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  1. Article ; Online: Visible-Light-Induced 1,7-Enyne Dicyclization: Synthesis of Ester-Substituted Benzo[

    Chen, Jian-Qiang / Luo, Xiangxiang / Chen, Meiling / Chen, Yi / Wu, Jie

    Organic letters

    2023  Volume 25, Issue 11, Page(s) 1978–1983

    Abstract: A novel alkoxycarbonyl-radical-triggered cascade cyclization of 1,7-enynes, with alkyloxalyl chlorides as the ester units, for the synthesis of benzo[ ...

    Abstract A novel alkoxycarbonyl-radical-triggered cascade cyclization of 1,7-enynes, with alkyloxalyl chlorides as the ester units, for the synthesis of benzo[
    Language English
    Publishing date 2023-03-13
    Publishing country United States
    Document type Journal Article
    ISSN 1523-7052
    ISSN (online) 1523-7052
    DOI 10.1021/acs.orglett.3c00544
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Synthesis of Ester-Substituted Indolo[2,1-a]isoquinolines via Photocatalyzed Alkoxycarbonylation/Cyclization Reactions

    Chen, Jian-Qiang / Tu, Xiaodong / Qin, Binyan / Huang, Shaoxin / Zhang, Jun / Wu, Jie

    Organic letters. 2022 Jan. 05, v. 24, no. 2

    2022  

    Abstract: A direct alkoxycarbonylation/cyclization reaction is accomplished under visible light-induced photoredox catalysis. With this approach, a variety of ester-substituted indolo[2,1-a]isoquinolines are prepared in good to excellent yields. It is worth noting ...

    Abstract A direct alkoxycarbonylation/cyclization reaction is accomplished under visible light-induced photoredox catalysis. With this approach, a variety of ester-substituted indolo[2,1-a]isoquinolines are prepared in good to excellent yields. It is worth noting that this method not only can afford the synthesis of indolo[2,1-a]isoquinolines but also can provide an alternative route for generating complex target structures bearing carboxylic esters.
    Keywords cyclization reactions ; isoquinolines ; photocatalysis ; redox reactions
    Language English
    Dates of publication 2022-0105
    Size p. 642-647.
    Publishing place American Chemical Society
    Document type Article
    ISSN 1523-7052
    DOI 10.1021/acs.orglett.1c04082
    Database NAL-Catalogue (AGRICOLA)

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  3. Article: Synthesis of β-fluorocarboxylic esters via organophotoredox-catalyzed fluoroalkoxycarbonylation of alkenes in EtOH

    Wang, Xinhua / Chen, Yi / Liang, Ping / Chen, Jian-Qiang / Wu, Jie

    Green chemistry. 2022 July 4, v. 24, no. 13

    2022  

    Abstract: An efficient and environmentally friendly organophotoredox-catalyzed method for the synthesis of β-fluorocarboxylic esters with a broad substrate scope in EtOH has been developed. With this approach, a variety of potential biologically active molecules ... ...

    Abstract An efficient and environmentally friendly organophotoredox-catalyzed method for the synthesis of β-fluorocarboxylic esters with a broad substrate scope in EtOH has been developed. With this approach, a variety of potential biologically active molecules containing both fluorine and ester functionalities have been prepared.
    Keywords alkenes ; fluorine ; green chemistry
    Language English
    Dates of publication 2022-0704
    Size p. 5077-5082.
    Publishing place The Royal Society of Chemistry
    Document type Article
    ZDB-ID 2006274-6
    ISSN 1463-9270 ; 1463-9262
    ISSN (online) 1463-9270
    ISSN 1463-9262
    DOI 10.1039/d2gc01609e
    Database NAL-Catalogue (AGRICOLA)

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  4. Article ; Online: Synthesis of Ester-Substituted Indolo[2,1-

    Chen, Jian-Qiang / Tu, Xiaodong / Qin, Binyan / Huang, Shaoxin / Zhang, Jun / Wu, Jie

    Organic letters

    2022  Volume 24, Issue 2, Page(s) 642–647

    Abstract: A direct alkoxycarbonylation/cyclization reaction is accomplished under visible light-induced photoredox catalysis. With this approach, a variety of ester-substituted indolo[2,1- ...

    Abstract A direct alkoxycarbonylation/cyclization reaction is accomplished under visible light-induced photoredox catalysis. With this approach, a variety of ester-substituted indolo[2,1-
    Language English
    Publishing date 2022-01-05
    Publishing country United States
    Document type Journal Article
    ISSN 1523-7052
    ISSN (online) 1523-7052
    DOI 10.1021/acs.orglett.1c04082
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: [Case-control study on carpal canal endoscopy and arthroscopy for the treatment of plantar fasciopathy].

    Pan, Le / Chen, Jian-Qiang / Chen, Min-Chang / Zhu, Hong-Yi / Wu, Zhong-Qing / Zhang, Zhan-Feng

    Zhongguo gu shang = China journal of orthopaedics and traumatology

    2022  Volume 35, Issue 6, Page(s) 538–542

    Abstract: Objective: To explore clinical effects of carpal canal endoscopy in treating patients with plantar fasciopathy who failed by conservative treatment.: Methods: From August 2018 to August 2019, 50 patients with plantar fascia were divided into two ... ...

    Abstract Objective: To explore clinical effects of carpal canal endoscopy in treating patients with plantar fasciopathy who failed by conservative treatment.
    Methods: From August 2018 to August 2019, 50 patients with plantar fascia were divided into two groups and 25 patients in each group. In carpal canal endoscopy group, included 11 males and 14 females, aged from 39 to 67 years old with an average of(57.7±6.4) years old;carpal canal endoscopy was used to plantar fascia release. In arthroscopy group, included 9 males and 16 females, aged from 41 to 73 years old with an average of (58.1±7.2) years old;conventional 4.0 mm arthroscopy Instruments was used to plantar fascia release. Operation time, hospitalization expense and postoperative complications between two groups were observed and compared. Postoperative visual analogue scale(VAS) and American Orthopedic Foot Ankle Society (AOFAS) score were used to evaluate clinical function.
    Results: All patients were followed up from 12 to 18 months with an average of (14.3±2.1) months. There were significant differentces in operation time and hospitalization expense between two groups (
    Conclusion: The outcome of carpal canal endoscopy and arthroscopy has similar effects in treating plantar fascia. While carpal canal endoscopy has advantages of need not perfusion during opertaion, protect soft tissue well, less operation time, and lower cost.
    MeSH term(s) Adult ; Aged ; Arthroscopy ; Carpal Tunnel Syndrome ; Case-Control Studies ; Endoscopy ; Fasciitis, Plantar/surgery ; Fasciotomy ; Female ; Humans ; Male ; Middle Aged ; Treatment Outcome
    Language Chinese
    Publishing date 2022-06-07
    Publishing country China
    Document type Journal Article
    ISSN 1003-0034
    ISSN 1003-0034
    DOI 10.12200/j.issn.1003-0034.2022.06.007
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Synthesis of indolo[2,1-a]isoquinoline derivatives via visible-light-induced radical cascade cyclization reactions.

    Wei, Yun-Long / Chen, Jian-Qiang / Sun, Bo / Xu, Peng-Fei

    Chemical communications (Cambridge, England)

    2019  Volume 55, Issue 42, Page(s) 5922–5925

    Abstract: We describe a photocatalyzed transformation for the synthesis of the indolo[2,1-a]isoquinoline core structure. This redox neutral reaction features mild reaction conditions and exceptional functional group tolerance. A series of valuable indolo[2,1-a] ... ...

    Abstract We describe a photocatalyzed transformation for the synthesis of the indolo[2,1-a]isoquinoline core structure. This redox neutral reaction features mild reaction conditions and exceptional functional group tolerance. A series of valuable indolo[2,1-a]isoquinoline derivatives bearing various functional groups were synthesized using this method in good to excellent yields.
    Language English
    Publishing date 2019-05-02
    Publishing country England
    Document type Journal Article
    ZDB-ID 1472881-3
    ISSN 1364-548X ; 1359-7345 ; 0009-241X
    ISSN (online) 1364-548X
    ISSN 1359-7345 ; 0009-241X
    DOI 10.1039/c9cc02388g
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Synthesis of indolo[2,1-a]isoquinoline derivatives via visible-light-induced radical cascade cyclization reactions

    Wei, Yun-Long / Chen, Jian-Qiang / Sun, Bo / Xu, Peng-Fei

    Chemical communications. 2019 May 21, v. 55, no. 42

    2019  

    Abstract: We describe a photocatalyzed transformation for the synthesis of the indolo[2,1-a]isoquinoline core structure. This redox neutral reaction features mild reaction conditions and exceptional functional group tolerance. A series of valuable indolo[2,1-a] ... ...

    Abstract We describe a photocatalyzed transformation for the synthesis of the indolo[2,1-a]isoquinoline core structure. This redox neutral reaction features mild reaction conditions and exceptional functional group tolerance. A series of valuable indolo[2,1-a]isoquinoline derivatives bearing various functional groups were synthesized using this method in good to excellent yields.
    Keywords chemical compounds ; cyclization reactions ; moieties
    Language English
    Dates of publication 2019-0521
    Size p. 5922-5925.
    Publishing place The Royal Society of Chemistry
    Document type Article
    ZDB-ID 1472881-3
    ISSN 1364-548X ; 1359-7345 ; 0009-241X
    ISSN (online) 1364-548X
    ISSN 1359-7345 ; 0009-241X
    DOI 10.1039/c9cc02388g
    Database NAL-Catalogue (AGRICOLA)

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  8. Article ; Online: Efficient access to aliphatic esters by photocatalyzed alkoxycarbonylation of alkenes with alkyloxalyl chlorides.

    Chen, Jian-Qiang / Tu, Xiaodong / Tang, Qi / Li, Ke / Xu, Liang / Wang, Siyu / Ji, Mingjuan / Li, Zhiming / Wu, Jie

    Nature communications

    2021  Volume 12, Issue 1, Page(s) 5328

    Abstract: Aliphatic esters are essential constituents of biologically active compounds and versatile chemical intermediates for the synthesis of drugs. However, their preparation from readily available olefins remains challenging. Here, we report a strategy to ... ...

    Abstract Aliphatic esters are essential constituents of biologically active compounds and versatile chemical intermediates for the synthesis of drugs. However, their preparation from readily available olefins remains challenging. Here, we report a strategy to access aliphatic esters from olefins through a photocatalyzed alkoxycarbonylation reaction. Alkyloxalyl chlorides, generated in situ from the corresponding alcohols and oxalyl chloride, are engaged as alkoxycarbonyl radical fragments under photoredox catalysis. This transformation tolerates a broad scope of electron-rich and electron-deficient olefins and provides the corresponding β-chloro esters in good yields. Additionally, a formal β-selective alkene alkoxycarbonylation is developed. Moreover, a variety of oxindole-3-acetates and furoindolines are prepared in good to excellent yields. A more concise formal synthesis of (±)-physovenine is accomplished as well. With these strategies, a wide range of natural-product-derived olefins and alkyloxalyl chlorides are also successfully employed.
    MeSH term(s) Alcohols/chemistry ; Alkenes/chemistry ; Catalysis ; Chemistry Techniques, Synthetic ; Chlorides/chemistry ; Esters/chemistry ; Humans ; Indoles/chemical synthesis ; Molecular Structure ; Oxalates/chemistry ; Oxidation-Reduction ; Oxindoles/chemical synthesis ; Photochemical Processes ; Physostigmine/analogs & derivatives ; Physostigmine/chemical synthesis ; Stereoisomerism
    Chemical Substances Alcohols ; Alkenes ; Chlorides ; Esters ; Indoles ; Oxalates ; Oxindoles ; physovenine (6091-05-0) ; Physostigmine (9U1VM840SP) ; oxalyl chloride (R4Y96317DW)
    Language English
    Publishing date 2021-09-07
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2553671-0
    ISSN 2041-1723 ; 2041-1723
    ISSN (online) 2041-1723
    ISSN 2041-1723
    DOI 10.1038/s41467-021-25628-x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Visible Light-Mediated Direct C-H Aroylation and Alkylation of Heteroarenes.

    Chang, Rui / Fang, Jie / Chen, Jian-Qiang / Liu, Dan / Xu, Guo-Qiang / Xu, Peng-Fei

    ACS omega

    2019  Volume 4, Issue 9, Page(s) 14021–14031

    Abstract: Herein, we describe the photocatalytic generation of nucleophilic aroyl radicals from simple aroyl chlorides as a universal and efficient cross-coupling strategy for the direct aroylation of heteroarenes. Furthermore, visible light-mediated direct ... ...

    Abstract Herein, we describe the photocatalytic generation of nucleophilic aroyl radicals from simple aroyl chlorides as a universal and efficient cross-coupling strategy for the direct aroylation of heteroarenes. Furthermore, visible light-mediated direct alkylation of heteroarenes has also been achieved using unactivated bromoalkanes as radical precursors. These two strategies feature high functional group tolerance, exclusive regioselectivity for reaction at the more electrophilic position of heteroarenes, easily accessible substrates, and mild reaction conditions. Moreover, mechanism studies of two reactions are carried out to support our hypotheses.
    Language English
    Publishing date 2019-08-14
    Publishing country United States
    Document type Journal Article
    ISSN 2470-1343
    ISSN (online) 2470-1343
    DOI 10.1021/acsomega.9b01674
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Artificial Intelligence Approach to Find Lead Compounds for Treating Tumors.

    Chen, Jian-Qiang / Chen, Hsin-Yi / Dai, Wen-Jie / Lv, Qiu-Jie / Chen, Calvin Yu-Chian

    The journal of physical chemistry letters

    2019  Volume 10, Issue 15, Page(s) 4382–4400

    Abstract: It has been demonstrated that MMP13 enzyme is related to most cancer cell tumors. The world's largest traditional Chinese medicine database was applied to screen for structure-based drug design and ligand-based drug design. To predict drug activity, ... ...

    Abstract It has been demonstrated that MMP13 enzyme is related to most cancer cell tumors. The world's largest traditional Chinese medicine database was applied to screen for structure-based drug design and ligand-based drug design. To predict drug activity, machine learning models (Random Forest (RF), AdaBoost Regressor (ABR), Gradient Boosting Regressor (GBR)), and Deep Learning models were utilized to validate the Docking results, and we obtained an
    MeSH term(s) Algorithms ; Antineoplastic Agents/chemistry ; Binding Sites ; Cyclin-Dependent Kinase 6/chemistry ; Cyclin-Dependent Kinase Inhibitor p16/chemistry ; Databases, Pharmaceutical ; Databases, Protein ; Deep Learning ; Drug Design ; Ligands ; Machine Learning ; Matrix Metalloproteinase 13/chemistry ; Models, Molecular ; Mutation ; Peptides/chemistry ; Proteins/chemistry ; Proto-Oncogene Proteins c-bcl-2/chemistry ; Proto-Oncogene Proteins c-mdm2/chemistry ; Tumor Suppressor Protein p53/chemistry ; Tumor Suppressor Protein p53/genetics
    Chemical Substances Antineoplastic Agents ; Cyclin-Dependent Kinase Inhibitor p16 ; Ligands ; Peptides ; Proteins ; Proto-Oncogene Proteins c-bcl-2 ; Tumor Suppressor Protein p53 ; Proto-Oncogene Proteins c-mdm2 (EC 2.3.2.27) ; Cyclin-Dependent Kinase 6 (EC 2.7.11.22) ; Matrix Metalloproteinase 13 (EC 3.4.24.-)
    Language English
    Publishing date 2019-07-22
    Publishing country United States
    Document type Journal Article
    ISSN 1948-7185
    ISSN (online) 1948-7185
    DOI 10.1021/acs.jpclett.9b01426
    Database MEDical Literature Analysis and Retrieval System OnLINE

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