN1/focal adhesion pathway.
MeSH term(s)	Mice ; Animals ; Humans ; Female ; Angiotensin II/metabolism ; Antihypertensive Agents ; Fibronectins ; Breast Neoplasms/drug therapy ; Poly (ADP-Ribose) Polymerase-1/genetics ; Benzimidazoles ; Biphenyl Compounds ; Tetrazoles
Chemical Substances	Angiotensin II (11128-99-7) ; candesartan (S8Q36MD2XX) ; Antihypertensive Agents ; Fibronectins ; PARP1 protein, human (EC 2.4.2.30) ; Poly (ADP-Ribose) Polymerase-1 (EC 2.4.2.30) ; Benzimidazoles ; Biphenyl Compounds ; Tetrazoles
Language	English
Publishing date	2024-01-20
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	60-7
ISSN	1879-260X ; 1879-2596 ; 1872-8006 ; 1879-2642 ; 1879-2618 ; 1879-2650 ; 0006-3002 ; 0005-2728 ; 0005-2736 ; 0304-4165 ; 0167-4838 ; 1388-1981 ; 0167-4889 ; 0167-4781 ; 0304-419X ; 1570-9639 ; 0925-4439 ; 1874-9399
ISSN (online)	1879-260X ; 1879-2596 ; 1872-8006 ; 1879-2642 ; 1879-2618 ; 1879-2650
ISSN	0006-3002 ; 0005-2728 ; 0005-2736 ; 0304-4165 ; 0167-4838 ; 1388-1981 ; 0167-4889 ; 0167-4781 ; 0304-419X ; 1570-9639 ; 0925-4439 ; 1874-9399
DOI	10.1016/j.bbadis.2024.167031
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Article ; Online: TPI1 activates the PI3K/AKT/mTOR signaling pathway to induce breast cancer progression by stabilizing CDCA5.

Jin, Xiaoying / Wang, Dandan / Lei, Mengxia / Guo, Yan / Cui, Yuqing / Chen, Fengzhi / Sun, Weiling / Chen, Xuesong

Journal of translational medicine

2022 Volume 20, Issue 1, Page(s) 191

Abstract: Background: Triosephosphate isomerase 1 (TPI1), as a key glycolytic enzyme, is upregulated in multiple cancers. However, expression profile and regulatory mechanism of TPI1 in breast cancer (BRCA) remain mysterious.: Methods: Western blotting and ... ...

Abstract	Background: Triosephosphate isomerase 1 (TPI1), as a key glycolytic enzyme, is upregulated in multiple cancers. However, expression profile and regulatory mechanism of TPI1 in breast cancer (BRCA) remain mysterious. Methods: Western blotting and immunohistochemistry (IHC) assays were used to investigate the expression of TPI1 in BRCA specimens and cell lines. TPI1 correlation with the clinicopathological characteristics and prognosis of 362 BRCA patients was analyzed using a tissue microarray. Overexpression and knockdown function experiments in cells and mice models were performed to elucidate the function and mechanisms of TPI1-induced BRCA progression. Related molecular mechanisms were clarified using co-IP, IF, mass spectrometric analysis, and ubiquitination assay. Results: We have found TPI1 is highly expressed in BRCA tissue and cell lines, acting as an independent indicator for prognosis in BRCA patients. TPI1 promotes BRCA cell glycolysis, proliferation and metastasis in vitro and in vivo. Mechanistically, TPI1 activates phosphoinositide 3-kinase (PI3K)/AKT/mammalian target of rapamycin (mTOR) pathway to regulate epithelial-mesenchymal transformation (EMT) and aerobic glycolysis, which is positively mediated by cell division cycle associated 5 (CDCA5). Moreover, TPI1 interacts with sequestosome-1 (SQSTM1)/P62, and P62 decreases the protein expression of TPI1 by promoting its ubiquitination in MDA-MB-231 cells. Conclusions: TPI1 promotes BRCA progression by stabilizing CDCA5, which then activates the PI3K/AKT/mTOR pathway. P62 promotes ubiquitin-dependent proteasome degradation of TPI1. Collectively, TPI1 promotes tumor development and progression, which may serve as a therapeutic target for BRCA.
MeSH term(s)	Adaptor Proteins, Signal Transducing/metabolism ; Animals ; Breast Neoplasms/genetics ; Cell Cycle Proteins/metabolism ; Cell Line, Tumor ; Cell Movement ; Cell Proliferation ; Female ; Gene Expression Regulation, Neoplastic ; Humans ; Mammals/metabolism ; Mice ; Phosphatidylinositol 3-Kinase/metabolism ; Phosphatidylinositol 3-Kinases/metabolism ; Proto-Oncogene Proteins c-akt/metabolism ; Signal Transduction ; TOR Serine-Threonine Kinases/metabolism
Chemical Substances	Adaptor Proteins, Signal Transducing ; CDCA5 protein, human ; Cell Cycle Proteins ; MTOR protein, human (EC 2.7.1.1) ; Phosphatidylinositol 3-Kinase (EC 2.7.1.137) ; Proto-Oncogene Proteins c-akt (EC 2.7.11.1) ; TOR Serine-Threonine Kinases (EC 2.7.11.1)
Language	English
Publishing date	2022-05-04
Publishing country	England
Document type	Journal Article
ZDB-ID	2118570-0
ISSN	1479-5876 ; 1479-5876
ISSN (online)	1479-5876
ISSN	1479-5876
DOI	10.1186/s12967-022-03370-2
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Article ; Online: Cytoplasmic YAP1-mediated ESCRT-III assembly promotes autophagic cell death and is ubiquitinated by NEDD4L in breast cancer.

Guo, Yan / Cui, Yuqing / Li, Yangyang / Jin, Xiaoying / Wang, Dandan / Lei, Mengxia / Chen, Fengzhi / Liu, Yali / Xu, Jinwen / Yao, Guanyu / Zeng, Guangchun / Chen, Xuesong

Cancer communications (London, England)

2023 Volume 43, Issue 5, Page(s) 582–612

Abstract: Background: Nuclear Yes1-associated transcriptional regulator (YAP1) promotes tumor progression. However, the function of cytoplasmic YAP1 in breast cancer cells and its impact on the survival of breast cancer patients remain unclear. Our research aimed ...

Abstract	Background: Nuclear Yes1-associated transcriptional regulator (YAP1) promotes tumor progression. However, the function of cytoplasmic YAP1 in breast cancer cells and its impact on the survival of breast cancer patients remain unclear. Our research aimed to explore the biological function of cytoplasmic YAP1 in breast cancer cells and the possibility of cytoplasmic YAP1 as a predictive marker of breast cancer survival. Methods: We constructed cell mutant models, including NLS-YAP1 Results: YAP1 was mainly expressed in the cytoplasm in breast cancer cells. Cytoplasmic YAP1 promoted autophagic death of breast cancer cells. Cytoplasmic YAP1 bound to the ESCRT-III complex subunits charged multivesicular body protein 2B (CHMP2B) and vacuolar protein sorting 4 homolog B (VPS4B), promoting assembly of CHMP2B-VPS4B and activating autophagosome formation. EGCG retained YAP1 in the cytoplasm, promoting the assembly of CHMP2B-VPS4B to promote autophagic death of breast cancer cells. YAP1 bound to NEDD4L, and NEDD4L mediated ubiquitination and degradation of YAP1. Breast tissue microarrays revealed that high levels of cytoplasmic YAP1 were beneficial to the survival of breast cancer patients. Conclusions: Cytoplasmic YAP1 mediated autophagic death of breast cancer cells by promoting assembly of the ESCRT-III complex; furthermore, we established a new breast cancer survival prediction model based on cytoplasmic YAP1 expression.
MeSH term(s)	Female ; Humans ; Autophagic Cell Death ; Breast Neoplasms ; Cytoplasm/metabolism ; Endosomal Sorting Complexes Required for Transport/genetics ; Endosomal Sorting Complexes Required for Transport/metabolism ; Transcription Factors/genetics
Chemical Substances	Endosomal Sorting Complexes Required for Transport ; Transcription Factors ; Nedd4L protein, human (EC 2.3.2.26)
Language	English
Publishing date	2023-04-02
Publishing country	United States
Document type	Journal Article
ISSN	2523-3548
ISSN (online)	2523-3548
DOI	10.1002/cac2.12417
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Article ; Online: Comprehensive landscape of the renin-angiotensin system in Pan-cancer: a potential downstream mediated mechanism of SARS-CoV-2.

Cui, Yuqing / Chen, Fengzhi / Gao, Jiayi / Lei, Mengxia / Wang, Dandan / Jin, Xiaoying / Guo, Yan / Shan, Liying / Chen, Xuesong

International journal of biological sciences

2021 Volume 17, Issue 14, Page(s) 3795–3817

Abstract: Background: ...

Abstract	Background:
MeSH term(s)	COVID-19/complications ; COVID-19/metabolism ; DNA Methylation ; Gene Expression Regulation, Neoplastic ; Humans ; Immunotherapy ; Neoplasms/etiology ; Neoplasms/metabolism ; Neoplasms/mortality ; Neoplasms/therapy ; Protein Processing, Post-Translational ; Proto-Oncogene Mas ; Renin-Angiotensin System ; SARS-CoV-2/metabolism
Chemical Substances	MAS1 protein, human ; Proto-Oncogene Mas
Language	English
Publishing date	2021-09-03
Publishing country	Australia
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2179208-2
ISSN	1449-2288 ; 1449-2288
ISSN (online)	1449-2288
ISSN	1449-2288
DOI	10.7150/ijbs.53312
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Article ; Online: Stem cell therapy for erectile dysfunction of cavernous nerve injury rats: a systematic review and meta-analysis.

Shan, Haitao / Chen, Fengzhi / Zhang, Tao / He, Shuhua / Xu, Le / Wei, Anyang

PloS one

2015 Volume 10, Issue 4, Page(s) e0121428

Abstract: Introduction: Stem cell treatment is a novel therapeutic strategy for erectile dysfunction (ED) patients with bilateral cavernous nerve injury (CNI). The relative animal studies provide important clues to design pre-clinical studies and clinical studies ...

Abstract	Introduction: Stem cell treatment is a novel therapeutic strategy for erectile dysfunction (ED) patients with bilateral cavernous nerve injury (CNI). The relative animal studies provide important clues to design pre-clinical studies and clinical studies further in the future. Purpose: This study aims to evaluate the effects and influential factors of stem cell transplantation on ED rats with CNI. Materials and methods: We searched PubMed and EBSCO databases published before April 30, 2014 for pre-clinical studies to evaluate the efficacy of stem cell transplantation in the treatment of ED rats with CNI. A systematic review and a planned subgroup analysis were performed to identify whether or not some certain influential factors could bring significant effects on stem cell treatment. Results: 12 studies with 319 rats were enrolled in this meta-analysis. Pooled analysis results confirmed the efficacy of stem cell transplantation. Subgroup analysis results showed that treatment effects were not related to CNI models, follow-up time, stem cell species, stem cell sources, markers and delivery approaches in the transplantation. Uncultured stem cells were poorly effective compared with cultured stem cells. Periprostatic implantation (PPI) with acellular scaffolds could promote cavernous nerve regeneration, but was less effective for smooth muscle cell recovery. Stem cells modified by NGF or BDNF combined with udenafil/bFGF seemed to be more effective than those modified by BDNF alone. Conclusion: This meta-analysis shows that stem cell therapy can be performed to recover erectile function. Future studies should focus on nerve restoration and vascular cell recovery. The synergistic actions of multiple growth factors following stem cell transplantation should also be considered as beneficial strategies to obtain preferable effects.
MeSH term(s)	Animals ; Brain-Derived Neurotrophic Factor/pharmacology ; Databases, Factual ; Erectile Dysfunction/therapy ; Male ; Nerve Growth Factor/pharmacology ; Penile Erection ; Peripheral Nerve Injuries/therapy ; Rats ; Stem Cell Transplantation ; Stem Cells/cytology ; Stem Cells/drug effects ; Stem Cells/metabolism
Chemical Substances	Brain-Derived Neurotrophic Factor ; Nerve Growth Factor (9061-61-4)
Language	English
Publishing date	2015-04-10
Publishing country	United States
Document type	Journal Article ; Meta-Analysis ; Review ; Systematic Review
ISSN	1932-6203
ISSN (online)	1932-6203
DOI	10.1371/journal.pone.0121428
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