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Article ; Online: SMAX1 interacts with DELLA protein to inhibit seed germination under weak light conditions via gibberellin biosynthesis in Arabidopsis.

Xu, Peipei / Hu, Jinbo / Chen, Haiying / Cai, Weiming

2023 Volume 42, Issue 7, Page(s) 112740

Abstract: Karrikins (KARs) were first identified as a class of small-molecule chemicals derived from smoke that promote seed germination. However, the implied mechanism is still not well understood. Here, we find that KAR signaling mutants have a lower germination ...

Abstract	Karrikins (KARs) were first identified as a class of small-molecule chemicals derived from smoke that promote seed germination. However, the implied mechanism is still not well understood. Here, we find that KAR signaling mutants have a lower germination percentage than that of wild type under weak light conditions, and KARs promote seed germination through transcriptional activation of gibberellin (GA) biosynthesis via SMAX1. SMAX1 interacts with the DELLA proteins REPRESSOR of ga1-3-LIKE 1 (RGL1) and RGL3. The interaction enhances the transcriptional activity of SMAX1 and inhibits GIBBERELLIN 3-oxidase 2 (GA3ox2) gene expression. The KAR signaling mutant seed germination defect under weak light is partially rescued by exogenous application of GA
MeSH term(s)	Arabidopsis/metabolism ; Arabidopsis Proteins/genetics ; Arabidopsis Proteins/metabolism ; Gene Expression Regulation, Plant ; Germination/genetics ; Gibberellins/metabolism ; Intracellular Signaling Peptides and Proteins/metabolism ; Seeds/genetics
Chemical Substances	Arabidopsis Proteins ; Gibberellins ; Intracellular Signaling Peptides and Proteins ; SMAX1 protein, Arabidopsis ; GAI protein, Arabidopsis
Language	English
Publishing date	2023-07-04
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2649101-1
ISSN	2211-1247 ; 2211-1247
ISSN (online)	2211-1247
ISSN	2211-1247
DOI	10.1016/j.celrep.2023.112740
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Regulatory mechanisms of miR-212-3p on the secretion of inflammatory factors in monocyte-macrophages and the directed differentiation into osteoclasts in ankylosing spondylitis.

Xie, Jianli / Xu, Jinrong / Chen, Haiying

Aging

2023 Volume 15, Issue 22, Page(s) 13411–13421

Abstract: To explore the mechanisms of action of micro ribonucleic acid (miR)-212-3p in the secretion of inflammatory factors in monocyte-macrophages and the directed differentiation into osteoclasts (OCs) in ankylosing spondylitis (AS), proteoglycan was used to ... ...

Abstract	To explore the mechanisms of action of micro ribonucleic acid (miR)-212-3p in the secretion of inflammatory factors in monocyte-macrophages and the directed differentiation into osteoclasts (OCs) in ankylosing spondylitis (AS), proteoglycan was used to establish an AS mouse model. The mouse monocyte-macrophages were cultured
MeSH term(s)	Animals ; Mice ; Calcitonin ; Cell Differentiation/genetics ; Macrophages/metabolism ; Matrix Metalloproteinase 1 ; Matrix Metalloproteinase 3 ; MicroRNAs/genetics ; MicroRNAs/metabolism ; Monocytes/metabolism ; Osteoclasts/metabolism ; Spondylitis, Ankylosing/genetics ; Tumor Necrosis Factor-alpha/metabolism
Chemical Substances	Calcitonin (9007-12-9) ; Matrix Metalloproteinase 1 (EC 3.4.24.7) ; Matrix Metalloproteinase 3 (EC 3.4.24.17) ; MicroRNAs ; Tumor Necrosis Factor-alpha
Language	English
Publishing date	2023-11-28
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	1945-4589
ISSN (online)	1945-4589
DOI	10.18632/aging.205249
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Article ; Online: Ascorbic Acid-Caused Quenching Effect of Protein Clusteroluminescence Probe: The Fast Fluorescent Detection of Ascorbic Acid in Vegetables.

Song, Jiying / Guo, Xinyan / Chen, Haiying / Tang, Yunge / Han, Lei

Molecules (Basel, Switzerland)

2023 Volume 28, Issue 5

Abstract: It is interesting and meaningful to explore fluorescent probes for novel rapid detection methods. In this study, we discovered a natural fluorescence probe, bovine serum albumin (BSA), for the assay of ascorbic acid (AA). Due to clusterization-triggered ... ...

Abstract	It is interesting and meaningful to explore fluorescent probes for novel rapid detection methods. In this study, we discovered a natural fluorescence probe, bovine serum albumin (BSA), for the assay of ascorbic acid (AA). Due to clusterization-triggered emission (CTE), BSA has the character of clusteroluminescence. AA shows an obvious fluorescence quenching effect on BSA, and the quenching effect increases with increasing concentrations of AA. After optimization, a method for the rapid detection of AA is established by the AA-caused fluorescence quenching effect. The fluorescence quenching effect reaches saturation after 5 min of incubation time and the fluorescence is stable within more than one hour, suggesting a rapid and stable fluorescence response. Moreover, the proposed assay method shows good selectivity and a wide linear range. To further study the mechanisms of AA-caused fluorescence quenching effect, some thermodynamic parameters are calculated. The main intermolecular force between BSA and AA is electrostatic, presumably leading to the inhibiting CTE process of BSA. This method also shows acceptable reliability for the real vegetable sample assay. In summary, this work will not only provide an assay strategy for AA, but also open an avenue for the application expansion of CTE effect of natural biomacromolecules.
MeSH term(s)	Vegetables ; Ascorbic Acid/analysis ; Reproducibility of Results ; Spectrometry, Fluorescence/methods ; Fluorescent Dyes ; Serum Albumin, Bovine ; Limit of Detection
Chemical Substances	Ascorbic Acid (PQ6CK8PD0R) ; Fluorescent Dyes ; Serum Albumin, Bovine (27432CM55Q)
Language	English
Publishing date	2023-02-25
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	1413402-0
ISSN	1420-3049 ; 1431-5165 ; 1420-3049
ISSN (online)	1420-3049
ISSN	1431-5165 ; 1420-3049
DOI	10.3390/molecules28052162
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Article ; Online: Drug Discovery Targeting Nuclear Receptor Binding SET Domain Protein 2 (NSD2).

Ma, Zonghui / Bolinger, Andrew A / Chen, Haiying / Zhou, Jia

Journal of medicinal chemistry

2023 Volume 66, Issue 16, Page(s) 10991–11026

Abstract: Nuclear receptor binding SET domain proteins (NSDs) catalyze the mono- or dimethylation of histone 3 lysine 36 (H3K36me1 and H3K36me2), ... ...

Abstract	Nuclear receptor binding SET domain proteins (NSDs) catalyze the mono- or dimethylation of histone 3 lysine 36 (H3K36me1 and H3K36me2), using
MeSH term(s)	Humans ; Drug Discovery ; Histones/metabolism ; Neoplasms ; PR-SET Domains/drug effects
Chemical Substances	Histones ; NSD2 protein, human (EC 2.1.1.43)
Language	English
Publishing date	2023-08-14
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S. ; Review
ZDB-ID	218133-2
ISSN	1520-4804 ; 0022-2623
ISSN (online)	1520-4804
ISSN	0022-2623
DOI	10.1021/acs.jmedchem.3c00948
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Zs.B 151: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)
Zs.MB 1: Show issues

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Article ; Online: Easily synthesized mesoporous aluminum phosphate for the enhanced adsorption performance of U(VI) from aqueous solution.

Wang, De / Chen, Haiying / Zhang, Jianfeng / Li, Jiaxing

Journal of hazardous materials

2022 Volume 432, Page(s) 128675

Abstract: High-yield selective adsorbents and suitable modification methods are both significant for the efficient treatment of U-contaminated wastewater. In this work, a rich-mesoporous aluminum phosphate adsorbent (APO-10) was synthesized by simply increasing ... ...

Abstract	High-yield selective adsorbents and suitable modification methods are both significant for the efficient treatment of U-contaminated wastewater. In this work, a rich-mesoporous aluminum phosphate adsorbent (APO-10) was synthesized by simply increasing the mass of reactants under a fixed solvent volume. After increasing the mass of reactants ten times, APO-10 has the added defect level, the increased specific surface area, and mesoporous structure, and the increased number and enhanced adsorption ability of adsorption active sites (phosphorus-oxygen groups) on the surface, resulting in an enhanced adsorption performance of U(VI) in various environmental conditions. Its ultrahigh adsorption capacity calculated by the Langmuir model can reach 826.44 mg g
Language	English
Publishing date	2022-03-11
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	1491302-1
ISSN	1873-3336 ; 0304-3894
ISSN (online)	1873-3336
ISSN	0304-3894
DOI	10.1016/j.jhazmat.2022.128675
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Article: Secular Trends in the Prevalence of and Disability-Adjusted Life Years Due to Common Micronutrient Deficiencies in China From 1990 to 2019: An Age-Period-Cohort Study and Joinpoint Analysis.

Chen, Haiying / Lu, Jinxin / Li, Yongze

Frontiers in nutrition

2022 Volume 9, Page(s) 754351

Abstract: Background: Understanding the national burdens and trends of micronutrient deficiencies can help guide effective intervention strategies. However, there is a lack of evidence of secular trends and age and sex differences in China. This study aims to ... ...

Abstract	Background: Understanding the national burdens and trends of micronutrient deficiencies can help guide effective intervention strategies. However, there is a lack of evidence of secular trends and age and sex differences in China. This study aims to elucidate trends in common micronutrient deficiencies, in particular, dietary iron, iodine and vitamin A deficiencies in China, from 1990 to 2019 using Global Burden of Disease (GBD) 2019 study data. Methods: Prevalence and DALYs trends of common micronutrient deficiencies from 1990 to 2019 were assessed by joinpoint regression analysis. Age, period and cohort effects on the prevalence of common micronutrient deficiencies were estimated by an age-period-cohort model. Results: From 1990 to 2019, the age-standardized prevalence rates of iodine, vitamin A and dietary iron deficiencies changed by -0.6% (95% CI: -0.7% to -0.5%), -6.3% (-6.6% to -6.0%), and -3.5% (-3.6% to -3.4%) in males and + 0.8% (+ 0.6% to + 1.0%), -4.5% (-4.8% to -4.2%), and -3.3% (-3.4% to -3.2%) in females, respectively. The average annual percent change (AAPC) in the iodine deficiency prevalence increased in females aged 20 years and older. The relative risk (RR) of iodine deficiency associated with the age effect peaked at 30-34 years of age and then decreased with increasing age. The RR of vitamin A deficiency decreased with age. The age distribution of the RR of iron deficiency differed significantly between sexes. The RRs of vitamin A deficiency and dietary iron deficiency decreased over time, whereas the RR of iodine deficiency substantially increased starting in 2004. The RRs of iodine deficiency and dietary iron deficiency associated with the cohort effect decreased, but the vitamin A deficiency prevalence increased in successive birth cohorts. Conclusion: Micronutrient deficiency prevalence rates and associated DALYs decreased from 1990 to 2019 in China. Young adults, children aged less than 5 years, and older individuals were disproportionately affected by iodine, vitamin A, and dietary iron deficiencies, respectively. The results of this study may help identify individuals who would benefit from interventions to improve micronutrient deficiency.
Language	English
Publishing date	2022-03-18
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2776676-7
ISSN	2296-861X
ISSN	2296-861X
DOI	10.3389/fnut.2022.754351
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Article: Arginyl-fructosyl-glucose from red ginseng alleviates TGF-β1-induced epithelial-mesenchymal transition of renal tubular epithelial cells.

Lin, Xiangdong / Xiang, Ming / Chen, Haiying / Chen, Xinyu

General physiology and biophysics

2022 Volume 41, Issue 4, Page(s) 329–338

Abstract: This study aims to explore the effect and mechanism of arginyl-fructosyl-glucose (AFG) on TGF-β1-induced epithelial-mesenchymal transition (EMT) of renal tubular epithelial cells. HK-2 cells were induced by TGF-β1 and then co-cultured with AFG at ... ...

Abstract	This study aims to explore the effect and mechanism of arginyl-fructosyl-glucose (AFG) on TGF-β1-induced epithelial-mesenchymal transition (EMT) of renal tubular epithelial cells. HK-2 cells were induced by TGF-β1 and then co-cultured with AFG at different concentrations (0, 25, 50, and 100 μmol/l) for 48 h. The morphology of HK-2 cells was observed under an inverted microscope and the expressions of α-SMA, Vimentin, and E-cadherin were assessed by qRT-PCR, Western blot, and immunofluorescence. The mRNA expressions of ERK and STAT3 were also examined by qRT-PCR, and the protein levels of ERK, STAT3, p-ERK, and p-STAT3 were measured by Western blot. Finally, CCK-8 and transwell assays were used to detect cell proliferation and invasion. TGF-β1 treatment significantly induced EMT in HK-2 cells. The expressions of p-ERK and p-STAT3 were signally increased after TGF-β1 induction, while Mogrol treatment inhibited p-ERK, p-STAT3, α-SMA, and Vimentin expression levels, enhanced E-cadherin expression, and suppressed cell proliferation and invasion. AFG exposure could also inhibit p-ERK, p-STAT3, α-SMA, and Vimentin expressions, promote E-cadherin expression, and markedly inhibit HK-2 cell proliferation and invasion. AFG inhibited TGF-β1-induced EMT of renal tubular epithelial cells by regulating phosphorylation of ERK and STAT3.
MeSH term(s)	Arginine/analogs & derivatives ; Cadherins/metabolism ; Cell Line ; Epithelial Cells ; Epithelial-Mesenchymal Transition ; Glucose ; Panax/metabolism ; Transforming Growth Factor beta1/metabolism ; Vimentin/metabolism
Chemical Substances	Cadherins ; Transforming Growth Factor beta1 ; Vimentin ; arginyl-fructosyl-glucose ; Arginine (94ZLA3W45F) ; Glucose (IY9XDZ35W2)
Language	English
Publishing date	2022-08-08
Publishing country	Slovakia
Document type	Journal Article
ZDB-ID	791184-1
ISSN	0231-5882
ISSN	0231-5882
DOI	10.4149/gpb_2022026
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Article: Easily synthesized mesoporous aluminum phosphate for the enhanced adsorption performance of U(VI) from aqueous solution

Wang, De / Chen, Haiying / Zhang, Jianfeng / Li, Jiaxing

Journal of hazardous materials. 2022 June 15, v. 432

2022

Abstract	High-yield selective adsorbents and suitable modification methods are both significant for the efficient treatment of U-contaminated wastewater. In this work, a rich-mesoporous aluminum phosphate adsorbent (APO-10) was synthesized by simply increasing the mass of reactants under a fixed solvent volume. After increasing the mass of reactants ten times, APO-10 has the added defect level, the increased specific surface area, and mesoporous structure, and the increased number and enhanced adsorption ability of adsorption active sites (phosphorus-oxygen groups) on the surface, resulting in an enhanced adsorption performance of U(VI) in various environmental conditions. Its ultrahigh adsorption capacity calculated by the Langmuir model can reach 826.44 mg g⁻¹ at pH = 5.5 and T = 298 K. Its crystal structure did not change after adsorption and remained at 584.40 mg g⁻¹ after 6 cycles. Additionally, APO-10 shows an excellent uranium-selectivity over 68% from a mixed aqueous solution and has excellent applicability in the acidic and alkaline environment based on dynamic adsorption and desorption column experiments. This study not only provides a high-yield efficient selective adsorbent (APO-10) with excellent anti-radiation structure stability for the treatment of radioactive contamination but also provides a feasible modification method by simply increasing the mass of reactants.
Keywords	adsorbents ; adsorption ; aluminum phosphate ; aqueous solutions ; crystal structure ; desorption ; pH ; porous media ; solvents ; sorption isotherms ; surface area ; wastewater
Language	English
Dates of publication	2022-0615
Publishing place	Elsevier B.V.
Document type	Article
ZDB-ID	1491302-1
ISSN	1873-3336 ; 0304-3894
ISSN (online)	1873-3336
ISSN	0304-3894
DOI	10.1016/j.jhazmat.2022.128675
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Intellectual Structure and Themes Evolution of Cluster Research

Wang Xiuqiong / Chen Haiying / Wu Xiaojie

Redai dili, Vol 41, Iss 1, Pp 190-

2021 Volume 205

Abstract: From the Institute of Scientific Information (ISI) Eigenfactor Project 2015 category, 115 journals in six disciplines which are ranked top 20 in order of impact scores in their own disciplines were selected. A total of 1002 industrial cluster research ... ...

Abstract	From the Institute of Scientific Information (ISI) Eigenfactor Project 2015 category, 115 journals in six disciplines which are ranked top 20 in order of impact scores in their own disciplines were selected. A total of 1002 industrial cluster research studies collected from the Web of Science between 1998 to 2019 were used as samples. BibExcel software was used for data cleaning and literature co-citation analysis, and co-occurrence matrix was inserted into SPSS software and Pajek software for exploratory factor analysis and network analysis, respectively. The differences and commonalities of the two results obtained from exploratory factor analysis and network analysis were compared by reading literature abstracts and manuscripts to robustly identify the knowledge base. According to the framework of 2W1H, the knowledge module was integrated into a problem-oriented system to understand the internal logic mechanism of the entire study. The top 41 studies in the citation frequency of each period from 1998 to 2005, 2006 to 2012, and 2013 to 2019 were selected to analyze the keyword co-occurrence in different periods, main theoretical basis, contextual focus, evolution of research topics, and important research trends. The results show that: 1) The knowledge base of industrial clusters can be divided into nine modules: external economics and new economic geography, new industrial district theory, competitive advantage theory, evolutionary economic geography, buzz and pipelines, regional innovation system, new economic sociology, absorptive capacity, and global chains; 2) The knowledge structure of these modules can be reflected through the 2W1H research framework, in which the WHAT part is composed of four modules: external economics, new economic geography, new industrial district theory, competitive advantage theory, and evolutionary economic geography. It answers the questions regarding concept, types and development stages of the cluster. The knowledge base of cluster type research in this part is less, which ...
Keywords	industrial cluster ; bibliometric literature review ; co-citation analysis ; network analysis ; Geography (General) ; G1-922
Subject code	910
Language	Chinese
Publishing date	2021-01-01T00:00:00Z
Publisher	Editorial Committee of Tropical Geography
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: OLFML3 suppresses trophoblast apoptosis via the PI3K/AKT pathway: A possible therapeutic target in preeclampsia.

Chen, Haiying / Li, Ruiping / Bian, Jiangyujing / Li, Xiaoqing / Su, Cunjing / Wang, Yang / Zhang, Hongping / Zheng, Jianqiong / Wang, Yeping / Zhang, Hong

Placenta

2024 Volume 147, Page(s) 1–11

Abstract: Introduction: Preeclampsia (PE) is a pregnancy complication that encompasses various pathogenic mechanisms. Shallow implantation of the placenta due to abnormal trophoblast behavior is considered an important mechanism underlying PE; however, its exact ... ...

Abstract	Introduction: Preeclampsia (PE) is a pregnancy complication that encompasses various pathogenic mechanisms. Shallow implantation of the placenta due to abnormal trophoblast behavior is considered an important mechanism underlying PE; however, its exact etiology remains unclear. Methods: The expression of OLFML3 in the placenta and important clinical indicators were performed, followed by a correlation analysis. The effect of OLFML3 on the behavior of HTR-8/SVneo cells was examined, and the downstream molecular mechanisms of OLFML3 were investigated in HTR-8/SVneo cells. Additionally, a rat model of PE was generated by adenovirus injection via the tail vein to verify the role of OLFML3. Results: OLFML3 is highly expressed in both syncytiotrophoblasts and cytotrophoblasts and deregulated in preeclamptic placentas. OLFML3 overexpression in HTR-8/SVneo cells promoted cell proliferation, migration, invasion, and impeded apoptosis, and triggered phosphorylation on ser473 of AKT. Conversely, OLFML3 knockdown exerted opposite effects. Furthermore, OLFML3 overexpression ameliorates CoCl Discussion: OLFML3 may alleviate PE development by inhibiting extravillous trophoblast cell apoptosis through the PI3K/AKT pathway. Our findings indicated that OLFML3 may provide a possible therapeutic target for PE.
MeSH term(s)	Animals ; Female ; Humans ; Pregnancy ; Rats ; Apoptosis ; Cell Movement ; Glycoproteins/metabolism ; Intercellular Signaling Peptides and Proteins/metabolism ; Phosphatidylinositol 3-Kinases/metabolism ; Placenta/metabolism ; Pre-Eclampsia/metabolism ; Proto-Oncogene Proteins c-akt/metabolism ; Signal Transduction ; Trophoblasts/metabolism
Chemical Substances	Glycoproteins ; Intercellular Signaling Peptides and Proteins ; OLFML3 protein, human ; Phosphatidylinositol 3-Kinases (EC 2.7.1.-) ; Proto-Oncogene Proteins c-akt (EC 2.7.11.1)
Language	English
Publishing date	2024-01-19
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	603951-0
ISSN	1532-3102 ; 0143-4004
ISSN (online)	1532-3102
ISSN	0143-4004
DOI	10.1016/j.placenta.2024.01.008
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