LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 10 of total 1321

Search options

  1. Article ; Online: Government R&D Investment, Knowledge Accumulation, and Regional Innovation Capability

    Chen Gong

    Complexity, Vol

    Evidence of a Threshold Effect Model from China

    2021  Volume 2021

    Abstract: Innovation is the primary driving force of development and the strategic support for building a modern economic system. For enterprises, continuous innovation capabilities can effectively deal with uncertainties in the business environment and can ... ...

    Abstract Innovation is the primary driving force of development and the strategic support for building a modern economic system. For enterprises, continuous innovation capabilities can effectively deal with uncertainties in the business environment and can enhance business competitiveness. Macropolicies can stimulate economic development and can try to promote enterprise innovation, but there is still widespread debate in academia about whether these policies successfully promote or, in fact, inhibit innovation. Looking at the provincial panel data from China between 2009 and 2018, the authors of this paper explored the complex nonlinear mechanism of government R&D investment in driving regional innovation capabilities from the perspective of knowledge accumulation. The empirical results show that, when the level of knowledge accumulation is used as the threshold variable, there is an obvious threshold effect between government R&D input and regional innovation capabilities. As the level of knowledge accumulation crosses the threshold, the influence of government R&D investment on regional innovation capabilities undergoes a structural mutation, shifting from an insignificant inhibitory effect to a significant promotional effect. The above conclusion has strong robustness. This article provides useful policy enlightenment for China to promote the development of scientific and technological civilization and the construction of an innovative country.
    Keywords Electronic computers. Computer science ; QA75.5-76.95
    Subject code 339
    Language English
    Publishing date 2021-01-01T00:00:00Z
    Publisher Hindawi-Wiley
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

    More links

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  2. Article ; Online: Google effects on memory

    Chen Gong / Yang Yang

    Frontiers in Public Health, Vol

    a meta-analytical review of the media effects of intensive Internet search behavior

    2024  Volume 12

    Abstract: People are increasingly using the web for fact-checking and other forms of information seeking. The “Google effects” refers to the idea that individuals rely on the Internet as a source of knowledge rather than remembering it for themselves. However, few ...

    Abstract People are increasingly using the web for fact-checking and other forms of information seeking. The “Google effects” refers to the idea that individuals rely on the Internet as a source of knowledge rather than remembering it for themselves. However, few literature review have yet comprehensively examined the media effects of this intensive Internet search behavior. In this study, by carrying out meta-analysis, we found that google effects is closely associated with cognitive load, behavioral phenotype and cognitive self-esteem. And this phenomenon is also more likely to happen while using a mobile phone to browse the Internet rather than a computer. People with a larger knowledge base are less susceptible to the consequences of Internet use than those with a smaller knowledge base. The media effect was stronger for persons who had used the Internet before than for those who had not. And meta-analyses show that participants in North America (parameter = −1.0365, 95%CI = [−1.8758, −0.1972], p < 0.05) are more susceptible to frequent Internet search behavior relative to other regions. Overall, google effects on memory challenges the way individuals seek and read information, and it may lead to changes in cognitive and memory mechanisms.
    Keywords Google effects ; meta-analysis ; Internet use ; cognition and memory ; media effects ; Public aspects of medicine ; RA1-1270
    Subject code 303
    Language English
    Publishing date 2024-01-01T00:00:00Z
    Publisher Frontiers Media S.A.
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

    More links

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  3. Article ; Online: Building, Integrating, and Sharing Our Aging Society: Improving Older Adults' Health Together.

    Chen, Gong

    China CDC weekly

    2021  Volume 3, Issue 40, Page(s) 835–836

    Language English
    Publishing date 2021-09-15
    Publishing country China
    Document type Editorial
    ISSN 2096-7071
    ISSN (online) 2096-7071
    DOI 10.46234/ccdcw2021.206
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  4. Article ; Online: In vivo confusion over in vivo conversion.

    Chen, Gong

    Molecular therapy : the journal of the American Society of Gene Therapy

    2021  Volume 29, Issue 11, Page(s) 3097–3098

    MeSH term(s) Confusion ; Humans
    Language English
    Publishing date 2021-10-25
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 2010592-7
    ISSN 1525-0024 ; 1525-0016
    ISSN (online) 1525-0024
    ISSN 1525-0016
    DOI 10.1016/j.ymthe.2021.10.017
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 5640: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  5. Article ; Online: Optical structuring and finishing toward mid-spatial-frequency error reduction using femtosecond lasers.

    Chen, Gong / Qiao, Jie

    Optics letters

    2024  Volume 49, Issue 6, Page(s) 1560–1563

    Abstract: We demonstrate nano-structuring and the reduction of mid-spatial-frequency errors using femtosecond laser figuring and finishing. For the first time, to the best of our knowledge, we have corrected mid-spatial-frequency errors from 17 nm to one nanometer ...

    Abstract We demonstrate nano-structuring and the reduction of mid-spatial-frequency errors using femtosecond laser figuring and finishing. For the first time, to the best of our knowledge, we have corrected mid-spatial-frequency errors from 17 nm to one nanometer in magnitude. We established a method for creating and predicting periodic nanostructures. This demonstration opens the path of using femtosecond lasers to correct surface errors that inherently result from sub-aperture manufacturing techniques.
    Language English
    Publishing date 2024-03-14
    Publishing country United States
    Document type Journal Article
    ISSN 1539-4794
    ISSN (online) 1539-4794
    DOI 10.1364/OL.520008
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  6. Article ; Online: PTSD, FOMO and fake news beliefs

    Chen Gong / Yijin Ren

    BMC Public Health, Vol 23, Iss 1, Pp 1-

    a cross-sectional study of Wenchuan earthquake survivors

    2023  Volume 11

    Abstract: Abstract Background Post-traumatic stress disorder (PTSD) sufferers show problematic patterns of Internet use such as fear of missing out (FOMO) and sharing misinformation and fake news. This study aimed to investigate these associations in survivors of ... ...

    Abstract Abstract Background Post-traumatic stress disorder (PTSD) sufferers show problematic patterns of Internet use such as fear of missing out (FOMO) and sharing misinformation and fake news. This study aimed to investigate these associations in survivors of the 2008 earthquake in Wenchuan, China. Methods A self-reported survey was completed by 356 survivors of the Wenchuan earthquake. A mediated structural equation model was constructed to test a proposed pattern of associations with FOMO as a mediator of the relationship between PTSD symptoms and belief in fake news, as well as moderators of this pathway. Results PTSD was directly associated with believing fake news (β = 0.444, p < .001) and with FOMO (β = 0.347, p < .001). FOMO mediated the association between PTSD and fake news belief (β = 0.373, p < .001). Age moderated the direct (β = 0.148, t = 3.097, p = .002) and indirect (β = 0.145, t = 3.122, p = .002) pathways, with effects more pronounced with increasing age. Gender was also a moderator, with the indirect effect present in females but not in males (β = 0.281, t = 6.737, p < .001). Conclusion Those with higher PTSD symptoms are more likely to believe fake news and this is partly explained by FOMO. This effect is present in females and not males and is stronger in older people. Findings extend knowledge of the role of psychological variables in problematic Internet use among those with PTSD.
    Keywords Wenchuan Earthquake ; Fake news ; Post-traumatic stress disorder ; Fear of missing out ; Social Media Use ; Public aspects of medicine ; RA1-1270
    Subject code 150
    Language English
    Publishing date 2023-11-01T00:00:00Z
    Publisher BMC
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

    More links

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  7. Article ; Online: Femtosecond-laser-enabled simultaneous figuring and finishing of glass with a subnanometer optical surface.

    Chen, Gong / Qiao, Jie

    Optics letters

    2022  Volume 47, Issue 15, Page(s) 3860–3863

    Abstract: We demonstrate simultaneous figuring and surface finishing of glass using a femtosecond laser. For the first time, to the best of our knowledge, we have achieved deterministic material removal with nanometer precision and maintained sub-nanometer surface ...

    Abstract We demonstrate simultaneous figuring and surface finishing of glass using a femtosecond laser. For the first time, to the best of our knowledge, we have achieved deterministic material removal with nanometer precision and maintained sub-nanometer surface roughness without inducing any mid-spatial-frequency errors to the initial surface. A dynamic pulse propagation model is established to predict the interaction process, including plasma generation and surface temperature. The interactive modeling and the experiments enable the selection of a set of laser parameters to achieve controllable optical figuring and finishing. This demonstration shows the potential for using femtosecond lasers for advanced freeform optic forming, finishing, and reduction of detrimental mid-spatial-frequency errors, and laser-ablation-based patterning used for fabrication of integrated photonics and lasers.
    Language English
    Publishing date 2022-05-18
    Publishing country United States
    Document type Journal Article
    ISSN 1539-4794
    ISSN (online) 1539-4794
    DOI 10.1364/OL.467413
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  8. Article ; Online: Development of generic metabolic Raman calibration models using solution titration in aqueous phase and data augmentation for in-line cell culture analysis.

    Zhang, Zhijun / Lang, Zhe / Chen, Gong / Zhou, Hang / Zhou, Weichang

    Biotechnology and bioengineering

    2024  

    Abstract: This study presents a novel approach for developing generic metabolic Raman calibration models for in-line cell culture analysis using glucose and lactate stock solution titration in an aqueous phase and data augmentation techniques. First, a successful ... ...

    Abstract This study presents a novel approach for developing generic metabolic Raman calibration models for in-line cell culture analysis using glucose and lactate stock solution titration in an aqueous phase and data augmentation techniques. First, a successful set-up of the titration method was achieved by adding glucose or lactate solution at several different constant rates into the aqueous phase of a bench-top bioreactor. Subsequently, the in-line glucose and lactate concentration were calculated and interpolated based on the rate of glucose and lactate addition, enabling data augmentation and enhancing the robustness of the metabolic calibration model. Nine different combinations of spectra pretreatment, wavenumber range selection, and number of latent variables were evaluated and optimized using aqueous titration data as training set and a historical cell culture data set as validation and prediction set. Finally, Raman spectroscopy data collected from 11 historical cell culture batches (spanning four culture modes and scales ranging from 3 to 200 L) were utilized to predict the corresponding glucose and lactate values. The results demonstrated a high prediction accuracy, with an average root mean square errors of prediction of 0.65 g/L for glucose, and 0.48 g/L for lactate. This innovative method establishes a generic metabolic calibration model, and its applicability can be extended to other metabolites, reducing the cost of deploying real-time cell culture monitoring using Raman spectroscopy in bioprocesses.
    Language English
    Publishing date 2024-04-19
    Publishing country United States
    Document type Journal Article
    ZDB-ID 280318-5
    ISSN 1097-0290 ; 0006-3592
    ISSN (online) 1097-0290
    ISSN 0006-3592
    DOI 10.1002/bit.28717
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.B 960: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  9. Article ; Online: Antimicrobial activity and mechanism of anti-MRSA of phloroglucinol derivatives.

    Yang, Xianjing / Gao, Xinjiao / Ou, Jiayi / Chen, Gong / Ye, Lianbao

    Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences

    2024  Volume 32, Issue 1, Page(s) 177–187

    Abstract: Background: In previous studies, authors have completed the total synthesis of several phloroglucinol natural products and synthesized a series of their derivatives, which were tested with good biological activities.: Objectives: To discover anti- ... ...

    Abstract Background: In previous studies, authors have completed the total synthesis of several phloroglucinol natural products and synthesized a series of their derivatives, which were tested with good biological activities.
    Objectives: To discover anti-MRSA lead compound and study their mechanism of action.
    Methods: Phloroglucinol derivatives were tested to investigate their activities against several gram-positive strains including Methicillin-resistant Staphylococcus aureus (MRSA). The mechanism study was conducted by determining extracellular potassium ion concentration, intracellular NADPH oxidase content, SOD activity, ROS amount in MRSA and MRSA survival rate under A5 treatment. The in vitro cytotoxicity test of A5 was conducted.
    Results: The activity of monocyclic compounds was stronger than that of bicyclic compounds, and compound A5 showed the best MIC value of 0.98 μg/mL and MBC value of 1.95 μg/mL, which were 4-8 times lower than that of vancomycin. The mechanism study of A5 showed that it achieved anti-MRSA effect through membrane damage, which is proved by increased concentration of extracellular potassium ion after A5 treatment. Another possible mechanism is the over ROS production induced cell death, which is suggested by observed alternation of several reactive oxygen species (ROS) related indicators including NADPH concentration, superoxide dismutase (SOD) activity, ROS content and bacterial survival rate after A5 treatment. The cytotoxicity results in vitro showed that A5 was basically non-toxic to cells.
    Conclusion: Acylphloroglucinol derivative A5 showed good anti-MRSA activity, possibly via membrane damage and ROS-mediated oxidative stress mechanism. It deserves further exploration to be a potential lead for the development of new anti-MRSA agent.
    MeSH term(s) Methicillin-Resistant Staphylococcus aureus/drug effects ; Phloroglucinol/pharmacology ; Phloroglucinol/chemistry ; Phloroglucinol/analogs & derivatives ; Microbial Sensitivity Tests ; Anti-Bacterial Agents/pharmacology ; Anti-Bacterial Agents/chemistry ; Reactive Oxygen Species/metabolism ; Humans ; Superoxide Dismutase/metabolism
    Chemical Substances Phloroglucinol (DHD7FFG6YS) ; Anti-Bacterial Agents ; Reactive Oxygen Species ; Superoxide Dismutase (EC 1.15.1.1)
    Language English
    Publishing date 2024-01-22
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2129183-4
    ISSN 2008-2231 ; 1560-8115
    ISSN (online) 2008-2231
    ISSN 1560-8115
    DOI 10.1007/s40199-024-00503-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  10. Article: Bone defect reconstruction using Masquelet technique for calcaneal chondroblastoma: a case report.

    Chen, Xianwei / Chen, Gong / Chen, Zhifu / Zhang, Jing

    Journal of surgical case reports

    2023  Volume 2023, Issue 7, Page(s) rjad401

    Abstract: Masquelet technique demonstrated superiority in reconstructing long bone defect after trauma or infection. However, reports in foot tumor were rare. A 24-year-old male diagnosed with calcaneal chondroblastoma who had a defect of calcaneal after ... ...

    Abstract Masquelet technique demonstrated superiority in reconstructing long bone defect after trauma or infection. However, reports in foot tumor were rare. A 24-year-old male diagnosed with calcaneal chondroblastoma who had a defect of calcaneal after intralesional curettage. We reconstructed the defect by Masquelet technique. This is the first case as far as we know that reported Masquelet technique for calcaneal tumor. The technique to treat irregular bone defects after operation can be considered in other similar situations.
    Language English
    Publishing date 2023-07-14
    Publishing country England
    Document type Case Reports
    ZDB-ID 2580919-2
    ISSN 2042-8812
    ISSN 2042-8812
    DOI 10.1093/jscr/rjad401
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

To top