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Article ; Online: A-to-I editing prevents self-RNA sensing.

Chen, Leilei

2022 Volume 24, Issue 2, Page(s) 85

MeSH term(s)	RNA/genetics ; Adenosine Deaminase/genetics
Chemical Substances	RNA (63231-63-0) ; Adenosine Deaminase (EC 3.5.4.4)
Language	English
Publishing date	2022-09-08
Publishing country	England
Document type	Journal Article ; Comment
ZDB-ID	2031313-5
ISSN	1471-0080 ; 1471-0072
ISSN (online)	1471-0080
ISSN	1471-0072
DOI	10.1038/s41580-022-00540-4
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Zs.A 5446: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MG 26: Show issues

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Article ; Online: Research hotspots and trends in internal fixation of femoral neck fractures from 2010 to 2022: A 12-year bibliometric analysis.

Ling, Wenkang / Chen, Leilei

Medicine

2023 Volume 102, Issue 23, Page(s) e34003

Abstract: Background: This study endeavors to scrutinize the hotspots and trends in the literature concerning the internal fixation of femoral neck fractures (INFNF) through a comprehensive bibliometric analysis. Notably, this analytical process encompasses both ... ...

Abstract	Background: This study endeavors to scrutinize the hotspots and trends in the literature concerning the internal fixation of femoral neck fractures (INFNF) through a comprehensive bibliometric analysis. Notably, this analytical process encompasses both qualitative and quantitative components. Methods: The present study has utilized the Science Citation Index-Expanded from the Web of Science Core Collection to extract datasets ranging from January 1, 2010, to August 31, 2022. Quantitative analysis was carried out using sophisticated analytical tools such as the Bibliographic Item Co-Occurrence Matrix Builder, the Online Analysis Platform of Literature Metrology, and CiteSpace software. Further, the major Medical Subject Headings terms and their subheading counterparts associated with INFNF were extracted from the PubMed2XL website using the corresponding PMIDs. These Medical Subject Headings terms were employed in conducting a co-word clustering analysis. Ultimately, the Graphical CLUstering TOolkit program was utilized to execute a co-word biclustering analysis to discern the prevailing hotspots in this domain. Results: Between January 1, 2010, and August 31, 2022, a total of 463 publications were issued on INFNF. The INJURY-INTERNAL JOURNAL OF THE CARE OF THE INJURED stood out as the most extensively perused journal in this area. Notably, China emerged as the foremost contributor to publishing articles within the last 12 years, followed by the United States and Canada. McMaster University was identified as the leading institution in INFNF research, while Bhandari M emerged as the most prolific author in this field. Moreover, the study identified five notable research hotspots within the domain of INFNF. Conclusions: This study has identified five critical areas of research in the field of INFNF. It suggests that the primary focus of future research is likely to center on advancing internal fixation methods and robot-assisted instrumentation for femoral neck fractures. As such, this study provides valuable insights into future research directions and ideas for those working in this field.
MeSH term(s)	Humans ; Bibliometrics ; Femoral Neck Fractures/surgery ; Fracture Fixation, Internal ; Research/trends
Language	English
Publishing date	2023-06-11
Publishing country	United States
Document type	Journal Article
ZDB-ID	80184-7
ISSN	1536-5964 ; 0025-7974
ISSN (online)	1536-5964
ISSN	0025-7974
DOI	10.1097/MD.0000000000034003
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Article: Commentary: The impact of iron deposition on the fear circuit of the brain in patients with Parkinson's disease and anxiety.

Chen, Leilei / Xie, Junxia

Frontiers in aging neuroscience

2023 Volume 15, Page(s) 1223421

Language	English
Publishing date	2023-06-19
Publishing country	Switzerland
Document type	Journal Article ; Comment
ZDB-ID	2558898-9
ISSN	1663-4365
ISSN	1663-4365
DOI	10.3389/fnagi.2023.1223421
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Article: PD-1 Blockade-Induced Hemophagocytic Lymphohistiocytosis, a Dilemma Therapeutic Outcome in 2 Patients with CAEBV: A Case Series.

Chen, LeiLei / Wang, Jingshi / Wang, Zhao

Infection and drug resistance

2024 Volume 17, Page(s) 1545–1550

Abstract: Hemophagocytic lymphohistiocytosis (HLH), whether primary or secondary, is a rare and fatal clinical syndrome of uncontrolled immune activation and inflammatory cascade. Immune checkpoint inhibitors (ICIs) induced HLH has no standard diagnostic and ... ...

Abstract	Hemophagocytic lymphohistiocytosis (HLH), whether primary or secondary, is a rare and fatal clinical syndrome of uncontrolled immune activation and inflammatory cascade. Immune checkpoint inhibitors (ICIs) induced HLH has no standard diagnostic and treatment guidelines. Early diagnosis and appropriate treatment according to different disease backgrounds are crucial. Herein, we first report 2 cases of patients with chronic active Epstein-Barr virus infection (CAEBV) who developed HLH after the use of sintilimab, a monoclonal antibody against programmed cell death protein 1 (PD-1), and the DEP (liposomal doxorubicin, etoposide, methylprednisolone) chemotherapy regimen in combination with ruxolitinib were used to successfully control the disease.
Language	English
Publishing date	2024-04-18
Publishing country	New Zealand
Document type	Case Reports
ZDB-ID	2494856-1
ISSN	1178-6973
ISSN	1178-6973
DOI	10.2147/IDR.S441460
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Article ; Online: Acute liver failure and aplastic crisis due to anorexia nervosa in an adolescent girl: a case report.

Chen, Leilei / Liu, Zhifeng / Zheng, Yucan

The Journal of international medical research

2023 Volume 51, Issue 11, Page(s) 3000605231214922

Abstract: Anorexia nervosa (AN) has a high mortality rate due to the widespread organ dysfunction caused by the underlying severe malnutrition. Malnutrition-induced hepatitis is common among individuals with AN especially as body mass index decreases, while acute ... ...

Abstract	Anorexia nervosa (AN) has a high mortality rate due to the widespread organ dysfunction caused by the underlying severe malnutrition. Malnutrition-induced hepatitis is common among individuals with AN especially as body mass index decreases, while acute liver failure and aplastic crisis related to coagulation disease and encephalopathy rarely occur in AN patients. The supervised increase of caloric intake can quickly improve the elevated aminotransferases caused by starvation and aplastic crisis. This current case report describes a 12-year-old adolescent girl who was admitted with a 3-month history of weight loss. Within 3 months, she had lost 10 kg of weight. The girl was diagnosed with AN, acute liver failure, severe malnutrition with emaciation, electrolyte disorder, bradycardia and aplastic crisis. She was gradually supplemented with vitamins and enteral nutrition to avoid refeeding syndrome. After treatment, her liver function and haematopoietic function returned to normal. In conclusion, acute liver failure and aplastic crisis are rare but potentially life-threatening complications of AN, which could be improved by supervised feeding and timely rehydration. AN should be considered as the potential aetiology of acute liver failure and aplastic crisis.
MeSH term(s)	Humans ; Adolescent ; Female ; Child ; Anorexia Nervosa/complications ; Anorexia Nervosa/therapy ; Anorexia Nervosa/diagnosis ; Malnutrition ; Hepatitis ; Enteral Nutrition ; Liver Failure, Acute/etiology ; Liver Failure, Acute/therapy
Language	English
Publishing date	2023-11-28
Publishing country	England
Document type	Case Reports ; Journal Article
ZDB-ID	184023-x
ISSN	1473-2300 ; 0300-0605 ; 0142-2596
ISSN (online)	1473-2300
ISSN	0300-0605 ; 0142-2596
DOI	10.1177/03000605231214922
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Zs.A 925: Show issues

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Article ; Online: The new insights of hyperbaric oxygen therapy: focus on inflammatory bowel disease.

Chen, Leilei / Wang, Yan / Zhou, Huihui / Liang, Yi / Zhu, Fengqin / Zhou, Guangxi

Precision clinical medicine

2024 Volume 7, Issue 1, Page(s) pbae001

Abstract: Inflammatory bowel diseases (IBD), with an increasing incidence, pose a significant health burden. Although there have been significant advances in the treatment of IBD, more progress is still needed. Hyperbaric oxygen therapy (HBOT) has been shown to ... ...

Abstract	Inflammatory bowel diseases (IBD), with an increasing incidence, pose a significant health burden. Although there have been significant advances in the treatment of IBD, more progress is still needed. Hyperbaric oxygen therapy (HBOT) has been shown to treat a host of conditions such as carbon monoxide poisoning, decompression sickness, and gas gangrene. In the last few years, there has been an increase in research into the use of HBOT as an adjunct to conventional treatment for IBD. Related research has shown that HBOT may exert its therapeutic effects by decreasing oxidative stress, inhibiting mucosal inflammation, promoting ulcer healing, influencing gut microbes, and reducing the incidence of IBD complications. This paper aims to provide a comprehensive review of experimental and clinical trials exploring HBOT as a supplement to IBD treatment strategies.
Language	English
Publishing date	2024-01-18
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	2948341-4
ISSN	2516-1571 ; 2096-5303
ISSN (online)	2516-1571
ISSN	2096-5303
DOI	10.1093/pcmedi/pbae001
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Article ; Online: Itaconate in host inflammation and defense.

Ye, Dan / Wang, Pu / Chen, Lei-Lei / Guan, Kun-Liang / Xiong, Yue

Trends in endocrinology and metabolism: TEM

2024

Abstract: Immune cells undergo rapid and extensive metabolic changes during inflammation. In addition to contributing to energetic and biosynthetic demands, metabolites can also function as signaling molecules. Itaconate (ITA) rapidly accumulates to high levels in ...

Abstract	Immune cells undergo rapid and extensive metabolic changes during inflammation. In addition to contributing to energetic and biosynthetic demands, metabolites can also function as signaling molecules. Itaconate (ITA) rapidly accumulates to high levels in myeloid cells under infectious and sterile inflammatory conditions. This metabolite binds to and regulates the function of diverse proteins intracellularly to influence metabolism, oxidative response, epigenetic modification, and gene expression and to signal extracellularly through binding the G protein-coupled receptor (GPCR). Administration of ITA protects against inflammatory diseases and blockade of ITA production enhances antitumor immunity in preclinical models. In this article, we review ITA metabolism and its regulation, discuss its target proteins and mechanisms, and conjecture a rationale for developing ITA-based therapeutics to treat inflammatory diseases and cancer.
Language	English
Publishing date	2024-03-05
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	1042384-9
ISSN	1879-3061 ; 1043-2760
ISSN (online)	1879-3061
ISSN	1043-2760
DOI	10.1016/j.tem.2024.02.004
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Zs.A 2999: Show issues

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Article ; Online: Occurrence of organophosphorus flame retardants in Xiangjiang River: Spatiotemporal variations, potential affecting factors, and source apportionment.

Liu, Yang / Chen, Leilei / Li, Haipu / Song, Yang / Yang, Zhaoguang / Cui, Yue

Chemosphere

2024 Volume 355, Page(s) 141822

Abstract: The environmental occurrence of organophosphorus flame retardants (OPFRs) is receiving increasing attention. However, their distribution in the Xiangjiang River, an important tributary in the middle reaches of the Yangtze River, is still uncharacterized, ...

Abstract	The environmental occurrence of organophosphorus flame retardants (OPFRs) is receiving increasing attention. However, their distribution in the Xiangjiang River, an important tributary in the middle reaches of the Yangtze River, is still uncharacterized, and the potential factors influencing their distribution have not been adequately surveyed. In this study, the occurrence of OPFRs in the Xiangjiang River was comprehensively investigated from upstream to downstream seasonally. Fourteen OPFRs were detected in the sampling area, with a total concentration (∑OPFRs) ranging from 3.16 to 462 ng/L, among which tris(1-chloro-2-propyl) phosphate was identified as the primary pollutant (ND - 379 ng/L). Specifically, ∑OPFRs were significantly lower in the wet season than in the dry season, which may be due to the dilution effect of river flow and enhanced volatilization caused by higher water temperatures. Additionally, Changsha (during the dry season) and Zhuzhou (during the wet season) exhibited higher pollution levels than other cities. According to the Redundancy analysis, water quality parameters accounted for 35.7% of the variation in the occurrence of OPFRs, in which temperature, ammonia nitrogen content, dissolved oxygen, and chemical oxygen demand were identified as the potential influencing factors, accounting for 28.1%, 27.2%, 24.1%, and 11.5% of the total variation, respectively. The results of the Positive Matrix Factorization analysis revealed that transport and industrial emissions were the major sources of OPFRs in Xiangjiang River. In addition, there were no high-ecological risk cases for any individual OPFRs, although tris(2-ethylhexyl) phosphate and tributoxyethyl phosphate presented a low-to-medium risk level. And the results of mixture risk quotients indicated that medium-risk sites were concentrated in the Chang-Zhu-Tan region. This study enriches the global data of OPFRs pollution and contributes to the scientific management and control of pollution.
MeSH term(s)	Organophosphorus Compounds/analysis ; Flame Retardants/analysis ; Environmental Exposure/analysis ; Phosphates/analysis ; Water Quality ; Organophosphates/analysis
Chemical Substances	Organophosphorus Compounds ; Flame Retardants ; Phosphates ; Organophosphates
Language	English
Publishing date	2024-03-30
Publishing country	England
Document type	Journal Article
ZDB-ID	120089-6
ISSN	1879-1298 ; 0045-6535 ; 0366-7111
ISSN (online)	1879-1298
ISSN	0045-6535 ; 0366-7111
DOI	10.1016/j.chemosphere.2024.141822
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Zs.A 2540: Show issues

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ab Jg. 2022: Lesesaal (EG)

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Article: Recent Advances in Adenosine-to-Inosine RNA Editing in Cancer.

Gan, Wei Liang / Ng, Larry / Ng, Bryan Y L / Chen, Leilei

Cancer treatment and research

2023 Volume 190, Page(s) 143–179

Abstract: RNA epigenetics, or epitranscriptome, is a growing group of RNA modifications historically classified into two categories: RNA editing and RNA modification. RNA editing is usually understood as post-transcriptional RNA processing (except capping, ... ...

Abstract	RNA epigenetics, or epitranscriptome, is a growing group of RNA modifications historically classified into two categories: RNA editing and RNA modification. RNA editing is usually understood as post-transcriptional RNA processing (except capping, splicing and polyadenylation) that changes the RNA nucleotide sequence encoded by the genome. This processing can be achieved through the insertion or deletion of nucleotides or deamination of nucleobases, generating either standard nucleotides such as uridine (U) or the rare nucleotide inosine (I). Adenosine-to-inosine (A-to-I) RNA editing is the most prevalent type of RNA modification in mammals and is catalyzed by adenosine deaminase acting on the RNA (ADAR) family of enzymes that recognize double-stranded RNAs (dsRNAs). Inosine mimics guanosine (G) in base pairing with cytidine (C), thereby A-to-I RNA editing alters dsRNA secondary structure. Inosine is also recognized as guanosine by the splicing and translation machineries, resulting in mRNA alternative splicing and protein recoding. Therefore, A-to-I RNA editing is an important mechanism that causes and regulates "RNA mutations" in both normal physiology and diseases including cancer. In this chapter, we reviewed current paradigms and developments in the field of A-to-I RNA editing in the context of cancer.
MeSH term(s)	Animals ; Humans ; RNA/genetics ; RNA/metabolism ; RNA Editing ; Neoplasms/genetics ; Nucleotides/metabolism ; Inosine/genetics ; Inosine/metabolism ; Adenosine/genetics ; Adenosine/metabolism ; Guanosine/metabolism ; Mammals/genetics ; Mammals/metabolism
Chemical Substances	RNA (63231-63-0) ; Nucleotides ; Inosine (5A614L51CT) ; Adenosine (K72T3FS567) ; Guanosine (12133JR80S)
Language	English
Publishing date	2023-12-19
Publishing country	United States
Document type	Review ; Journal Article
ISSN	0927-3042
ISSN	0927-3042
DOI	10.1007/978-3-031-45654-1_5
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: L-DEP regimen is effective as an initial therapy for adult EBV-HLH.

Chen, Leilei / Wang, Jingshi / Wang, Zhao

Annals of hematology

2022 Volume 101, Issue 11, Page(s) 2461–2470

Abstract: We performed a single-center, prospective trial to investigate the efficacy of PEG- asparaginase combined with liposomal doxorubicin, etoposide, and methylprednisolone (L-DEP) as an initial therapy for Epstein-Barr virus driven hemophagocytic ... ...

Abstract	We performed a single-center, prospective trial to investigate the efficacy of PEG- asparaginase combined with liposomal doxorubicin, etoposide, and methylprednisolone (L-DEP) as an initial therapy for Epstein-Barr virus driven hemophagocytic lymphohistiocytosis (EBV-HLH). None of the patients received any chemotherapy after the diagnosis of EBV-HLH between September 2019 and September 2021. The efficacy was evaluated 2 weeks and 4 weeks after initiating L-DEP primary therapy. Forty-seven eligible patients with EBV-HLH were enrolled. The overall response rate (ORR) was 80.9% (38/47, 12 in clinical CR, 26 in clinical PR) at 2 weeks after the L-DEP regimen; at 4 weeks, the ORR was 75.6% (34/45, 21 in clinical CR, 13 in clinical PR). EBV-DNA loads in blood and plasma were significantly decreased 2 and 4 weeks after the L-DEP regimen (P < 0.001). Ferritin, soluble CD25 (sCD25), triglycerides (TGs), and ultrasonic spleen longitude, and thickness were all decreased significantly 2 and 4 weeks after the L-DEP regimen (P < 0.001). Thus, the L-DEP regimen is an effective initial therapy for EBV-HLH. However, the L-DEP regimen was poor in terms of long-term prognosis and that allo-HSCT should be received as soon as possible once a complete response is achieved.
MeSH term(s)	Adult ; Asparaginase/therapeutic use ; Epstein-Barr Virus Infections/complications ; Epstein-Barr Virus Infections/drug therapy ; Etoposide/therapeutic use ; Ferritins ; Herpesvirus 4, Human ; Humans ; Lymphohistiocytosis, Hemophagocytic/therapy ; Methylprednisolone/therapeutic use ; Prospective Studies ; Triglycerides/therapeutic use
Chemical Substances	Triglycerides ; Etoposide (6PLQ3CP4P3) ; Ferritins (9007-73-2) ; Asparaginase (EC 3.5.1.1) ; Methylprednisolone (X4W7ZR7023)
Language	English
Publishing date	2022-09-12
Publishing country	Germany
Document type	Clinical Trial ; Journal Article
ZDB-ID	1064950-5
ISSN	1432-0584 ; 0939-5555 ; 0945-8077
ISSN (online)	1432-0584
ISSN	0939-5555 ; 0945-8077
DOI	10.1007/s00277-022-04946-0
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