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Article ; Online: Animal influenza virus

CHEN Hua-lan

Journal of Integrative Agriculture, Vol 18, Iss 7, Pp 1419-

2019 Volume 1420

Keywords	Agriculture (General) ; S1-972
Language	English
Publishing date	2019-07-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Advances in deciphering the interactions between viral proteins of influenza A virus and host cellular proteins.

Jiang, Li / Chen, Hualan / Li, Chengjun

Cell insight

2023 Volume 2, Issue 2, Page(s) 100079

Abstract: Influenza A virus (IAV) poses a severe threat to the health of animals and humans. The genome of IAV consists of eight single-stranded negative-sense RNA segments, encoding ten essential proteins as well as certain accessory proteins. In the process of ... ...

Abstract	Influenza A virus (IAV) poses a severe threat to the health of animals and humans. The genome of IAV consists of eight single-stranded negative-sense RNA segments, encoding ten essential proteins as well as certain accessory proteins. In the process of virus replication, amino acid substitutions continuously accumulate, and genetic reassortment between virus strains readily occurs. Due to this high genetic variability, new viruses that threaten animal and human health can emerge at any time. Therefore, the study on IAV has always been a focus of veterinary medicine and public health. The replication, pathogenesis, and transmission of IAV involve intricate interplay between the virus and host. On one hand, the entire replication cycle of IAV relies on numerous proviral host proteins that effectively allow the virus to adapt to its host and support its replication. On the other hand, some host proteins play restricting roles at different stages of the viral replication cycle. The mechanisms of interaction between viral proteins and host cellular proteins are currently receiving particular interest in IAV research. In this review, we briefly summarize the current advances in our understanding of the mechanisms by which host proteins affect virus replication, pathogenesis, or transmission by interacting with viral proteins. Such information about the interplay between IAV and host proteins could provide insights into how IAV causes disease and spreads, and might help support the development of antiviral drugs or therapeutic approaches.
Language	English
Publishing date	2023-01-31
Publishing country	Netherlands
Document type	Journal Article ; Review
ISSN	2772-8927
ISSN (online)	2772-8927
DOI	10.1016/j.cellin.2023.100079
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: H7N9 Influenza Virus in China.

Li, Chengjun / Chen, Hualan

Cold Spring Harbor perspectives in medicine

2021 Volume 11, Issue 8

Abstract: In early 2013, human infections caused by a novel H7N9 avian influenza virus (AIV) were first reported in China; these infections caused severe disease and death. The virus was initially low pathogenic to poultry, enabling it to spread widely in ... ...

Abstract	In early 2013, human infections caused by a novel H7N9 avian influenza virus (AIV) were first reported in China; these infections caused severe disease and death. The virus was initially low pathogenic to poultry, enabling it to spread widely in different provinces, especially in live poultry markets. Importantly, the H7N9 low pathogenic AIVs (LPAIVs) evolved into highly pathogenic AIVs (HPAIVs) in the beginning of 2017, causing a greater threat to human health and devastating losses to the poultry industry. Fortunately, nationwide vaccination of chickens with an H5/H7 bivalent inactivated avian influenza vaccine since September 2017 has successfully controlled H7N9 avian influenza infections in poultry and, importantly, has also prevented human infections. In this review, we summarize the biological properties of the H7N9 viruses, specifically their genetic evolution, adaptation, pathogenesis, receptor binding, transmission, drug resistance, and antigenic variation, as well as the prevention and control measures. The information obtained from investigating and managing the H7N9 viruses could improve our ability to understand other novel AIVs and formulate effective measures to control their threat to humans and animals.
MeSH term(s)	China/epidemiology ; Communicable Disease Control ; Drug Resistance ; Humans ; Immunogenicity, Vaccine ; Influenza A Virus, H7N9 Subtype/genetics ; Influenza A Virus, H7N9 Subtype/immunology ; Influenza, Human/epidemiology ; Influenza, Human/prevention & control ; Influenza, Human/transmission
Language	English
Publishing date	2021-08-02
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ISSN	2157-1422
ISSN (online)	2157-1422
DOI	10.1101/cshperspect.a038349
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: G1 Interacts with OsMADS1 to Regulate the Development of the Sterile Lemma in Rice.

Fang, Huimin / Chen, Hualan / Wang, Jianing / Li, Ning / Zhang, Long / Wei, Cunxu

Plants (Basel, Switzerland)

2024 Volume 13, Issue 4

Abstract: Flower development, as the basis for plant seed development, is principally conserved in angiosperms. At present, a number of genes regulating flower organ differentiation have been identified, and an ABCDE model has also been proposed. In contrast, the ... ...

Abstract	Flower development, as the basis for plant seed development, is principally conserved in angiosperms. At present, a number of genes regulating flower organ differentiation have been identified, and an ABCDE model has also been proposed. In contrast, the mechanism that regulates the development of the sterile lemma remains unclear. In this study, we identified and characterized a rice floral organ mutant, M15, in which the sterile lemma transformed into a lemma-like organ. Positional cloning combined with a complementary experiment demonstrated that the mutant phenotype was restored by
Language	English
Publishing date	2024-02-11
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2704341-1
ISSN	2223-7747
ISSN	2223-7747
DOI	10.3390/plants13040505
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Alarming situation of emerging H5 and H7 avian influenza and effective control strategies.

Shi, Jianzhong / Zeng, Xianying / Cui, Pengfei / Yan, Cheng / Chen, Hualan

Emerging microbes & infections

2022 Volume 12, Issue 1, Page(s) 2155072

Abstract: Avian influenza viruses continue to present challenges to animal and human health. Viruses bearing the hemagglutinin (HA) gene of the H5 subtype and H7 subtype have caused 2634 human cases around the world, including more than 1000 deaths. These viruses ... ...

Abstract	Avian influenza viruses continue to present challenges to animal and human health. Viruses bearing the hemagglutinin (HA) gene of the H5 subtype and H7 subtype have caused 2634 human cases around the world, including more than 1000 deaths. These viruses have caused numerous disease outbreaks in wild birds and domestic poultry, and are responsible for the loss of at least 422 million domestic birds since 2005. The H5 influenza viruses are spread by migratory wild birds and have caused three waves of influenza outbreaks across multiple continents, and the third wave that started in 2020 is ongoing. Many countries in Europe and North America control highly pathogenic avian influenza by culling alone, whereas some countries, including China, have adopted a "cull plus vaccination" strategy. As the largest poultry-producing country in the world, China lost relatively few poultry during the three waves of global H5 avian influenza outbreaks, and nearly eliminated the pervasive H7N9 viruses that emerged in 2013. In this review, we briefly summarize the damages the H5 and H7 influenza viruses have caused to the global poultry industry and public health, analyze the origin, evolution, and spread of the H5 viruses that caused the waves, and discuss how and why the vaccination strategy in China has been a success. Given that the H5N1 viruses are widely circulating in wild birds and causing problems in domestic poultry around the world, we recommend that any unnecessary obstacles to vaccination strategies should be removed immediately and forever.
MeSH term(s)	Animals ; Humans ; Influenza in Birds/epidemiology ; Influenza in Birds/prevention & control ; Influenza A Virus, H5N1 Subtype/genetics ; Influenza A Virus, H7N9 Subtype/genetics ; Poultry ; Birds ; Animals, Wild
Language	English
Publishing date	2022-11-15
Publishing country	United States
Document type	Review ; Journal Article
ZDB-ID	2681359-2
ISSN	2222-1751 ; 2222-1751
ISSN (online)	2222-1751
ISSN	2222-1751
DOI	10.1080/22221751.2022.2155072
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Screening and identification of rice non-floury endosperm mutants with different starch components

Zhao, Shengnan / Wang, Hao / Chen, Hualan / Lin, Lingshang / Liu, Qiaoquan / Wei, Cunxu

Journal of cereal science. 2022 Jan., v. 103

2022

Abstract: Starch components determine rice quality and utilization. Rice floury endosperm grains have poor quality. In this study, we screened 27 non-floury endosperm mutants with different starch components from a mutant population derived from japonica rice ... ...

Abstract	Starch components determine rice quality and utilization. Rice floury endosperm grains have poor quality. In this study, we screened 27 non-floury endosperm mutants with different starch components from a mutant population derived from japonica rice variety Nipponbare using urea gelatinizing grain-iodine staining method. Nine mutants of MY03, MY12, MY16, MA06, MA15, MP09, MP20, MP31 and MP40 were chosen for identification of homozygous mutant and analysis of starch components and grain properties. The amylose content in single grain indicated that the screened mutants were homozygous and the stained solution color of gelatinized grain could reflect the starch components of brown rice grain. The MY03, MY12 and MY16 grains had altered amylopectin structures and exhibited high gelatinization temperatures and strong resistances to urea gelatinization. Compared with Nipponbare grains, MA06 and MA15 grains had very high amylose and lipid contents. The MP09, MP20, MP31 and MP40 grains had significantly lower amylose contents than Nipponbare grains. The screened mutants had similar grain transparency to Nipponbare. This study provided a method reference for rapidly screening rice non-floury endosperm mutants from thousands of mutant lines, and the screened mutants were important genetic materials for revealing starch synthesis and regulation and good germplasm resources for rice quality breeding.
Keywords	amylopectin ; amylose ; brown rice ; color ; endosperm ; gelatinization ; germplasm ; homozygosity ; lipids ; mutants ; urea
Language	English
Dates of publication	2022-01
Publishing place	Elsevier Ltd
Document type	Article
ZDB-ID	408468-8
ISSN	0733-5210
ISSN	0733-5210
DOI	10.1016/j.jcs.2021.103397
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: H1N1 Influenza A Virus Protein NS2 Inhibits Innate Immune Response by Targeting IRF7.

Zhang, Bo / Liu, Minxuan / Huang, Jiaxin / Zeng, Qiaoying / Zhu, Qiyun / Xu, Shuai / Chen, Hualan

Viruses

2022 Volume 14, Issue 11

Abstract: Influenza A virus (IAV) is a globally distributed zoonotic pathogen and causes a highly infectious respiratory disease with high morbidity and mortality in humans and animals. IAV has evolved various strategies to counteract the innate immune response, ... ...

Abstract	Influenza A virus (IAV) is a globally distributed zoonotic pathogen and causes a highly infectious respiratory disease with high morbidity and mortality in humans and animals. IAV has evolved various strategies to counteract the innate immune response, using different viral proteins. However, the mechanisms are not fully elucidated. In this study, we demonstrated that the nonstructural protein 2 (NS2) of H1N1 IAV negatively regulate the induction of type-I interferon. Co-immunoprecipitation experiments revealed that NS2 specifically interacts with interferon regulatory factor 7 (IRF7). NS2 blocks the nuclear translocation of IRF7 by inhibiting the formation of IRF7 dimers, thereby prevents the activation of IRF7 and inhibits the production of interferon-beta. Taken together, these findings revealed a novel mechanism by which the NS2 of H1N1 IAV inhibits IRF7-mediated type-I interferon production.
MeSH term(s)	Humans ; Animals ; Influenza A virus/physiology ; Interferon Regulatory Factor-7/genetics ; Interferon Regulatory Factor-7/metabolism ; Influenza A Virus, H1N1 Subtype/metabolism ; Host-Pathogen Interactions ; Immunity, Innate ; Interferon Type I/metabolism ; Viral Nonstructural Proteins/metabolism
Chemical Substances	Interferon Regulatory Factor-7 ; Interferon Type I ; Viral Nonstructural Proteins
Language	English
Publishing date	2022-10-31
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2516098-9
ISSN	1999-4915 ; 1999-4915
ISSN (online)	1999-4915
ISSN	1999-4915
DOI	10.3390/v14112411
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Article ; Online: The SUMO-interacting motif in NS2 promotes adaptation of avian influenza virus to mammals.

Sun, Liuke / Kong, Huihui / Yu, Mengmeng / Zhang, Zhenyu / Zhang, Haili / Na, Lei / Qu, Yuxing / Zhang, Yuan / Chen, Hualan / Wang, Xiaojun

Science advances

2023 Volume 9, Issue 28, Page(s) eadg5175

Abstract: Species differences in the host factor ANP32A/B result in the restriction of avian influenza virus polymerase (vPol) in mammalian cells. Efficient replication of avian influenza viruses in mammalian cells often requires adaptive mutations, such as PB2- ... ...

Abstract	Species differences in the host factor ANP32A/B result in the restriction of avian influenza virus polymerase (vPol) in mammalian cells. Efficient replication of avian influenza viruses in mammalian cells often requires adaptive mutations, such as PB2-E627K, to enable the virus to use mammalian ANP32A/B. However, the molecular basis for the productive replication of avian influenza viruses without prior adaptation in mammals remains poorly understood. We show that avian influenza virus NS2 protein help to overcome mammalian ANP32A/B-mediated restriction to avian vPol activity by promoting avian vRNP assembly and enhancing mammalian ANP32A/B-vRNP interactions. A conserved SUMO-interacting motif (SIM) in NS2 is required for its avian polymerase-enhancing properties. We also demonstrate that disrupting SIM integrity in NS2 impairs avian influenza virus replication and pathogenicity in mammalian hosts, but not in avian hosts. Our results identify NS2 as a cofactor in the adaptation process of avian influenza virus to mammals.
MeSH term(s)	Animals ; Influenza in Birds/genetics ; Acclimatization ; Influenza A virus/genetics ; Mammals ; Mutation ; Nucleotidyltransferases
Chemical Substances	Nucleotidyltransferases (EC 2.7.7.-)
Language	English
Publishing date	2023-07-12
Publishing country	United States
Document type	Journal Article
ZDB-ID	2810933-8
ISSN	2375-2548 ; 2375-2548
ISSN (online)	2375-2548
ISSN	2375-2548
DOI	10.1126/sciadv.adg5175
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Article: Emergence of a novel reassortant H3N6 canine influenza virus.

Meng, Bo / Li, Hailing / Feng, Chong / Guo, Weiwei / Feng, Yali / Zhu, Dawei / Chen, Hualan / Zhang, Ying

Frontiers in microbiology

2023 Volume 14, Page(s) 1186869

Abstract: Although the natural hosts of avian influenza viruses (AIVs) are wild birds, multiple subtypes of AIVs have established epidemics in numerous mammals due to their cross-species spillover. Replication and evolution in intermedia mammalian hosts may ... ...

Abstract	Although the natural hosts of avian influenza viruses (AIVs) are wild birds, multiple subtypes of AIVs have established epidemics in numerous mammals due to their cross-species spillover. Replication and evolution in intermedia mammalian hosts may facilitate AIV adaptation in humans. Because of their large population and intimacy with humans, dogs could act as such an intermedia host. To monitor the epidemiology of canine influenza viruses (CIVs) in Liaoning, China, we performed three surveillances in November 2018, March 2019, and April 2019. Five H3N2 and seven novel H3N6 CIVs had been isolated. Since the N6 neuraminidase (NA) genes were clustered with the H5N6 AIV, there is a high possibility that these H3N6 CIVs were generated from a H3N2 CIVs and H5N6 AIVs reassortment case. In addition, the H3N6 CIV showed increased mammalian adaptation ability compared to all the H3N2 strains in both
Language	English
Publishing date	2023-05-11
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2587354-4
ISSN	1664-302X
ISSN	1664-302X
DOI	10.3389/fmicb.2023.1186869
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Article: A single amino acid at position 158 in haemagglutinin affects the antigenic property of Eurasian avian‐like H1N1 swine influenza viruses

Wang, Zeng / Chen, Yan / Chen, Huayuan / Meng, Fei / Tao, Shiyu / Ma, Shujie / Qiao, Chuanling / Chen, Hualan / Yang, Huanliang

Transboundary and emerging diseases. 2022 July, v. 69, no. 4

2022

Abstract: Influenza viruses have been posing a great threat to public health and animal industry. The developed vaccines have been widely used to reduce the risk of potential pandemic; however, the ongoing antigenic drift makes influenza virus escape from host ... ...

Abstract	Influenza viruses have been posing a great threat to public health and animal industry. The developed vaccines have been widely used to reduce the risk of potential pandemic; however, the ongoing antigenic drift makes influenza virus escape from host immune response and hampers vaccine efficacy. Until now, the genetic basis of antigenic variation remains largely unknown. In this study, we used A/swine/Guangxi/18/2011 (GX/18) and A/swine/Guangdong/104/2013 (GD/104) as models to explore the molecular determinant for antigenic variation of Eurasian avian‐like H1N1 (EA H1N1) swine influenza viruses (SIVs) and found that the GD/104 virus exhibited 32‐ to 64‐fold lower antigenic cross‐reactivity with antibodies against GX/18 virus. Therefore, we generated polyclonal antibodies against GX/18 or GD/104 virus and a monoclonal antibody (mAb), named mAb102‐95, targeted to the haemagglutinin (HA) protein of GX/18 virus and found that a single amino acid substitution at position 158 in HA protein substantially altered the antigenicity of the virus. The reactivity of GX/18 virus containing G158E mutation with the mAb102‐95 decreased eightfold than that of the parental strain. Contrarily, the reactivity of GD/104 virus bearing E158G mutation with the mAb102‐95 increased by 32 times as compared with that of the parental virus. Structural analysis showed that the amino acid mutation from G to E was accompanied with the R group changing from ‐H to ‐(CH₂)₂‐COOH. The induced steric effect and increased hydrophilicity of HA protein surface probably jointly contributed to the antigenic drift of EA H1N1 SIVs. Our study provides experimental evidence that G158E mutation in HA protein affects the antigenic property of EA H1N1 SIVs and widens our horizon on the antigenic drift of influenza virus.
Keywords	Orthomyxoviridae ; amino acid substitution ; amino acids ; antigenic variation ; cross reaction ; hemagglutinins ; hydrophilicity ; livestock and meat industry ; monoclonal antibodies ; pandemic ; public health ; risk reduction ; swine ; swine influenza ; vaccines ; viruses
Language	English
Dates of publication	2022-07
Size	p. e236-e243.
Publishing place	John Wiley & Sons, Ltd
Document type	Article
Note	JOURNAL ARTICLE
ZDB-ID	2414822-2
ISSN	1865-1682 ; 1865-1674
ISSN (online)	1865-1682
ISSN	1865-1674
DOI	10.1111/tbed.14288
Database	NAL-Catalogue (AGRICOLA)

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