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  1. Article: Chemical Constituents of

    Hung, Hsin-Yi / Cheng, Kun-Ching / Kuo, Ping-Chung / Chen, I-Tsen / Li, Yue-Chiun / Hwang, Tsong-Long / Lam, Sio-Hong / Wu, Tian-Shung

    Antioxidants (Basel, Switzerland)

    2022  Volume 11, Issue 2

    Abstract: Seven new anthraquinones with rare 2-isopropyldihydrofuran ( ...

    Abstract Seven new anthraquinones with rare 2-isopropyldihydrofuran (
    Language English
    Publishing date 2022-02-09
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2704216-9
    ISSN 2076-3921
    ISSN 2076-3921
    DOI 10.3390/antiox11020335
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Chemical Constituents of Hedyotis diffusa and Their Anti-Inflammatory Bioactivities

    Hung, Hsin-Yi / Cheng, Kun-Ching / Kuo, Ping-Chung / Chen, I-Tsen / Li, Yue-Chiun / Hwang, Tsong-Long / Lam, Sio-Hong / Wu, Tian-Shung

    Antioxidants. 2022 Feb. 09, v. 11, no. 2

    2022  

    Abstract: Seven new anthraquinones with rare 2-isopropyldihydrofuran (1–3) and 2,2-dimethylpyrano (4–7) moieties together with thirty-four known compounds were isolated from the extracts of whole Hedyotis diffusa plants. Their structures were elucidated and ... ...

    Abstract Seven new anthraquinones with rare 2-isopropyldihydrofuran (1–3) and 2,2-dimethylpyrano (4–7) moieties together with thirty-four known compounds were isolated from the extracts of whole Hedyotis diffusa plants. Their structures were elucidated and established by various spectroscopic and spectrometric analytical methods. Among these isolates, selected compounds were examined for their anti-inflammatory activity. The results showed that rare substituted anthraquinones displayed potent inhibitory activity with IC₅₀ values ranging from 0.15 ± 0.01 to 5.52 ± 1.59 µM on the N-formyl-methionyl-leucyl-phenylalanine/cytochalasin B (fMLP/CB)-induced superoxide anion generation and elastase release cellular models. Meanwhile, the proposed drug target of the active anthraquinone was studied by computer modeling. The binding affinity between the anti-inflammatory anthraquinone and elastase was evaluated by molecular docking. These results provided the scientific insight into the medicinal values of Hedyotis diffusa and vision of development as lead compounds.
    Keywords Oldenlandia diffusa ; anthraquinones ; anti-inflammatory activity ; computers ; drugs ; elastase ; spectroscopy ; superoxide anion ; vision
    Language English
    Dates of publication 2022-0209
    Publishing place Multidisciplinary Digital Publishing Institute
    Document type Article
    ZDB-ID 2704216-9
    ISSN 2076-3921
    ISSN 2076-3921
    DOI 10.3390/antiox11020335
    Database NAL-Catalogue (AGRICOLA)

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    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

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