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  1. Article: [Summary of Hui prescriptions for stroke].

    Li, Ting-Ting / Dong, Lin / Chen, Guo-Ting / Chen, Jing / Fu, Xue-Yan

    Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica

    2013  Volume 38, Issue 14, Page(s) 2412–2415

    Abstract: Current Hui prescriptions are mostly recorded in the Arabic language. Their fussy and inconsistent names (Arabic names) result in the restriction in the clinical application of Hui prescriptions. Having collected and screened out 101 Hui prescriptions ... ...

    Abstract Current Hui prescriptions are mostly recorded in the Arabic language. Their fussy and inconsistent names (Arabic names) result in the restriction in the clinical application of Hui prescriptions. Having collected and screened out 101 Hui prescriptions for stroke, the author further studied some of their names in literatures, in order to facilitate clinical application of these prescriptions (i. e. unification of their Arabic and Chinese names, and textual research of identical drugs with different Arabic names). This lays a foundation for the clinical application of Hui prescriptions and the analysis on compatibility regulatory, and provides scientific basis for studies on new Hui medicines.
    MeSH term(s) Asian Continental Ancestry Group ; Drugs, Chinese Herbal/therapeutic use ; Humans ; Medicine, Arabic ; Medicine, Chinese Traditional/methods ; Plant Extracts/therapeutic use ; Stroke/drug therapy
    Chemical Substances Drugs, Chinese Herbal ; Plant Extracts
    Language Chinese
    Publishing date 2013-07
    Publishing country China
    Document type English Abstract ; Journal Article ; Review
    ZDB-ID 1004649-5
    ISSN 1001-5302 ; 0254-0029
    ISSN 1001-5302 ; 0254-0029
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3056: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: Decreased expression of microRNA-130a correlates with TNF-α in the development of osteoarthritis.

    Li, Zeng-Chun / Han, Ning / Li, Xin / Li, Guang / Liu, Yang-Zhou / Sun, Gui-Xin / Wang, Yong / Chen, Guo-Ting / Li, Guo-Feng

    International journal of clinical and experimental pathology

    2015  Volume 8, Issue 3, Page(s) 2555–2564

    Abstract: Objective: Increased expression of tumor necrosis factor a (TNF-α) has emerged as an important inflammatory factor in osteoarthritis (OA) and other joint diseases. The study was performed to investigate whether the expression of TNF-α in human ... ...

    Abstract Objective: Increased expression of tumor necrosis factor a (TNF-α) has emerged as an important inflammatory factor in osteoarthritis (OA) and other joint diseases. The study was performed to investigate whether the expression of TNF-α in human chondrocytes was regulated by miRNAs.
    Methods: MiRNA-130a and TNF-α expression in cartilage specimens was examined in patients with knee osteoarthritis, chondrocytes and osteoarthritis rat model. Chondrocytes were transfected with siRNAs as a gene silencing methods. Expression of genes and proteins were analyzed by real-time PCR and western blotting respectively.
    Results: Increased TNF-α and decreased miRNA-130a were observed in tissues from osteoarthritis patients. Moreover, we found a highly negitive correlation between miRNA-130a and TNF-α. Next, miRNA-130a loss-of-function increased the expression of TNF-α and promoted inflammation in chondrocytes. It was reasonable that miRNA-130a regulated a distinct underlying molecular and pathogenic mechanism of OA by forming a negative feedback loop with TNF-α. Furthermore, there were the abnormalities of bone metabolism in OA rat, which showed the miRNA-130a and TNF-α dysfunction that was one of important factors for the occurrence and development of OA.
    Conclusions: Our results indicated that miR-130a played an important role in regulating the expression of TNF-α in human chondrocytes and identified miR-130a as a novel therapeutic target in OA.
    MeSH term(s) Animals ; Blotting, Western ; Chondrocytes/metabolism ; Gene Expression Regulation/physiology ; Humans ; Male ; MicroRNAs/biosynthesis ; Osteoarthritis, Knee/genetics ; Osteoarthritis, Knee/metabolism ; Rats ; Rats, Sprague-Dawley ; Real-Time Polymerase Chain Reaction ; Transfection ; Tumor Necrosis Factor-alpha/biosynthesis
    Chemical Substances MIRN130 microRNA, human ; MicroRNAs ; Tumor Necrosis Factor-alpha
    Language English
    Publishing date 2015
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2418306-4
    ISSN 1936-2625 ; 1936-2625
    ISSN (online) 1936-2625
    ISSN 1936-2625
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: [The relationship between frameshift mutations of transforming growth factor-beta type II receptor, insulin growth factor II receptor, bcl-2 associated X protein, E2F4 and microsatellite instability in gastric carcinoma].

    Chen, Guo-ting / Zhu, Zheng-gang / Yin, Hao-ran / Liu, Bing-ya / Ji, Jun / Zhang, Jun / Lin, Yan-zhen

    Zhonghua wai ke za zhi [Chinese journal of surgery

    2006  Volume 44, Issue 5, Page(s) 344–348

    Abstract: Objective: To determine the microsatellite instability in gastric carcinomas, examine the frameshift mutations of transforming growth factor-beta type II receptor (TGFbetaRII), insulin growth factor II receptor (IGFIIR), bcl-2 associated X protein (BAX) ...

    Abstract Objective: To determine the microsatellite instability in gastric carcinomas, examine the frameshift mutations of transforming growth factor-beta type II receptor (TGFbetaRII), insulin growth factor II receptor (IGFIIR), bcl-2 associated X protein (BAX) and E2F4, and investigate whether or how alterations of the TGFbetaRII, IGFIIR, BAX and E2F4 gene are associated with MSI in gastric cancer.
    Methods: Formalin-fixed, paraffin-embedded gastrectomy specimens and matching normal tissues of 65 cases of gastric carcinomas were retrieved from shanghai Ruijin Hospital and Shanghai East Hospital. DNA was extracted from tissue sections using phenol chloral isoamyl alcohol. Sections with no more than 50% of tumor cell areas were isolated by microdissection. DNA was amplified by PCR-based single strand conformation polymorphism (SSCP) for microsatellite analysis and was sequenced directly. Frameshift mutations in the coding regions, repetitive mononucleotide tracts of (A)10 for TGFbetaRII, (G)8 for IGFIIR, (G)8 for BAX, and trinucleotide repeats of (AGC)13 for transcription factors E2F4 were detected using PCR. Tumors were classified as being microsatellite stable (MSS) or having a low frequency of MSI (MSI-L, one of markers different in the tumor) or a high frequency of MSI (MSI-H, two or more of markers different).
    Results: Eleven cases (18.0%) showed MSI-L, 12 (19.7%) showed MSI-H and 38 (62.3%) cases showed MSS. The mutation rates of TGFbetaRII, IGFIIR, BAX and E2F4 gene were 19.7%, 4.9%, 6.6% and 16.4% respectively. Among the 12 MSI-H gastric cancers, there were 10 TGFbetaRII mutations, 3 IGFIIR mutations, 4 BAX mutations and 10 E2F4 gene mutations. The alterations in the repeats of the related genes presented polymorphisms. Associations of MSI-H status and mutations of the 4 genes were highly significant (P < 0.01, respectively). No repeat tracts mutations in TGFbetaRII, IGFIIR, BAX and E2F4 gene were found in MSS tumors.
    Conclusions: The repeat coding regions within TGFbetaRII, IGFIIR, BAX and E2F4 gene are the targets of microsatellite instability. Frameshift mutations of the 4 genes play an important role in the development and progression of gastric cancers with microsatellite instability.
    MeSH term(s) Adult ; Aged ; Aged, 80 and over ; China ; E2F4 Transcription Factor/genetics ; Female ; Frameshift Mutation ; Humans ; Male ; Microsatellite Instability ; Middle Aged ; Polymerase Chain Reaction ; Protein-Serine-Threonine Kinases ; Receptor, IGF Type 2/genetics ; Receptors, Transforming Growth Factor beta/genetics ; Stomach Neoplasms/genetics ; bcl-2-Associated X Protein/genetics
    Chemical Substances E2F4 Transcription Factor ; Receptor, IGF Type 2 ; Receptors, Transforming Growth Factor beta ; bcl-2-Associated X Protein ; Protein-Serine-Threonine Kinases (EC 2.7.11.1) ; transforming growth factor-beta type II receptor (EC 2.7.11.30)
    Language Chinese
    Publishing date 2006-03-01
    Publishing country China
    Document type English Abstract ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 604573-x
    ISSN 0529-5815
    ISSN 0529-5815
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 2469: Show issues Location:
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    Zs.MO 218: Show issues

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  4. Article: [Experimental research of the inhibition of vascular endothelial growth factor C expression in gastric cancer by targeting RNA interference].

    Chen, Guo-Ting / Niu, Xian-Ping / Li, Qi / Ji, Sheng-Chao / Han, Qing-Hui / Liu, Yang-Zhou / Li, Xia / Zhang, Hui / Cai, Duan

    Zhonghua wei chang wai ke za zhi = Chinese journal of gastrointestinal surgery

    2010  Volume 13, Issue 1, Page(s) 64–67

    Abstract: Objective: To construct the plasmid expression vector pSIH1-H1-copGFP for RNA interference against vascular endothelial growth factor C (VEGF-C) and to evaluate its effect on the expression of VEGF-C mRNA in gastric cancer cells after transfection.: ... ...

    Abstract Objective: To construct the plasmid expression vector pSIH1-H1-copGFP for RNA interference against vascular endothelial growth factor C (VEGF-C) and to evaluate its effect on the expression of VEGF-C mRNA in gastric cancer cells after transfection.
    Methods: Three siRNAs of genome sequence of VEGF-C gene were retrieved from GenBank and one negative chain was used as control. Four siRNAs were cloned into plasmid pSIH1-H1-copGFP,which were then transfected into gastric cancer cells (SGC7901). The expression of VEGF-C mRNA was analyzed by RT-PCR.
    Results: The recombinant plasmid of pSIH1-H1-copGFP specific for VEGF-C was confirmed by gene sequencing analysis. The target sequence obtained was completely consistent with the design. Transfection efficiency of the three siRNAs ranged from 60% to 70%. After transfection, the expression of VEGF-C mRNA in SGC7901 cells was significantly inhibited. Inhibition rates of VEGF-C mRNA expression were 35.4%, 33.8% and 81.5% in the three siRNA plasmid vectors, respectively.
    Conclusion: The siRNA expression plasmid vector against VEGF-C mRNA is successfully constructed, and RNAi may be a useful technique to inhibit the lymphangiogenesis of gastric cancer.
    MeSH term(s) Cell Line, Tumor ; Genetic Vectors ; Humans ; Plasmids ; RNA Interference ; RNA, Small Interfering ; Stomach Neoplasms/genetics ; Transfection ; Vascular Endothelial Growth Factor C/genetics
    Chemical Substances RNA, Small Interfering ; Vascular Endothelial Growth Factor C
    Language Chinese
    Publishing date 2010-01
    Publishing country China
    Document type English Abstract ; Journal Article
    ISSN 1671-0274
    ISSN 1671-0274
    Database MEDical Literature Analysis and Retrieval System OnLINE

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