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  1. Book ; Online: Emerging Diagnostic and Therapeutic Approaches for Gastric Cancer

    Chen, Lin / Park, Sungsoo / Zhang, Kecheng

    2020  

    Keywords Medicine ; Oncology ; Stomach cancer ; Minimally invasive surgery ; Multidisciplinary treatment ; Metastasis ; ERAS
    Size 1 electronic resource (218 pages)
    Publisher Frontiers Media SA
    Document type Book ; Online
    Note English ; Open Access
    HBZ-ID HT021230680
    ISBN 9782889663163 ; 2889663167
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Article ; Online: Network-level pavement maintenance and rehabilitation decision-making with the optimized annual budget.

    Chen, Lin

    PloS one

    2023  Volume 18, Issue 10, Page(s) e0287426

    Abstract: Maintenance and rehabilitation (M&R) is necessary to keep pavement networks in good condition. Due to the capital intensity, M&R funding is always insufficient. The annual budget, determining the available funding, is a critical criterion when planning M& ...

    Abstract Maintenance and rehabilitation (M&R) is necessary to keep pavement networks in good condition. Due to the capital intensity, M&R funding is always insufficient. The annual budget, determining the available funding, is a critical criterion when planning M&R treatments. However, its values are often given, and the determination of the values is seldom discussed. To fill the gap, this paper focuses on both the determination of annual budgets and the budget allocations, and therefore enhances the network-level decision-making on M&R by developing a Multi-Objective Optimization (MOO) method. This method does not only optimize and trade off the annual budgets and their consequences, but also allocates the funding across the entire network through generating the optimized M&R decisions. According to a case study with 50 segments, the developed method successfully and effectively identified non-linear discrete relationship between the minimized annual budgets and the maximized M&R benefits subject to all the constraints, and generated the optimized annual budget allocation for each M&R decision. The achievements of this paper can be used to enhance the efficiency of M&R decisions and contribute to informed pavement management.
    Language English
    Publishing date 2023-10-26
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2267670-3
    ISSN 1932-6203 ; 1932-6203
    ISSN (online) 1932-6203
    ISSN 1932-6203
    DOI 10.1371/journal.pone.0287426
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Genomic analysis of Lactobacillus reuteri WHH1689 reveals its probiotic properties and stress resistance

    Chen, Lin / Gu, Qing

    Food Science & Nutrition, 7(2):844-857

    2019  

    Abstract: Lactobacillus reuteri (L. reuteri) WHH1689, which was isolated from Chinese traditional highland barley wine, exhibited high survival period at room temperature in drinkable probiotic yogurt. This article aimed to indicate the genes involved in probiotic ...

    Abstract Lactobacillus reuteri (L. reuteri) WHH1689, which was isolated from Chinese traditional highland barley wine, exhibited high survival period at room temperature in drinkable probiotic yogurt. This article aimed to indicate the genes involved in probiotic function of WHH1689 and reveal potential stress resistance based on genomic analysis. Analysis of comparative genome with closely related L. reuteri strains identified special stress adaptation. MUMmer and ACT softwares were applied for collinear analysis, and OrthoMCL program was used for sequence alignment involved in distribution of protein cluster. We identified genes coding for carbohydrate transport and enzymes, carbon metabolism pathway, gastrointestinal tract resistance, adhesive ability, and folic acid biosynthesis, etc. Genome sequence and comparative genome analysis of L. reuteri WHH1689 demonstrated specific genes for genetic adaptation and stress resistance. Tolerance, adhesion, and folate test indicated the strain had multiple probiotics. L. reuteri WHH1689 has the potential to be a probiotic candidate in dairy foods.
    Keywords Lactobacillus reuteri WHH1689 ; comparative genomics ; stress resistance ; probiotics
    Language English
    Document type Article
    Database Repository for Life Sciences

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  4. Article ; Online: A Tunable Cascade Reaction of Ureidomalonates and Alkenyl Azlactones for the Divergent Synthesis of Hydantoins with Distinct Functional Groups.

    Chen, Lin / Wang, Di

    The Journal of organic chemistry

    2024  Volume 89, Issue 5, Page(s) 3365–3382

    Abstract: A tunable cascade reaction of ureidomalonates and alkenyl azlactones was disclosed, which gave rise to the construction ... ...

    Abstract A tunable cascade reaction of ureidomalonates and alkenyl azlactones was disclosed, which gave rise to the construction of
    Language English
    Publishing date 2024-02-16
    Publishing country United States
    Document type Journal Article
    ZDB-ID 123490-0
    ISSN 1520-6904 ; 0022-3263
    ISSN (online) 1520-6904
    ISSN 0022-3263
    DOI 10.1021/acs.joc.3c02814
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 4473: Show issues Location:
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  5. Article ; Online: Carotid Artery Perivascular Adipose Tissue Density as a Novel Biomarker for Prognosis.

    Chen, Lin-Lin / Qin, Zhan-Zhong

    Angiology

    2024  Volume 75, Issue 5, Page(s) 494–495

    MeSH term(s) Humans ; Carotid Arteries/diagnostic imaging ; Adipose Tissue/diagnostic imaging ; Carotid Artery, Common ; Biomarkers ; Prognosis
    Chemical Substances Biomarkers
    Language English
    Publishing date 2024-02-15
    Publishing country United States
    Document type Letter
    ZDB-ID 80040-5
    ISSN 1940-1574 ; 0003-3197
    ISSN (online) 1940-1574
    ISSN 0003-3197
    DOI 10.1177/00033197241233634
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: The Function of Root Exudates in the Root Colonization by Beneficial Soil Rhizobacteria.

    Chen, Lin / Liu, Yunpeng

    Biology

    2024  Volume 13, Issue 2

    Abstract: Soil-beneficial microbes in the rhizosphere play important roles in improving plant growth and health. Root exudates play key roles in plant-microbe interactions and rhizobacterial colonization. This review describes the factors influencing the dynamic ... ...

    Abstract Soil-beneficial microbes in the rhizosphere play important roles in improving plant growth and health. Root exudates play key roles in plant-microbe interactions and rhizobacterial colonization. This review describes the factors influencing the dynamic interactions between root exudates and the soil microbiome in the rhizosphere, including plant genotype, plant development, and environmental abiotic and biotic factors. We also discuss the roles of specific metabolic mechanisms, regulators, and signals of beneficial soil bacteria in terms of colonization ability. We highlight the latest research progress on the roles of root exudates in regulating beneficial rhizobacterial colonization. Organic acids, amino acids, sugars, sugar alcohols, flavonoids, phenolic compounds, volatiles, and other secondary metabolites are discussed in detail. Finally, we propose future research objectives that will help us better understand the role of root exudates in root colonization by rhizobacteria and promote the sustainable development of agriculture and forestry.
    Language English
    Publishing date 2024-02-02
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2661517-4
    ISSN 2079-7737
    ISSN 2079-7737
    DOI 10.3390/biology13020095
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Remote ischemic conditioning reduces postoperative bleeding in adult cardiac surgical patients: a systematic review and meta-analysis.

    Chen, Lin-Lin / Yao, Yun-Tai

    The Journal of cardiovascular surgery

    2024  

    Abstract: Introduction: The current study was designed to systemically investigate the impact of RIC on intra- and postoperative bleeding and transfusion in patients undergoing cardiac surgery.: Evidence acquisition: We included all randomized controlled ... ...

    Abstract Introduction: The current study was designed to systemically investigate the impact of RIC on intra- and postoperative bleeding and transfusion in patients undergoing cardiac surgery.
    Evidence acquisition: We included all randomized controlled trials (RCTs) comparing RIC with control on intra- and postoperative blood loss and blood transfusion. The inclusion criteria were as follows: 1) adult patients undergoing cardiac surgery; 2) RCT; 3) perioperative administration of RIC compared to control; 4) outcomes of interest reported. Exclusion criteria included: 1) case reports, reviews, or abstracts; 2) animal or cell studies; 3) duplicate publications; 4) studies lacking information about outcomes of interest.
    Evidence synthesis: Databases search yielded 24 RCTs including 3530 patients, 1765 patients were allocated into RIC group and 1765 into control group. The current study suggested that RIC administration was associated with reduced postoperative blood loss (WMD=-57.89; 95% CI: -89.89 to -25.89; P=0.0004). RIC did not affect the incidence of intraoperative blood loss (WMD=-4.02; 95% CI: -14.09 to 6.05; P=0.43), the volume of intra- and postoperative transfusion of RBC (WMD=-15.66; 95% CI: -39.35 to 8.03; P=0.20), the re-exploration for bleeding (WMD=-0.01; 95% CI: -0.03 to 0.01; P=0.21).
    Conclusions: RIC might reduce postoperative blood loss in adult cardiac surgical patients and reduced intraoperative RBC transfusion in patients undergoing coronary artery bypass grafting. However, RIC did not influence intraoperative bleeding, the volume of re-exploration for bleeding or blood transfusion postoperatively.
    Language English
    Publishing date 2024-02-27
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 80143-4
    ISSN 1827-191X ; 0021-9509
    ISSN (online) 1827-191X
    ISSN 0021-9509
    DOI 10.23736/S0021-9509.24.12827-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 469: Show issues Location:
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  8. Article ; Online: MiR-182 in Glioma: An insufficiently explored and controversial research area.

    Chen, Lin-Lin / Zhao, Xiao-Yang

    Journal of the neurological sciences

    2024  Volume 458, Page(s) 122911

    MeSH term(s) Humans ; Glioma/genetics ; MicroRNAs/genetics ; Cell Proliferation ; Gene Expression Regulation, Neoplastic ; Cell Line, Tumor ; Brain Neoplasms/genetics ; Cell Movement
    Chemical Substances MicroRNAs ; Mirn182 microRNA, human
    Language English
    Publishing date 2024-02-01
    Publishing country Netherlands
    Document type Letter
    ZDB-ID 80160-4
    ISSN 1878-5883 ; 0022-510X ; 0374-8642
    ISSN (online) 1878-5883
    ISSN 0022-510X ; 0374-8642
    DOI 10.1016/j.jns.2024.122911
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 308: Show issues Location:
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  9. Article ; Online: COBRA improves the completeness and contiguity of viral genomes assembled from metagenomes.

    Chen, LinXing / Banfield, Jillian F

    Nature microbiology

    2024  Volume 9, Issue 3, Page(s) 737–750

    Abstract: Viruses are often studied using metagenome-assembled sequences, but genome incompleteness hampers comprehensive and accurate analyses. Contig Overlap Based Re-Assembly (COBRA) resolves assembly breakpoints based on the de Bruijn graph and joins contigs. ... ...

    Abstract Viruses are often studied using metagenome-assembled sequences, but genome incompleteness hampers comprehensive and accurate analyses. Contig Overlap Based Re-Assembly (COBRA) resolves assembly breakpoints based on the de Bruijn graph and joins contigs. Here we benchmarked COBRA using ocean and soil viral datasets. COBRA accurately joined the assembled sequences and achieved notably higher genome accuracy than binning tools. From 231 published freshwater metagenomes, we obtained 7,334 bacteriophage clusters, ~83% of which represent new phage species. Notably, ~70% of these were circular, compared with 34% before COBRA analyses. We expanded sampling of huge phages (≥200 kbp), the largest of which was curated to completion (717 kbp). Improved phage genomes from Rotsee Lake provided context for metatranscriptomic data and indicated the in situ activity of huge phages, whiB-encoding phages and cysC- and cysH-encoding phages. COBRA improves viral genome assembly contiguity and completeness, thus the accuracy and reliability of analyses of gene content, diversity and evolution.
    MeSH term(s) Metagenome ; Reproducibility of Results ; Genome, Viral ; Bacteriophages/genetics ; Viruses
    Language English
    Publishing date 2024-02-06
    Publishing country England
    Document type Journal Article
    ISSN 2058-5276
    ISSN (online) 2058-5276
    DOI 10.1038/s41564-023-01598-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Imported Buruli ulcer-is there risk for travellers?

    Norman, Francesca F / Chen, Lin H

    Journal of travel medicine

    2024  

    Language English
    Publishing date 2024-04-09
    Publishing country England
    Document type Journal Article
    ZDB-ID 1212504-0
    ISSN 1708-8305 ; 1195-1982
    ISSN (online) 1708-8305
    ISSN 1195-1982
    DOI 10.1093/jtm/taae057
    Database MEDical Literature Analysis and Retrieval System OnLINE

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