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Article: Advancements and Perspectives in Polysaccharide-Based Nanoparticles for Theranostic Nanomedicine.

Chen, Jingdi

2023 Volume 17, Issue 1

Abstract: It is with great enthusiasm [ ... ]. ...

Abstract	It is with great enthusiasm [...].
Language	English
Publishing date	2023-12-26
Publishing country	Switzerland
Document type	Editorial
ZDB-ID	2193542-7
ISSN	1424-8247
ISSN	1424-8247
DOI	10.3390/ph17010036
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Injectable and photothermal antibacterial bacterial cellulose cryogel for rapid hemostasis and repair of irregular and deep skin wounds.

Cao, Shujun / Zhang, Kun / Li, Qiujing / Zhang, Shukun / Chen, Jingdi

Carbohydrate polymers

2023 Volume 320, Page(s) 121239

Abstract: For irregular and deep skin wounds, it's difficult for wound dressing to reach the injured site to achieve rapid hemostasis and provide wound protection. Bacterial cellulose (BC) has high strength and natural three-dimensional pore structure, which ... ...

Abstract	For irregular and deep skin wounds, it's difficult for wound dressing to reach the injured site to achieve rapid hemostasis and provide wound protection. Bacterial cellulose (BC) has high strength and natural three-dimensional pore structure, which endows it shape recovery ability after absorbing blood when injected to the wound. Therefore, in the study, an injectable aldehyde bacterial cellulose/polydopamine (DBC/PDA) photothermal cryogel was prepared by oxidation polymerization method for hemostasis and repair of irregular and deep skin wounds. BC was oxidized by NaIO
Language	English
Publishing date	2023-07-27
Publishing country	England
Document type	Journal Article
ZDB-ID	1501516-6
ISSN	1879-1344 ; 0144-8617
ISSN (online)	1879-1344
ISSN	0144-8617
DOI	10.1016/j.carbpol.2023.121239
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Book ; Online: RGMComm

Chen, Jingdi / Lan, Tian / Joe-Wong, Carlee

Return Gap Minimization via Discrete Communications in Multi-Agent Reinforcement Learning

2023

Abstract: Communication is crucial for solving cooperative Multi-Agent Reinforcement Learning tasks in partially observable Markov Decision Processes. Existing works often rely on black-box methods to encode local information/features into messages shared with ... ...

Abstract	Communication is crucial for solving cooperative Multi-Agent Reinforcement Learning tasks in partially observable Markov Decision Processes. Existing works often rely on black-box methods to encode local information/features into messages shared with other agents, leading to the generation of continuous messages with high communication overhead and poor interpretability. Prior attempts at discrete communication methods generate one-hot vectors trained as part of agents' actions and use the Gumbel softmax operation for calculating message gradients, which are all heuristic designs that do not provide any quantitative guarantees on the expected return. This paper establishes an upper bound on the return gap between an ideal policy with full observability and an optimal partially observable policy with discrete communication. This result enables us to recast multi-agent communication into a novel online clustering problem over the local observations at each agent, with messages as cluster labels and the upper bound on the return gap as clustering loss. To minimize the return gap, we propose the Return-Gap-Minimization Communication (RGMComm) algorithm, which is a surprisingly simple design of discrete message generation functions and is integrated with reinforcement learning through the utilization of a novel Regularized Information Maximization loss function, which incorporates cosine-distance as the clustering metric. Evaluations show that RGMComm significantly outperforms state-of-the-art multi-agent communication baselines and can achieve nearly optimal returns with few-bit messages that are naturally interpretable.
Keywords	Computer Science - Artificial Intelligence
Subject code	006
Publishing date	2023-08-07
Publishing country	us
Document type	Book ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Double Network Physical Crosslinked Hydrogel for Healing Skin Wounds: New Formulation Based on Polysaccharides and Zn

Cui, Shenghao / Yang, Faming / Yu, Dingyi / Shi, Chao / Zhao, Di / Chen, Liqi / Chen, Jingdi

International journal of molecular sciences

2023 Volume 24, Issue 17

Abstract: Developing convenient, efficient, and natural wound dressings remain the foremost strategy for treating skin wounds. Thus, we innovatively combined the semi-dissolved acidified sol-gel conversion method with the internal gelation method to fabricate SA ( ... ...

Abstract	Developing convenient, efficient, and natural wound dressings remain the foremost strategy for treating skin wounds. Thus, we innovatively combined the semi-dissolved acidified sol-gel conversion method with the internal gelation method to fabricate SA (sodium alginate)/CS (chitosan)/Zn
MeSH term(s)	Hydrogels/pharmacology ; Skin ; Polysaccharides/pharmacology ; Alginates ; Zinc
Chemical Substances	Hydrogels ; Polysaccharides ; Alginates ; Zinc (J41CSQ7QDS)
Language	English
Publishing date	2023-08-22
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms241713042
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Article ; Online: Shape memory and antibacterial chitosan-based cryogel with hemostasis and skin wound repair.

Cao, Shujun / Bi, Zhanjian / Li, Qiujing / Zhang, Shukun / Singh, Moganavelli / Chen, Jingdi

Carbohydrate polymers

2023 Volume 305, Page(s) 120545

Abstract: Massive damage to the skin can lead to heavy bleeding and potential wound infection. Therefore, the preparation of low-cost wound dressings that meet these requirements by simple methods has a good application prospect. In the study, a shape memory ... ...

Abstract	Massive damage to the skin can lead to heavy bleeding and potential wound infection. Therefore, the preparation of low-cost wound dressings that meet these requirements by simple methods has a good application prospect. In the study, a shape memory cryogel prepared at low temperatures by mixing chitosan (CS) and citric acid (CA). Silver nanoparticles (Ag NPs) introduced into the cryogel through the reduction of Ag
MeSH term(s)	Humans ; Chitosan/pharmacology ; Chitosan/chemistry ; Wound Healing ; Cryogels/chemistry ; Metal Nanoparticles/therapeutic use ; Metal Nanoparticles/chemistry ; Escherichia coli ; Staphylococcus aureus ; Silver/pharmacology ; Silver/chemistry ; Anti-Bacterial Agents/pharmacology ; Anti-Bacterial Agents/chemistry ; Hemostasis ; Soft Tissue Injuries
Chemical Substances	Chitosan (9012-76-4) ; Cryogels ; Silver (3M4G523W1G) ; Anti-Bacterial Agents
Language	English
Publishing date	2023-01-07
Publishing country	England
Document type	Journal Article
ZDB-ID	1501516-6
ISSN	1879-1344 ; 0144-8617
ISSN (online)	1879-1344
ISSN	0144-8617
DOI	10.1016/j.carbpol.2023.120545
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Article ; Online: Marine-Derived Bioactive Peptides Self-Assembled Multifunctional Materials: Antioxidant and Wound Healing

Yu, Dingyi / Cui, Shenghao / Chen, Liqi / Zheng, Shuang / Zhao, Di / Yin, Xinyu / Yang, Faming / Chen, Jingdi

Antioxidants. 2023 May 31, v. 12, no. 6

2023

Abstract: Peptide self-assembling materials have received significant attention from researchers in recent years, emerging as a popular field in biological, environmental, medical, and other new materials studies. In this study, we utilized controllable enzymatic ... ...

Abstract	Peptide self-assembling materials have received significant attention from researchers in recent years, emerging as a popular field in biological, environmental, medical, and other new materials studies. In this study, we utilized controllable enzymatic hydrolysis technology (animal proteases) to obtain supramolecular peptide self-assembling materials (CAPs) from the Pacific oyster (Crassostrea gigas). We conducted physicochemical analyses to explore the pro-healing mechanisms of CAPs on skin wounds in both in vitro and in vivo experiments through a topical application. The results demonstrated that CAPs exhibit a pH-responsive behavior for self-assembly and consist of peptides ranging from 550 to 2300 Da in molecular weight, with peptide chain lengths of mainly 11–16 amino acids. In vitro experiments indicated that CAPs display a procoagulant effect, free radical scavenging activity, and promote the proliferation of HaCaTs (112.74% and 127.61%). Moreover, our in vivo experiments demonstrated that CAPs possess the ability to mitigate inflammation, boost fibroblast proliferation, and promote revascularization, which accelerates the epithelialization process. Consequently, a balanced collagen I/III ratio in the repaired tissue and the promotion of hair follicle regeneration were observed. With these remarkable findings, CAPs can be regarded as a natural and secure treatment option with high efficacy for skin wound healing. The potential of CAPs to be further developed for traceless skin wound healing is an exciting area for future research and development.
Keywords	Crassostrea gigas ; animals ; antioxidants ; collagen ; enzymatic hydrolysis ; fibroblasts ; free radicals ; hair follicles ; inflammation ; molecular weight ; peptides ; proteinases ; research and development ; topical application
Language	English
Dates of publication	2023-0531
Publishing place	Multidisciplinary Digital Publishing Institute
Document type	Article ; Online
ZDB-ID	2704216-9
ISSN	2076-3921
ISSN	2076-3921
DOI	10.3390/antiox12061190
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Moringa oleifera gum capped MgO nanoparticles: Synthesis, characterization, cyto- and ecotoxicity assessment

Vijayakumar, Sekar / Chen, Jingdi / González Sánchez, Zaira I. / Tungare, Kanchanlata / Bhori, Mustansir / Durán-Lara, Esteban F. / Anbu, Periasamy

International Journal of Biological Macromolecules. 2023 Apr., v. 233 p.123514-

2023

Abstract: Nano-based drug delivery research is increasing due to the therapeutic applications for human health care. However, traditional chemical capping-based synthesis methods lead to unwanted toxicity effects. Hence, there is an urgent need for green synthesis- ...

Abstract	Nano-based drug delivery research is increasing due to the therapeutic applications for human health care. However, traditional chemical capping-based synthesis methods lead to unwanted toxicity effects. Hence, there is an urgent need for green synthesis-based and biocompatible synthesis methods. The current work describes for the first time the green synthesis of Moringa gum-capped MgO nanoparticles (Mgm-MgO NPs). Their antioxidant activity, hemolysis potential, cytotoxicity, phytotoxicity, toxicity by chorioallantoic membrane (CAM) chick embryo assay and in vivo toxicity in zebrafish embryos were described. The Mgm-MgO NPs exhibited significant antioxidant activity. The Mgm-MgO NPs at 500 μg/ml produced significant hemolysis (72.54 %), while lower concentrations did not. Besides, the cytotoxicity assessment of the Mgm-MgO NPs was conducted in PA-1 cells from human ovarian teratocarcinoma by MTT assay. The Mgm-MgO NPs (0.1–500 μg/ml) considerably reduced the viability of PA-1 cells. Furthermore, Mgm-MgO NPs had no significant effect on seed germination but had a significant effect on root and shoot length of mungbean (Vigna radiata). Additionally, the CAM assay was used to analyze the antiangiogenic potential of Mgm-MgO NPs, exhibiting no significant alterations after 72 h. Finally, the zebrafish embryotoxicity assay revealed that the Mgm-MgO NPs (0.1–500 μg/ml) did not affect morphology, mortality or survival rate.
Keywords	Danio rerio ; Moringa oleifera ; Vigna radiata ; antioxidant activity ; chick embryos ; chorioallantoic membrane ; cytotoxicity ; drugs ; ecotoxicology ; embryotoxicity ; health services ; hemolysis ; human health ; humans ; mung beans ; nanoparticles ; phytotoxicity ; seed germination ; survival rate ; therapeutics ; toxicity testing ; viability ; Moringa gum ; MgO ; Antioxidant ; Angiogenesis
Language	English
Dates of publication	2023-04
Publishing place	Elsevier B.V.
Document type	Article ; Online
ZDB-ID	282732-3
ISSN	1879-0003 ; 0141-8130
ISSN (online)	1879-0003
ISSN	0141-8130
DOI	10.1016/j.ijbiomac.2023.123514
Database	NAL-Catalogue (AGRICOLA)

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Book ; Online: Learning Multi-agent Options for Tabular Reinforcement Learning using Factor Graphs

Chen, Jiayu / Chen, Jingdi / Lan, Tian / Aggarwal, Vaneet

2022

Abstract: Covering option discovery has been developed to improve the exploration of reinforcement learning in single-agent scenarios with sparse reward signals, through connecting the most distant states in the embedding space provided by the Fiedler vector of ... ...

Abstract	Covering option discovery has been developed to improve the exploration of reinforcement learning in single-agent scenarios with sparse reward signals, through connecting the most distant states in the embedding space provided by the Fiedler vector of the state transition graph. However, these option discovery methods cannot be directly extended to multi-agent scenarios, since the joint state space grows exponentially with the number of agents in the system. Thus, existing researches on adopting options in multi-agent scenarios still rely on single-agent option discovery and fail to directly discover the joint options that can improve the connectivity of the joint state space of agents. In this paper, we show that it is indeed possible to directly compute multi-agent options with collaborative exploratory behaviors among the agents, while still enjoying the ease of decomposition. Our key idea is to approximate the joint state space as a Kronecker graph -- the Kronecker product of individual agents' state transition graphs, based on which we can directly estimate the Fiedler vector of the joint state space using the Laplacian spectrum of individual agents' transition graphs. This decomposition enables us to efficiently construct multi-agent joint options by encouraging agents to connect the sub-goal joint states which are corresponding to the minimum or maximum values of the estimated joint Fiedler vector. The evaluation based on multi-agent collaborative tasks shows that the proposed algorithm can successfully identify multi-agent options, and significantly outperforms prior works using single-agent options or no options, in terms of both faster exploration and higher cumulative rewards.
Keywords	Computer Science - Multiagent Systems ; Computer Science - Artificial Intelligence ; Computer Science - Machine Learning
Subject code	006
Publishing date	2022-01-20
Publishing country	us
Document type	Book ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Preparation of biodegradable carboxymethyl cellulose/dopamine/Ag NPs cryogel for rapid hemostasis and bacteria-infected wound repair

Cao, Shujun / Li, Qiujing / Zhang, Shukun / Liu, Zhuochen / Lv, Xiaoyu / Chen, Jingdi

International journal of biological macromolecules. 2022 Dec. 01, v. 222

2022

Abstract: Massive hemorrhage caused by accident or surgery is a major factor in accidental death. In addition, bacterial infection is also an important threat after bleeding. Cryogels with interpenetrating macroporous structures pose great application prospects in ...

Abstract	Massive hemorrhage caused by accident or surgery is a major factor in accidental death. In addition, bacterial infection is also an important threat after bleeding. Cryogels with interpenetrating macroporous structures pose great application prospects in rapid hemostasis and infected wound repair. In this study, cryogels with different pore size are prepared by carboxymethyl cellulose (CMC) and dopamine (DA). The CMC grafted with different DA amounts is crosslinked by free DA through oxidative polymerization at low temperatures to form cryogels with different pore sizes. And the CMC/DA-3 cryogel is chosen as the optimal group for its high porosity, suitable mechanical, and good hemostatic ability. CMC/DA-3 cryogel is loaded with silver nanoparticles (Ag NPs) to prepare hemostatic cryogel with antibacterial properties. Antibacterial tests and animal hemostasis experiments confirm that the CMC/DA-3/Ag cryogel has good antibacterial properties and can finish rapid hemostasis. In the S. aureus infection skin defect model, the wound healing is significantly improved compared with commercial gelatin sponge. In summary, the novel cryogel has great potential in rapid hemostasis and infected wound healing.
Keywords	accidents ; animals ; bacterial infections ; biodegradability ; carboxymethylcellulose ; crosslinking ; cryogels ; death ; dopamine ; gelatin ; hemorrhage ; hemostasis ; models ; nanosilver ; polymerization ; porosity ; porous media ; surgery
Language	English
Dates of publication	2022-1201
Size	p. 272-284.
Publishing place	Elsevier B.V.
Document type	Article
ZDB-ID	282732-3
ISSN	1879-0003 ; 0141-8130
ISSN (online)	1879-0003
ISSN	0141-8130
DOI	10.1016/j.ijbiomac.2022.09.172
Database	NAL-Catalogue (AGRICOLA)

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Article: Oxidized bacterial cellulose reinforced nanocomposite scaffolds for bone repair

Cao, Shujun / Li, Qiujing / Zhang, Shukun / Liu, Kaihua / Yang, Yifan / Chen, Jingdi

Colloids and surfaces. 2022 Mar., v. 211

2022

Abstract: Bone tissue engineering has been widely used in promoting the repair and regeneration of bone defects. Tissue-engineered bone scaffolds can simulate the extracellular matrix environment and induce the proliferation and differentiation of osteoblasts. The ...

Abstract	Bone tissue engineering has been widely used in promoting the repair and regeneration of bone defects. Tissue-engineered bone scaffolds can simulate the extracellular matrix environment and induce the proliferation and differentiation of osteoblasts. The first issues to be considered when constructing bone repair scaffolds include biocompatibility, stress resistance, degradability and stability. Here, a low-cost manufacturing introduces a new bone repair composite scaffold (CS/OBC/nHAP). The scaffolds were composed of only natural derived components, including nano hydroxyapatite (nHAP) formed by in-situ crystallization of Ca²⁺/PO₄²⁻ solution and evenly dispersed in oxidized bacterial cellulose (OBC) and chitosan (CS) scaffolds. The experimental results showed that compared with CS/nHAP scaffold, CS/OBC/nHAP scaffold has significantly improve mechanical properties and water retention performance, and has a more stable degradation rate. Cell experiments showed that the CS/OBC/nHAP scaffold has good biocompatibility and significantly promote the proliferation of MC3T3-E1 cells. The rat skull defect model further proves that the CS/OBC/nHAP scaffold could induce the formation of bone tissue. Meanwhile, H&E staining experiment show that the CS/OBC/nHAP scaffold has good stability in vivo and could better promote the formation of bone tissue.
Keywords	biocompatibility ; cellulose ; chitosan ; crystallization ; extracellular matrix ; hydroxyapatite ; models ; nanocomposites ; osteoblasts ; oxidation ; rats ; skull ; stress tolerance
Language	English
Dates of publication	2022-03
Publishing place	Elsevier B.V.
Document type	Article
ZDB-ID	1500523-9
ISSN	1873-4367 ; 0927-7765
ISSN (online)	1873-4367
ISSN	0927-7765
DOI	10.1016/j.colsurfb.2021.112316
Database	NAL-Catalogue (AGRICOLA)

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