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  1. Article ; Online: Medical report generation based on multimodal federated learning.

    Chen, Jieying / Pan, Rong

    Computerized medical imaging and graphics : the official journal of the Computerized Medical Imaging Society

    2024  Volume 113, Page(s) 102342

    Abstract: Medical image reports are integral to clinical decision-making and patient management. Despite their importance, the confidentiality and private nature of medical data pose significant issues for the sharing and analysis of medical image data. This paper ...

    Abstract Medical image reports are integral to clinical decision-making and patient management. Despite their importance, the confidentiality and private nature of medical data pose significant issues for the sharing and analysis of medical image data. This paper addresses these concerns by introducing a multimodal federated learning-based methodology for medical image reporting. This methodology harnesses distributed computing for co-training models across various medical institutions. Under the federated learning framework, every medical institution is capable of training the model locally and aggregating the updated model parameters to curate a top-tier medical image report model. Initially, we advocate for an architecture facilitating multimodal federated learning, including model creation, parameter consolidation, and algorithm enhancement steps. In the model selection phase, we introduce a deep learning-based strategy that utilizes multimodal data for training to produce medical image reports. In the parameter aggregation phase, the federal average algorithm is applied to amalgamate model parameters trained by each institution, which leads to a comprehensive global model. In addition, we introduce an evidence-based optimization algorithm built upon the federal average algorithm. The efficacy of the proposed architecture and scheme is showcased through a series of experiments. Our experimental results validate the proficiency of the proposed multimodal federated learning approach in generating medical image reports. Compared to conventional centralized learning methods, our proposal not only enhances the protection of patient confidentiality but also enriches the accuracy and overall quality of medical image reports. Through this research, we offer a novel solution for the privacy issues linked with the sharing and analyzing of medical data. Expected to assume a crucial role in medical image report generation and other medical applications, the multimodal federated learning method is set to deliver more precise, efficient, and privacy-secured medical services for healthcare professionals and patients.
    MeSH term(s) Humans ; Algorithms
    Language English
    Publishing date 2024-01-26
    Publishing country United States
    Document type Journal Article
    ZDB-ID 639451-6
    ISSN 1879-0771 ; 0895-6111
    ISSN (online) 1879-0771
    ISSN 0895-6111
    DOI 10.1016/j.compmedimag.2024.102342
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Adenosine deaminase acting on RNA 1 (ADAR1) as crucial regulators in cardiovascular diseases: structures, pathogenesis, and potential therapeutic approach.

    Chen, Jieying / Jin, Junyan / Jiang, Jun / Wang, Yaping

    Frontiers in pharmacology

    2023  Volume 14, Page(s) 1194884

    Abstract: Cardiovascular diseases (CVDs) are a group of diseases that have a major impact on global health and are the leading cause of death. A large number of chemical base modifications in ribonucleic acid (RNA) are associated with cardiovascular diseases. A ... ...

    Abstract Cardiovascular diseases (CVDs) are a group of diseases that have a major impact on global health and are the leading cause of death. A large number of chemical base modifications in ribonucleic acid (RNA) are associated with cardiovascular diseases. A variety of ribonucleic acid modifications exist in cells, among which adenosine deaminase-dependent modification is one of the most common ribonucleic acid modifications. Adenosine deaminase acting on ribonucleic acid 1 (Adenosine deaminase acting on RNA 1) is a widely expressed double-stranded ribonucleic acid adenosine deaminase that forms inosine (A-to-I) by catalyzing the deamination of adenosine at specific sites of the target ribonucleic acid. In this review, we provide a comprehensive overview of the structure of Adenosine deaminase acting on RNA 1 and summarize the regulatory mechanisms of ADAR1-mediated ribonucleic acid editing in cardiovascular diseases, indicating Adenosine deaminase acting on RNA 1 as a promising therapeutic target in cardiovascular diseases.
    Language English
    Publishing date 2023-08-17
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2587355-6
    ISSN 1663-9812
    ISSN 1663-9812
    DOI 10.3389/fphar.2023.1194884
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: The Multi-Center Spatial Structure in the Guangdong-Hong Kong-Macao Greater Bay Area Urban Agglomeration Based on Luojia1-01 Nighttime Light Data and POI Data

    Zhi Qiuying / Chen Jieying / Fu Yingchun / Guo Biyun

    Redai dili, Vol 42, Iss 3, Pp 444-

    2022  Volume 456

    Abstract: The Guangdong-Hong Kong-Macao Greater Bay Area (referred to as "GBA") is an important strategic deployment for China's current economic development. Clarifying the spatial structure characteristics of the GBA urban agglomeration is conducive to ... ...

    Abstract The Guangdong-Hong Kong-Macao Greater Bay Area (referred to as "GBA") is an important strategic deployment for China's current economic development. Clarifying the spatial structure characteristics of the GBA urban agglomeration is conducive to optimizing its spatial structure to develop into a multi-center network spatial structure and promoting coordinated regional development. This study uses the advantage of Luojia1-01 nighttime light data, which can distinguish the difference in urban night light intensity. Through multi-scale segmentation of nighttime light intensity, the potential center range is established. The point of interest (POI) data are used for spatial autocorrelation analysis and geographically weighted regression to identify the multi-center distribution of the GBA urban agglomeration, and to analyze its spatial structure characteristics from multiple perspectives such as functional structure identification, spatial correlation measurement, and main center service range. The following list illustrates what the results show. 1) The GBA has five main centers and 14 sub-centers, including the main centers of Guangfo, Shenguan, Hong Kong, Aozhu, and Zhongshan. The functional structures of the five main centers are mainly mixed functional areas, and 14 sub-centers (such as Huadu, Zengcheng, Conghua, Huicheng, Duanzhou, Xinhui, Shiqi) are distributed around the periphery of the main centers. 2) The correlation strength of the five main centers and nine cities plus two special administrative regions in the urban agglomeration, calculated based on the Luojia1-01 nighttime light data, shows characteristics of "strong in the east and weak in the west" and "strong inside and weak outside." 3) The study considered the distribution of the main centers of the urban agglomeration and their spatial correlation strength characteristics, as well as the three groups served by the main centers (Guangfozhao group, Gang-Shenguanhui group and Ao-Zhuzhongjiang group), combined with the planning requirements of the "Outline Development Plan for the Guangdong-Hong Kong-Macao Greater Bay Area" and "Guangdong Province Land and Space Planning (2020-2035)." The findings suggest that the GBA should build a regional spatial structure of "five centers, one area, three groups and four axes" to achieve pole-driven, axis-supported, and group cooperation and promote its coordinated development into a world-class urban agglomeration.
    Keywords luojia1-01 ; poi ; guangdong-hong kong-macao greater bay area ; urban agglomeration multi-center ; spatial correlation ; nighttime light data ; Geography (General) ; G1-922
    Subject code 910
    Language Chinese
    Publishing date 2022-03-01T00:00:00Z
    Publisher Editorial Committee of Tropical Geography
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: Aldehyde dehydrogenase 2 and arrhythmogenesis.

    Jin, Junyan / Chen, Jieying / Wang, Yaping

    Heart rhythm

    2022  Volume 19, Issue 9, Page(s) 1541–1547

    Abstract: Cardiac arrhythmia is a common cardiovascular disease that leads to considerable economic burdens and significant global public health challenges. Despite the remarkable progress made in recent decades, antiarrhythmic therapy remains suboptimal. Aldehyde ...

    Abstract Cardiac arrhythmia is a common cardiovascular disease that leads to considerable economic burdens and significant global public health challenges. Despite the remarkable progress made in recent decades, antiarrhythmic therapy remains suboptimal. Aldehyde dehydrogenase 2 (ALDH2), a critical detoxifying enzyme, catalyzes toxic aldehydes and protects individuals from damage caused by oxidative stress. Accumulating evidence has demonstrated that ALDH2 activation has potential antiarrhythmic benefits. The correlation between ALDH2 deficiency and arrhythmogenesis has been widely recognized. In this review, we summarize recent research on the potential role of ALDH2 activation and antiarrhythmic protection, as well as the role played by the ALDH2∗2 polymorphism (rs671) in promoting arrhythmic risk. Additionally, we discuss important new findings illustrating the use of ALDH2 activators, which may prove to be promising antiarrhythmic therapy agents.
    MeSH term(s) Aldehyde Dehydrogenase, Mitochondrial/genetics ; Aldehydes ; Arrhythmias, Cardiac/genetics ; Humans ; Oxidative Stress ; Polymorphism, Genetic
    Chemical Substances Aldehydes ; ALDH2 protein, human (EC 1.2.1.3) ; Aldehyde Dehydrogenase, Mitochondrial (EC 1.2.1.3)
    Language English
    Publishing date 2022-05-12
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2229357-7
    ISSN 1556-3871 ; 1547-5271
    ISSN (online) 1556-3871
    ISSN 1547-5271
    DOI 10.1016/j.hrthm.2022.05.008
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Bone marrow fatty acids affect osteoblastic differentiation through miR-92b-3p in the early stages of postmenopausal osteoporosis

    Wang, Sizhu / Tang, Cuisong / Chen, Jieying / Tang, Huan / Zhang, Lin / Tang, Guangyu

    Heliyon. 2023 May 22, p.e16513-

    2023  

    Abstract: Osteoporosis is partially caused by dysfunctions in the commitment, differentiation or survival of osteoblasts. Bone marrow fatty acids affect bone resorption and formation. In this study, we aimed to explore the role of fatty acids in the early stages ... ...

    Abstract Osteoporosis is partially caused by dysfunctions in the commitment, differentiation or survival of osteoblasts. Bone marrow fatty acids affect bone resorption and formation. In this study, we aimed to explore the role of fatty acids in the early stages of postmenopausal osteoporosis and determine whether they influence osteogenic differentiation through microRNAs. A quantitative analysis of bone marrow fatty acids early after ovariectomy or sham surgery in a rat osteoporotic model was performed using gas chromatography/mass spectrometry. The results showed that palmitoleate was significantly decreased on postoperative day 3 while both pentadecanoate and palmitoleate were significantly decreased on postoperative day 5 in rats in the ovariectomized group compared with those in the sham group. Palmitoleate promotes osteogenic differentiation, whereas pentadecanoate inhibits this process. Palmitoleate levels were higher than those of pentadecanoate; therefore, the early overall effect of significant bone marrow fatty acid changes was a decrease in osteogenic differentiation. We also found that miR-92b-3p inhibited osteoblastogenesis via the miR-92b-3p/phosphatase and tensin homolog regulatory axis. Palmitoleate, pentadecanoate, and palmitate influenced the osteoblastogenesis of MC3T3-E1 cells through miR-92b-3p. Taken together, we propose that miR-92b-3p mediates the effect of bone marrow fatty acids on osteoblast differentiation in the early stages of osteoporosis. These findings may provide molecular insights for the treatment of osteoporosis.
    Keywords bone formation ; bone marrow ; bone resorption ; fatty acids ; gas chromatography ; mass spectrometry ; microRNA ; models ; osteoblasts ; osteoporosis ; ovariectomy ; palmitates ; postmenopause ; quantitative analysis ; rats ; Osteoblast ; Lipids ; Fatty acid ; Gas chromatography/mass spectrometry
    Language English
    Dates of publication 2023-0522
    Publishing place Elsevier Ltd
    Document type Article ; Online
    Note Pre-press version ; Use and reproduction
    ZDB-ID 2835763-2
    ISSN 2405-8440
    ISSN 2405-8440
    DOI 10.1016/j.heliyon.2023.e16513
    Database NAL-Catalogue (AGRICOLA)

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  6. Article: Preoperative Prediction of Central Cervical Lymph Node Metastasis in Fine-Needle Aspiration Reporting Suspicious Papillary Thyroid Cancer or Papillary Thyroid Cancer Without Lateral Neck Metastasis.

    Zhang, Kai / Qian, Lang / Chen, Jieying / Zhu, Qian / Chang, Cai

    Frontiers in oncology

    2022  Volume 12, Page(s) 712723

    Abstract: Purpose: No non-invasive method can accurately determine the presence of central cervical lymph node (CCLN) metastasis in papillary thyroid cancer (PTC) until now. This study aimed to investigate factors significantly associated with CCLN metastasis and ...

    Abstract Purpose: No non-invasive method can accurately determine the presence of central cervical lymph node (CCLN) metastasis in papillary thyroid cancer (PTC) until now. This study aimed to investigate factors significantly associated with CCLN metastasis and then develop a model to preoperatively predict CCLN metastasis in fine-needle aspiration (FNA) reporting suspicious papillary thyroid cancer (PTC) or PTC without lateral neck metastasis.
    Patients and methods: Consecutive inpatients who were diagnosed as suspicious PTC or PTC in FNA and underwent partial or total thyroidectomy and CCLN dissection between May 1
    Results: A total of 770 patients were eligible in this study. Among them, 268 patients had histologically confirmed CCLN metastasis, while the remaining patients did not. Factors including age,
    Conclusion: Age,
    Language English
    Publishing date 2022-03-23
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2649216-7
    ISSN 2234-943X
    ISSN 2234-943X
    DOI 10.3389/fonc.2022.712723
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: PIM-1 kinase: a potential biomarker of triple-negative breast cancer.

    Chen, Jieying / Tang, Guangyu

    OncoTargets and therapy

    2019  Volume 12, Page(s) 6267–6273

    Abstract: Triple-negative breast cancer is associated with a poor prognosis, and effective biomarkers for targeted diagnosis and treatment are lacking. The tumorigenicity of the provirus integration site for Moloney murine leukemia virus 1 ( ...

    Abstract Triple-negative breast cancer is associated with a poor prognosis, and effective biomarkers for targeted diagnosis and treatment are lacking. The tumorigenicity of the provirus integration site for Moloney murine leukemia virus 1 (
    Language English
    Publishing date 2019-08-08
    Publishing country New Zealand
    Document type Journal Article
    ZDB-ID 2495130-4
    ISSN 1178-6930
    ISSN 1178-6930
    DOI 10.2147/OTT.S212752
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Doping effect on a two-electron silver nanocluster.

    Yen, Wei-Jung / Liao, Jian-Hong / Chiu, Tzu-Hao / Chen, Jie-Ying / Chen, Yuan Jang / Kahlal, Samia / Saillard, Jean-Yves / Liu, C W

    Nanoscale

    2024  Volume 16, Issue 14, Page(s) 7011–7018

    Abstract: This study investigates the effects of metal addition and doping of a 2-electron silver superatom, [ ... ...

    Abstract This study investigates the effects of metal addition and doping of a 2-electron silver superatom, [Ag
    Language English
    Publishing date 2024-04-04
    Publishing country England
    Document type Journal Article
    ZDB-ID 2515664-0
    ISSN 2040-3372 ; 2040-3364
    ISSN (online) 2040-3372
    ISSN 2040-3364
    DOI 10.1039/d4nr00326h
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Early changes of bone metabolites and lymphocyte subsets may participate in osteoporosis onset: a preliminary study of a postmenopausal osteoporosis mouse model.

    Wang, Sizhu / Qiu, Yuyou / Tang, Cuisong / Tang, Huan / Liu, Jinchuan / Chen, Jieying / Zhang, Lin / Tang, Guangyu

    Frontiers in endocrinology

    2024  Volume 15, Page(s) 1323647

    Abstract: Purpose: Metabolic and immune changes in the early stages of osteoporosis are not well understood. This study aimed to explore the changes in bone metabolites and bone marrow lymphocyte subsets and their relationship during the osteoporosis onset.: ... ...

    Abstract Purpose: Metabolic and immune changes in the early stages of osteoporosis are not well understood. This study aimed to explore the changes in bone metabolites and bone marrow lymphocyte subsets and their relationship during the osteoporosis onset.
    Methods: We established OVX and Sham mouse models. After 5, 15, and 40 days, five mice in each group were sacrificed. Humeri were analyzed by microCT. The bone marrow cells of the left femur and tibia were collected for flow cytometry analysis. The right femur and tibia were analyzed by LC-MS/MS for metabolomics analysis.
    Results: Bone microarchitecture was significantly deteriorated 15 days after OVX surgery. Analysis of bone metabolomics showed that obvious metabolite changes had happened since 5 days after surgery. Lipid metabolism was significant at the early stage of the osteoporosis. The proportion of immature B cells was increased, whereas the proportion of mature B cells was decreased in the OVX group. Metabolites were significantly correlated with the proportion of lymphocyte subsets at the early stage of the osteoporosis.
    Conclusion: Lipid metabolism was significant at the early stage of the osteoporosis. Bone metabolites may influence bone formation by interfering with bone marrow lymphocyte subsets.
    MeSH term(s) Humans ; Female ; Mice ; Animals ; Osteoporosis, Postmenopausal/etiology ; Osteoporosis, Postmenopausal/metabolism ; Chromatography, Liquid ; Tandem Mass Spectrometry ; Osteoporosis/etiology ; Osteoporosis/metabolism ; Disease Models, Animal ; Lymphocyte Subsets/metabolism
    Language English
    Publishing date 2024-02-28
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2592084-4
    ISSN 1664-2392
    ISSN 1664-2392
    DOI 10.3389/fendo.2024.1323647
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Integrated micro/nano drug delivery system based on magnetically responsive phase-change droplets for ultrasound theranostics.

    Chen, Jieying / Zhao, Chan / Liu, Hao / Wang, Zhangchao / Ma, Luyao / Zhang, Jiamin / Xu, Ning / Hu, Ke / Duan, Lei

    Frontiers in bioengineering and biotechnology

    2024  Volume 12, Page(s) 1323056

    Abstract: Phase-change droplets (PCDs) are intelligent responsive micro and nanomaterials developed based on micro/nano bubbles. Subject to external energy inputs such as temperature and ultrasound, the core substance, perfluorocarbon (PFC), undergoes a phase ... ...

    Abstract Phase-change droplets (PCDs) are intelligent responsive micro and nanomaterials developed based on micro/nano bubbles. Subject to external energy inputs such as temperature and ultrasound, the core substance, perfluorocarbon (PFC), undergoes a phase transition from liquid to gas. This transformation precipitates alterations in the PCDs' structure, size, ultrasound imaging capabilities, drug delivery efficiency, and other pertinent characteristics. This gives them the ability to exhibit "intelligent responses". This study utilized lipids as the membrane shell material and perfluorohexane (PFH) as the core to prepare lipid phase-change droplets. Superparamagnetic nanoparticles (PEG-functionalized Fe
    Language English
    Publishing date 2024-04-11
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2719493-0
    ISSN 2296-4185
    ISSN 2296-4185
    DOI 10.3389/fbioe.2024.1323056
    Database MEDical Literature Analysis and Retrieval System OnLINE

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