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  1. Article: Prevalence and Prognostic Significance of Malnutrition in Hypertensive Patients in a Community Setting.

    Yang, Zhi-Wen / Wei, Xue-Biao / Fu, Bing-Qi / Chen, Ji-Yan / Yu, Dan-Qing

    Frontiers in nutrition

    2022  Volume 9, Page(s) 822376

    Abstract: Background: Malnutrition is a significantly poor prognostic factor for a variety of cardiovascular diseases. However, its prevalence and prognostic value in hypertensive patients is still unclear. The present study sought to determine the prevalence and ...

    Abstract Background: Malnutrition is a significantly poor prognostic factor for a variety of cardiovascular diseases. However, its prevalence and prognostic value in hypertensive patients is still unclear. The present study sought to determine the prevalence and prognostic value of malnutrition in hypertensive patients in a community setting.
    Methods: We included 9,949 hypertensive patients from the National Health and Nutrition Examination Survey (NHANES) (2005-2014). The Controlling Nutritional Status (CONUT) score, the Nutritional Risk Index (NRI), and the Naples Prognostic Score (NPS) were applied to assess the nutritional status of participants. A Cox regression model was established to examine the association between malnutrition and cardiovascular and all-cause mortality.
    Results: In all, 19.9, 3.9, and 82.9% hypertensive patients were considered to have malnutrition as evaluated by the CONUT, NRI, and NPS, respectively. Malnutrition assessed by CONUT and NRI was independently associated with cardiovascular mortality (HR [95% CI]) for mild and moderate-to-severe degree of malnutrition, respectively: 1.41 (1.04-1.91) and 5.79 (2.34-14.29) for CONUT; 2.60 (1.34-5.07) and 3.30 (1.66-6.56) for NRI (all
    Conclusions: Malnutrition was common among hypertensive patients and was closely associated with both long-term cardiovascular and all-cause mortality.
    Language English
    Publishing date 2022-02-23
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2776676-7
    ISSN 2296-861X
    ISSN 2296-861X
    DOI 10.3389/fnut.2022.822376
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Corrigendum: Prevalence and Prognostic Significance of Malnutrition in Hypertensive Patients in a Community Setting.

    Yang, Zhi-Wen / Wei, Xue-Biao / Fu, Bing-Qi / Chen, Ji-Yan / Yu, Dan-Qing

    Frontiers in nutrition

    2022  Volume 9, Page(s) 903202

    Abstract: This corrects the article DOI: 10.3389/fnut.2022.822376.]. ...

    Abstract [This corrects the article DOI: 10.3389/fnut.2022.822376.].
    Language English
    Publishing date 2022-04-21
    Publishing country Switzerland
    Document type Published Erratum
    ZDB-ID 2776676-7
    ISSN 2296-861X
    ISSN 2296-861X
    DOI 10.3389/fnut.2022.903202
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  3. Article ; Online: Association of serum uric acid levels with cardiovascular and all-cause mortality in hypertensive patients in China: a cohort study.

    Zhang, Shu-Xian / Yu, Yu-Ling / Tang, Song-Tao / Lo, Kenneth / Feng, Ying-Qing / Chen, Ji-Yan

    Postgraduate medical journal

    2023  Volume 99, Issue 1173, Page(s) 708–714

    Abstract: Purpose: The present study aimed to assess the association of elevated serum uric acid (SUA) and hypouricemia with all-cause mortality and cardiovascular mortality in Chinese hypertensive patients.: Methods: In the present prospective cohort, 9325 ... ...

    Abstract Purpose: The present study aimed to assess the association of elevated serum uric acid (SUA) and hypouricemia with all-cause mortality and cardiovascular mortality in Chinese hypertensive patients.
    Methods: In the present prospective cohort, 9325 hypertensive patients from Dongguan, China were enrolled from 2014 to 2018 for analysis. Participants were categorised by quintiles of SUA. The HRs and 95% CIs for the association between SUA, all-cause and cardiovascular mortality were evaluated using the multivariate Cox regression model. After adjusting for multiple confounders, restricted cubic spline analysis was conducted to demonstrate the shape of relationship.
    Results: After a median follow-up of 4.18 years for 9325 participants, there were 409 (4.4%) and 151 (1.6%) reported cases of all-cause and cardiovascular mortality, respectively. By using the third quintile of SUA (6.68 mg/dL to <7.55 mg/dL for men, 5.63 mg/dL to <6.42 mg/dL for women) as reference, the highest quintiles of SUA were associated with an elevated risk of all cause (HR: 1.34, 95% CI 1.00 to 1.80) in the crude model, but the association was not significant after adjusting for multiple comparisons. The association between low SUA and mortality and the dose-response analysis on the non-linearity of SUA-mortality relationship were not statistically significant.
    Conclusions: Although the association between SUA levels, all-cause and cardiovascular disease mortality did not appear to be significant among Chinese hypertensive patients, the findings might be confounded by their medical conditions. Further studies are needed to verify the optimal SUA levels for hypertensive patients.
    MeSH term(s) Male ; Humans ; Female ; Cohort Studies ; Uric Acid ; Prospective Studies ; Risk Factors ; Hypertension/epidemiology ; Cardiovascular Diseases ; China/epidemiology
    Chemical Substances Uric Acid (268B43MJ25)
    Language English
    Publishing date 2023-04-28
    Publishing country England
    Document type Journal Article
    ZDB-ID 80325-x
    ISSN 1469-0756 ; 0032-5473
    ISSN (online) 1469-0756
    ISSN 0032-5473
    DOI 10.1136/pmj-2021-141313
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  4. Article ; Online: Contrast-Induced Nephropathy: Further Investigations About Risk Factors Are Required.

    Sun, Guoli / Chen, Ji-Yan / Liu, Yong

    Angiology

    2019  Volume 70, Issue 8, Page(s) 784–785

    MeSH term(s) Humans ; Kidney Diseases ; Myocardial Infarction ; Percutaneous Coronary Intervention ; Risk Factors
    Language English
    Publishing date 2019-06-25
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 80040-5
    ISSN 1940-1574 ; 0003-3197
    ISSN (online) 1940-1574
    ISSN 0003-3197
    DOI 10.1177/0003319719857376
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  5. Article ; Online: Response to Commentary on "Predictors of Mortality After Percutaneous Coronary Intervention in Patients With Acute Myocardial Infarction".

    Sun, Guoli / Chen, Ji-Yan / Liu, Yong

    Angiology

    2019  Volume 70, Issue 7, Page(s) 673

    MeSH term(s) Humans ; Myocardial Infarction ; Percutaneous Coronary Intervention
    Language English
    Publishing date 2019-02-11
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 80040-5
    ISSN 1940-1574 ; 0003-3197
    ISSN (online) 1940-1574
    ISSN 0003-3197
    DOI 10.1177/0003319719827185
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  6. Article: Quotient of Waist Circumference and Body Mass Index: A Valuable Indicator for the High-Risk Phenotype of Obesity.

    Liu, Xiao-Cong / Huang, Yu / Lo, Kenneth / Huang, Yu-Qing / Chen, Ji-Yan / Feng, Ying-Qing

    Frontiers in endocrinology

    2021  Volume 12, Page(s) 697437

    Abstract: Objective: Measuring the body mass index (BMI) or waist circumference (WC) alone is insufficient for assessing possible health risks due to obesity. This study aimed to investigate whether the quotient of WC and BMI can be used as a proxy of the high- ... ...

    Abstract Objective: Measuring the body mass index (BMI) or waist circumference (WC) alone is insufficient for assessing possible health risks due to obesity. This study aimed to investigate whether the quotient of WC and BMI can be used as a proxy of the high-risk phenotype of obesity.
    Methods: Data for analysis were derived from the National Health and Nutrition Examination Survey (NHANES 1999-2014). The Waist-BMI Ratio was defined as WC divided by BMI. The associations between Waist-BMI Ratio and mortality were estimated using Cox regression models. Restricted cubic spline and two-piecewise linear regression models were used to identify non-linear relationships. The discriminative abilities of different anthropometric measures were compared using receiver operating characteristic curves (ROC).
    Results: This study is based on data from 35557 adults (51.1% female, mean age 44.9 years). During an average follow-up of 101.8 months, 3680 participants died, including 807 of cardiovascular causes. In fully adjusted models, Waist-BMI Ratio was independently associated with overall (hazard ratio [HR], 1.78; 95% confidence interval [CI], 1.48-2.13) and cardiovascular (HR, 1.77; 95% CI, 1.25-2.52) mortality. Spline analyses revealed that dose-response relationships existed between Waist-BMI Ratio and death. The mortality risk rises dramatically above the cut-off point of the Waist-BMI Ratio (HR, 3.22; 95% CI, 2.43-4.26 for overall mortality and HR, 3.07; 95% CI, 1.71-5.52 for cardiovascular mortality). ROC curve analysis suggested that Waist-BMI Ratio was a better discriminator of mortality (AUC 0.637 for overall and 0.639 for cardiovascular mortality) than BMI, WC, and waist-to-height ratio (Delong's test all P <0.001).
    Conclusions: Waist-BMI Ratio was independently associated with overall and cardiovascular mortality in a J-shaped pattern, offering an immense potential risk marker for obesity in the clinical setting.
    Language English
    Publishing date 2021-05-31
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2592084-4
    ISSN 1664-2392
    ISSN 1664-2392
    DOI 10.3389/fendo.2021.697437
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  7. Article ; Online: Protocol for the PORT study: short-term perioperative rehabilitation to improve outcomes in cardiac valvular surgery - a randomised control trial.

    Zhou, Haofeng / Liu, Fengyao / Liu, Yuanhui / He, Xuyu / Ma, Huan / Xu, Mingyu / Wang, Haochen / Zhang, Guolin / Cai, Xiangyu / Chen, Ji-Yan / Guo, Lan / Chen, Jimei

    BMJ open

    2023  Volume 13, Issue 12, Page(s) e074837

    Abstract: Introduction: Perioperative rehabilitation (PORT) has shown a positive effect on patients undergoing cardiac surgery. However, there are minimal data on the impact of short-term PORT in cardiac surgery, which is associated with higher postoperative ... ...

    Abstract Introduction: Perioperative rehabilitation (PORT) has shown a positive effect on patients undergoing cardiac surgery. However, there are minimal data on the impact of short-term PORT in cardiac surgery, which is associated with higher postoperative morbidity and mortality. The trial will assess the efficacy of short-term PORT in reducing in-hospital mortality, postoperative pulmonary complications and length of stay, compared with the usual care in cardiac surgical patients.
    Methods and analysis: This is a single-centre prospective, randomised, open, controlled trial with a 1:1 ratio. Consecutive 800 adult patients undergoing elective valve surgery will be randomised to either usual care or in-hospital short-term PORT that consists of education, inspiratory muscle training, active cycle of breathing techniques and early mobilisation. The primary outcome of this study will be a composite of in-hospital all-cause mortality, incidence of postoperative pulmonary complications and the ratio of postoperative hospitalisation >7 days.
    Ethics and dissemination: The PORT study was granted by the Medical Research Ethics Committee of Guangdong Provincial People's Hospital in August 2018. Findings will be disseminated to patients, clinicians and commissioning groups through peer-reviewed publication.
    Trial registration number: NCT03709511.
    MeSH term(s) Adult ; Humans ; Prospective Studies ; Postoperative Complications/etiology ; Cardiac Surgical Procedures/adverse effects ; Heart ; Elective Surgical Procedures ; Randomized Controlled Trials as Topic
    Language English
    Publishing date 2023-12-21
    Publishing country England
    Document type Clinical Trial Protocol ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2599832-8
    ISSN 2044-6055 ; 2044-6055
    ISSN (online) 2044-6055
    ISSN 2044-6055
    DOI 10.1136/bmjopen-2023-074837
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  8. Article: The U-Shaped Association of Non-High-Density Lipoprotein Cholesterol Levels With All-Cause and Cardiovascular Mortality Among Patients With Hypertension.

    Cheng, Qi / Liu, Xiao-Cong / Chen, Chao-Lei / Huang, Yu-Qing / Feng, Ying-Qing / Chen, Ji-Yan

    Frontiers in cardiovascular medicine

    2021  Volume 8, Page(s) 707701

    Abstract: Background: ...

    Abstract Background:
    Language English
    Publishing date 2021-07-14
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2781496-8
    ISSN 2297-055X
    ISSN 2297-055X
    DOI 10.3389/fcvm.2021.707701
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  9. Article ; Online: Prognostic value of D-dimer for adverse outcomes in patients with infective endocarditis: an observational study.

    Lin, Ying-Wen / Jiang, Mei / Wei, Xue-Biao / Huang, Jie-Leng / Su, Zedazhong / Wang, Yu / Chen, Ji-Yan / Yu, Dan-Qing

    BMC cardiovascular disorders

    2021  Volume 21, Issue 1, Page(s) 279

    Abstract: Background: Increased D-dimer levels have been shown to correlate with adverse outcomes in various clinical conditions. However, few studies with a large sample size have been performed thus far to evaluate the prognostic value of D-dimer in patients ... ...

    Abstract Background: Increased D-dimer levels have been shown to correlate with adverse outcomes in various clinical conditions. However, few studies with a large sample size have been performed thus far to evaluate the prognostic value of D-dimer in patients with infective endocarditis (IE).
    Methods: 613 patients with IE were included in the study and categorized into two groups according to the cut-off of D-dimer determined by receiver operating characteristic (ROC) curve analysis for in-hospital death: > 3.5 mg/L (n = 89) and ≤ 3.5 mg/L (n = 524). Multivariable regression analysis was used to determine the association of D-dimer with in-hospital adverse events and six-month death.
    Results: In-hospital death (22.5% vs. 7.3%), embolism (33.7% vs 18.2%), and stroke (29.2% vs 15.8%) were significantly higher in patients with D-dimer > 3.5 mg/L than in those with D-dimer ≤ 3.5 mg/L. Multivariable analysis showed that D-dimer was an independent risk factor for in-hospital adverse events (odds ratio = 1.11, 95% CI 1.03-1.19, P = 0.005). In addition, the Kaplan-Meier curve showed that the cumulative 6-month mortality was significantly higher in patients with D-dimer > 3.5 mg/L than in those with D-dimer ≤ 3.5 mg/L (log-rank test = 39.19, P < 0.0001). Multivariable Cox regression analysis showed that D-dimer remained a significant predictor for six-month death (HR 1.11, 95% CI 1.05-1.18, P < 0.001).
    Conclusions: D-dimer is a reliable prognostic biomarker that independently associated with in-hospital adverse events and six-month mortality in patients with IE.
    MeSH term(s) Adult ; Aged ; Biomarkers/blood ; Embolism/etiology ; Embolism/mortality ; Endocarditis/blood ; Endocarditis/complications ; Endocarditis/diagnosis ; Endocarditis/mortality ; Female ; Fibrin Fibrinogen Degradation Products/analysis ; Hospital Mortality ; Humans ; Male ; Middle Aged ; Predictive Value of Tests ; Prognosis ; Reproducibility of Results ; Retrospective Studies ; Risk Assessment ; Risk Factors ; Stroke/etiology ; Stroke/mortality ; Time Factors ; Up-Regulation
    Chemical Substances Biomarkers ; Fibrin Fibrinogen Degradation Products ; fibrin fragment D
    Language English
    Publishing date 2021-06-05
    Publishing country England
    Document type Journal Article ; Observational Study ; Research Support, Non-U.S. Gov't
    ZDB-ID 2059859-2
    ISSN 1471-2261 ; 1471-2261
    ISSN (online) 1471-2261
    ISSN 1471-2261
    DOI 10.1186/s12872-021-02078-3
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  10. Article: A U-Shaped Relationship Between Selenium Concentrations and All-Cause or Cardiovascular Mortality in Patients With Hypertension.

    Tan, Qiu-Hong / Huang, Yu-Qing / Liu, Xiao-Cong / Liu, Lin / Lo, Kenneth / Chen, Ji-Yan / Feng, Ying-Qing

    Frontiers in cardiovascular medicine

    2021  Volume 8, Page(s) 671618

    Abstract: Background: ...

    Abstract Background:
    Language English
    Publishing date 2021-07-30
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2781496-8
    ISSN 2297-055X
    ISSN 2297-055X
    DOI 10.3389/fcvm.2021.671618
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