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Article ; Online: Serum exosome-derived miR-146a-3p promotes macrophage M2 polarization in allergic rhinitis by targeting VAV3 via PI3K/AKT/mTOR pathway.

Xia, Cui / Zhu, Kang / Zhang, Yanni / Chen, Jingguo / Yu, Chao / Gao, Tianxi / Zheng, Guoxi

2023 Volume 124, Issue Pt B, Page(s) 110997

Abstract: Background: Our previous study showed that miR-146a-3p was elevated in serum exosomes of allergic rhinitis (AR) patients, but the underlying mechanisms were unclarified. This study was to investigate the impact of exosome-derived miR-146a-3p on ... ...

Abstract	Background: Our previous study showed that miR-146a-3p was elevated in serum exosomes of allergic rhinitis (AR) patients, but the underlying mechanisms were unclarified. This study was to investigate the impact of exosome-derived miR-146a-3p on macrophage polarization in the pathology of AR. Method: We detected the expression of miR-146a-3p in nasal tissues of AR patients and healthy controls (HCs), and investigated its correlation with macrophage polarization markers. The impact of miR-146a-3p derived from AR serum exosomes on macrophage polarization was examined. Transcriptome sequencing was performed on macrophages treated with a miR-146a-3p inhibitor, and target genes of miR-146a-3p were explored through a combination of bioinformatics analysis and experimental validation. Results: The expressions of miR-146a-3p and macrophage polarization markers were increased in the AR nasal tissues, and a positive association was observed between the expressions of miR-146a-3p and the levels of CD163 and CD206. The AR serum exosomes could be uptake by macrophages, and promote M2 polarization and cytokine secretions. Mechanistically, miR-146a-3p regulation could impact both macrophage M2 polarization and cytokine secretion. Inhibition of miR-146a-3p altered the gene transcriptions within macrophages. Bioinformatics analysis and clinical pathological specimen research confirmed that VAV3 was a target gene of miR-146a-3p, and it exerted a detrimental effect on macrophage M2 polarization via the PI3K/AKT/mTOR pathway. Functional recovery experiments and dual-luciferase reporter gene assays confirmed that miR-146a-3p could selectively target and inhibit the expression of VAV3, thereby promoting macrophage M2 polarization through the PI3K/AKT/mTOR pathway. Conclusion: Serum exosome-derived miR-146a-3p facilitated macrophage M2 polarization in AR by targeting VAV3 through the PI3K/AKT/mTOR pathway. These findings implied that miR-146a-3p and VAV3 could serve as potential targets for the development of novel therapeutic strategies in AR management.
MeSH term(s)	Humans ; MicroRNAs/genetics ; MicroRNAs/metabolism ; Phosphatidylinositol 3-Kinases/metabolism ; Proto-Oncogene Proteins c-akt/metabolism ; Exosomes/genetics ; Exosomes/metabolism ; Macrophages/metabolism ; Rhinitis, Allergic/pathology ; TOR Serine-Threonine Kinases/genetics ; TOR Serine-Threonine Kinases/metabolism ; Cytokines/metabolism ; Proto-Oncogene Proteins c-vav/metabolism
Chemical Substances	MicroRNAs ; Phosphatidylinositol 3-Kinases (EC 2.7.1.-) ; Proto-Oncogene Proteins c-akt (EC 2.7.11.1) ; TOR Serine-Threonine Kinases (EC 2.7.11.1) ; Cytokines ; VAV3 protein, human ; Proto-Oncogene Proteins c-vav
Language	English
Publishing date	2023-09-30
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2043785-7
ISSN	1878-1705 ; 1567-5769
ISSN (online)	1878-1705
ISSN	1567-5769
DOI	10.1016/j.intimp.2023.110997
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Article ; Online: Targeted delivery of inhalable drug particles in the tracheobronchial tree model of a pediatric patient with bronchopneumonia: A numerical study.

Wang, Jianwei / Zhang, Ya / Chen, Xiaole / Tao, Feng / Sun, Baobin / Xie, Jun / Chen, Jingguo

Respiratory physiology & neurobiology

2023 Volume 311, Page(s) 104024

Abstract: Pneumonia is a common cause of hospitalization and death in children worldwide. Inhalation therapy is one of the methods treating pneumonia However, there are limited studies that distinguish between the physiology of children and adults, especially with ...

Abstract	Pneumonia is a common cause of hospitalization and death in children worldwide. Inhalation therapy is one of the methods treating pneumonia However, there are limited studies that distinguish between the physiology of children and adults, especially with respect to targeted drug delivery. A tracheobronchial (TB) tree model of an 11-year-old child with bronchopneumonia is selected as a testbed for in silico trials of targeted drug delivery. The airflow and particle transport are solved by the computational fluid dynamics method at an airflow rate of 15 LPM. The results indicate that the distribution of deposited particles shows aggregation on the particle release map. Point-source aerosol release (PSAR) method can significantly reduce the deposition efficiency (DE) of particles in the TB tree model. Specifically, the PSAR method can reduce the DE of large particles (i.e., 7.5 µm and 10 µm) by 7.57% and 9.61%, respectively. This enables rapid design of patient-specific treatment for different population age groups and different airway diseases.
MeSH term(s)	Adult ; Child ; Humans ; Bronchopneumonia ; Pharmaceutical Preparations ; Respiratory Aerosols and Droplets ; Bronchi ; Lung ; Particle Size ; Computer Simulation ; Administration, Inhalation ; Models, Biological
Chemical Substances	Pharmaceutical Preparations
Language	English
Publishing date	2023-01-31
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2077867-3
ISSN	1878-1519 ; 1569-9048
ISSN (online)	1878-1519
ISSN	1569-9048
DOI	10.1016/j.resp.2023.104024
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Article: The effects of comorbidities on the change of taste and smell in COVID-19 patients.

Chen, Jingguo / Mi, Baibing / Yan, Miaojia / Wang, Yutong / Zhu, Kang / Yu, Chao / Zhang, Yanni / Koyama, Sachiko / Ren, Xiaoyong

Laryngoscope investigative otolaryngology

2023 Volume 8, Issue 1, Page(s) 25–33

Abstract: Background: Sudden chemosensory changes were considered an early predictor of COVID-19. Here, the effects of comorbidities on changes in taste and smell in COVID-19 patients were investigated based on a worldwide study.: Methods: Data analyzed here ... ...

Abstract	Background: Sudden chemosensory changes were considered an early predictor of COVID-19. Here, the effects of comorbidities on changes in taste and smell in COVID-19 patients were investigated based on a worldwide study. Methods: Data analyzed here were collected from the Global Consortium for Chemosensory Research (GCCR) core questionnaire, including questions regarding preexisting disease conditions. Overall, the final sample of 12,438 participants who were diagnosed with COVID-19 included patients with preexisting conditions. Mixed linear regression models were used to test our hypothesis, and the Results: A total of 61,067 participants completed the GCCR questionnaire, including 16,016 participants had preexisting diseases. The multivariate regression analysis showed that individuals with high blood pressure, lung disease, or sinus problems, or neurological diseases exhibited worse self-reported smell loss ( Conclusions: COVID-19 patients with high blood pressure, lung disease, or sinus problems, or neurological diseases exhibited worse self-reported smell loss, but no differences in the smell or taste recovery. COVID-19 patients with seasonal allergy/hay fever had greater loss of smell and taste, poorer smell and taste recovery. Level of evidence: 4.
Language	English
Publishing date	2023-01-20
Publishing country	United States
Document type	Journal Article
ISSN	2378-8038
ISSN	2378-8038
DOI	10.1002/lio2.1012
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Article: [The application of waterless empirical taste test（WETT

Zhao, Bingjie / Wang, Yutong / She, Ningning / Yuan, Yuqi / Zhang, Cui / Qin, Qing / Richard, L Doty / Ren, Xiaoyong / Chen, Jingguo

Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology, head, and neck surgery

2022 Volume 37, Issue 1, Page(s) 13–19

Abstract: Objective: ...

Abstract	Objective:
MeSH term(s)	Aged ; Middle Aged ; Male ; Humans ; Female ; Taste ; Healthy Volunteers ; East Asian People ; Taste Perception
Language	Chinese
Publishing date	2022-12-22
Publishing country	China
Document type	English Abstract ; Journal Article
ISSN	2096-7993
ISSN	2096-7993
DOI	10.13201/j.issn.2096-7993.2023.01.003
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Article: Multiple-Cytokine Profiling: A Novel Method for Early Prediction of the Efficacy of Sublingual Immunotherapy in Allergic Rhinitis Patients.

Zhang, Yanni / Zhu, Kang / Xia, Cui / Chen, Jingguo / Yu, Chao / Gao, Tianxi / Yan, Jing / Zhang, Huihui / Ren, Xiaoyong

Journal of inflammation research

2022 Volume 15, Page(s) 603–612

Abstract: Background: Allergic rhinitis (AR) is a common inflammatory airway disease, and allergen-specific immunotherapy (AIT) is the only disease-modifying treatment for it. However, not all AR patients respond to AIT, and early prediction of patient response ... ...

Abstract	Background: Allergic rhinitis (AR) is a common inflammatory airway disease, and allergen-specific immunotherapy (AIT) is the only disease-modifying treatment for it. However, not all AR patients respond to AIT, and early prediction of patient response is extremely important. This study aimed to example serum levels of multiple cytokines in AR and explore their association with the efficacy of AIT. Methods: A total of 74 AR patients treated with sublingual immunotherapy (SLIT) were prospectively recruited. Serum samples were obtained before the onset of SLIT and cytokine levels detected by multiplex analysis. All patients were followed for >1 year, and associations between cytokine levels and the early efficacy of SLIT were evaluated. Significantly distinctive cytokines were further verified in another independent cohort. Results: Sixty patients completed the visit schedule set: 35 patients were put into a responder group and 25 a nonresponder group. Multiple-cytokine profiling showed that cytokine levels differed significantly between the two groups. The responder group had higher concentrations of BAFF and CCL11 and lower levels of CCL2, CCL7, IFNγ, IL8, IL10, IL16, and IL33 than the nonresponder group ( Conclusion: Our data indicated that serum multiple-cytokine profiling was associated with response to SLIT and that IL10 and IL33 might serve as novel biomarkers for early prediction of efficacy and be involved in the therapeutic mechanisms of SLIT in AR patients.
Language	English
Publishing date	2022-01-27
Publishing country	New Zealand
Document type	Journal Article
ZDB-ID	2494878-0
ISSN	1178-7031
ISSN	1178-7031
DOI	10.2147/JIR.S350003
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Article ; Online: Predictive Values of Serum IL-33 and sST2 in Endotypes and Postoperative Recurrence of Chronic Rhinosinusitis with Nasal Polyps.

Zhang, Yanni / Zhu, Kang / Chen, Jingguo / Xia, Cui / Yu, Chao / Gao, Tianxi / Yan, Jing / Zhao, Bingjie / Ren, Xiaoyong

Mediators of inflammation

2022 Volume 2022, Page(s) 9155080

Abstract: Background: Chronic rhinosinusitis with nasal polyps (CRSwNP) is a common inflammatory disease with high heterogeneity and postoperative recidivation. The IL-33/ST2 axis is known to be involved in Th2 immune responses. This study is aimed at exploring ... ...

Abstract	Background: Chronic rhinosinusitis with nasal polyps (CRSwNP) is a common inflammatory disease with high heterogeneity and postoperative recidivation. The IL-33/ST2 axis is known to be involved in Th2 immune responses. This study is aimed at exploring levels of serum IL-33 and soluble ST2 (sST2) in CRSwNP patients and their potential for predicting CRSwNP endotypes and postoperative recurrence. Methods: The present study recruited 149 CRSwNP patients, 80 of whom were noneosinophilic (neCRSwNP) and 69 eosinophilic (eCRSwNP), as well as 60 healthy controls (HCs). Serum samples were collected from all participants, and sST2 and IL-33 concentrations were measured using ELISA. Multivariate analysis, receiver operating characteristic (ROC) curves, and Kaplan-Meier curves were used to evaluate the value of serum sST2 and IL-33 levels in distinguishing CRSwNP endotypes and predicting postoperative recurrence. Results: The levels of serum sST2 and IL-33 in CRSwNP patients were significantly higher than those in HCs, especially in the eCRSwNP group. Increased sST2 and IL-33 levels were associated with eosinophil counts and percentages in both tissue and blood. Multivariate regression and ROC curve analysis showed that serum sST2 and IL-33 exhibited potential for distinguishing CRSwNP endotypes, and the combination of serum IL-33 and sST2 showed even more predictive power. Finally, 124 CRSwNP patients completed the entire 3-year follow-up. Multivariate analysis and Kaplan-Meier curves showed that serum sST2 and IL-33 levels were associated with recurrence; serum sST2 and IL-33 each exhibited potential for predicting postoperative recurrence, and combining serum sST2 and IL-33 exhibited better accuracy and practicability. Conclusion: Our results suggested that serum sST2 and IL-33 levels were upregulated in CRSwNP patients and related to the degree of mucosal eosinophil infiltration and postoperative recurrence. Serum sST2 and IL-33 might serve as objective biomarkers for distinguishing phenotypes and predicting recurrence in CRSwNP, and their combined use outperformed either marker alone.
MeSH term(s)	Biomarkers/blood ; Chronic Disease ; Eosinophils/pathology ; Humans ; Interleukin-33/blood ; Nasal Polyps/blood ; Rhinitis/blood ; Rhinitis/surgery ; Sinusitis/blood ; Sinusitis/surgery
Chemical Substances	Biomarkers ; IL33 protein, human ; Interleukin-33
Language	English
Publishing date	2022-05-19
Publishing country	United States
Document type	Journal Article
ZDB-ID	1137605-3
ISSN	1466-1861 ; 0962-9351
ISSN (online)	1466-1861
ISSN	0962-9351
DOI	10.1155/2022/9155080
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Article: Comparison of Chinese and American subjects on the self-administered Waterless Empirical Taste Test.

Chen, Jingguo / Ren, Xiaoyong / Yan, Huanhuan / Zhao, Bingjie / Chen, Jingyan / Zhu, Kang / Lyu, Hui / Li, Zhihui / Doty, Richard L

Journal of sensory studies

2022 , Page(s) e12745

Abstract: Cultural differences have been reported between the taste sensitivity of persons of Asian and European ancestry, although findings have been mixed. This study sought to determine whether American and Chinese adults perform differently on a novel taste ... ...

Abstract	Cultural differences have been reported between the taste sensitivity of persons of Asian and European ancestry, although findings have been mixed. This study sought to determine whether American and Chinese adults perform differently on a novel taste test that requires no water, can be self-administered, and employs a representative of umami as one of its tastants. This 53-trial test was administered to 113 Chinese and 214 Americans. The subjects orally sampled monomer cellulose pads containing one of four dried concentrations of sucrose, citric acid, NaCl, caffeine, and monosodium glutamate and indicated whether a sweet, sour, bitter, salty, brothy, or no taste sensation was perceived. Separate gender by culture analyses of covariance with age as the covariate were performed on the total score and the scores of each taste stimulus. For all taste qualities, women outperformed men and test scores declined with age. No difference between American and Chinese subjects was found for the total taste score (
Language	English
Publishing date	2022-03-26
Publishing country	United States
Document type	Journal Article
ZDB-ID	55457-1
ISSN	1745-459X ; 0887-8250
ISSN (online)	1745-459X
ISSN	0887-8250
DOI	10.1111/joss.12745
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Article: Comparison of Chinese and American subjects on the self‐administered Waterless Empirical Taste Test

Chen, Jingguo / Ren, Xiaoyong / Yan, Huanhuan / Zhao, Bingjie / Chen, Jingyan / Zhu, Kang / Lyu, Hui / Li, Zhihui / Doty, Richard L.

Journal of sensory studies. 2022 Aug., v. 37, no. 4

2022

Abstract	Cultural differences have been reported between the taste sensitivity of persons of Asian and European ancestry, although findings have been mixed. This study sought to determine whether American and Chinese adults perform differently on a novel taste test that requires no water, can be self‐administered, and employs a representative of umami as one of its tastants. This 53‐trial test was administered to 113 Chinese and 214 Americans. The subjects orally sampled monomer cellulose pads containing one of four dried concentrations of sucrose, citric acid, NaCl, caffeine, and monosodium glutamate and indicated whether a sweet, sour, bitter, salty, brothy, or no taste sensation was perceived. Separate gender by culture analyses of covariance with age as the covariate were performed on the total score and the scores of each taste stimulus. For all taste qualities, women outperformed men and test scores declined with age. No difference between American and Chinese subjects was found for the total taste score (p = .129) or for the sucrose (p = .129) or NaCl (p = .368) scores. However, for monosodium glutamate, the scores were 28.40% higher for the Chinese than for the American subjects (p = .024), and for citric acid and caffeine, the scores were 24.12 and 21.79% higher for the American subjects (p's = .001 and .029). The basis for these differences is unclear, although both anatomical (e.g., differences in density or distribution of taste buds) and cultural factors may be involved. Future work is needed to determine the cause of these largely novel findings and whether they generalize to other Chinese and American samples. Practical applicationsIn this study, a practical self‐administered quantitative taste test that requires no water was found to be sensitive to quality‐specific differences in test scores between Chinese and American subjects, as well as to age and gender. The Chinese subjects outperformed the American subjects in correctly identifying the quality of monosodium glutamate (umami), whereas the American subjects outperformed Chinese subjects in correctly identifying the bitter and sour qualities of caffeine and citric acid, respectively. Experiential factors related to culture‐specific cuisines may explain some of these differences. This research indicates that a relatively rapid taste test, which can be sent through the mail and which requires no test administrator or source of water, can be used in cross‐cultural studies to elucidate individual differences in taste perception.
Keywords	ancestry ; caffeine ; cellulose ; citric acid ; gender ; monosodium glutamate ; sensory evaluation ; sucrose ; taste sensitivity ; umami
Language	English
Dates of publication	2022-08
Publishing place	John Wiley & Sons, Inc.
Document type	Article
Note	JOURNAL ARTICLE
ZDB-ID	55457-1
ISSN	1745-459X ; 0887-8250
ISSN (online)	1745-459X
ISSN	0887-8250
DOI	10.1111/joss.12745
Database	NAL-Catalogue (AGRICOLA)

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Article: [Analysis of influencing factors of excessive daytime sleepiness in adults with different degrees of sleep-disordered breathing].

Liu, Haiqin / Feng, Yani / Zhang, Yitong / Chen, Jingguo / Luo, Huanan / Hou, Jin / Ren, Xiaoyong

Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology, head, and neck surgery

2020 Volume 34, Issue 3, Page(s) 266–269

Abstract: Objective: ...

Abstract	Objective:
MeSH term(s)	Adult ; Humans ; Middle Aged ; Polysomnography ; Retrospective Studies ; Sleep Apnea Syndromes ; Sleep Apnea, Obstructive ; Snoring
Language	Chinese
Publishing date	2020-07-19
Publishing country	China
Document type	Journal Article
ISSN	2096-7993
ISSN	2096-7993
DOI	10.13201/j.issn.2096-7993.2020.03.020
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Article ; Online: Serum exosomal miR-146a-3p associates with disease severity and efficacy of sublingual immunotherapy in allergic rhinitis.

Zhang, Yanni / Zhu, Kang / Lv, Hui / Chen, Jingguo / Yu, Chao / Gao, Tianxi / Yan, Jing / Yang, Fangli / Fan, Lina / Ren, Xiaoyong / Xia, Cui

International immunopharmacology

2023 Volume 116, Page(s) 109777

Abstract: Background: Sublingual immunotherapy (SLIT) is an effective treatment for allergic rhinitis (AR), but its efficacy is variable among individuals. This study aimed to characterize serum exosome-derived microRNAs (miRNAs) and evaluate their abilities in ... ...

Abstract	Background: Sublingual immunotherapy (SLIT) is an effective treatment for allergic rhinitis (AR), but its efficacy is variable among individuals. This study aimed to characterize serum exosome-derived microRNAs (miRNAs) and evaluate their abilities in predicting the efficacy of SLIT in AR. Methods: RNA sequencing was performed to explore differentially expressed exosomal miRNAs in serum exosomes between AR patients and healthy controls (HCs). Sequencing analysis results were verified in an independent cohort, and the correlations between the levels of exosome-derived miRNAs and disease severity were evaluated. The most promising miRNAs were further tested in two AR cohorts treated with SLIT to assess their abilities in predicting short and long-term efficacy, respectively. Results: The exosome-derived miRNAs profiling in the AR group was significantly different from the HC group, and differentially expressed genes were enriched and clustered in pathways such as PI3K-Akt and ErbB signalling pathways. The top three most significant miRNAs were verified by reverse transcription-polymerase chain reaction (qRT-PCR), and results showed that miR-146a-3p levels were significantly elevated in the AR group and correlated with the total and specific gE levels, the visual analogue scale of the total nasal symptom score (all p < 0.05). Further data in the first validation cohort suggested that miR-146a-3p levels were significantly downregulated in the effective group, and logistic regression showed that miR-146a-3p levels were associated with the short-term efficacy of SLIT(p < 0.05). The receiver operating characteristic (ROC) curve showed that miR-146a-3p could early predict SLIT efficacy (AUC = 0.669, p = 0.047). In the second validation cohort, miR-146a-3p levels were also decreased in the effective group and the ROC curve further confirmed its reliable accuracy in predicting the long-term efficacy of SLIT in AR patients (AUC = 0.749, p < 0.001). Conclusion: Serum exosome-derived miRNAs may be involved in the development of AR and associated with its disease severity. Serum exosome-derived miR-146a-3p seems to be a novel biomarker for predicting the short and long-term efficacies of SLIT in AR patients.
MeSH term(s)	Humans ; Phosphatidylinositol 3-Kinases ; Sublingual Immunotherapy ; MicroRNAs/metabolism ; Rhinitis, Allergic/genetics ; Rhinitis, Allergic/therapy ; Patient Acuity
Chemical Substances	Phosphatidylinositol 3-Kinases (EC 2.7.1.-) ; MicroRNAs
Language	English
Publishing date	2023-01-28
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2043785-7
ISSN	1878-1705 ; 1567-5769
ISSN (online)	1878-1705
ISSN	1567-5769
DOI	10.1016/j.intimp.2023.109777
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