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  1. Article ; Online: Counterion influence on near-infrared-II heptamethine cyanine salts for photothermal therapy.

    Zheng, Yilin / Chen, Tingyan / Gao, Yu / Chen, Haijun

    Bioorganic chemistry

    2024  Volume 145, Page(s) 107206

    Abstract: Photothermal therapy (PTT) has attracted extensive attention in cancer treatment. Heptamethine cyanine dyes with near-infrared (NIR) absorption performance have been investigated for PTT. However, they are often accompanied by poor photostability, ... ...

    Abstract Photothermal therapy (PTT) has attracted extensive attention in cancer treatment. Heptamethine cyanine dyes with near-infrared (NIR) absorption performance have been investigated for PTT. However, they are often accompanied by poor photostability, suboptimal photothermal conversion and limited therapeutic efficacy. The photophysical properties of fluorescent organic salts can be tuned through counterion pairing. However, whether the counterion can influence the photostability and photothermal properties of heptamethine cyanine salts has not been clarified. In this work, we investigated the effects of eleven counter anions on the physical and photothermal properties of NIR-II heptamethine cyanine salts with the same heptamethine cyanine cation. The anions have great impacts on the physiochemical properties of dyes in solution including aggregation, photostability and photothermal conversion efficiency. The physical tuning enables the control over the cytotoxicity and phototoxicity of the dyes. The selected salts have been demonstrated to significantly suppress 4T1 breast tumor growth with low toxicity. The findings that the counterion has great effects on the photothermal properties of cationic NIR-II heptamethine cyanine dyes will provide a reference for the preparation of improved photothermal agents through counterion pairing with possible translation to humans.
    MeSH term(s) Humans ; Salts/pharmacology ; Photothermal Therapy ; Coloring Agents/chemistry ; Anions ; Fluorescent Dyes/pharmacology ; Fluorescent Dyes/chemistry ; Carbocyanines
    Chemical Substances Salts ; Coloring Agents ; heptamethine cyanine dye ; Anions ; Fluorescent Dyes ; Carbocyanines
    Language English
    Publishing date 2024-02-13
    Publishing country United States
    Document type Journal Article
    ZDB-ID 120080-x
    ISSN 1090-2120 ; 0045-2068
    ISSN (online) 1090-2120
    ISSN 0045-2068
    DOI 10.1016/j.bioorg.2024.107206
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4207: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
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  2. Article ; Online: Exploring Different Ultrasonic Parameters and Treatment Conditions to Optimize In Vitro Sonodynamic Therapeutic Effects in Cancer Cells.

    Zheng, Yilin / Wang, Jun / Chen, Haijun / Gao, Yu

    Cell biochemistry and biophysics

    2023  Volume 82, Issue 1, Page(s) 303–314

    Abstract: The effects of ultrasonic parameters and treatment conditions on the in vitro cellular experiments of sonodynamic therapy (SDT) have not been fully studied. Exploring the factors that affect the efficacy of SDT can provide a reference for screening ... ...

    Abstract The effects of ultrasonic parameters and treatment conditions on the in vitro cellular experiments of sonodynamic therapy (SDT) have not been fully studied. Exploring the factors that affect the efficacy of SDT can provide a reference for screening effective sonosensitizers in vitro. The aim of this work is to investigate the factors that affected the SDT effects in cancer cells. Cancer cells in culture plates were exposed to ultrasound and sonosensitizers. The intracellular drug concentration was measured by using flow cytometry and the cell viability was determined by MTT assay. The SDT effects of cancer cells treated with different ultrasonic parameters under the same sonosensitizer concentration were different. The ultrasonic parameters, intracellular drug concentration, drug treatment time, cell amount, and cell status could affect the sonodynamic therapeutic effects. It is necessary to select appropriate ultrasound conditions and optimize the cellular status to make the results of the in vitro cellular experiments more reliable.
    MeSH term(s) Humans ; Ultrasonic Therapy/methods ; Ultrasonics ; Reactive Oxygen Species ; Neoplasms/diagnostic imaging ; Neoplasms/therapy ; Cell Line, Tumor
    Chemical Substances Reactive Oxygen Species
    Language English
    Publishing date 2023-10-13
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1357904-6
    ISSN 1559-0283 ; 1085-9195
    ISSN (online) 1559-0283
    ISSN 1085-9195
    DOI 10.1007/s12013-023-01189-2
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    Zs.A 1498: Show issues Location:
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  3. Article ; Online: Exploring the mechanism of action of Sparganii Rhizoma-Curcumae Rhizoma for in treating castration-resistant prostate cancer: a network-based pharmacology and experimental validation study.

    Wu, Litong / Chen, Haijun / Long, Yan / Qiu, Junfeng / Dai, Xinjun / You, Xujun / Li, Tiantian

    Scientific reports

    2024  Volume 14, Issue 1, Page(s) 3099

    Abstract: Sparganii Rhizoma-Curcumae Rhizoma (SR-CR) is a classic drug pair for the treatment of castration-resistant prostate cancer (CRPC), but its mechanism has not been clarified. The study aims to elucidate the potential mechanism of SR-CR in the management ... ...

    Abstract Sparganii Rhizoma-Curcumae Rhizoma (SR-CR) is a classic drug pair for the treatment of castration-resistant prostate cancer (CRPC), but its mechanism has not been clarified. The study aims to elucidate the potential mechanism of SR-CR in the management of CRPC. The present study employed the TCMSP as well as the SwissTargetPrediction platform to retrieve the chemical composition and targets of SR-CR. The therapeutic targets of CRPC were identified through screening the GeneCards, Disgenet, and OMIM databases. Subsequently, the Venny online platform was utilized to identify the shared targets between the SR-CR and CRPC. The shared targets were enrichment analysis using the Bioconductor and Kyoto encyclopedia of genes and genomes (KEGG) databases. The active ingredients and core targets were verified through molecular docking and were validated using PC3 cells in the experimental validation phase. A total of 7 active ingredients and 1126 disease targets were screened from SR-CR, leading to a total of 59 shared targets. Gene Ontology (GO) analysis resulted in 1309 GO entries. KEGG pathways analysis yielded 121 pathways, primarily involving cancer-related signaling pathways. The results from molecular docking revealed stable binding interactions between the core ingredients and the core targets. In vitro cellular assays further demonstrated that SR-CR effectively suppressed the activation of the Prostate cancer signaling pathway in PC3 cells, leading to the inhibition of cell proliferation and promotion of apoptosis. The SR-CR exert therapeutic effects on CRPC by inhibiting cell proliferation and promoting apoptosis through the Prostate cancer signaling pathway.
    MeSH term(s) Male ; Humans ; Molecular Docking Simulation ; Prostatic Neoplasms, Castration-Resistant/drug therapy ; Apoptosis ; Cell Proliferation ; Databases, Factual ; Drugs, Chinese Herbal/pharmacology ; Drugs, Chinese Herbal/therapeutic use
    Chemical Substances Drugs, Chinese Herbal
    Language English
    Publishing date 2024-02-07
    Publishing country England
    Document type Journal Article
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-024-53699-5
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Author Correction: Exploring the mechanism of action of Sparganii Rhizoma-Curcumae Rhizoma for in treating castration-resistant prostate cancer: a network-based pharmacology and experimental validation study.

    Wu, Litong / Chen, Haijun / Long, Yan / Qiu, Junfeng / Dai, Xinjun / You, Xujun / Li, Tiantian

    Scientific reports

    2024  Volume 14, Issue 1, Page(s) 5103

    Language English
    Publishing date 2024-03-01
    Publishing country England
    Document type Published Erratum
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-024-55386-x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Synthesis of Double Trivalent Perovskite Quantum Dots Cs

    Tian, Jie / Wang, Zhijian / Hou, Yaqin / Yang, Yatao / Chen, Haijun / Huang, Zhanggen

    Small (Weinheim an der Bergstrasse, Germany)

    2024  , Page(s) e2401301

    Abstract: Non-toxic Bi halides have great potential in the field of ... ...

    Abstract Non-toxic Bi halides have great potential in the field of CO
    Language English
    Publishing date 2024-04-26
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2168935-0
    ISSN 1613-6829 ; 1613-6810
    ISSN (online) 1613-6829
    ISSN 1613-6810
    DOI 10.1002/smll.202401301
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  6. Article ; Online: A carrier-free tri-component nanoreactor for multi-pronged synergistic cancer therapy.

    Shi, Huifang / Zheng, Fangying / Zheng, Yilin / Sun, Xianbin / Chen, Haijun / Gao, Yu

    Journal of photochemistry and photobiology. B, Biology

    2024  Volume 253, Page(s) 112886

    Abstract: Non-invasive therapies such as photodynamic therapy (PDT) and chemodynamic therapy (CDT) have received wide attention due to their low toxicity and side effects, but their efficacy is limited by the tumor microenvironment (TME), and monotherapy cannot ... ...

    Abstract Non-invasive therapies such as photodynamic therapy (PDT) and chemodynamic therapy (CDT) have received wide attention due to their low toxicity and side effects, but their efficacy is limited by the tumor microenvironment (TME), and monotherapy cannot achieve satisfactory efficacy. In this work, a multifunctional nanoparticle co-assembled from oleanolic acid (OA), chlorin e6 (Ce6) and hemin was developed. The as-constructed nanoparticle named OCH with diameters of around 130 nm possessed good biostability, pH/GSH dual-responsive drug release properties, and remarkable cellular internalization and tumor accumulation capabilities. OCH exhibited prominent catalytic activities to generate •OH, deplete GSH, and produce O
    MeSH term(s) Humans ; Combined Modality Therapy ; Neoplasms/drug therapy ; Drug Liberation ; Hypoxia ; Nanomedicine ; Nanoparticles ; Tumor Microenvironment ; Cell Line, Tumor ; Photochemotherapy ; Hydrogen Peroxide
    Chemical Substances Hydrogen Peroxide (BBX060AN9V)
    Language English
    Publishing date 2024-03-07
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 623022-2
    ISSN 1873-2682 ; 1011-1344
    ISSN (online) 1873-2682
    ISSN 1011-1344
    DOI 10.1016/j.jphotobiol.2024.112886
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2347: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
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  7. Article ; Online: Photosensitizers Dispersed on Nanosized Triterpenoid Matrix with Deaggregation-Enhanced Singlet Oxygen Production.

    Li, Ziying / Xie, Huanzhang / Shi, Huifang / Chen, Haijun / Gao, Yu

    ACS applied materials & interfaces

    2023  Volume 15, Issue 4, Page(s) 4973–4983

    Abstract: Aggregation-caused quenching (ACQ) effects of photosensitizers severely cut down the generation of quantum yield of singlet oxygen ( ...

    Abstract Aggregation-caused quenching (ACQ) effects of photosensitizers severely cut down the generation of quantum yield of singlet oxygen (
    MeSH term(s) Humans ; Photosensitizing Agents/pharmacology ; Photosensitizing Agents/therapeutic use ; Singlet Oxygen ; Photochemotherapy ; Neoplasms/drug therapy
    Chemical Substances Photosensitizing Agents ; Singlet Oxygen (17778-80-2)
    Language English
    Publishing date 2023-01-20
    Publishing country United States
    Document type Journal Article
    ISSN 1944-8252
    ISSN (online) 1944-8252
    DOI 10.1021/acsami.2c20364
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  8. Article ; Online: BODIPY-Based NO Probe for Macrophage-Targeted Immunotherapy Response Monitoring.

    Li, Xudong / Chen, Hui / Wang, Yuran / Chen, Haijun / Gao, Yu

    Analytical chemistry

    2023  Volume 95, Issue 18, Page(s) 7320–7328

    Abstract: Precise and rapid detection of immune responses is critical for timely therapeutic regimen adjustment. Immunomodulation of tumor-associated macrophages (TAMs) from a protumorigenic phenotype (M2) to an antitumorigenic phenotype (M1) is crucial in ... ...

    Abstract Precise and rapid detection of immune responses is critical for timely therapeutic regimen adjustment. Immunomodulation of tumor-associated macrophages (TAMs) from a protumorigenic phenotype (M2) to an antitumorigenic phenotype (M1) is crucial in macrophage-targeted immunotherapy. Herein, we developed a boron dipyrromethene (BODIPY)-based fluorescence probe
    MeSH term(s) Animals ; Nitric Oxide/metabolism ; Boron/chemistry ; Macrophages/metabolism ; Immunotherapy/methods ; Fluorescent Dyes/chemistry ; Tumor Microenvironment
    Chemical Substances 4,4-difluoro-4-bora-3a,4a-diaza-s-indacene ; dipyrromethene ; Nitric Oxide (31C4KY9ESH) ; Boron (N9E3X5056Q) ; alpha-amino-(4-hydroxybenzylidene)diphosphonate (73332-33-9) ; Fluorescent Dyes
    Language English
    Publishing date 2023-04-27
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1508-8
    ISSN 1520-6882 ; 0003-2700
    ISSN (online) 1520-6882
    ISSN 0003-2700
    DOI 10.1021/acs.analchem.3c00409
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    Zs.A 4033: Show issues Location:
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  9. Article ; Online: The progress of autoimmune hepatitis research and future challenges

    Zhang Yang / Zhang Dehe / Chen Ling / Zhou Jing / Ren Binbin / Chen Haijun

    Open Medicine, Vol 18, Iss 1, Pp 1094-

    2023  Volume 106

    Abstract: Autoimmune hepatitis (AIH) is a chronic liver inflammatory disease with various immune system manifestations, showing a global trend of increased prevalence. AIH is diagnosed through histological abnormalities, clinical manifestations, and biochemical ... ...

    Abstract Autoimmune hepatitis (AIH) is a chronic liver inflammatory disease with various immune system manifestations, showing a global trend of increased prevalence. AIH is diagnosed through histological abnormalities, clinical manifestations, and biochemical indicators. The biochemical markers involve interfacial hepatitis, transaminase abnormalities, positive autoantibodies, etc. Although AIH pathogenesis is unclear, gene mutations and immunological factors could be the leading factors. AIH usually presents as a chronic liver disease and sometimes as acute hepatitis, making it challenging to distinguish it from drug-related hepatitis due to similar clinical symptoms. Normalizing transaminases and serum IgG levels is essential in assessing the remission status of AIH treatment. Glucocorticoids and azathioprine are the first-line AIH treatment, with lifelong maintenance therapy in some patients. The quality of life and survival can be improved after appropriate treatment. However, certain limitations jeopardize the quality of treatment, including long treatment cycles, side effects, poor patient compliance, and inability to inhibit liver fibrosis and cirrhosis. Accurate AIH animal models will help us understand the pathophysiology of the disease while providing fresh perspectives for avoiding and treating AIH. This review will help us understand AIH better, from the cellular and molecular causes to the clinical features, and will provide insight into new therapy techniques with fewer side effects.
    Keywords autoimmune hepatitis ; pathogenic mechanism ; diagnosis ; treatment ; animal models ; Medicine ; R
    Subject code 610
    Language English
    Publishing date 2023-10-01T00:00:00Z
    Publisher De Gruyter
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article ; Online: Photostability investigation of a near-infrared-II heptamethine cyanine dye.

    Chen, Tingyan / Zheng, Yilin / Gao, Yu / Chen, Haijun

    Bioorganic chemistry

    2022  Volume 126, Page(s) 105903

    Abstract: The development of small-molecule organic fluorophores in the second near-infrared region (NIR-II, 1000-1700 nm) has recently received immense attention due to deep tissue light penetration and reduced autofluorescence. Polymethine cyanine dyes as ... ...

    Abstract The development of small-molecule organic fluorophores in the second near-infrared region (NIR-II, 1000-1700 nm) has recently received immense attention due to deep tissue light penetration and reduced autofluorescence. Polymethine cyanine dyes as important building blocks are frequently used to design NIR-II light-activated fluorophores. However, applications of these fluorophores were restricted by their poor photostability. Herein, we synthesized a NIR-II heptamethine cyanine dye 4 as the model compound to investigate its photostability and identify its photoproducts. Compound 4 shows improved photostability compared to ICG, and remains relatively stable even under sunlight irradiation. The cyanine scaffold's good photostability promoted its stable photothermal properties. The effective photothermal activity of cyanine dye 4 and the low toxicity of its one major photoproduct demonstrated its potential for further photo-therapeutic applications. This work would pave the way for the development of NIR-II cyanines with photostability through delicate structure design.
    MeSH term(s) Carbocyanines/chemistry ; Fluorescent Dyes/chemistry
    Chemical Substances Carbocyanines ; Fluorescent Dyes ; heptamethine cyanine dye
    Language English
    Publishing date 2022-05-25
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 120080-x
    ISSN 1090-2120 ; 0045-2068
    ISSN (online) 1090-2120
    ISSN 0045-2068
    DOI 10.1016/j.bioorg.2022.105903
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