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  1. Article ; Online: Topological Assembly of a Deployable Hoberman Flight Ring from DNA.

    Li, Ruixin / Chen, Haorong / Choi, Jong Hyun

    Small (Weinheim an der Bergstrasse, Germany)

    2021  Volume 17, Issue 11, Page(s) e2007069

    Abstract: Deployable geometries are finite auxetic structures that preserve their overall shapes during expansion and contraction. The topological behaviors emerge from intricately arranged elements and their connections. Despite the considerable utility of such ... ...

    Abstract Deployable geometries are finite auxetic structures that preserve their overall shapes during expansion and contraction. The topological behaviors emerge from intricately arranged elements and their connections. Despite the considerable utility of such configurations in nature and in engineering, deployable nanostructures have never been demonstrated. Here a deployable flight ring, a simplified planar structure of Hoberman sphere is shown, using DNA origami. The DNA flight ring consists of topologically assembled six triangles in two layers that can slide against each other, thereby switching between two distinct (open and closed) states. The origami topology is a trefoil knot, and its auxetic reconfiguration results in negative Poisson's ratios. This work shows the feasibility of deployable nanostructures, providing a versatile platform for topological studies and opening new opportunities for bioengineering.
    MeSH term(s) DNA ; Nanostructures
    Chemical Substances DNA (9007-49-2)
    Language English
    Publishing date 2021-02-22
    Publishing country Germany
    Document type Journal Article ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 2168935-0
    ISSN 1613-6829 ; 1613-6810
    ISSN (online) 1613-6829
    ISSN 1613-6810
    DOI 10.1002/smll.202007069
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  2. Article ; Online: Auxetic Two-Dimensional Nanostructures from DNA*.

    Li, Ruixin / Chen, Haorong / Choi, Jong Hyun

    Angewandte Chemie (International ed. in English)

    2021  Volume 60, Issue 13, Page(s) 7165–7173

    Abstract: Architectured materials exhibit negative Poisson's ratios and enhanced mechanical properties compared with regular materials. Their auxetic behaviors emerge from periodic cellular structures regardless of the materials used. The majority of such ... ...

    Abstract Architectured materials exhibit negative Poisson's ratios and enhanced mechanical properties compared with regular materials. Their auxetic behaviors emerge from periodic cellular structures regardless of the materials used. The majority of such metamaterials are constructed by top-down approaches and macroscopic with unit cells of microns or larger. There are also molecular auxetics including natural crystals which are not designable. There is a gap from few nanometers to microns, which may be filled by biomolecular self-assembly. Herein, we demonstrate two-dimensional auxetic nanostructures using DNA origami. Structural reconfigurations are performed by two-step DNA reactions and complemented by mechanical deformation studies using molecular dynamics simulations. We find that the auxetic behaviors are mostly defined by geometrical designs, yet the properties of the materials also play an important role. From elasticity theory, we introduce design principles for auxetic DNA metamaterials.
    Language English
    Publishing date 2021-02-22
    Publishing country Germany
    Document type Journal Article ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 2011836-3
    ISSN 1521-3773 ; 1433-7851
    ISSN (online) 1521-3773
    ISSN 1433-7851
    DOI 10.1002/anie.202014729
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  3. Article: Baicalein Inhibits the

    Mao, Yanni / Liu, Panpan / Chen, Haorong / Wang, Yuxia / Li, Caixia / Wang, Quiqin

    Infection and drug resistance

    2023  Volume 16, Page(s) 2861–2882

    Abstract: Introduction: Staphylococcus aureus: Methods: This study evaluated the effects of different Baicalin (BAI) concentrations on the growth and the biofilm of : Results: According to the docking experiments, they were able to engage with the amino ... ...

    Abstract Introduction: Staphylococcus aureus
    Methods: This study evaluated the effects of different Baicalin (BAI) concentrations on the growth and the biofilm of
    Results: According to the docking experiments, they were able to engage with the amino acid residues in LuxS and BAI through hydrogen bonding. The results of molecular dynamics simulations and the binding free energy also confirmed the stability of the complex and supported the experimental results. BAI showed weak inhibitory activity against
    Discussion: We thus report that BAI inhibits the
    Language English
    Publishing date 2023-05-09
    Publishing country New Zealand
    Document type Journal Article
    ZDB-ID 2494856-1
    ISSN 1178-6973
    ISSN 1178-6973
    DOI 10.2147/IDR.S406243
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  4. Article ; Online: Conformational Control of DNA Origami by DNA Oligomers, Intercalators and UV Light.

    Li, Ruixin / Chen, Haorong / Lee, Hyeongwoon / Choi, Jong Hyun

    Methods and protocols

    2021  Volume 4, Issue 2

    Abstract: DNA origami has garnered great attention due to its excellent programmability and precision. It offers a powerful means to create complex nanostructures which may not be possible by other methods. The macromolecular structures may be used as static ... ...

    Abstract DNA origami has garnered great attention due to its excellent programmability and precision. It offers a powerful means to create complex nanostructures which may not be possible by other methods. The macromolecular structures may be used as static templates for arranging proteins and other molecules. They are also capable of undergoing structural transformation in response to external signals, which may be exploited for sensing and actuation at the nanoscale. Such on-demand reconfigurations are executed mostly by DNA oligomers through base-pairing and/or strand displacement, demonstrating drastic shape changes between two different states, for example, open and close. Recent studies have developed new mechanisms to modulate the origami conformation in a controllable, progressive manner. Here we present several methods for conformational control of DNA origami nanostructures including chemical adducts and UV light as well as widely applied DNA oligomers. The detailed methods should be useful for beginners in the field of DNA nanotechnology.
    Language English
    Publishing date 2021-05-22
    Publishing country Switzerland
    Document type Journal Article
    ISSN 2409-9279
    ISSN (online) 2409-9279
    DOI 10.3390/mps4020038
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  5. Article ; Online: Exploring Novel Antidepressants Targeting G Protein-Coupled Receptors and Key Membrane Receptors Based on Molecular Structures.

    Yao, Hanbo / Wang, Xiaodong / Chi, Jiaxin / Chen, Haorong / Liu, Yilin / Yang, Jiayi / Yu, Jiaqi / Ruan, Yongdui / Xiang, Xufu / Pi, Jiang / Xu, Jun-Fa

    Molecules (Basel, Switzerland)

    2024  Volume 29, Issue 5

    Abstract: Major Depressive Disorder (MDD) is a complex mental disorder that involves alterations in signal transmission across multiple scales and structural abnormalities. The development of effective antidepressants (ADs) has been hindered by the dominance of ... ...

    Abstract Major Depressive Disorder (MDD) is a complex mental disorder that involves alterations in signal transmission across multiple scales and structural abnormalities. The development of effective antidepressants (ADs) has been hindered by the dominance of monoamine hypothesis, resulting in slow progress. Traditional ADs have undesirable traits like delayed onset of action, limited efficacy, and severe side effects. Recently, two categories of fast-acting antidepressant compounds have surfaced, dissociative anesthetics S-ketamine and its metabolites, as well as psychedelics such as lysergic acid diethylamide (LSD). This has led to structural research and drug development of the receptors that they target. This review provides breakthroughs and achievements in the structure of depression-related receptors and novel ADs based on these. Cryo-electron microscopy (cryo-EM) has enabled researchers to identify the structures of membrane receptors, including the N-methyl-D-aspartate receptor (NMDAR) and the 5-hydroxytryptamine 2A (5-HT
    MeSH term(s) Humans ; Depressive Disorder, Major/drug therapy ; Serotonin ; Molecular Structure ; Cryoelectron Microscopy ; Antidepressive Agents/pharmacology ; Receptors, G-Protein-Coupled/metabolism ; Receptors, N-Methyl-D-Aspartate/metabolism
    Chemical Substances Serotonin (333DO1RDJY) ; Antidepressive Agents ; Receptors, G-Protein-Coupled ; Receptors, N-Methyl-D-Aspartate
    Language English
    Publishing date 2024-02-22
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 1413402-0
    ISSN 1420-3049 ; 1431-5165 ; 1420-3049
    ISSN (online) 1420-3049
    ISSN 1431-5165 ; 1420-3049
    DOI 10.3390/molecules29050964
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.MO 81: Show issues

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  6. Article ; Online: Promising Roles of Circular RNAs as Biomarkers and Targets for Potential Diagnosis and Therapy of Tuberculosis.

    Huang, Yifan / Li, Ying / Lin, Wensen / Fan, Shuhao / Chen, Haorong / Xia, Jiaojiao / Pi, Jiang / Xu, Jun-Fa

    Biomolecules

    2022  Volume 12, Issue 9

    Abstract: Tuberculosis (TB), caused ... ...

    Abstract Tuberculosis (TB), caused by
    MeSH term(s) Biomarkers/metabolism ; Humans ; MicroRNAs/metabolism ; RNA Splicing ; RNA, Circular/genetics ; Tuberculosis/diagnosis ; Tuberculosis/drug therapy ; Tuberculosis/genetics
    Chemical Substances Biomarkers ; MicroRNAs ; RNA, Circular
    Language English
    Publishing date 2022-09-04
    Publishing country Switzerland
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2701262-1
    ISSN 2218-273X ; 2218-273X
    ISSN (online) 2218-273X
    ISSN 2218-273X
    DOI 10.3390/biom12091235
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  7. Article: Engineered exosomes as drug and RNA co-delivery system: new hope for enhanced therapeutics?

    Chen, Haorong / Yao, Hanbo / Chi, Jiaxin / Li, Chaowei / Liu, Yilin / Yang, Jiayi / Yu, Jiaqi / Wang, Jiajun / Ruan, Yongdui / Pi, Jiang / Xu, Jun-Fa

    Frontiers in bioengineering and biotechnology

    2023  Volume 11, Page(s) 1254356

    Abstract: Chemotherapy often faces some obstacles such as low targeting effects and drug resistance, which introduce the low therapeutic efficiency and strong side effects. Recent advances in nanotechnology allows the use of novel nanosystems for targeted drug ... ...

    Abstract Chemotherapy often faces some obstacles such as low targeting effects and drug resistance, which introduce the low therapeutic efficiency and strong side effects. Recent advances in nanotechnology allows the use of novel nanosystems for targeted drug delivery, although the chemically synthesized nanomaterials always show unexpected low biocompability. The emergence of exosome research has offered a better understanding of disease treatment and created novel opportunities for developing effective drug delivery systems with high biocompability. Moreover, RNA interference has emerged as a promising strategy for disease treatments by selectively knocking down or over-expressing specific genes, which allows new possibilities to directly control cell signaling events or drug resistance. Recently, more and more interests have been paid to develop optimal delivery nanosystems with high efficiency and high biocompability for drug and functional RNA co-delivery to achieve enhanced chemotherapy. In light of the challenges for developing drug and RNA co-delivery system, exosomes have been found to show very attractive prospects. This review aims to explore current technologies and challenges in the use of exosomes as drug and RNA co-delivery system with a focus on the emerging trends and issues associated with their further applications, which may contribute to the accelerated developments of exosome-based theraputics.
    Language English
    Publishing date 2023-09-26
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2719493-0
    ISSN 2296-4185
    ISSN 2296-4185
    DOI 10.3389/fbioe.2023.1254356
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  8. Article ; Online: Zoonotic pathogens identified in rodents and shrews from four provinces, China, 2015-2022.

    Tian, Shen / Jiang, Bao-Gui / Liu, Wan-Shuang / Chen, Hao-Rong / Gao, Zi-Hou / Pu, En-Nian / Li, Yu-Qiong / Chen, Jin-Jin / Fang, Li-Qun / Wang, Guo-Lin / Du, Chun-Hong / Wei, Yue-Hong

    Epidemiology and infection

    2023  Volume 151, Page(s) e174

    Abstract: Rodents and shrews are major reservoirs of various pathogens that are related to zoonotic infectious diseases. The purpose of this study was to investigate co-infections of zoonotic pathogens in rodents and shrews trapped in four provinces of China. We ... ...

    Abstract Rodents and shrews are major reservoirs of various pathogens that are related to zoonotic infectious diseases. The purpose of this study was to investigate co-infections of zoonotic pathogens in rodents and shrews trapped in four provinces of China. We sampled different rodent and shrew communities within and around human settlements in four provinces of China and characterised several important zoonotic viral, bacterial, and parasitic pathogens by PCR methods and phylogenetic analysis. A total of 864 rodents and shrews belonging to 24 and 13 species from
    MeSH term(s) Animals ; Bartonella/genetics ; China/epidemiology ; Coinfection ; Leptospira ; Phylogeny ; Rodentia/microbiology ; Shrews/microbiology
    Language English
    Publishing date 2023-09-07
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 632982-2
    ISSN 1469-4409 ; 0950-2688
    ISSN (online) 1469-4409
    ISSN 0950-2688
    DOI 10.1017/S0950268823001450
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Un I Zs.271: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  9. Article ; Online: Characterizing chemical signaling between engineered "microbial sentinels" in porous microplates.

    Vaiana, Christopher A / Kim, Hyungseok / Cottet, Jonathan / Oai, Keiko / Ge, Zhifei / Conforti, Kameron / King, Andrew M / Meyer, Adam J / Chen, Haorong / Voigt, Christopher A / Buie, Cullen R

    Molecular systems biology

    2022  Volume 18, Issue 3, Page(s) e10785

    Abstract: Living materials combine a material scaffold, that is often porous, with engineered cells that perform sensing, computing, and biosynthetic tasks. Designing such systems is difficult because little is known regarding signaling transport parameters in the ...

    Abstract Living materials combine a material scaffold, that is often porous, with engineered cells that perform sensing, computing, and biosynthetic tasks. Designing such systems is difficult because little is known regarding signaling transport parameters in the material. Here, the development of a porous microplate is presented. Hydrogel barriers between wells have a porosity of 60% and a tortuosity factor of 1.6, allowing molecular diffusion between wells. The permeability of dyes, antibiotics, inducers, and quorum signals between wells were characterized. A "sentinel" strain was constructed by introducing orthogonal sensors into the genome of Escherichia coli MG1655 for IPTG, anhydrotetracycline, L-arabinose, and four quorum signals. The strain's response to inducer diffusion through the wells was quantified up to 14 mm, and quorum and antibacterial signaling were measured over 16 h. Signaling distance is dictated by hydrogel adsorption, quantified using a linear finite element model that yields adsorption coefficients from 0 to 0.1 mol m
    MeSH term(s) Escherichia coli/genetics ; Hydrogels ; Porosity ; Quorum Sensing ; Signal Transduction
    Chemical Substances Hydrogels
    Language English
    Publishing date 2022-03-22
    Publishing country England
    Document type Journal Article ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 2193510-5
    ISSN 1744-4292 ; 1744-4292
    ISSN (online) 1744-4292
    ISSN 1744-4292
    DOI 10.15252/msb.202110785
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Conformational Effects of UV Light on DNA Origami

    Chen, Haorong / Andréasson Joakim / Choi Jong Hyun / Li Ruixin / Li Shiming

    Journal of the American Chemical Society. 2017 Feb. 01, v. 139, no. 4

    2017  

    Abstract: The responses of DNA origami conformation to UV radiation of different wavelengths and doses are investigated. Short- and medium-wavelength UV light can cause photo-lesions in DNA origami. At moderate doses, the lesions do not cause any visible defects ... ...

    Abstract The responses of DNA origami conformation to UV radiation of different wavelengths and doses are investigated. Short- and medium-wavelength UV light can cause photo-lesions in DNA origami. At moderate doses, the lesions do not cause any visible defects in the origami, nor do they significantly affect the hybridization capability. Instead, they help relieve the internal stress in the origami structure and restore it to the designed conformation. At high doses, staple dissociation increases which causes structural disintegration. Long-wavelength UV does not show any effect on origami conformation by itself. We show that this UV range can be used in conjunction with photoactive molecules for photo-reconfiguration, while avoiding any damage to the DNA structures.
    Keywords dissociation ; DNA ; ultraviolet radiation ; wavelengths
    Language English
    Dates of publication 2017-0201
    Size p. 1380-1383.
    Publishing place American Chemical Society
    Document type Article
    ZDB-ID 3155-0
    ISSN 1520-5126 ; 0002-7863
    ISSN (online) 1520-5126
    ISSN 0002-7863
    DOI 10.1021%2Fjacs.6b10821
    Database NAL-Catalogue (AGRICOLA)

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    In stock of ZB MED Bonn / Germany

    Z 4' 55/32: Show issues
    Z 7.3: Show issues

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