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  1. Article: [Development and clinical application of lateral segmental positioning plates of the body surface spine].

    Fang, Dan-Dan / Chen, Li-Jun / Huang, Jun-Min

    Zhongguo gu shang = China journal of orthopaedics and traumatology

    2024  Volume 37, Issue 4, Page(s) 358–362

    Abstract: Objective: To investigate the clinical efficacy of body-surface guide plates for lateral segmental positioning in the thoracolumbar spine.: Methods: From March 2018 to March 2021, 768 gerontal patientss underwent percutaneous vertebroplasty with ... ...

    Abstract Objective: To investigate the clinical efficacy of body-surface guide plates for lateral segmental positioning in the thoracolumbar spine.
    Methods: From March 2018 to March 2021, 768 gerontal patientss underwent percutaneous vertebroplasty with balloon dilatation due to thoracolumbar compression fracturess, 356 males and 412 females. aged from 64 to 92 years old with an average of (77.9±13.5) years old. All patients were treated in hospital within 1 week after injury. All patients underwent preoperative localization, and were divided into localization plate group and locator group according to different localization methods. There were 390 patients in the localization plate group, 180 males and 210 females, aged from 64 to 92 years old, with an average age of (78.4±14.3) years old. There were 378 patients in the locator group, 176 males and 202 females, aged from 64 to 90 years old, with an average age of (77.5±13.4) years old. After preliminary positioning with the above two methods, skin markers were made, cloth was routinely disinfected, and the spinal lateral position was fluoroscopically examined after the fine needle was inserted into the marked point and the vertical body at the near tail end. The accuracy of the original positioning method was evaluated. The number of times, time and accuracy of positioning of the two groups of patients were compared and analyzed.
    Results: The specific data of patient positioning in the two groups were collected for statistical analysis. The number of times of fluoroscopy in the positioning plate group and the locator group was(3.3±0.5) times and (5.0±1.2) times, and the positioning time was (60.4±9.4) s and (105.0±30.9) s, respectively. The accuracy of fluoroscopy was 97.5% (380/390) and 85.7% (324/378), respectively, with statistical significance (
    Conclusion: The lateral segmental positioning plate of the body surface spine has the advantages of simple operation, accurate positioning, and reducing X-ray radiation for patients, which is worthy of clinical application.
    MeSH term(s) Humans ; Male ; Female ; Aged ; Middle Aged ; Aged, 80 and over ; Lumbar Vertebrae/surgery ; Bone Plates ; Thoracic Vertebrae/surgery ; Vertebroplasty/methods ; Spinal Fractures/surgery ; Patient Positioning/methods ; Fractures, Compression/surgery
    Language Chinese
    Publishing date 2024-04-25
    Publishing country China
    Document type English Abstract ; Journal Article
    ISSN 1003-0034
    ISSN 1003-0034
    DOI 10.12200/j.issn.1003-0034.20221039
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  2. Article: A Flower Bud from the Lower Cretaceous of China.

    Chen, Li-Jun / Wang, Xin

    Biology

    2022  Volume 11, Issue 11

    Abstract: Background: Although various angiosperms (including their flowers) have been reported from the Yixian Formation (Lower Cretaceous) of China, which is famous worldwide for its fossils of early angiosperms, no flower bud has hitherto been seen in the ... ...

    Abstract Background: Although various angiosperms (including their flowers) have been reported from the Yixian Formation (Lower Cretaceous) of China, which is famous worldwide for its fossils of early angiosperms, no flower bud has hitherto been seen in the Early Cretaceous. Such a lack of examples hinders our understanding of the evolution of flowers.
    Methods: The specimen studied in the present paper was collected from an outcrop of the Yixian Formation (the Barremian-Aptian, Lower Cretaceous) of Dawangzhangzi in Lingyuan, Liaoning, China. The specimen was photographed using a Nikon D200 digital camera, its details were observed and photographed using a Nikon SMZ1500 stereomicroscope, and some of its details were observed using a Leo 1530 VP SEM.
    Results: We report a fossilized flower bud,
    Language English
    Publishing date 2022-11-01
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2661517-4
    ISSN 2079-7737
    ISSN 2079-7737
    DOI 10.3390/biology11111598
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  3. Article ; Online: CT features of calcified micro-gastric gastrointestinal stromal tumors: a case series.

    Chen, Li-Jun / Han, Yue-Dong / Zhang, Ming

    BMC medical imaging

    2023  Volume 23, Issue 1, Page(s) 192

    Abstract: Background: Due to the lack of corresponding clinical symptoms, small calcified gastric gastrointestinal stromal tumors (GISTs) are often overlooked in clinical practice. Therefore, there is an unmet need to define the imaging features of calcified ... ...

    Abstract Background: Due to the lack of corresponding clinical symptoms, small calcified gastric gastrointestinal stromal tumors (GISTs) are often overlooked in clinical practice. Therefore, there is an unmet need to define the imaging features of calcified micro-gastric GISTs to facilitate diagnosis. This study retrospectively analyzed the computed tomography (CT) features of pathologically confirmed calcified micro-gastric GISTs.
    Methods: The medical records (gastroscopy, pre-treatment gastric CT imaging [pre- and post-contrast scans], pathology) of patients with calcified gastric GISTs < 1 cm in diameter confirmed pathologically after endoscopic submucosal dissection, endoscopic submucosal excavation, or endoscopic full-thickness resection were retrospectively reviewed.
    Results: Seven patients had 8 calcified gastric GISTs < 1 cm in diameter. Six patients hadsingle lesions, and 1patients had multiple lesions. Six patients had lesions in the gastric fundus, 1 patient had a lesion in the body of the stomach. Lesions had a mean diameter of 5.2 mm (range, 1.3 mm ~ 7 mm). Unenhanced CT scans showed spots and high-density nodular calcifications in 3 submucosal lesions, 2 lesions in the muscularis propria, and 3 subserosal lesions that protruded outside the stomach. Among the 8 lesions, only two had solid soft tissue components surrounding the calcification, with one of these two showing post contrast enhancement of the solid soft tissue component.
    Conclusions: Novel CT features of gastric GISTs included: commonly found in the gastric antrum, small size (< 1 cm in diameter), calcification, few solid soft tissue components, and no abnormal enhancement in most cases.
    MeSH term(s) Humans ; Gastrointestinal Stromal Tumors/diagnostic imaging ; Gastrointestinal Stromal Tumors/surgery ; Retrospective Studies ; Treatment Outcome ; Stomach Neoplasms/diagnostic imaging ; Stomach Neoplasms/surgery ; Tomography, X-Ray Computed ; Calcinosis
    Language English
    Publishing date 2023-11-20
    Publishing country England
    Document type Journal Article
    ZDB-ID 2061975-3
    ISSN 1471-2342 ; 1471-2342
    ISSN (online) 1471-2342
    ISSN 1471-2342
    DOI 10.1186/s12880-023-01146-8
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  4. Article ; Online: The efficacy of endoscopic dacryocystorhinostomy in the treatment of dacryocystitis: A systematic review and meta-analysis.

    Liu, Shui / Zhang, Huang / Zhang, Yue-Rui / Chen, Li-Jun / Yu, Xiao-Yi

    Medicine

    2024  Volume 103, Issue 11, Page(s) e37312

    Abstract: Background: This article aimed to discuss the efficacy and safety of endoscopic dacryocystorhinostomy (EDCR) versus external dacryocystorhinostomy (EX-DCR) for the treatment of dacryocystitis by meta-analysis.: Methods: All randomized controlled ... ...

    Abstract Background: This article aimed to discuss the efficacy and safety of endoscopic dacryocystorhinostomy (EDCR) versus external dacryocystorhinostomy (EX-DCR) for the treatment of dacryocystitis by meta-analysis.
    Methods: All randomized controlled trials that met the inclusion and exclusion criteria were collected by searching the following databases: PubMed, Web of Science, China National Knowledge Infrastructure, and Wanfang, from the establishment of the database to June 2023. Meta-analysis was performed using Stata 17.0 software and review manager 5.4 software. In the collected trials, the observation group was treated with EDCR, whereas the control group was treated with EX-DCR.
    Results: A total of 10 studies involving 969 patients were included in this analysis. There was a similar surgical success rate in the treatment of dacryocystitis between the 2 groups (RR = 1.021, 95% CI [0. 803, 1.297], P = 0. 865). However, compared with the control group, patients in the observation group had a higher total effective rate of treatment (RR = 1. 195, 95% CI [1. 063, 1.343], P = .003), and shorter operative time (WMD = -23.640, 95% CI [-35.533, -11.747], P < .001), and less intraoperative blood loss (WMD = -50.797, 95% CI [-80.339, -21.255], P = .001), shorter length of hospital stays (WMD = -4.570, 95% CI [-5.992, -3.148], P < .001), and lower incidence of adverse events (RR = 0.295, 95% CI [0.173, 0.504], P < .001).
    Conclusion: EDCR is an effective and safe surgical procedure for the treatment of dacryocystitis and can be used as an alternative to EX-DCR.
    MeSH term(s) Humans ; Dacryocystorhinostomy/methods ; Dacryocystitis/surgery ; Dacryocystitis/etiology ; Blood Loss, Surgical ; China ; Treatment Outcome ; Endoscopy
    Language English
    Publishing date 2024-03-15
    Publishing country United States
    Document type Meta-Analysis ; Systematic Review ; Journal Article
    ZDB-ID 80184-7
    ISSN 1536-5964 ; 0025-7974
    ISSN (online) 1536-5964
    ISSN 0025-7974
    DOI 10.1097/MD.0000000000037312
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  5. Article: Transcriptomic analysis of cadmium toxicity and molecular response in the spiderling of Pirata subpiraticus.

    Li, Zhe-Zhi / Zhou, Xuan-Wei / Chen, Li-Jun

    Comparative biochemistry and physiology. Toxicology & pharmacology : CBP

    2022  Volume 261, Page(s) 109441

    Abstract: Cadmium (Cd) is a kind of toxic heavy metal widely distributed in the environment, posing life-threatening challenges to organisms. The paddy field spider is a natural enemy of pests and an essential component of rice biodiversity. Nonetheless, the ... ...

    Abstract Cadmium (Cd) is a kind of toxic heavy metal widely distributed in the environment, posing life-threatening challenges to organisms. The paddy field spider is a natural enemy of pests and an essential component of rice biodiversity. Nonetheless, the effects of Cd stress on the postembryonic development of spiders and its detailed mechanism remain to be investigated. In the present study, we found that Cd stress posed adverse impacts on the growth indicators (e.g., carapace length, development duration, and survival rate) and increased the levels of three antioxidants (i.e., superoxide dismutase, glutathione S-transferase, and glutathione peroxidase) in the spiderlings of Pirata subpiraticus. An in-depth transcriptome analysis was employed in the study, and the results displayed that differentially expressed genes (DEGs) involved in postembryonic morphogenesis, development involved in symbiotic interaction, postembryonic development, and growth were distinctively altered under Cd stress. Further enrichment analysis showed that Cd exposure could activate the apoptosis pathway in the spider via the up-regulation of several key factors, including caspase-10, α-tubulin, actin, etc. In addition, we demonstrated that the increased level of glutathione-related enzymes in spiderlings was caused by the activation of glutathione metabolic pathway. The altered hedgehog signaling pathway might affect cell proliferation, tissue patterning, and development of spiderlings. Further protein interaction network displayed that Cd stress could affect multiple biological processes in spiderlings, particularly cellular response to stimulus and system development. To sum up, this study can provide multi-level perspectives to understand the toxicity of Cd on the growth and development of spiders.
    MeSH term(s) Animals ; Cadmium/toxicity ; Gene Expression Profiling ; Glutathione ; Hedgehog Proteins/genetics ; Hedgehog Proteins/pharmacology ; Spiders/genetics ; Transcriptome
    Chemical Substances Hedgehog Proteins ; Cadmium (00BH33GNGH) ; Glutathione (GAN16C9B8O)
    Language English
    Publishing date 2022-08-15
    Publishing country United States
    Document type Journal Article
    ZDB-ID 189285-x
    ISSN 1532-0456 ; 0306-4492 ; 0742-8413
    ISSN 1532-0456 ; 0306-4492 ; 0742-8413
    DOI 10.1016/j.cbpc.2022.109441
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  6. Article: [Cognitive Frailty in Older Adults: A Concept Analysis].

    Chen, Li-Jun / Liao, Yu-Chi / Hu, Fang-Wen

    Hu li za zhi The journal of nursing

    2021  Volume 68, Issue 5, Page(s) 92–99

    Abstract: Healthy aging is the primary goal of healthcare for older adults in aging societies. The prevention of physical disabilities and dementia is becoming more important. As frailty involves both the physical and cognitive domains, detecting and preventing ... ...

    Abstract Healthy aging is the primary goal of healthcare for older adults in aging societies. The prevention of physical disabilities and dementia is becoming more important. As frailty involves both the physical and cognitive domains, detecting and preventing cognitive frailty early on is key to reversing cognitive diseases such as dementia. In this study, a concept analysis strategy (Walker & Avant, 2019) was applied to define the concept of cognitive frailty in older adults and identify the attributes of (1) presence of subjective cognitive decline or mild cognitive impairment, (2) exclusion of concurrent Alzheimer's disease or other dementia, (3) concomitant physical frailty, and (4) it is revisable. Using the constructed model, borderline and contrary cases were used to explain the concept of cognitive frailty. Finally, the antecedent and consequence factors of cognitive frailty were identified and the empirical measurement tools were evaluated. This analysis may be used to improve nurses' understanding of cognitive frailty in older adults and to benefit clinical practice and further research.
    MeSH term(s) Aged ; Aging ; Cognition ; Cognitive Dysfunction ; Frail Elderly ; Frailty ; Humans
    Language Chinese
    Publishing date 2021-09-21
    Publishing country China (Republic : 1949- )
    Document type Journal Article
    ISSN 0047-262X
    ISSN 0047-262X
    DOI 10.6224/JN.202110_68(5).12
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  7. Article: [Development and clinical application of universal screwdriver].

    Chu, Wu / Chen, Li-Jun / Xue, Fang-Zheng

    Zhongguo gu shang = China journal of orthopaedics and traumatology

    2021  Volume 34, Issue 7, Page(s) 622–627

    Abstract: Objective: To develop a universal screwdriver for sealing the end of the central hole of the femoral interlocking intramedullary nail, so as to shorten the operation time of the tail cap implantation of the intramedullary nail and improve the accuracy ... ...

    Abstract Objective: To develop a universal screwdriver for sealing the end of the central hole of the femoral interlocking intramedullary nail, so as to shorten the operation time of the tail cap implantation of the intramedullary nail and improve the accuracy of implantation.
    Methods: Total 77 patients with intertrochanteric fractures underwent femoral interlocking intramedullary nail (FIIN) surgery from June 2018 to June 2019. There were 28 males and 49 females, aged 55 to 80 (76.22± 7.32) years old, and course of disease was 20 to 40 h. All patients were divided into universal screwdriver group (39 cases) and ordinary screwdriver group (38 cases) according to whether the self-developed universal screw was applicable during the operation. The blood loss during tail cap implantation, the time of tail cap implantation, the success rate of one-time implantation, and the postoperative curative effect were compared between two groups.
    Results: All patients were followed up for 12 to 36 months, with an average of(20.00±6.38) months. The bleeding volume and the time of tail cap implantation in the universal screwdriver group were significantly lower thanthose in the ordinary screwdriver group (
    Conclusion: The universal screwdriver is easy to operate during the operation when using the cap of the femoral intramedullary nail, the operation time is shortened, the amount of bleeding is reduced, and the treatment effect is satisfactory.
    MeSH term(s) Aged ; Aged, 80 and over ; Bone Nails ; Female ; Femoral Fractures ; Fracture Fixation, Intramedullary ; Fracture Healing ; Hip Fractures/surgery ; Humans ; Male ; Retrospective Studies ; Treatment Outcome
    Language Chinese
    Publishing date 2021-07-27
    Publishing country China
    Document type Journal Article
    ISSN 1003-0034
    ISSN 1003-0034
    DOI 10.12200/j.issn.1003-0034.2021.07.007
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Metabolome analysis reveals the toxic effects of cadmium exposure on the egg sac of spider Pardosa pseudoannulata.

    Chen, Li-Jun / Zhou, Xuan-Wei / Li, Zhe-Zhi / Lyu, Bo

    Ecotoxicology and environmental safety

    2022  Volume 249, Page(s) 114459

    Abstract: The investigation of the toxic effects of cadmium (Cd) on rice field invertebrates has attracted accumulating attention. Spider grants a novel insight into the impacts of Cd stress on invertebrates, but the effects of Cd-induced toxicity and molecular ... ...

    Abstract The investigation of the toxic effects of cadmium (Cd) on rice field invertebrates has attracted accumulating attention. Spider grants a novel insight into the impacts of Cd stress on invertebrates, but the effects of Cd-induced toxicity and molecular response mechanism of related metabolites in spider's egg sacs remain elusive. This investigation found that Cd stress distinctively decreased vitellogenin (Vg) content and hatched spiderlings numbers in the egg sac of Pardosa pseudoannulata. In addition, Cd stress exerted oxidative stress in the egg sac, manifested as the increase of superoxide dismutase and malondialdehyde levels. Further results showed that Cd exposure could affect egg sacs' energy metabolism, including protein and lipid contents. Metabolome analysis generated 73 up-regulated and 63 down-regulated differentially expressed metabolites (DEMs), mainly affecting phenylalanine metabolism, alpha-linolenic acid metabolism, pentose phosphate pathway, and biosynthesis of amino acids. Specifically, pathway analysis showed that Cd exposure down-regulated several key factors, including tyrosine, L-phenylalanine, O-phospho-L-serine, and L-cystathionine, and inhibited the metabolism of amino acids in the egg sacs. The subsequent correlation analysis found that three metabolite indicators, 9-Oxo-ODE, PG (17:0/18:2), and PE (17:0/20:5), were the dominant contributors to the egg sec's properties (i.e., Vg content and gained spiderlings). Collectively, this study hopes to provide valuable data for the protection of rice field spiders and offer novel perspectives for Cd pollution assessment and management.
    MeSH term(s) Animals ; Transcriptome ; Cadmium/toxicity ; Spiders ; Metabolome ; Oryza ; Amino Acids ; Animals, Poisonous
    Chemical Substances Cadmium (00BH33GNGH) ; Amino Acids
    Language English
    Publishing date 2022-12-22
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 436536-7
    ISSN 1090-2414 ; 0147-6513
    ISSN (online) 1090-2414
    ISSN 0147-6513
    DOI 10.1016/j.ecoenv.2022.114459
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  9. Article ; Online: Organoplatinum Compounds as Anion-Tuneable Uphill Hydroxide Transporters.

    Chen, Li-Jun / Wu, Xin / Gilchrist, Alexander M / Gale, Philip A

    Angewandte Chemie (International ed. in English)

    2022  Volume 61, Issue 19, Page(s) e202116355

    Abstract: Active transport of ions uphill, creating a concentration gradient across a cell membrane, is essential for life. It remains a significant challenge to develop synthetic systems that allow active uphill transport. Here, a transport process fuelled by ... ...

    Abstract Active transport of ions uphill, creating a concentration gradient across a cell membrane, is essential for life. It remains a significant challenge to develop synthetic systems that allow active uphill transport. Here, a transport process fuelled by organometallic compounds is reported that creates a pH gradient. The hydrolysis reaction of Pt
    MeSH term(s) Anions ; Biological Transport ; Hydrogen-Ion Concentration ; Hydroxides ; Kinetics ; Membrane Potentials ; Membrane Transport Proteins ; Organoplatinum Compounds
    Chemical Substances Anions ; Hydroxides ; Membrane Transport Proteins ; Organoplatinum Compounds ; hydroxide ion (9159UV381P)
    Language English
    Publishing date 2022-03-11
    Publishing country Germany
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2011836-3
    ISSN 1521-3773 ; 1433-7851
    ISSN (online) 1521-3773
    ISSN 1433-7851
    DOI 10.1002/anie.202116355
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  10. Article ; Online: Discovery of Tetrazolamide-benzimidazol-2-ones as Novel 4-Hydroxyphenylpyruvate Dioxygenase Inhibitors.

    Cai, Zhuo-Mei / Huang, Guang-Yi / Dong, Jin / Chen, Li-Jun / Ye, Bao-Qing / Lin, Hong-Yan / Wang, Da-Wei / Yang, Guang-Fu

    Journal of agricultural and food chemistry

    2024  Volume 72, Issue 8, Page(s) 3884–3893

    Abstract: 4-Hydroxyphenylpyruvate dioxygenase (HPPD, EC 1.13.11.27) is one of the most valuable herbicide targets due to its unique biological functions. In search of HPPD inhibitors with promising biological performance, we designed and synthesized a series of ... ...

    Abstract 4-Hydroxyphenylpyruvate dioxygenase (HPPD, EC 1.13.11.27) is one of the most valuable herbicide targets due to its unique biological functions. In search of HPPD inhibitors with promising biological performance, we designed and synthesized a series of novel tetrazolamide-benzimidazol-2-ones using a structure-based drug design strategy. Among the synthesized compounds, 1-(2-chlorobenzyl)-3-methyl-
    MeSH term(s) Molecular Structure ; Structure-Activity Relationship ; 4-Hydroxyphenylpyruvate Dioxygenase/chemistry ; Herbicides/pharmacology ; Herbicides/chemistry ; Arabidopsis/metabolism ; Enzyme Inhibitors/pharmacology ; Enzyme Inhibitors/chemistry ; Benzimidazoles
    Chemical Substances benzimidazol-2-one (43135-91-7) ; 4-Hydroxyphenylpyruvate Dioxygenase (EC 1.13.11.27) ; Herbicides ; Enzyme Inhibitors ; Benzimidazoles
    Language English
    Publishing date 2024-02-20
    Publishing country United States
    Document type Journal Article
    ZDB-ID 241619-0
    ISSN 1520-5118 ; 0021-8561
    ISSN (online) 1520-5118
    ISSN 0021-8561
    DOI 10.1021/acs.jafc.3c06798
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