Article ; Online: Psoralen and Isopsoralen,
Chemical research in toxicology
2024
Abstract: With the increasing use of oral contraceptives and estrogen replacement therapy, the incidence of estrogen-induced cholestasis (EC) has tended to rise. Psoralen (P) and isopsoralen (IP) are the major bioactive components in Psoraleae Fructus, and their ... ...
| Abstract | With the increasing use of oral contraceptives and estrogen replacement therapy, the incidence of estrogen-induced cholestasis (EC) has tended to rise. Psoralen (P) and isopsoralen (IP) are the major bioactive components in Psoraleae Fructus, and their estrogen-like activities have already been recognized. Recent studies have also reported that ERK1/2 plays a critical role in EC in mice. This study aimed to investigate whether P and IP induce EC and reveal specific mechanisms. It was found that P and IP increased the expression of |
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| Language | English | |||||
| Publishing date | 2024-04-22 | |||||
| Publishing country | United States | |||||
| Document type | Journal Article | |||||
| ZDB-ID | 639353-6 | |||||
| ISSN | 1520-5010 ; 0893-228X | |||||
| ISSN (online) | 1520-5010 | |||||
| ISSN | 0893-228X | |||||
| DOI | 10.1021/acs.chemrestox.4c00054 | |||||
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| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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