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Article ; Online: Oncological and functional outcome of robotic-assisted radical cystectomy with total intracorporeal stentless J-pouch neobladder reconstruction.

Chen, Hao Xiang / Huang, Chi-Ping

The international journal of medical robotics + computer assisted surgery : MRCAS

2023 , Page(s) e2583

Abstract: Background: Robotic-assisted radical cystectomy (RARC) with neobladder reconstruction has gained popularity in recent years.: Methods: We conducted a retrospective study of 17 consecutive patients who underwent RARC with totally intracorporeal J- ... ...

Abstract	Background: Robotic-assisted radical cystectomy (RARC) with neobladder reconstruction has gained popularity in recent years. Methods: We conducted a retrospective study of 17 consecutive patients who underwent RARC with totally intracorporeal J-pouch neobladder reconstruction without ureteral stent by a single experienced surgeon to evaluate perioperative, oncological and functional outcomes. Results: The median follow-up duration was 32.8 months (range: 17.4-59.0 months), and the 2-year disease-free survival rate was 88.2%. Five out of 12 patients were totally continent, and none required more than one pad per day. The overall complication rate was 41.2%, and hydronephrosis was the most common adverse event. The renal function remained stable, and no long-term renal function impairment was detected. Conclusion: Our study suggests that RARC with totally intracorporeal J-pouch neobladder reconstruction without ureteral stent is a safe and feasible option for the treatment of muscle-invasive bladder cancer, with good oncological and functional outcomes.
Language	English
Publishing date	2023-10-09
Publishing country	England
Document type	Journal Article
ZDB-ID	2151860-9
ISSN	1478-596X ; 1478-5951
ISSN (online)	1478-596X
ISSN	1478-5951
DOI	10.1002/rcs.2583
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Article ; Online: SPS: Accurate and Real-Time Semantic Positioning System Based on Low-Cost DEM Maps.

Cai, Jun-Xiong / Feng, Wensen / Chen, Hao-Xiang / Mu, Tai-Jiang

IEEE transactions on image processing : a publication of the IEEE Signal Processing Society

2023 Volume 32, Page(s) 6401–6412

Abstract: This paper presents a Semantic Positioning System (SPS) to enhance the accuracy of mobile device geo-localization in outdoor urban environments. Although the traditional Global Positioning System (GPS) can offer a rough localization, it lacks the ... ...

Abstract	This paper presents a Semantic Positioning System (SPS) to enhance the accuracy of mobile device geo-localization in outdoor urban environments. Although the traditional Global Positioning System (GPS) can offer a rough localization, it lacks the necessary accuracy for applications such as Augmented Reality (AR). Our SPS integrates Geographic Information System (GIS) data, GPS signals, and visual image information to estimate the 6 Degree-of-Freedom (DoF) pose through cross-view semantic matching. This approach has excellent scalability to support GIS context with Levels of Detail (LOD). The map data representation is Digital Elevation Model (DEM), a cost-effective aerial map that allows for fast deployment for large-scale areas. However, the DEM lacks geometric and texture details, making it challenging for traditional visual feature extraction to establish pixel/voxel level cross-view correspondences. To address this, we sample observation pixels from the query ground-view image using predicted semantic labels. We then propose an iterative homography estimation method with semantic correspondences. To improve the efficiency of the overall system, we further employ a heuristic search to speedup the matching process. The proposed method is robust, real-time, and automatic. Quantitative experiments on the challenging Bund dataset show that we achieve a positioning accuracy of 73.24%, surpassing the baseline skyline-based method by 20%. Compared with the state-of-the-art semantic-based approach on the Kitti dataset, we improve the positioning accuracy by an average of 5%.
Language	English
Publishing date	2023-11-28
Publishing country	United States
Document type	Journal Article
ISSN	1941-0042
ISSN (online)	1941-0042
DOI	10.1109/TIP.2023.3332212
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Article ; Online: Combination of Durvalumab and Chemotherapy to Potentially Convert Unresectable Stage IV Penile Squamous Cell Carcinoma to Resectable Disease: A Case Report.

Chen, Hao Xiang / Lin, Ching-Chan / Lin, Che-Hung / Yang, Chi-Rei

Current oncology (Toronto, Ont.)

2022 Volume 30, Issue 1, Page(s) 326–332

Abstract: Penile squamous cell carcinoma is a rare disease entity with poor overall survival in an advanced stage. Few studies have investigated the role of immunotherapy in advanced penile squamous cell carcinoma. Herein, we report a case of stage IV unresectable ...

Abstract	Penile squamous cell carcinoma is a rare disease entity with poor overall survival in an advanced stage. Few studies have investigated the role of immunotherapy in advanced penile squamous cell carcinoma. Herein, we report a case of stage IV unresectable penile squamous cell carcinoma presenting with anal bleeding and urethra obstruction who responded dramatically to combination therapy of durvalumab and cisplatin-based chemotherapy. The patient had HPV-positive penile squamous cell carcinoma, cT3N3M0, with concomitant anus squamous cell carcinoma. After 2 months of the combination treatment, almost all bulky inguinal lymph nodes shrank, and the main tumor of the anus and penis responded completely. A durable response was seen 16 months after initiating the combination therapy. This case report highlights the potential role of the combination of immunotherapy and chemotherapy in patients with advanced penile cancer. The promising results of this combination resulted in the conversion of unresectable disease to a potentially curable disease.
MeSH term(s)	Male ; Humans ; Penile Neoplasms/drug therapy ; Penile Neoplasms/pathology ; Carcinoma, Squamous Cell/pathology ; Combined Modality Therapy ; Lymph Nodes/pathology
Chemical Substances	durvalumab (28X28X9OKV)
Language	English
Publishing date	2022-12-26
Publishing country	Switzerland
Document type	Case Reports
ZDB-ID	1236972-x
ISSN	1718-7729 ; 1198-0052
ISSN (online)	1718-7729
ISSN	1198-0052
DOI	10.3390/curroncol30010026
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Zs.A 4305: Show issues

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Book ; Online: SLS4D

Feng, Qi-Yuan / Chen, Hao-Xiang / Xu, Qun-Ce / Mu, Tai-Jiang

Sparse Latent Space for 4D Novel View Synthesis

2023

Abstract: Neural radiance field (NeRF) has achieved great success in novel view synthesis and 3D representation for static scenarios. Existing dynamic NeRFs usually exploit a locally dense grid to fit the deformation field; however, they fail to capture the global ...

Abstract	Neural radiance field (NeRF) has achieved great success in novel view synthesis and 3D representation for static scenarios. Existing dynamic NeRFs usually exploit a locally dense grid to fit the deformation field; however, they fail to capture the global dynamics and concomitantly yield models of heavy parameters. We observe that the 4D space is inherently sparse. Firstly, the deformation field is sparse in spatial but dense in temporal due to the continuity of of motion. Secondly, the radiance field is only valid on the surface of the underlying scene, usually occupying a small fraction of the whole space. We thus propose to represent the 4D scene using a learnable sparse latent space, a.k.a. SLS4D. Specifically, SLS4D first uses dense learnable time slot features to depict the temporal space, from which the deformation field is fitted with linear multi-layer perceptions (MLP) to predict the displacement of a 3D position at any time. It then learns the spatial features of a 3D position using another sparse latent space. This is achieved by learning the adaptive weights of each latent code with the attention mechanism. Extensive experiments demonstrate the effectiveness of our SLS4D: it achieves the best 4D novel view synthesis using only about $6\%$ parameters of the most recent work. Comment: 10 pages, 6 figures
Keywords	Computer Science - Computer Vision and Pattern Recognition ; Computer Science - Graphics
Subject code	004
Publishing date	2023-12-15
Publishing country	us
Document type	Book ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Combined Immunotherapy and Tyrosine Kinase Inhibitor Treatment for Metastatic Renal Cell Carcinoma With Unknown Primary Origin: A Report of Two Cases and Literature Review.

Chen, Hao Xiang / Yu, Lu-Ting / Chang, Han / Huang, Wei-Hsuan / Lin, Wei-Ching / Chang, Chao-Hsiang

In vivo (Athens, Greece)

2023 Volume 37, Issue 4, Page(s) 1905–1913

Abstract: Background/aim: Renal cell carcinoma (RCC) of unknown primary origin is rarely identified and accounts for only 5% of cancers of unknown primary origin (CUP). The disease prognosis is typically poor because of no standard and effective therapy. Our ... ...

Abstract	Background/aim: Renal cell carcinoma (RCC) of unknown primary origin is rarely identified and accounts for only 5% of cancers of unknown primary origin (CUP). The disease prognosis is typically poor because of no standard and effective therapy. Our review indicated that 23 cases have been reported and treated with conventional chemotherapy or tyrosine-kinase inhibitors alone; accordingly, most patients showed partial response or progression diseases with short survival time. Case report: Herein, we present two cases of metastatic RCC of unknown primary origin. One case was papillary type and the other was clear cell type. According to the recent clinical trials in patients with metastatic RCC, a combination of immunotherapy and tyrosine-kinase inhibitors exhibited better response than conventional therapy or tyrosine-kinase inhibitors alone. Both present cases accepted a combination treatment with immunotherapy and tyrosine-kinase inhibitor and showed stable diseases. The radiological progression-free time for the case with metastatic papillary RCC was 5 months, and that with clear cell RCC was 6 months until now. Conclusion: The combination of immunotherapy and tyrosine-kinase inhibitors is at least as effective as a tyrosine-kinase inhibitor alone, and superior to conventional chemotherapy for treating metastatic RCC of unknown primary origin.
MeSH term(s)	Humans ; Carcinoma, Renal Cell/diagnosis ; Carcinoma, Renal Cell/drug therapy ; Immunotherapy ; Kidney Neoplasms/drug therapy ; Neoplasms, Unknown Primary/diagnosis ; Neoplasms, Unknown Primary/drug therapy ; Protein Kinase Inhibitors/therapeutic use ; Tyrosine/metabolism ; Tyrosine Kinase Inhibitors
Chemical Substances	Protein Kinase Inhibitors ; Tyrosine (42HK56048U) ; Tyrosine Kinase Inhibitors
Language	English
Publishing date	2023-06-25
Publishing country	Greece
Document type	Review ; Case Reports ; Journal Article
ZDB-ID	807031-3
ISSN	1791-7549 ; 0258-851X
ISSN (online)	1791-7549
ISSN	0258-851X
DOI	10.21873/invivo.13285
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Zs.A 2288: Show issues

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Article ; Online: Chronic heat stress induces lung injury in broiler chickens by disrupting the pulmonary blood-air barrier and activating TLRs/NF-κB signaling pathway.

Wu, Xing-Yue / Wang, Fei-Yao / Chen, Hao-Xiang / Dong, Hui-Li / Zhao, Zhan-Qin / Si, Li-Fang

Poultry science

2023 Volume 102, Issue 12, Page(s) 103066

Abstract: As an important respiratory organ, the lung is susceptible to damage during heat stress due to the accelerated breathing frequency caused by an increase in environmental temperature. This can affect the growth performance of animals and endanger their ... ...

Abstract	As an important respiratory organ, the lung is susceptible to damage during heat stress due to the accelerated breathing frequency caused by an increase in environmental temperature. This can affect the growth performance of animals and endanger their health. This study aimed to explore the mechanism of lung tissue damage caused by heat stress. Broilers were randomly divided into a control group (Control) and a heat stress group (HS). The HS group was exposed to 35°C heat stress for 12 h per d from 21-days old, and samples were taken from selected broilers at 28, 35, and 42-days old. The results showed a significant increase in lactate dehydrogenase (LDH) activity in the serum and myeloperoxidase (MPO) activity in the lungs of broiler chickens across all 3 age groups after heat stress (P < 0.01), while the total antioxidant capacity (T-AOC) was significantly enhanced at 35-days old (P < 0.01). Heat stress also led to significant increases in various proinflammatory factors in serum and expression levels of HSP60 and HSP70 in lung tissue. Histopathological results showed congestion and bleeding in lung blood vessels, shedding of pulmonary epithelial cells, and a large amount of inflammatory infiltration in the lungs after heat stress. The mRNA expression of TLRs/NF-κB-related genes showed an upward trend (P < 0.05) after heat stress, while the mRNA expression of MLCK, a gene related to pulmonary blood-air barrier, significantly increased after heat stress, and the expression levels of MLC, ZO-1, and occludin decreased in contrast. This change was also confirmed by Western blotting, indicating that the pulmonary blood-air barrier is damaged after heat stress. Heat stress can cause damage to the lung tissue of broiler chickens by disrupting the integrity of the blood-air barrier and increasing permeability. This effect is further augmented by the activation of TLRs/NF-κB signaling pathways leading to an intensified inflammatory response. As heat stress duration progresses, broiler chickens develop thermotolerance, which gradually mitigates the damaging effects induced by heat stress.
MeSH term(s)	Animals ; Dietary Supplements/analysis ; NF-kappa B/genetics ; NF-kappa B/metabolism ; Chickens/physiology ; Lung Injury/veterinary ; Blood-Air Barrier/metabolism ; Heat-Shock Response ; Signal Transduction ; RNA, Messenger/metabolism ; Hot Temperature
Chemical Substances	NF-kappa B ; RNA, Messenger
Language	English
Publishing date	2023-09-07
Publishing country	England
Document type	Randomized Controlled Trial, Veterinary ; Journal Article
ZDB-ID	242586-5
ISSN	1525-3171 ; 0032-5791
ISSN (online)	1525-3171
ISSN	0032-5791
DOI	10.1016/j.psj.2023.103066
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Article ; Online: Multi-UAV Reconnaissance Task Assignment for Heterogeneous Targets Based on Modified Symbiotic Organisms Search Algorithm.

Chen, Hao-Xiang / Nan, Ying / Yang, Yi

Sensors (Basel, Switzerland)

2019 Volume 19, Issue 3

Abstract: This paper considers a reconnaissance task assignment problem for multiple unmanned aerial vehicles (UAVs) with different sensor capacities. A modified Multi-Objective Symbiotic Organisms Search algorithm (MOSOS) is adopted to optimize UAVs' task ... ...

Abstract	This paper considers a reconnaissance task assignment problem for multiple unmanned aerial vehicles (UAVs) with different sensor capacities. A modified Multi-Objective Symbiotic Organisms Search algorithm (MOSOS) is adopted to optimize UAVs' task sequence. A time-window based task model is built for heterogeneous targets. Then, the basic task assignment problem is formulated as a Multiple Time-Window based Dubins Travelling Salesmen Problem (MTWDTSP). Double-chain encoding rules and several criteria are established for the task assignment problem under logical and physical constraints. Pareto dominance determination and global adaptive scaling factors is introduced to improve the performance of original MOSOS. Numerical simulation and Monte-Carlo simulation results for the task assignment problem are also presented in this paper, whereas comparisons with non-dominated sorting genetic algorithm (NSGA-II) and original MOSOS are made to verify the superiority of the proposed method. The simulation results demonstrate that modified SOS outperforms the original MOSOS and NSGA-II in terms of optimality and efficiency of the assignment results in MTWDTSP.
MeSH term(s)	Aircraft/instrumentation ; Algorithms ; Artificial Intelligence ; Monte Carlo Method
Language	English
Publishing date	2019-02-12
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2052857-7
ISSN	1424-8220 ; 1424-8220
ISSN (online)	1424-8220
ISSN	1424-8220
DOI	10.3390/s19030734
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Article: LuxS modulates motility and secretion of extracellular protease in fish pathogen Vibrio harveyi

Zhang, Ya-Qiu / Deng, Yi-Qin / Feng, Juan / Hu, Jian-Mei / Chen, Hao-Xiang / Guo, Zhi-Xun / Su, You-Lu

Canadian journal of microbiology. 2022, v. 68, no. 3

2022

Abstract: Vibrio harveyi can cause infections and diseases in a variety of marine vertebrates and invertebrates, which are harmful to the aquaculture industry. The LuxS quorum-sensing system regulates the expression of virulence factors in a wide variety of ... ...

Abstract	Vibrio harveyi can cause infections and diseases in a variety of marine vertebrates and invertebrates, which are harmful to the aquaculture industry. The LuxS quorum-sensing system regulates the expression of virulence factors in a wide variety of pathogenic bacteria. In this study, an in-frame deletion of the luxS gene was constructed to reveal the role of LuxS in the physiology and virulence of V. harveyi. Statistical analysis showed no significant differences in the growth ability, biofilm formation, antibiotic susceptibility, virulence by intraperitoneal injection, and ability of V. harveyi to colonize the spleen and liver of the pearl gentian grouper between the wild-type (WT) and luxS mutant. However, deletion of luxS decreased the secretion of extracellular protease, while increasing swimming and swarming abilities. Simultaneously, a luxS-deleted mutant showed overproduction of lateral flagella, and an intact luxS complemented this defect. Since motility is flagella dependent, 16 V. harveyi flagella biogenesis related genes were selected for further analysis. Based on quantitative real-time reverse transcription-PCR (qRT-PCR), the expression levels of these genes, including the polar flagella genes flaB, flhA, flhF, flhB, flhF, fliS, and flrA and the lateral flagella genes flgA, flgB, fliE, fliF, lafA, lafK, and motY, were significantly upregulated in the ΔluxS: pMMB207 (ΔluxS⁺) strain as compared with the V. harveyi 345: pMMB207 (WT⁺) and C-ΔluxS strains during the early, mid-exponential, and stationary growth phases. Our results indicate that LuxS plays an important role in controlling motility, flagella biogenesis, and extracellular protease secretion in V. harveyi.
Keywords	Vibrio harveyi ; antibiotic resistance ; aquaculture industry ; biofilm ; biogenesis ; flagellum ; genes ; grouper ; intraperitoneal injection ; liver ; mutants ; pathogens ; proteinases ; quorum sensing ; reverse transcriptase polymerase chain reaction ; secretion ; spleen ; statistical analysis ; virulence
Language	English
Size	p. 215-226.
Publishing place	Canadian Science Publishing
Document type	Article
ZDB-ID	280534-0
ISSN	1480-3275 ; 0008-4166
ISSN (online)	1480-3275
ISSN	0008-4166
DOI	10.1139/cjm-2021-0311
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Mirabegron is better tolerated than solifenacin in Sjogren's syndrome patients with overactive bladder symptoms-A randomized controlled trial.

Chen, Hao Xiang / Chang, Shih-Hsin / Chen, Der-Yuan / Lan, Joung-Liang / Yeo, Kai-Jieh / Huang, Po-Hao / Huang, Chung-Ming / Huang, Chi-Ping / Chou, Eric Chieh-Lung / Wu, Po-Chang

Lower urinary tract symptoms

2023 Volume 15, Issue 4, Page(s) 139–147

Abstract: Objectives: This study investigates the efficacy and adverse events of beta-3 agonists and antimuscarinic agents for managing overactive bladder syndrome in Sjogren syndrome.: Methods: Sjogren's syndrome patients with an Overactive Bladder Symptom ... ...

Abstract	Objectives: This study investigates the efficacy and adverse events of beta-3 agonists and antimuscarinic agents for managing overactive bladder syndrome in Sjogren syndrome. Methods: Sjogren's syndrome patients with an Overactive Bladder Symptom Score (OABSS) >5 were enrolled and were randomly assigned to mirabegron 50 mg/day or solifenacin 5 mg/day. Patients were evaluated on the recruitment day and reassessed at Week 1, 2, 4, and 12. The study's primary endpoint was to have a significant change in OABSS at Week 12. The secondary endpoint was the adverse event and crossover rate. Results: A total of 41 patients were included in the final analysis, with 24 in the mirabegron group and 17 in the solifenacin group. The study's primary outcome was a change of the OABSS at Week 12. We found that both mirabegron and solifenacin significantly reduce patients' OABSS after 12 weeks of treatment. The evolution of the OABSS was -3.08 for mirabegron and -3.71 for solifenacin (p = .56). Six out of 17 patients from the solifenacin group crossed over to the mirabegron arm due to severe dry mouth or constipation, while none from the mirabegron arm crossed over to the solifenacin group. Sjogren's syndrome-related pain was also improved in the mirabegron group (4.96-1.67, p = .008) compared to the solifenacin group (4.39-3.4, p = .49). Conclusions: Our study showed that mirabegron is equally effective as solifenacin in treating Sjogren's syndrome patients with overactive bladder. Mirabegron is superior to solifenacin in terms of treatment-related adverse events.
MeSH term(s)	Humans ; Solifenacin Succinate/adverse effects ; Urinary Bladder, Overactive/etiology ; Urinary Bladder, Overactive/complications ; Sjogren's Syndrome/complications ; Sjogren's Syndrome/drug therapy ; Treatment Outcome ; Drug Therapy, Combination ; Acetanilides/adverse effects ; Muscarinic Antagonists/adverse effects ; Urological Agents/adverse effects
Chemical Substances	Solifenacin Succinate (KKA5DLD701) ; mirabegron (MVR3JL3B2V) ; Acetanilides ; Muscarinic Antagonists ; Urological Agents
Language	English
Publishing date	2023-05-16
Publishing country	Australia
Document type	Randomized Controlled Trial ; Journal Article
ZDB-ID	2519111-1
ISSN	1757-5672 ; 1757-5664
ISSN (online)	1757-5672
ISSN	1757-5664
DOI	10.1111/luts.12481
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Article ; Online: LuxS modulates motility and secretion of extracellular protease in fish pathogen

Zhang, Ya-Qiu / Deng, Yi-Qin / Feng, Juan / Hu, Jian-Mei / Chen, Hao-Xiang / Guo, Zhi-Xun / Su, You-Lu

Canadian journal of microbiology

2021 Volume 68, Issue 3, Page(s) 215–226

Abstract: ... Vibrio ... ...

Abstract	Vibrio harveyi
MeSH term(s)	Animals ; Bacterial Proteins/metabolism ; Carbon-Sulfur Lyases/metabolism ; Gene Expression Regulation, Bacterial ; Peptide Hydrolases/genetics ; Peptide Hydrolases/metabolism ; Vibrio/genetics
Chemical Substances	Bacterial Proteins ; Peptide Hydrolases (EC 3.4.-) ; Carbon-Sulfur Lyases (EC 4.4.-)
Language	English
Publishing date	2021-12-02
Publishing country	Canada
Document type	Journal Article
ZDB-ID	280534-0
ISSN	1480-3275 ; 0008-4166
ISSN (online)	1480-3275
ISSN	0008-4166
DOI	10.1139/cjm-2021-0311
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