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Article ; Online: Vaccination status of non-national immunization program vaccines in Changning District of Shanghai 2016‒2020

CHEN Jinyan / PANG Hong

Shanghai yufang yixue, Vol 35, Iss 8, Pp 768-

2023 Volume 772

Abstract: ObjectiveTo understand the vaccination situation of non-national immunization program （non-NIP） vaccines in Changning District， and to provide evidence for further strengthening the management of vaccination services and guiding community health service ... ...

Abstract	ObjectiveTo understand the vaccination situation of non-national immunization program （non-NIP） vaccines in Changning District， and to provide evidence for further strengthening the management of vaccination services and guiding community health service centers to construct vaccination clinics for children and adults.MethodsNumber of non-NIP vaccine doses in community health service centers， Changning District， was collected from Shanghai Immunization Information System from 2016 to 2020. Descriptive epidemiological analysis was conducted.ResultsIn 2020， the overall number of non-NIP vaccine doses， proportion of non-NIP vaccine doses and average number of non-NIP vaccine doses in the community health service centers， Changning District， reached up to 115 361 doses， 63.41% and 1 664.54 per 10 000 persons， respectively. Furthermore， the proportion of non-NIP vaccine doses showed a significantly upward trend （χtrend2=131.110， P<0.01）. The number of non-NIP vaccine doses increased mostly in adults aged >18 years. Human papillomavirus vaccines （HPV） and influenza vaccines （InfV） had the highest increase in vaccine doses. Additionally， non-NIP vaccination peaked from September to December in adults.ConclusionAlong with the number of non-NIP vaccine doses increase， it is necessary to strengthen the management of non-NIP vaccination and explore effective measures for construction of adult vaccination clinics to meet the public demand for vaccination.
Keywords	non-nip vaccine ; vaccination ; vaccination doses ; children ; adults ; vaccination clinics ; Medicine ; R
Language	Chinese
Publishing date	2023-08-01T00:00:00Z
Publisher	Shanghai Preventive Medicine Association
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Disrupting the gut microbiota/metabolites axis by Di-(2-ethylhexyl) phthalate drives intestinal inflammation via AhR/NF-κB pathway in mice.

Cheng, Xinyi / Chen, Jinyan / Guo, Xiaoquan / Cao, Huabin / Zhang, Caiying / Hu, Guoliang / Zhuang, Yu

Environmental pollution (Barking, Essex : 1987)

2024 Volume 343, Page(s) 123232

Abstract: Di-(2-ethylhexyl) phthalate (DEHP) is a widely used plasticizer known for its environmental endocrine-disrupting properties, posing potential risks to various organs. However, the precise impact of DEHP on intestinal health and its contribution to the ... ...

Abstract	Di-(2-ethylhexyl) phthalate (DEHP) is a widely used plasticizer known for its environmental endocrine-disrupting properties, posing potential risks to various organs. However, the precise impact of DEHP on intestinal health and its contribution to the initiation of intestinal inflammation remains elucidated. This study aims to investigate the underlying mechanisms of DEHP-induced intestinal inflammation in mice, specifically focusing on the complex interplay between the gut microbiota-metabolite axis and associated pathophysiological alterations. Our findings showed that DEHP-induced damage of multiple organs systemically, as indicated by abnormal liver and kidney biochemical markers, along with a disrupted ileum morphology. Additionally, DEHP exposure disrupted gut barrier function, causing intestinal inflammation characterized by bacterial translocation and alterations in defense and inflammation-related gene expressions. Moreover, 16S rRNA analysis suggested that DEHP-induced gut microbial remodeling is characterized by an upregulation of detrimental bacteria (Erysipelotrichaceae) and a downregulation of beneficial bacteria (Muribaculaceae, Ruminococcaceae, and Lachnospiraceae). Metabolomics analysis revealed DEHP perturbed gut metabolic homeostasis, particularly affecting the degradation of aromatic compounds, which generated an aberrant activation of the AhR and NF-κB, subsequently causing intestinal inflammation. Consequently, our results elucidate the mechanistic link between disrupted gut microbiota and metabolome and the initiation of DEHP-induced intestinal inflammation, mediated through the AhR/NF-κB signaling pathway.
MeSH term(s)	Mice ; Animals ; Diethylhexyl Phthalate/toxicity ; Diethylhexyl Phthalate/metabolism ; NF-kappa B/metabolism ; Gastrointestinal Microbiome ; RNA, Ribosomal, 16S ; Inflammation/chemically induced ; Phthalic Acids
Chemical Substances	phthalic acid (6O7F7IX66E) ; Diethylhexyl Phthalate (C42K0PH13C) ; NF-kappa B ; RNA, Ribosomal, 16S ; Phthalic Acids
Language	English
Publishing date	2024-01-01
Publishing country	England
Document type	Journal Article
ZDB-ID	280652-6
ISSN	1873-6424 ; 0013-9327 ; 0269-7491
ISSN (online)	1873-6424
ISSN	0013-9327 ; 0269-7491
DOI	10.1016/j.envpol.2023.123232
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Article: Design of a Magnetically Anchored Laparoscope Using Miniature Ultrasonic Motors.

Li, Jingwu / Sun, Zhijun / Yan, He / Chen, Jinyan

Micromachines

2022 Volume 13, Issue 6

Abstract: Images taken by an endoscope in single-port-access surgery are the most important information for directing surgeons to operate, so acquiring images taken at better position and a more desired perspective has profound significance for improving the ... ...

Abstract	Images taken by an endoscope in single-port-access surgery are the most important information for directing surgeons to operate, so acquiring images taken at better position and a more desired perspective has profound significance for improving the efficiency and safety of surgery. The magnetically anchored laparoscope can help to realize this goal compared with the traditional laparoscope used in single-port-access surgery. In this paper, we propose the concept of applying ultrasonic motors in the magnetically anchored laparoscope. Two types of ultrasonic motors used for driving the laparoscope, namely a miniature traveling wave-rotating ultrasonic motor and a miniature traveling wave-tilt ultrasonic motor, are designed. The prototype of the magnetically anchored laparoscope using these two types of ultrasonic motors is fabricated and evaluated by experiments. The results show that the maximum output torque of the miniature traveling wave-rotating ultrasonic motor is 1.2 mN·m, and that of the miniature traveling wave-tilt ultrasonic motor is 1.4 mN·m, which is enough to actuate the magnetically anchored laparoscope. Additionally, it is proven that the two designed ultrasonic motors can be applied successfully in the laparoscope.
Language	English
Publishing date	2022-05-30
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2620864-7
ISSN	2072-666X
ISSN	2072-666X
DOI	10.3390/mi13060855
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Article ; Online: A cable-driven highly compact single port laparoscopic surgical robot with sequentially inserted arms.

Yang, Jianlin / Sun, Zhijun / Chen, Jinyan / Guo, Yu

The international journal of medical robotics + computer assisted surgery : MRCAS

2022 Volume 19, Issue 2, Page(s) e2480

Abstract: Background: The single port surgical robot causes only one incision and brings many benefits to patients. It is very challenging to design a single port surgical robot that causes a smaller incision than current products.: Methods: This paper ... ...

Abstract	Background: The single port surgical robot causes only one incision and brings many benefits to patients. It is very challenging to design a single port surgical robot that causes a smaller incision than current products. Methods: This paper presents a highly compact single port laparoscopy surgical robot, which makes full use of the space of the port and only needs a 15 mm-diameter port. The robot is composed of a camera manipulator and two operating manipulators. The non-fully cylindrical manipulators enter the port sequentially, and the equivalent diameter of each operating manipulator is 12 mm. An additional 9 mm-diameter channel is left for other surgical tools to pass through after all manipulators entering the port. Results: The kinematics model of the robot is established, including detailed forward kinematics model and inverse kinematics solution based on geometric iteration method. The teleoperation experiment shows that the manipulator can complete the object-grasping, object-transfer and weight-lifting tasks. Conclusions: The proposed single port surgical robot design concept can also be extended to the field of natural orifice transluminal endoscopic surgical robots.
MeSH term(s)	Humans ; Robotics ; Equipment Design ; Laparoscopy ; Biomechanical Phenomena
Language	English
Publishing date	2022-11-25
Publishing country	England
Document type	Journal Article
ZDB-ID	2151860-9
ISSN	1478-596X ; 1478-5951
ISSN (online)	1478-596X
ISSN	1478-5951
DOI	10.1002/rcs.2480
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Article ; Online: Prognosis and Efficacy of Laparoscopic Surgery on Patients with Endometrial Carcinoma: Systematic Evaluation and Meta-Analysis.

Ma, Jiong / Zhou, Chunxia / Chen, Jinyan / Chen, Xuejun

Computational and mathematical methods in medicine

2022 Volume 2022, Page(s) 9384134

Abstract: Objective: The prognosis and efficacy of laparoscopic surgery (LPS) and open surgery or robotic surgery (RS) on endometrial carcinoma (EC) patients were compared.: Methods: Data as of May 2021 were retrieved from databases like PubMed, Embase, ... ...

Abstract	Objective: The prognosis and efficacy of laparoscopic surgery (LPS) and open surgery or robotic surgery (RS) on endometrial carcinoma (EC) patients were compared. Methods: Data as of May 2021 were retrieved from databases like PubMed, Embase, Cochrane Library, and Web of Science. The study involved randomized controlled trials (RCTs), cohort studies, or case-control studies for comparing the effects of LPS and open surgery or robotic surgery (RS) on EC treatment. The primary outcomes included duration of operation, blood loss, length of stay (LOS), postoperative complications, and recurrence rate. Secondary outcomes included 3-year progression-free survival (PFS) rate/disease-free survival (DFS) rate and 3-year overall survival (OS) rate. Results: A total of 24 studies were involved, and all of them were cohort studies except 1 RCT and 1 case-control study. There was no significant difference in duration of operation between LPS and open surgery (MD = -0.06, 95% CI: -0.37 to 0.25) or RS (MD = -0.15, 95% CI: -1.27 to 0.96). In comparison with the open surgery, LPS remarkably reduced blood loss (MD = -0.43, 95% CI: -0.58 to -0.29), LOS (MD = -0.71, 95% CI: -0.92 to -0.50), and the complication occurrence rate (RR = 0.83, 95% CI: 0.73 to 0.95). However, LPS and RS saw no difference in blood loss (MD = 0.01, 95% CI: -0.77 to 0.79). Besides, in comparison with RS, LPS prominently shortened the LOS (MD = 0.26, 95% CI: 0.12 to 0.40) but increased the complication occurrence rate (RR = 1.74, 95% CI: 1.57 to 1.92). In contrast to open surgery or RS, LPS saw no difference in occurrence rate (RR = 0.75, 95% CI: 0.56 to 1.01; RR = 0.97, 95% CI: 0.62 to 1.53), 3-year PFS/DFS (RR = 0.99, 95% CI: 0.90 to 1.09; RR = 1.30, 95% CI: 0.87 to 1.96), and 3-year OS (RR = 0.97, 95% CI: 0.91 to 1.04; RR = 1.21, 95% CI: 0.91 to 1.60). Conclusion: In sum, LPS was better than open surgery, which manifested in the aspects of less blood loss, shorter LOS, and fewer complications. LPS, therefore, was the most suitable option for EC patients. Nevertheless, LPS had no advantage over RS, and sufficient prospective RCTs are needed to further confirm its strengths.
MeSH term(s)	Disease-Free Survival ; Endometrial Neoplasms/surgery ; Female ; Humans ; Laparoscopy ; Lipopolysaccharides ; Robotic Surgical Procedures/adverse effects
Chemical Substances	Lipopolysaccharides
Language	English
Publishing date	2022-09-22
Publishing country	United States
Document type	Journal Article ; Meta-Analysis
ZDB-ID	2252430-7
ISSN	1748-6718 ; 1748-670X ; 1027-3662
ISSN (online)	1748-6718
ISSN	1748-670X ; 1027-3662
DOI	10.1155/2022/9384134
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Article ; Online: Gait correlation analysis based human identification.

Chen, Jinyan

TheScientificWorldJournal

2014 Volume 2014, Page(s) 168275

Abstract: Human gait identification aims to identify people by a sequence of walking images. Comparing with fingerprint or iris based identification, the most important advantage of gait identification is that it can be done at a distance. In this paper, ... ...

Abstract	Human gait identification aims to identify people by a sequence of walking images. Comparing with fingerprint or iris based identification, the most important advantage of gait identification is that it can be done at a distance. In this paper, silhouette correlation analysis based human identification approach is proposed. By background subtracting algorithm, the moving silhouette figure can be extracted from the walking images sequence. Every pixel in the silhouette has three dimensions: horizontal axis (x), vertical axis (y), and temporal axis (t). By moving every pixel in the silhouette image along these three dimensions, we can get a new silhouette. The correlation result between the original silhouette and the new one can be used as the raw feature of human gait. Discrete Fourier transform is used to extract features from this correlation result. Then, these features are normalized to minimize the affection of noise. Primary component analysis method is used to reduce the features' dimensions. Experiment based on CASIA database shows that this method has an encouraging recognition performance.
MeSH term(s)	Algorithms ; Biometric Identification/methods ; Gait ; Humans
Language	English
Publishing date	2014-01-29
Publishing country	United States
Document type	Journal Article
ZDB-ID	2075968-X
ISSN	1537-744X ; 1537-744X
ISSN (online)	1537-744X
ISSN	1537-744X
DOI	10.1155/2014/168275
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Article ; Online: Design of an array of piezoresistive airflow sensors based on pressure loading mode for simultaneous detection of airflow velocity and direction.

Chen, Jinyan / Liu, Pengzhan / Hu, Jie / Yang, Jianlin / Chen, Chao

The Review of scientific instruments

2022 Volume 93, Issue 2, Page(s) 25001

Abstract: As an irreplaceable element for obtaining airflow information in many engineering scenarios, airflow sensors have gained increasing attention across the fields of aerospace engineering, environmental engineering, sustainable energy exploitation, ... ...

Abstract	As an irreplaceable element for obtaining airflow information in many engineering scenarios, airflow sensors have gained increasing attention across the fields of aerospace engineering, environmental engineering, sustainable energy exploitation, meteorology research, and so on. As one of the mainstream airflow sensing principles, piezoresistive airflow velocity sensors have experienced rapid growth over the years, while effective vector airflow sensors with the ability of detecting both airflow velocity and direction based on the piezoresistive principle are scarce. Here, on the basis of our developed piezoresistive airflow velocity sensors based on pressure loading mode, we design an array of these sensors and propose a corresponding explicit algorithm for simultaneous detection of airflow velocity and direction. This sensor array configuration enables an automatic recognition function of the quadrant of incoming airflow, which can significantly simplify the reverse calculation of airflow information compared with conventional vector airflow sensors. The experimental results demonstrate the decent performance of this sensor array for identifying both airflow velocity and direction. This study not only fills the gap between our developed airflow velocity sensor and the ability of detecting airflow direction but also presents a simple and universal array-based strategy for vector airflow sensing, which could be widely applied in airflow sensors based on other principles.
MeSH term(s)	Air Movements ; Wearable Electronic Devices
Language	English
Publishing date	2022-03-01
Publishing country	United States
Document type	Journal Article
ZDB-ID	209865-9
ISSN	1089-7623 ; 0034-6748
ISSN (online)	1089-7623
ISSN	0034-6748
DOI	10.1063/5.0073669
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Article ; Online: Curcumin alleviates atrazine-induced cardiotoxicity by inhibiting endoplasmic reticulum stress-mediated apoptosis in mice through ATF6/Chop/Bcl-2 signaling pathway.

Liang, Jiahua / Chen, Jinyan / Yang, Lingling / Wu, Dan / Xiong, Lijuan / Guo, Xiaoquan / Cao, Huabin / Zhang, Caiying / Hu, Guoliang / Zhuang, Yu

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

2024 Volume 171, Page(s) 116205

Abstract: Atrazine (ATR), a water-soluble herbicide commonly used to control broad-leaf and monocotyledonous weeds, presents a significant risk to environmental soil and water quality. Exposure to ATR adversely affects human and animal health, frequently resulting ...

Abstract	Atrazine (ATR), a water-soluble herbicide commonly used to control broad-leaf and monocotyledonous weeds, presents a significant risk to environmental soil and water quality. Exposure to ATR adversely affects human and animal health, frequently resulting in cardiac impairment. Curcumin (Cur), an acidic polyphenol derivative from plants acclaimed for its pronounced anti-inflammatory and antioxidant properties, has garnered interest as a potential therapeutic agent. However, whether it has the potential to ameliorate ATR-induced cardiac toxicity via modulation of endoplasmic reticulum stress (ERS) and apoptosis pathways in mice remains unclear. Our results showed that Cur supplementation attenuates ATR-induced cardiotoxicity, evidenced by decrease in creatine kinase and lactate dehydrogenase, key biochemical markers of myocardial injury, which have a more significant protecting effect in high-dose ATR induced injury. Histopathological and electron microscopy examinations further solidified these findings, demonstrating an amelioration in organellar damage, particularly in endoplasmic reticulum swelling and subsequent mitochondrial impairment. Additionally, ATR exposure augments ERS and triggers apoptotic pathways, as indicated by the upregulation of ERS-related gene expression (ATF6, CHOP, IRE1, GRP78) and pro-apoptotic markers (BAX, BAK1, Caspase3, Caspase. Intriguingly, Cur counteracts this detrimental response, significantly reducing ERS and pro-apoptotic signals at both transcriptional and translational levels. Collectively, our findings illuminate Cur's cardioprotective effect against ATR-induced injury, primarily through its anti-ERS and anti-apoptotic activities, underscoring Cur's potential as a therapeutic for ATR-induced cardiotoxicity.
MeSH term(s)	Humans ; Mice ; Animals ; Atrazine ; Cardiotoxicity/metabolism ; Curcumin/pharmacology ; Apoptosis ; Endoplasmic Reticulum Stress ; Signal Transduction ; Activating Transcription Factor 6/metabolism
Chemical Substances	Atrazine (QJA9M5H4IM) ; Curcumin (IT942ZTH98) ; ATF6 protein, human ; Activating Transcription Factor 6
Language	English
Publishing date	2024-01-29
Publishing country	France
Document type	Journal Article
ZDB-ID	392415-4
ISSN	1950-6007 ; 0753-3322 ; 0300-0893
ISSN (online)	1950-6007
ISSN	0753-3322 ; 0300-0893
DOI	10.1016/j.biopha.2024.116205
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Article ; Online: TRPV1 modulated NLRP3 inflammasome activation via calcium in experimental subarachnoid hemorrhage.

Zhang, Keke / Qin, Zhen / Chen, Jinyan / Guo, Gengyin / Jiang, Xiaokun / Wang, Feng / Zhuang, Jianfeng / Zhang, Zhen

Aging

2024 Volume 16, Issue 2, Page(s) 1096–1110

Abstract: Neuroinflammation plays a key role in early brain injury (EBI) of subarachnoid hemorrhage (SAH), and NLRP3 inflammasome plays an important role in the development of neuroinflammation after SAH, but the mechanism of NLRP3 inflammasome activation after ... ...

Abstract	Neuroinflammation plays a key role in early brain injury (EBI) of subarachnoid hemorrhage (SAH), and NLRP3 inflammasome plays an important role in the development of neuroinflammation after SAH, but the mechanism of NLRP3 inflammasome activation after SAH is still unclear. TRPV1 is a non-selective calcium channel that is involved in the pathology of neuroinflammation, but its role in SAH has not been revealed. Our study showed that TRPV1 was significantly upregulated after SAH and was predominantly expressed in microglia/macrophages. Antagonism of TRPV1 was effective in ameliorating neurological impairment, brain edema, neuronal damage, and reducing the inflammatory response (evidenced by reducing the number of CD16/32 positive microglia/macrophages, inhibiting the expression of CD16, CD32, CD86, IL-1b, TNF-a and blocking NLRP3 inflammasome activation). However, this effect can be abolished by NLRP3 inflammasome antagonist MCC950.
MeSH term(s)	Animals ; Brain Injuries/drug therapy ; Calcium/therapeutic use ; Calcium, Dietary/therapeutic use ; Inflammasomes/metabolism ; Neuroinflammatory Diseases ; NLR Family, Pyrin Domain-Containing 3 Protein/metabolism ; Rats, Sprague-Dawley ; Subarachnoid Hemorrhage/pathology ; Mice ; Rats
Chemical Substances	Calcium (SY7Q814VUP) ; Calcium, Dietary ; Inflammasomes ; NLR Family, Pyrin Domain-Containing 3 Protein
Language	English
Publishing date	2024-01-04
Publishing country	United States
Document type	Journal Article
ISSN	1945-4589
ISSN (online)	1945-4589
DOI	10.18632/aging.205379
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Article: Sodium Butyrate Alleviates Free Fatty Acid-Induced Steatosis in Primary Chicken Hepatocytes via Regulating the ROS/GPX4/Ferroptosis Pathway.

Cheng, Xinyi / Hu, Yang / Yu, Xiaoqing / Chen, Jinyan / Guo, Xiaoquan / Cao, Huabin / Hu, Guoliang / Zhuang, Yu

Antioxidants (Basel, Switzerland)

2024 Volume 13, Issue 2

Abstract: Fatty liver hemorrhagic syndrome (FLHS) in laying hens is a nutritional metabolic disease commonly observed in high-yielding laying hens. Sodium butyrate (NaB) and ferroptosis were reported to contribute to the pathogenesis of fatty liver-related ... ...

Abstract	Fatty liver hemorrhagic syndrome (FLHS) in laying hens is a nutritional metabolic disease commonly observed in high-yielding laying hens. Sodium butyrate (NaB) and ferroptosis were reported to contribute to the pathogenesis of fatty liver-related diseases. However, the underlying mechanism of NaB in FLHS and whether it mediates ferroptosis remains unclear. A chicken primary hepatocyte induced by free fatty acids (FFAs, keeping the ratio of sodium oleate and sodium palmitate concentrations at 2:1) was established, which received treatments with NaB, the ferroptosis inducer RAS-selective lethal 3 (RSL3), and the inhibitor ferrostatin-1 (Fer-1). As a result, NaB increased biochemical and lipid metabolism indices, and the antioxidant level, while inhibiting intracellular ROS accumulation and the activation of the ferroptosis signaling pathway, as evidenced by a reduction in intracellular iron concentration, upregulated GPX4 and xCT expression, and inhibited NCOA4 and ACSL4 expression. Furthermore, treatment with Fer-1 reinforced the protective effects of NaB, while RSL3 reversed it by blocking the ROS/GPX4/ferroptosis pathway, leading to the accumulation of lipid droplets and oxidative stress. Collectively, our findings demonstrated that NaB protects hepatocytes by regulating the ROS/GPX4-mediated ferroptosis pathway, providing a new strategy and target for the treatment of FLHS.
Language	English
Publishing date	2024-01-23
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2704216-9
ISSN	2076-3921
ISSN	2076-3921
DOI	10.3390/antiox13020140
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