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  1. Article: Online flipped learning methods for teaching hospitality skills and management practices in an epidemic situation: A study on learning attitude and effectiveness.

    Chen, Kuo-Wei / Wang, Ze-Yung

    Frontiers in psychology

    2023  Volume 13, Page(s) 915992

    Abstract: Starting in 2019, the ongoing COVID-19 pandemic has lasted 3 years and will likely continue to affect the lives of people all over the world. According to a United Nations Educational, Scientific and Cultural Organization (UNESCO) survey, more than 91% ... ...

    Abstract Starting in 2019, the ongoing COVID-19 pandemic has lasted 3 years and will likely continue to affect the lives of people all over the world. According to a United Nations Educational, Scientific and Cultural Organization (UNESCO) survey, more than 91% of students from all over the world have been affected by the spread of COVID-19. The application of technological networks can help solve problems related to being unable to attend school in person, as online teaching can effectively help reduce learning loss in the short term. In Taiwan, the higher education system has been using online learning, but now faces a new and huge crisis, as some courses do not readily translate to this setting. In professional courses run by hospitality departments, it is essentially impossible to accurately convey the practical skills required, for example, aspects of color, aroma, and taste through online teaching. Moreover, the learning level of each student varies greatly. During the online teaching process, instructors teach professional skills and movements through a single teaching video, which may not meet the needs of all students. In response, this study explores using the flipped teaching method, to not only enable students to master and control their learning and effectively adjust their self- adaptive learning progress but also to help teachers solve problems and impart professional skills using a two-way, interactive, online teaching method. This approach, flipping a class in an online learning environment, could effectively make up for the one-way teaching sometimes created by video content, and address the problem of gaps in learning professional practical skills. It can also induce students with poor learning attitudes to actively participate in learning. This study involved 55 bachelor students from a university of science and technology in Taiwan. The research results are as follows: (1) Students who participated in the flipped teaching mode, which involved two-way interaction showed better professional understanding of the course and improved willingness to learn, thereby improving the learning effect. (2) Awareness of these poor practical catering professional skills in students, assisted in laying the professional foundation for students to gradually improve their learning attitude and their advanced skills. This indicates that students with poor academic performance in an online environment might benefit from two-way interactive teaching. Teachers should clarify detailed descriptions of professional practical actions that confuse students. (3) In flipped learning, the grouping of "game/toy-based e-learning" can not only improve the performance of students who actively study to achieve good grades but also help and motivate other students to learn together. These results indicate that in flipped classrooms that use an online learning environment, the active learning and learning attitudes of students were positive and that their interest in learning and learning efficiency was also significantly improved. At the same time, this approach stimulated the innovation, creativity, and creative development of students in using professional technology in the hospitality industry. It transformed the passive learning situation of online one-way teaching into an active two-way teaching environment.
    Language English
    Publishing date 2023-01-18
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2563826-9
    ISSN 1664-1078
    ISSN 1664-1078
    DOI 10.3389/fpsyg.2022.915992
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: A Study on Flipped Learning Concerning Learning Motivation and Learning Attitude in Language Learning.

    Chou, Chi-Pu / Chen, Kuo-Wei / Hung, Chia-Jen

    Frontiers in psychology

    2021  Volume 12, Page(s) 753463

    Abstract: From the popularity of flipped teaching in United States primary and high schools, it is thought that students have more learning control to adjust to the learning progress and are assisted in problem solving and learning guidance during class period. It ...

    Abstract From the popularity of flipped teaching in United States primary and high schools, it is thought that students have more learning control to adjust to the learning progress and are assisted in problem solving and learning guidance during class period. It is believed that flipped teaching could prompt underachieving learners' active learning and thereby enhance learning effectiveness. A total of 386 high school students in Chungli, Taiwan, were part of an experimental study and the research results are summarized below: (1) Students who participated in the flipped teaching models demonstrated better comprehension levels with the teaching content due to this change in learning style and attitude, which in turn, enhanced learning effectiveness. (2) To eliminate poor language performance of underachieving students, it is necessary to lay solid foundations to gradually enhance language learning effectiveness regarding this particular group of students. Films suitable for students' individual ability could be combined with new language learned in the unit to genuinely assist underachieving learners' language learning effectiveness. (3) For students who care about their performance, a "system of play" style grouping should be determined in order to enable the tracking of group performance and term performance. According to the results, further developments regarding active learning ability, boosts in learning interests, enhanced learning effectiveness, and the prompting of creativity resulting in a shift from passive learner to active learner have been proposed.
    Language English
    Publishing date 2021-09-22
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2563826-9
    ISSN 1664-1078
    ISSN 1664-1078
    DOI 10.3389/fpsyg.2021.753463
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Recombinant soluble form of receptor for advanced glycation end products ameliorates microcirculation impairment and neuroinflammation after subarachnoid hemorrhage.

    Yang, Ling-Yu / Tang, Sung-Chun / Lee, Jing-Er / Chen, Yong-Ren / Chen, Yi-Tzu / Chen, Kuo-Wei / Hsieh, Sung-Tsang / Wang, Kuo-Chuan

    Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics

    2024  Volume 21, Issue 2, Page(s) e00312

    Abstract: Impaired cerebral microcirculation after subarachnoid hemorrhage (SAH) has been shown to be related to delayed ischemic neurological deficits (DIND). We previously demonstrated the involvement of the receptor for advanced glycation end products (RAGE) in ...

    Abstract Impaired cerebral microcirculation after subarachnoid hemorrhage (SAH) has been shown to be related to delayed ischemic neurological deficits (DIND). We previously demonstrated the involvement of the receptor for advanced glycation end products (RAGE) in the pathogenesis of SAH related neuronal death. In the present study, we aimed to investigate the therapeutic effects of a recombinant soluble form of RAGE (sRAGE) on microcirculation impairment following SAH. Intrathecal injection of autologous blood in rats, mixed primary astrocyte and microglia cultures exposed to hemolysates and endothelial cells ​(ECs) from human brain microvascular exposed to glia-conditioned medium or SAH patient's CSF were used as experimental SAH models in vivo and in vitro. The results indicated that intrathecal administration of recombinant sRAGE significantly ameliorated the vasoconstriction of cortical arterioles and associated perfusion impairment, brain edema, reduced cell death, endothelial dysfunction, and improved motor performance at 24 and 48 ​h after SAH induction in rats. The in vitro results further showed that recombinant sRAGE significantly reduced astrocyte swelling and microglia activation, in parallel with decreased mRNA expression levels of pro-inflammatory cytokines including interleukin-6 (IL-6) and interleukin-1β (IL-1β) in vitro. Moreover, the in vitro model of SAH-induced p-eNOS and eNOS suppression, along with stress fiber formation in brain microvascular ECs, was effectively reversed by sRAGE treatment and led to a decrease in cleaved-caspase 3 expression. In summary, recombinant sRAGE effectively lessened microcirculation impairment and vascular injury after SAH via the mechanism of anti-inflammation, which may provide a potential therapeutic strategy for SAH.
    MeSH term(s) Rats ; Humans ; Animals ; Receptor for Advanced Glycation End Products/metabolism ; Subarachnoid Hemorrhage/complications ; Subarachnoid Hemorrhage/drug therapy ; Subarachnoid Hemorrhage/metabolism ; Rats, Sprague-Dawley ; Neuroinflammatory Diseases ; Microcirculation ; Endothelial Cells/metabolism ; Endothelial Cells/pathology
    Chemical Substances Receptor for Advanced Glycation End Products
    Language English
    Publishing date 2024-01-04
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2316693-9
    ISSN 1878-7479 ; 1933-7213
    ISSN (online) 1878-7479
    ISSN 1933-7213
    DOI 10.1016/j.neurot.2023.e00312
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Nanoparticles for Augmenting Therapeutic Potential and Alleviating the Effect of Di(2-ethylhexyl) Phthalate on Gastric Cancer.

    Huang, Hau-Lun / Chen, Kuo-Wei / Liao, Hsiao-Wei / Wang, Ling-Yu / Peng, Shin-Lei / Lai, Chih-Ho / Lin, Yu-Hsin

    ACS applied materials & interfaces

    2024  Volume 16, Issue 15, Page(s) 18285–18299

    Abstract: Changes in diet culture and modern lifestyle contributed to a higher incidence of gastrointestinal-related diseases, including gastritis, implicated in the pathogenesis of gastric cancer. This observation raised concerns regarding exposure to di(2- ... ...

    Abstract Changes in diet culture and modern lifestyle contributed to a higher incidence of gastrointestinal-related diseases, including gastritis, implicated in the pathogenesis of gastric cancer. This observation raised concerns regarding exposure to di(2-ethylhexyl) phthalate (DEHP), which is linked to adverse health effects, including reproductive and developmental problems, inflammatory response, and invasive adenocarcinoma. Research on the direct link between DEHP and gastric cancer is ongoing, and further studies are required to establish a conclusive association. In our study, extremely low concentrations of DEHP exerted significant effects on cell migration by promoting the epithelial-mesenchymal transition in gastric cancer cells. This effect was mediated by the modulation of the PI3K/AKT/mTOR and Smad2 signaling pathways. To address the DEHP challenges, our initial design of TPGS-conjugated fucoidan, delivered via pH-responsive nanoparticles, successfully demonstrated binding to the P-selectin protein. This achievement has not only enhanced the antigastric tumor efficacy but has also led to a significant reduction in the expression of malignant proteins associated with the condition. These findings underscore the promising clinical therapeutic potential of our approach.
    MeSH term(s) Humans ; Diethylhexyl Phthalate ; Plasticizers ; Stomach Neoplasms ; Phosphatidylinositol 3-Kinases ; Phthalic Acids
    Chemical Substances phthalic acid (6O7F7IX66E) ; Diethylhexyl Phthalate (C42K0PH13C) ; Plasticizers ; Phosphatidylinositol 3-Kinases (EC 2.7.1.-) ; Phthalic Acids
    Language English
    Publishing date 2024-04-04
    Publishing country United States
    Document type Journal Article
    ISSN 1944-8252
    ISSN (online) 1944-8252
    DOI 10.1021/acsami.3c15976
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Book ; Online: Screentone-Aware Manga Super-Resolution Using DeepLearning

    Yao, Chih-Yuan / Chou, Husan-Ting / Lin, Yu-Sheng / Chen, Kuo-wei

    2023  

    Abstract: Manga, as a widely beloved form of entertainment around the world, have shifted from paper to electronic screens with the proliferation of handheld devices. However, as the demand for image quality increases with screen development, high-quality images ... ...

    Abstract Manga, as a widely beloved form of entertainment around the world, have shifted from paper to electronic screens with the proliferation of handheld devices. However, as the demand for image quality increases with screen development, high-quality images can hinder transmission and affect the viewing experience. Traditional vectorization methods require a significant amount of manual parameter adjustment to process screentone. Using deep learning, lines and screentone can be automatically extracted and image resolution can be enhanced. Super-resolution can convert low-resolution images to high-resolution images while maintaining low transmission rates and providing high-quality results. However, traditional Super Resolution methods for improving manga resolution do not consider the meaning of screentone density, resulting in changes to screentone density and loss of meaning. In this paper, we aims to address this issue by first classifying the regions and lines of different screentone in the manga using deep learning algorithm, then using corresponding super-resolution models for quality enhancement based on the different classifications of each block, and finally combining them to obtain images that maintain the meaning of screentone and lines in the manga while improving image resolution.
    Keywords Computer Science - Computer Vision and Pattern Recognition ; Electrical Engineering and Systems Science - Image and Video Processing
    Subject code 006
    Publishing date 2023-05-14
    Publishing country us
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article ; Online: Reinforcement learning strategies in cancer chemotherapy treatments: A review.

    Yang, Chan-Yun / Shiranthika, Chamani / Wang, Chung-Yih / Chen, Kuo-Wei / Sumathipala, Sagara

    Computer methods and programs in biomedicine

    2022  Volume 229, Page(s) 107280

    Abstract: Background and objective: Cancer is one of the major causes of death worldwide and chemotherapies are the most significant anti-cancer therapy, in spite of the emerging precision cancer medicines in the last 2 decades. The growing interest in developing ...

    Abstract Background and objective: Cancer is one of the major causes of death worldwide and chemotherapies are the most significant anti-cancer therapy, in spite of the emerging precision cancer medicines in the last 2 decades. The growing interest in developing the effective chemotherapy regimen with optimal drug dosing schedule to benefit the clinical cancer patients has spawned innovative solutions involving mathematical modeling since the chemotherapy regimens are administered cyclically until the futility or the occurrence of intolerable adverse events. Thus, in this present work, we reviewed the emerging trends involved in forming a computational solution from the aspect of reinforcement learning.
    Methods: Initially, this survey in-depth focused on the details of the dynamic treatment regimens from a broad perspective and then narrowed down to inspirations from reinforcement learning that were advantageous to chemotherapy dosing, including both offline reinforcement learning and supervised reinforcement learning.
    Results: The insights established in the chemotherapy-planning problem associated with the Reinforcement Learning (RL) has been discussed in this study. It showed that the researchers were able to widen their perspectives in comprehending the theoretical basis, dynamic treatment regimens (DTR), use of the adaptive control on DTR, and the associated RL techniques.
    Conclusions: This study reviewed the recent researches relevant to the topic, and highlighted the challenges, open questions, possible solutions, and future steps in inventing a realistic solution for the aforementioned problem.
    MeSH term(s) Humans ; Reinforcement, Psychology ; Learning ; Neoplasms/drug therapy ; Machine Learning ; Models, Theoretical
    Language English
    Publishing date 2022-11-26
    Publishing country Ireland
    Document type Journal Article ; Review
    ZDB-ID 632564-6
    ISSN 1872-7565 ; 0169-2607
    ISSN (online) 1872-7565
    ISSN 0169-2607
    DOI 10.1016/j.cmpb.2022.107280
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Nanoparticle-enhanced postbiotics: Revolutionizing cancer therapy through effective delivery.

    Huang, Hau-Lun / Lai, Chih-Ho / Tsai, Wan-Hua / Chen, Kuo-Wei / Peng, Shin-Lei / Lin, Jui-Hsiang / Lin, Yu-Hsin

    Life sciences

    2023  Volume 337, Page(s) 122379

    Abstract: Aim: Gastric cancer contributes to cancer-related fatalities. Conventional chemotherapy faces challenges due to severe adverse effects, prompting recent research to focus on postbiotics, which are safer biomolecules derived from nonviable probiotics. ... ...

    Abstract Aim: Gastric cancer contributes to cancer-related fatalities. Conventional chemotherapy faces challenges due to severe adverse effects, prompting recent research to focus on postbiotics, which are safer biomolecules derived from nonviable probiotics. Despite promising in vitro results, efficient in vivo delivery systems remain a challenge. This study aimed to design a potential nanoparticle (NP) formulation encapsulating the Lacticaseibacillus paracasei GMNL-133 (SGMNL-133) isolate to enhance its therapeutic efficacy in treating gastric cancer.
    Main methods: We successfully isolated GMNL-133 (SGMNL-133) by optimizing the lysate extraction and column elution processes for L. paracasei GMNL-133, resulting in substantial enhancement of its capacity to inhibit the proliferation of gastric cancer cells. Additionally, we developed a potential NP utilizing arginine-chitosan and fucoidan encapsulating SGMNL-133.
    Key findings: This innovative approach protected the SGMNL-133 from degradation by gastric acid, facilitated its penetration through the mucus layer, and enabled interaction with gastric cancer cells. Furthermore, in vivo experiments demonstrated that the encapsulation of SGMNL-133 in NPs significantly enhanced its efficacy in the treatment of orthotopic gastric tumors while simultaneously reducing tissue inflammation levels.
    Significance: Recent research highlights postbiotics as a safe alternative, but in vivo delivery remains a challenge. Our study optimized the extraction of the lysate and column elution of GMNL-133, yielding SGMNL-133. We also developed NPs to protect SGMNL-133 from gastric acid, enhance mucus penetration, and improve the interaction with gastric cancer cells. This combination significantly enhanced drug delivery and anti-gastric tumor activity.
    MeSH term(s) Humans ; Stomach Neoplasms/drug therapy ; Cell Line, Tumor ; Drug Delivery Systems/methods ; Nanoparticles
    Language English
    Publishing date 2023-12-23
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 3378-9
    ISSN 1879-0631 ; 0024-3205
    ISSN (online) 1879-0631
    ISSN 0024-3205
    DOI 10.1016/j.lfs.2023.122379
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Does a negative correlation of heme oxygenase-1 with hematoma thickness in chronic subdural hematomas affect neovascularization and microvascular leakage? A retrospective study with preliminary validation.

    Luh, Hui-Tzung / Chen, Kuo-Wei / Yang, Ling-Yu / Chen, Yi-Tzu / Lin, Sheng-Hsuan / Wang, Kuo-Chuan / Lai, Dar-Ming / Hsieh, Sung-Tsang

    Journal of neurosurgery

    2023  , Page(s) 1–8

    Abstract: Objective: Chronic subdural hematoma (CSDH) is a common neurological disease among elderly adults. The progression of CSDH is an angiogenic process, involving inflammatory mediators that affect vascular permeability, microvascular leakage, and hematoma ... ...

    Abstract Objective: Chronic subdural hematoma (CSDH) is a common neurological disease among elderly adults. The progression of CSDH is an angiogenic process, involving inflammatory mediators that affect vascular permeability, microvascular leakage, and hematoma thickness. The authors aimed to identify biomarkers associated with angiogenesis and vascular permeability that might influence midline shift and hematoma thickness.
    Methods: Medical records and laboratory data of consecutive patients who underwent surgery for CSDH were analyzed. Collected data were basic demographic data, CSDH classification, CSDH thickness, midline shift, heme oxygenase-1 (HO-1) levels in hematomas, and common laboratory markers. Linear regression analysis was used to evaluate the relationship of CSDH thickness with characteristic variables. The chick chorioallantoic membrane (CAM) assay was used to test the angiogenic potency of identified variables in ex ovo culture of chick embryos.
    Results: In total, 93 patients with CSDH (71.0% male) with a mean age of 71.0 years were included. The mean CSDH thickness and midline shift were 19.7 and 9.8 mm, respectively. The mean levels of HO-1, ferritin, total bilirubin, white blood cells, segmented neutrophils, lymphocytes, platelets, international normalized ratio, and partial thromboplastin time were 36 ng/mL, 14.8 μg/mL, 10.5 mg/dL, 10.3 × 103 cells/μL, 69%, 21.7%, 221.1 × 109 cells/μL, 1.0, and 27.8 seconds, respectively. Pearson correlation analysis revealed that CSDH thickness was positively correlated with midline shift distance (r = 0.218, p < 0.05) but negatively correlated with HO-1 concentration (r = -0.364, p < 0.01) and ferritin level (r = -0.222, p < 0.05). Multivariate linear regression analysis revealed that HO-1 was an independent predictor of CSDH thickness (β = -0.084, p = 0.006). The angiogenic potency of HO-1 in hematoma fluid was tested with the chick CAM assay; topical addition of CSDH fluid with low HO-1 levels promoted neovascularization and microvascular leakage. Addition of HO-1 in a rescue experiment inhibited CSDH fluid-mediated angiogenesis and microvascular leakage.
    Conclusions: HO-1 is an independent risk factor in CSDH hematomas and is negatively correlated with CSDH thickness. HO-1 may play a role in the pathophysiology and development of CSDH, possibly by preventing neovascularization and reducing capillary fragility and hyperpermeability.
    Language English
    Publishing date 2023-01-06
    Publishing country United States
    Document type Journal Article
    ZDB-ID 3089-2
    ISSN 1933-0693 ; 0022-3085
    ISSN (online) 1933-0693
    ISSN 0022-3085
    DOI 10.3171/2022.11.JNS221790
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Outcome of endovascular thrombectomy in patients with end-stage renal disease undergoing dialysis.

    Chen, Kuo-Wei / Chen, Chih-Hao / Lin, Yen-Heng / Lee, Chung-Wei / Tsai, Kun-Chang / Tsai, Li-Kai / Tang, Sung-Chun / Jeng, Jiann-Shing

    Journal of neurointerventional surgery

    2023  Volume 15, Issue e3, Page(s) e337–e342

    Abstract: Background: Patients with end-stage renal disease (ESRD) are often excluded from clinical trials of endovascular thrombectomy (EVT). This study investigated the outcome in these patients.: Methods: From September 2014 to July 2021, all patients ... ...

    Abstract Background: Patients with end-stage renal disease (ESRD) are often excluded from clinical trials of endovascular thrombectomy (EVT). This study investigated the outcome in these patients.
    Methods: From September 2014 to July 2021, all patients undergoing EVT for anterior circulation stroke in two stroke centers in Taiwan were included. They were divided into no renal dysfunction (non-RD, estimated glomerular filtration rate (eGFR) ≥60 mL/min/1.73 m
    Results: Of 482 patients included, there were 20 ESRD-dialysis, 110 RD, and 352 non-RD patients. The Alberta Stroke Program Early CT Score (ASPECTS), National Institutes of Health Stroke Scale (NIHSS), use of intravenous thrombolysis, EVT-related time metrics, and successful recanalization rates were comparable among the three groups. However, the ESRD-dialysis patients had more symptomatic intracerebral hemorrhage (ICH, 15% vs 3.6% vs 3.7%), more contrast-induced encephalopathy (15% vs 1.8% vs 0.9%), and a higher mortality at 90 days (35% vs 18% vs 11%) than the other groups. Multivariable analysis revealed that ESRD-dialysis was associated with a less favorable outcome (OR 0.21, 95% CI 0.04 to 0.77) and more severe disability or mortality (modified Rankin Scale 5 or 6; OR 13.1, 95% CI 3.93 to 48.1) at 90 days. In the ESRD-dialysis group, the patients with premorbid functional dependence had a significantly higher mortality than those without (75% vs 8.3%; P=0.004).
    Conclusion: ESRD-dialysis patients were associated with symptomatic ICH and less favorable outcome at 90 days. Patients with premorbid functional dependency had an excessively high mortality.
    MeSH term(s) Humans ; Renal Dialysis ; Treatment Outcome ; Stroke/diagnostic imaging ; Stroke/surgery ; Thrombectomy/adverse effects ; Kidney Failure, Chronic/complications ; Kidney Failure, Chronic/therapy ; Endovascular Procedures/adverse effects ; Brain Ischemia/etiology ; Retrospective Studies
    Language English
    Publishing date 2023-12-21
    Publishing country England
    Document type Journal Article
    ZDB-ID 2514982-9
    ISSN 1759-8486 ; 1759-8478
    ISSN (online) 1759-8486
    ISSN 1759-8478
    DOI 10.1136/jnis-2022-019666
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Acute Posttraumatic Cerebral Venous Sinus Thrombosis-Induced Malignant Increased Intracranial Pressure Treated with Endovascular Dural Sinus Thrombectomy and Stenting.

    Chen, Kuo-Wei / Lin, Yen-Heng / Lee, Chung-Wei

    World neurosurgery

    2019  Volume 128, Page(s) 393–397

    Abstract: Background: Posttraumatic cerebral venous sinus thrombosis (CVST) is a major complication after head injury. Impaired venous outflow caused by CVST leads to increased intracranial pressure (IICP) refractory to medications and surgical decompression and ... ...

    Abstract Background: Posttraumatic cerebral venous sinus thrombosis (CVST) is a major complication after head injury. Impaired venous outflow caused by CVST leads to increased intracranial pressure (IICP) refractory to medications and surgical decompression and often results in devastating consequences. Currently, there is no consensus on the treatment strategy.
    Case description: Here we report a case of posttraumatic CVST in a young male motorcyclist involved in a high-speed traffic accident. On admission, the patient immediately underwent decompressive hemicraniectomy. However, refractory malignant IICP developed within 24 hours after the operation. Computed tomography venography revealed compression of the right sigmoid sinus by the fractured temporal bone and extensive thrombosis toward the jugular bulb. Dural sinus thrombectomy and stenting were performed accordingly. After the procedure, IICP was alleviated immediately and the sedatives and medications were tapered off within days. The patient gradually recovered from deep comatose status and underwent cranioplasty 5 weeks later. Finally, the patient was discharged with only mild left wrist weakness.
    Conclusions: Acute cerebral sinus thrombosis caused by trauma may result in malignant IICP refractory to medications and surgical decompression. We have demonstrated that endovascular angioplasty and sinus stenting are effective in restoring venous outflow and reducing intracranial pressure. We have also demonstrated that appropriate and timely interventions are important to ensure quick and good recovery in patients with CVST.
    MeSH term(s) Accidents, Traffic ; Cerebral Veins/injuries ; Decompressive Craniectomy ; Dura Mater/injuries ; Dura Mater/surgery ; Endovascular Procedures/methods ; Hematoma, Epidural, Cranial/diagnostic imaging ; Hematoma, Epidural, Cranial/surgery ; Humans ; Intracranial Hemorrhages/diagnostic imaging ; Intracranial Hemorrhages/surgery ; Intracranial Hypertension/etiology ; Intracranial Hypertension/surgery ; Male ; Sinus Thrombosis, Intracranial/etiology ; Sinus Thrombosis, Intracranial/surgery ; Skull Fractures/complications ; Stents ; Thrombectomy/methods ; Tomography, X-Ray Computed ; Young Adult
    Language English
    Publishing date 2019-05-21
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 2534351-8
    ISSN 1878-8769 ; 1878-8750
    ISSN (online) 1878-8769
    ISSN 1878-8750
    DOI 10.1016/j.wneu.2019.05.105
    Database MEDical Literature Analysis and Retrieval System OnLINE

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