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Article: [The intervention of ginkgo biloba extract on monocrotaline-induced right ventricular hypertrophy in rats and its mechanism].

Chen, Hui Qin / Cai, Ke Feng

Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology

2019 Volume 35, Issue 2, Page(s) 169–172

Abstract: Objective: To study the protective effects of ginkgo biloba extract on the right ventricular hypertrophy.: Methods: Seventy-two SD male rats were randomly divided into 3 groups: control group(CON), monocrotaline-induced right ventricular hypertrophy ... ...

Abstract	Objective: To study the protective effects of ginkgo biloba extract on the right ventricular hypertrophy. Methods: Seventy-two SD male rats were randomly divided into 3 groups: control group(CON), monocrotaline-induced right ventricular hypertrophy group (MCT) and ginkgo biloba extract treated group (EGB) (n=24 in each group). Group MCT and group EGB were intraperitoneally injected with 2%MCT at the dose of 60 mg /kg on the first day. From the second day, group MCT was injected with 2 ml 0.9% sodium chloride, and 60 mg/kg ginkgo leaf extract was administered to the stomach in group EGB. The control group was injected with 2 ml 0.9% sodium chloride on the first day. After 3 weeks, in each group,cardiac hemodynamic changes were measured, heart weight index was calculated, and myocardial pathological changes were observed by HE staining. The expression of TRPC6 was detected by real-time polymerase chain reaction (real-time -PCR) and Western blot. Results: Compared with the control group, the right ventricular systolic pressure (RVSP) was increased significantly in the MCT group(P＜0.01), the maximum or decline rate of descent (RV ±dp/dt Conclusion: Ginkgo biloba extract may inhibit the signal pathway of CaN / NFAT in cardiac myocytes by reducing the expression of TRPC6 protein, and then play an early protective effect on myocardial hypertrophy.
MeSH term(s)	Animals ; Hypertrophy, Right Ventricular/chemically induced ; Hypertrophy, Right Ventricular/drug therapy ; Male ; Monocrotaline ; Plant Extracts/pharmacology ; Random Allocation ; Rats ; Rats, Sprague-Dawley
Chemical Substances	Plant Extracts ; Ginkgo biloba extract (19FUJ2C58T) ; Monocrotaline (73077K8HYV)
Language	Chinese
Publishing date	2019-06-27
Publishing country	China
Document type	Journal Article
ISSN	1000-6834
ISSN	1000-6834
DOI	10.12047/j.cjap.5759.2019.037
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Article ; Online: Sesquiterpenoids and bibenzyl derivative from Dendrobium hercoglossum.

Chen, Hui-Qin / Guo, Dong-Sheng / Wang, Hao / Cai, Cai-Hong / Yuan, Jing-Zhe / Dai, Hao-Fu / Yang, Li / Mei, Wen-Li

Fitoterapia

2023 Volume 172, Page(s) 105748

Abstract: Three new sesquiterpenoids, dendrohercoglin A - C (1-3), and one new bibenzyl derivative, dendronbiline D (4), together with nine known sesquiterpenoids (5-13) were isolated from Dendrobium hercoglossum. The structures of the new compounds were ... ...

Abstract	Three new sesquiterpenoids, dendrohercoglin A - C (1-3), and one new bibenzyl derivative, dendronbiline D (4), together with nine known sesquiterpenoids (5-13) were isolated from Dendrobium hercoglossum. The structures of the new compounds were elucidated by extensive spectroscopic analysis as well as NMR and ECD calculations. All the compounds were evaluated for their neuroprotective and anti-inflammatory activities. Compounds 2 and 3 increased the H
MeSH term(s)	Humans ; Dendrobium/chemistry ; Molecular Structure ; Hydrogen Peroxide ; Neuroblastoma ; Magnetic Resonance Spectroscopy ; Sesquiterpenes/pharmacology ; Bibenzyls/pharmacology ; Bibenzyls/chemistry ; Anti-Inflammatory Agents/pharmacology
Chemical Substances	Hydrogen Peroxide (BBX060AN9V) ; Sesquiterpenes ; Bibenzyls ; Anti-Inflammatory Agents
Language	English
Publishing date	2023-11-13
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	412385-2
ISSN	1873-6971 ; 0367-326X
ISSN (online)	1873-6971
ISSN	0367-326X
DOI	10.1016/j.fitote.2023.105748
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Article ; Online: Six unprecedented 2-(2-phenethyl)chromone dimers from agarwood of Aquilaria filaria.

Wei, Yuan / Dong, Wen-Hua / Li, Wei / Zeng, Jun / Chen, Hui-Qin / Huang, Sheng-Zhuo / Yang, Li / Mei, Wen-Li / Wang, Ya-Li / Guo, Zhi-Yong / Dai, Hao-Fu / Wang, Hao

Fitoterapia

2024 Volume 175, Page(s) 105905

Abstract: Six new dimeric 2-(2-phenylethyl)chromones (1-6) were successfully isolated from the ethanol extract of agarwood of Aquilaria filaria from Philippines under HPLC-MS guidance. Compounds 1-6 are all dimers formed by linking 5,6,7,8-tetrahydro-2-(2- ... ...

Abstract	Six new dimeric 2-(2-phenylethyl)chromones (1-6) were successfully isolated from the ethanol extract of agarwood of Aquilaria filaria from Philippines under HPLC-MS guidance. Compounds 1-6 are all dimers formed by linking 5,6,7,8-tetrahydro-2-(2-phenylethyl)chromone and flindersia 2-(2-phenylethyl)chromone via a single ether bond, and the linkage site (C5-O-C8'') of compound 2 is extremely rare. A variety of spectroscopic methods were used to ascertain their structures, including extensive 1D and 2D NMR spectroscopic analysis, HRESIMS, and comparison with literature. The in vitro tyrosinase inhibitory and anti-inflammatory activities of each isolate were assessed. Among these compounds, compound 2 had a tyrosinase inhibition effect with an IC
Language	English
Publishing date	2024-03-11
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	412385-2
ISSN	1873-6971 ; 0367-326X
ISSN (online)	1873-6971
ISSN	0367-326X
DOI	10.1016/j.fitote.2024.105905
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Article: Natural products in agarwood and Aquilaria plants: chemistry, biological activities and biosynthesis

Li, Wei / Chen, Hui-Qin / Wang, Hao / Mei, Wen-Li / Dai, Hao-Fu

Natural product reports. 2021 Apr. 1, v. 38, no. 3

2021

Abstract: Agarwood is a resinous portion of Aquilaria trees, which is formed in response to environmental stress factors such as physical injury or microbial attack. It is very sought-after among the natural incenses, as well as for its medicinal properties in ... ...

Abstract	Agarwood is a resinous portion of Aquilaria trees, which is formed in response to environmental stress factors such as physical injury or microbial attack. It is very sought-after among the natural incenses, as well as for its medicinal properties in traditional Chinese and Ayurvedic medicine. Interestingly, the chemical constituents of agarwood and healthy Aquilaria trees are quite different. Sesquiterpenes and 2-(2-phenethyl)chromones with diverse scaffolds commonly accumulate in agarwood. Similar structures have rarely been reported from the original trees that mainly contain flavonoids, benzophenones, xanthones, lignans, simple phenolic compounds, megastigmanes, diterpenoids, triterpenoids, steroids, alkaloids, etc. This review summarizes the chemical constituents and biological activities both in agarwood and Aquilaria trees, and their biosynthesis is discussed in order to give a comprehensive overview of the research progress on agarwood.
Keywords	Aquilaria ; Ayurvedic medicine ; benzophenones ; biosynthesis ; diterpenoids ; flavonoids ; lignans ; norisoprenoids ; sesquiterpenoids ; triterpenoids ; xanthones
Language	English
Dates of publication	2021-0401
Size	p. 528-565.
Publishing place	The Royal Society of Chemistry
Document type	Article
ZDB-ID	2002546-4
ISSN	1460-4752 ; 0265-0568
ISSN (online)	1460-4752
ISSN	0265-0568
DOI	10.1039/d0np00042f
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Article ; Online: Triterpenoids as bivalent and dual inhibitors of acetylcholinesterase/butyrylcholinesterase from the fruiting bodies of Inonotus obliquus.

Wei, Yan-Mei / Yang, Li / Wang, Hao / Cai, Cai-Hong / Chen, Zhi-Bao / Chen, Hui-Qin / Mei, Wen-Li / Dai, Hao-Fu

Phytochemistry

2022 Volume 200, Page(s) 113182

Abstract: Inonotus obliquus, an edible and medicinal mushroom parasitic on birches, has been used in human diet and for traditional therapies in the high latitude regions of Europe and Asia for a long time. Our phytochemical study of this fungus led to the ... ...

Abstract	Inonotus obliquus, an edible and medicinal mushroom parasitic on birches, has been used in human diet and for traditional therapies in the high latitude regions of Europe and Asia for a long time. Our phytochemical study of this fungus led to the identification of fourteen triterpenoids including four undescribed ones, and two pairs of undescribed phenolic enantiomers. The undescribed compounds were elucidated by extensive spectroscopic analysis including 1D and 2D NMR and HRESIMS, quantum chemical NMR and ECD calculations, as well as single-crystal X-ray diffraction analysis. Bioassays revealed that eight compounds showed dual inhibition against acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) with IC
MeSH term(s)	Acetylcholinesterase/metabolism ; Butyrylcholinesterase/metabolism ; Cholinesterase Inhibitors/chemistry ; Cholinesterase Inhibitors/pharmacology ; Fruiting Bodies, Fungal/metabolism ; Inonotus ; Kinetics ; Molecular Docking Simulation ; Structure-Activity Relationship ; Triterpenes/chemistry ; Triterpenes/pharmacology
Chemical Substances	Cholinesterase Inhibitors ; Triterpenes ; Acetylcholinesterase (EC 3.1.1.7) ; Butyrylcholinesterase (EC 3.1.1.8)
Language	English
Publishing date	2022-04-12
Publishing country	England
Document type	Journal Article
ZDB-ID	208884-8
ISSN	1873-3700 ; 0031-9422
ISSN (online)	1873-3700
ISSN	0031-9422
DOI	10.1016/j.phytochem.2022.113182
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Article: Three new 2-(2-phenylethyl)chromones from ‘Chong-lou’ agarwood of Aquilaria sinensis

Su, Xin / Cai, Cai-Hong / Dong, Wen-Hua / Gai, Cui-Juan / Wang, Ya-Li / Mei, Wen-Li / Xu, Xing-Lian / Dai, Hao-Fu / Chen, Hui-Qin

Phytochemical Society of Europe Phytochemistry letters. 2022 Oct., v. 51

2022

Abstract: Three new 2-(2-phenylethyl)chromones (1, 2 and 3), together with four known analogues 4~7 were isolated from ‘Chong-lou’ agarwood originating from Aquilaria sinensis for the first time. Their new structures were elucidated on the basis of spectroscopic ... ...

Abstract	Three new 2-(2-phenylethyl)chromones (1, 2 and 3), together with four known analogues 4~7 were isolated from ‘Chong-lou’ agarwood originating from Aquilaria sinensis for the first time. Their new structures were elucidated on the basis of spectroscopic techniques (UV, IR, MS, 1D and 2D NMR), as well as by comparison with the literature data. Compounds 6 and 7 exhibited significant cytotoxicity against human cancer cell line K562 with IC₅₀ values of 19.79 ± 0.03 and 21.39 ± 0.05 μM, respectively.
Keywords	Aquilaria sinensis ; cytotoxicity ; humans ; neoplasm cells ; plant biochemistry
Language	English
Dates of publication	2022-10
Size	p. 86-90.
Publishing place	Elsevier Ltd
Document type	Article
ISSN	1874-3900
DOI	10.1016/j.phytol.2022.07.009
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Article: Triterpenoids as bivalent and dual inhibitors of acetylcholinesterase/butyrylcholinesterase from the fruiting bodies of Inonotus obliquus

Wei, Yan-Mei / Yang, Li / Wang, Hao / Cai, Cai-Hong / Chen, Zhi-Bao / Chen, Hui-Qin / Mei, Wen-Li / Dai, Hao-Fu

Phytochemistry. 2022 Aug., v. 200

2022

Abstract	Inonotus obliquus, an edible and medicinal mushroom parasitic on birches, has been used in human diet and for traditional therapies in the high latitude regions of Europe and Asia for a long time. Our phytochemical study of this fungus led to the identification of fourteen triterpenoids including four undescribed ones, and two pairs of undescribed phenolic enantiomers. The undescribed compounds were elucidated by extensive spectroscopic analysis including 1D and 2D NMR and HRESIMS, quantum chemical NMR and ECD calculations, as well as single-crystal X-ray diffraction analysis. Bioassays revealed that eight compounds showed dual inhibition against acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) with IC₅₀ values ranging from 2.40 ± 0.05 to 28.72 ± 0.46 μM, while 3β-hydroxy-lanosra-8,24-dien-21-al and trametenolic acid only presented BuChE inhibitory activities with IC₅₀ values of 22.21 ± 1.01 and 7.68 ± 0.13 μM, respectively. In the kinetic studies, the most active three compounds acted as non-competitive inhibitors for both cholinesterases. Furthermore, molecular docking simulations revealed that three compounds demonstrated dual-sites bounding to AChE/BuChE. These triterpenoids emerged as bivalent and dual inhibitors of AChE/BuChE and could be effective drug candidates to prevent and treat Alzheimer's disease in the future.
Keywords	Alzheimer disease ; Inonotus obliquus ; X-ray diffraction ; acetylcholinesterase ; cholinesterase ; drugs ; enantiomers ; human nutrition ; latitude ; medicinal fungi ; phytochemicals ; quantum mechanics ; spectral analysis ; triterpenoids ; Asia ; Europe
Language	English
Dates of publication	2022-08
Publishing place	Elsevier Ltd
Document type	Article
ZDB-ID	208884-8
ISSN	1873-3700 ; 0031-9422
ISSN (online)	1873-3700
ISSN	0031-9422
DOI	10.1016/j.phytochem.2022.113182
Database	NAL-Catalogue (AGRICOLA)

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Article: Phenolic compounds from the sclerotia of Inonotus obliquus

Wei, Yan-Mei / Yang, Li / Mei, Wen-Li / Chen, Hui-Qin / Cai, Cai-Hong / Li, Wei / Dong, Wen-Hua / Chen, Zhi-Bao / Dai, Hao-Fu

Natural product research. 2022 May 3, v. 36, no. 9

2022

Abstract: Three phenolic compounds (±1 and 2) including a pair of new enantiomers were isolated from the sclerotia of Inonotus obliquus. Their structures were assigned by extensive spectroscopic analyses. All the compounds were evaluated for the neuroprotective ... ...

Abstract	Three phenolic compounds (±1 and 2) including a pair of new enantiomers were isolated from the sclerotia of Inonotus obliquus. Their structures were assigned by extensive spectroscopic analyses. All the compounds were evaluated for the neuroprotective activity against oxidative damage on human neuroblastoma SH-SY5Y cells induced by H₂O₂. Compound 2 showed remarkable neuroprotective effect and significantly improved the cell viability of SH-SY5Y cells treated by H₂O₂.
Keywords	Inonotus obliquus ; cell viability ; enantiomers ; humans ; neuroprotective effect ; research ; sclerotia ; spectroscopy
Language	English
Dates of publication	2022-0503
Size	p. 2413-2417.
Publishing place	Taylor & Francis
Document type	Article
ZDB-ID	2185747-7
ISSN	1478-6427 ; 1478-6419
ISSN (online)	1478-6427
ISSN	1478-6419
DOI	10.1080/14786419.2020.1833202
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Article ; Online: New 2-(2-Phenylethyl)chromone derivatives from agarwood originating from Aquilaria sinensis

Li, Jun-Tao / Kuang, Tong-Dong / Chen, Hui-Qin / Yang, Li / Wang, Hao / Cai, Cai-Hong / Liu, Shou-Bai / Mei, Wen-Li / Dai, Hao-Fu

Journal of Asian Natural Products Research. 2022 Nov. 2, v. 24, no. 11 p.1033-1040

2022

Abstract: Two new dimeric 2-(2-phenylethyl)chromones, aquilasinenones L and M (1 and 2), and one new monomer analogue, 5S, 6 R, 7S, 8 R-tetrahydroxy-[2-(3-methoxy-4-hydroxyphenyl)ethyl]- 5,6,7,8-tetrahydrochromone (3), together with two known compounds, were ... ...

Abstract	Two new dimeric 2-(2-phenylethyl)chromones, aquilasinenones L and M (1 and 2), and one new monomer analogue, 5S, 6 R, 7S, 8 R-tetrahydroxy-[2-(3-methoxy-4-hydroxyphenyl)ethyl]- 5,6,7,8-tetrahydrochromone (3), together with two known compounds, were isolated from the artificial agarwood originating from Aquilaria sinensis. Compound 1 was the first structure found with C8-O-C4"' linkage among 2-(2-phenylethyl)chromone dimers. Their structures were unambiguously elucidated based on 1 D and 2 D NMR spectroscopy, as well as by comparison with the literature. The absolute configuration was determined by ECD calculation. None of the compounds exhibited acetylcholinesterase inhibitory activity.
Keywords	Aquilaria sinensis ; acetylcholinesterase ; nuclear magnetic resonance spectroscopy ; research ; Agarwood ; 2-(2-phenylethyl)chromone ; ECD calculation
Language	English
Dates of publication	2022-1102
Size	p. 1033-1040.
Publishing place	Taylor & Francis
Document type	Article ; Online
ZDB-ID	2077926-4
ISSN	1477-2213 ; 1028-6020
ISSN (online)	1477-2213
ISSN	1028-6020
DOI	10.1080/10286020.2021.2019222
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Article ; Online: Natural products in agarwood and Aquilaria plants: chemistry, biological activities and biosynthesis.

Li, Wei / Chen, Hui-Qin / Wang, Hao / Mei, Wen-Li / Dai, Hao-Fu

Natural product reports

2020 Volume 38, Issue 3, Page(s) 528–565

Abstract: Covering: Up to the end of 2019.Agarwood is a resinous portion of Aquilaria trees, which is formed in response to environmental stress factors such as physical injury or microbial attack. It is very sought-after among the natural incenses, as well as for ...

Abstract	Covering: Up to the end of 2019.Agarwood is a resinous portion of Aquilaria trees, which is formed in response to environmental stress factors such as physical injury or microbial attack. It is very sought-after among the natural incenses, as well as for its medicinal properties in traditional Chinese and Ayurvedic medicine. Interestingly, the chemical constituents of agarwood and healthy Aquilaria trees are quite different. Sesquiterpenes and 2-(2-phenethyl)chromones with diverse scaffolds commonly accumulate in agarwood. Similar structures have rarely been reported from the original trees that mainly contain flavonoids, benzophenones, xanthones, lignans, simple phenolic compounds, megastigmanes, diterpenoids, triterpenoids, steroids, alkaloids, etc. This review summarizes the chemical constituents and biological activities both in agarwood and Aquilaria trees, and their biosynthesis is discussed in order to give a comprehensive overview of the research progress on agarwood.
MeSH term(s)	Alkaloids/chemistry ; Alkaloids/pharmacology ; Animals ; Anti-Bacterial Agents/chemistry ; Anti-Bacterial Agents/pharmacology ; Anti-Inflammatory Agents, Non-Steroidal/chemistry ; Anti-Inflammatory Agents, Non-Steroidal/pharmacology ; Biological Products/chemistry ; Biological Products/metabolism ; Biological Products/pharmacology ; Flavonoids/chemistry ; Flavonoids/pharmacology ; Humans ; Hypoglycemic Agents/chemistry ; Hypoglycemic Agents/pharmacology ; Phenols/chemistry ; Phenols/pharmacology ; Sesquiterpenes/chemistry ; Sesquiterpenes/pharmacology ; Thymelaeaceae/chemistry ; Thymelaeaceae/metabolism ; Wood/chemistry ; Wood/metabolism
Chemical Substances	Alkaloids ; Anti-Bacterial Agents ; Anti-Inflammatory Agents, Non-Steroidal ; Biological Products ; Flavonoids ; Hypoglycemic Agents ; Phenols ; Sesquiterpenes
Language	English
Publishing date	2020-09-29
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	2002546-4
ISSN	1460-4752 ; 0265-0568
ISSN (online)	1460-4752
ISSN	0265-0568
DOI	10.1039/d0np00042f
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