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  1. Book: Current practice in pediatric surgery

    Chen, Mike K.

    (Surgical clinics of North America ; 86,2)

    2006  

    Author's details guest ed. Mike K. Chen
    Series title Surgical clinics of North America ; 86,2
    Collection
    Language English
    Size XX S., S. 227 - 535 : Ill., graph. Darst.
    Publisher Saunders
    Publishing place Philadelphia u.a.
    Publishing country United States
    Document type Book
    HBZ-ID HT014852033
    ISBN 1-4160-3558-3 ; 978-1-4160-3558-9
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    Uk I Zs 75 -86,2- verfügbar in Königswinter Königswinter

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  2. Book: Atlas of pediatric surgical techniques

    Chung, Dai H. / Chen, Mike K.

    (Surgical techniques atlas series ; An expert consult title)

    2010  

    Author's details ed. Dai H. Chung ; Mike K. Chen
    Series title Surgical techniques atlas series
    An expert consult title
    Language English
    Size XVII, 388 S. : zahlr. Ill., ill. (chiefly col.)
    Publisher Elsevier Saunders
    Publishing place Philadelphia, Pa
    Publishing country United States
    Document type Book
    Accompanying material Zugang zur Internetausgabe über Code
    HBZ-ID HT016537453
    ISBN 978-1-4160-4689-9 ; 1-4160-4689-5
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2010 C 84 order for loan Magazin
    Zugang zur Internetausgabe über Code aus lizenzrechtlichen Gründen nicht verfügbar

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  3. Article ; Online: Invited Commentary: Low Cost Gastroschisis Silo for Sub-Saharan Africa-Testing in a Porcine Model.

    Chen, Mike / Radulescu, Andrei

    World journal of surgery

    2022  Volume 47, Issue 2, Page(s) 552–553

    MeSH term(s) Swine ; Animals ; Gastroschisis/diagnosis ; Gastroschisis/surgery ; Africa South of the Sahara
    Language English
    Publishing date 2022-11-07
    Publishing country United States
    Document type Journal Article
    ZDB-ID 224043-9
    ISSN 1432-2323 ; 0364-2313
    ISSN (online) 1432-2323
    ISSN 0364-2313
    DOI 10.1007/s00268-022-06822-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1336: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  4. Article ; Online: Retraction Note: Human induced pluripotent stem cell-derived platelets loaded with lapatinib effectively target HER2+ breast cancer metastasis to the brain.

    Bhan, Arunoday / Ansari, Khairul / Chen, Mike Y / Jandial, Rahul

    Scientific reports

    2024  Volume 14, Issue 1, Page(s) 5972

    Language English
    Publishing date 2024-03-12
    Publishing country England
    Document type Retraction of Publication
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-024-56291-z
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Intestinal Atresias: A Ten-Year Evaluation of Outcomes.

    Koenig, Samantha M / Russell, Robert T / Quevedo, Oswaldo G / Chen, Mike K

    The Journal of surgical research

    2024  Volume 296, Page(s) 130–134

    Abstract: Introduction: Intestinal atresia is a common cause of neonatal bowel obstruction. Atresias are often associated with other congenital anomalies. The purpose of the study was to evaluate associated anomalies, operative management, and postoperative ... ...

    Abstract Introduction: Intestinal atresia is a common cause of neonatal bowel obstruction. Atresias are often associated with other congenital anomalies. The purpose of the study was to evaluate associated anomalies, operative management, and postoperative outcomes of infants with intestinal atresia.
    Methods: A review of patients presenting to a single free-standing children's hospital from March 2012 through February 2022 was performed. The variables examined were type of atresia, additional congenital anomalies, type of operative intervention, and postoperative outcomes. Standard statistical methods were utilized.
    Results: A total of 75 patients with intestinal atresia were identified and several of these patients had multiple atresias. Isolated duodenal atresia patients were the most common (49.3%), followed by jejunal (32%) and ileal (12%). Mixed atresias were rare at 4%, with isolated pyloric and colonic also rare at 1.3% each. Malrotation was associated with 13% of patients and equally associated with duodenal and jejunoileal atresias. A low percentage (3%) of intestinal atresias was seen in conjunction with gastroschisis and concomitant malrotation. A majority of infants with duodenal atresia underwent standard duodenoduodenostomy (19% laparoscopic, 81% open). In infants with jejunoileal atresia, most underwent resection with primary anastomosis. A tapering enteroplasty was performed primarily in 13% of atresias. There were no significant differences noted in time to first feed or length of stay between those with and without tapering enteroplasty. Eleven percent of patients required subsequent intervention for stricture or small bowel obstruction. There was one death in this series.
    Conclusions: Consistent with other literature, duodenal atresia was the most common type of intestinal atresia. However, we demonstrated that malrotation was equally associated with duodenal and jejunoileal atresias while prior reports had shown a higher association with duodenal atresia. In our patient population, the use of tapering enteroplasty did not appear to be associated with outcomes. Overall, these infants have a low morbidity and mortality rate with a rare need for reoperation.
    MeSH term(s) Infant ; Infant, Newborn ; Child ; Humans ; Intestinal Atresia/complications ; Intestinal Atresia/surgery ; Duodenal Obstruction/complications ; Intestine, Small ; Jejunum/surgery ; Retrospective Studies
    Language English
    Publishing date 2024-01-25
    Publishing country United States
    Document type Review ; Journal Article
    ZDB-ID 80170-7
    ISSN 1095-8673 ; 0022-4804
    ISSN (online) 1095-8673
    ISSN 0022-4804
    DOI 10.1016/j.jss.2023.12.015
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 178: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  6. Article ; Online: Tamoxifen retinopathy: A comprehensive review.

    Tenney, Stephen / Oboh-Weilke, Aruoriwo / Wagner, David / Chen, Mike Yuan

    Survey of ophthalmology

    2023  Volume 69, Issue 1, Page(s) 42–50

    Abstract: Tamoxifen is a selective estrogen receptor modulator used mainly for the treatment of breast cancer. Based on the case reports and studies performed to date on the retinal toxicity of tamoxifen, retinopathy appears to occur in as many as 12% of patients ... ...

    Abstract Tamoxifen is a selective estrogen receptor modulator used mainly for the treatment of breast cancer. Based on the case reports and studies performed to date on the retinal toxicity of tamoxifen, retinopathy appears to occur in as many as 12% of patients taking 20 mg tamoxifen a day for over 2 years. Of this 12%, as many as half develop symptomatic changes in visual acuity. Retinal changes consist primarily of crystalline deposits, cystoid macular edema, hyperreflective deposits in the inner retinal layers, and telangiectasia. Tamoxifen retinopathy is currently managed by discontinuing tamoxifen therapy as the cancer prognosis permits; however, discontinuing therapy demonstrates little to no improvement in visual acuity once visual changes have taken place. Intravitreal injections of steroids or antivascular endothelial growth factor therapy have been performed, but require further studying before conclusions can be made. Until then, optical coherence tomography screening for retinal changes should be performed every 6 months for patients who have been on tamoxifen therapy for 2 years or more. This way, patients can become aware of retinal changes, and their physicians can consider adjusting tamoxifen therapy before they risk developing changes in visual acuity.
    MeSH term(s) Humans ; Female ; Retinal Diseases/chemically induced ; Retinal Diseases/diagnosis ; Retinal Diseases/drug therapy ; Retina ; Tamoxifen/adverse effects ; Macular Edema/chemically induced ; Macular Edema/diagnosis ; Macular Edema/drug therapy ; Breast Neoplasms/drug therapy ; Intravitreal Injections ; Tomography, Optical Coherence/methods ; Diabetic Retinopathy ; Retrospective Studies ; Angiogenesis Inhibitors/therapeutic use
    Chemical Substances Tamoxifen (094ZI81Y45) ; Angiogenesis Inhibitors
    Language English
    Publishing date 2023-07-22
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 391346-6
    ISSN 1879-3304 ; 0039-6257
    ISSN (online) 1879-3304
    ISSN 0039-6257
    DOI 10.1016/j.survophthal.2023.07.003
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 283: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  7. Article: GM-CSF - an oncogenic driver of HER2+ breast leptomeningeal metastasis.

    Garg, Rachana / Jandial, Kai / Chen, Mike

    Oncoscience

    2022  Volume 9, Page(s) 57–59

    Language English
    Publishing date 2022-10-10
    Publishing country United States
    Document type Editorial
    ISSN 2331-4737
    ISSN 2331-4737
    DOI 10.18632/oncoscience.566
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Book ; Online: Changing the Narrative Perspective

    Chen, Mike / Bunescu, Razvan

    From Deictic to Anaphoric Point of View

    2021  

    Abstract: We introduce the task of changing the narrative point of view, where characters are assigned a narrative perspective that is different from the one originally used by the writer. The resulting shift in the narrative point of view alters the reading ... ...

    Abstract We introduce the task of changing the narrative point of view, where characters are assigned a narrative perspective that is different from the one originally used by the writer. The resulting shift in the narrative point of view alters the reading experience and can be used as a tool in fiction writing or to generate types of text ranging from educational to self-help and self-diagnosis. We introduce a benchmark dataset containing a wide range of types of narratives annotated with changes in point of view from deictic (first or second person) to anaphoric (third person) and describe a pipeline for processing raw text that relies on a neural architecture for mention selection. Evaluations on the new benchmark dataset show that the proposed architecture substantially outperforms the baselines by generating mentions that are less ambiguous and more natural.

    Comment: To appear in Information Processing & Management, Special Issue on Creative Language Processing
    Keywords Computer Science - Computation and Language ; Computer Science - Artificial Intelligence ; I.2.7 ; J.5
    Subject code 401
    Publishing date 2021-03-06
    Publishing country us
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article ; Online: Bilateral simultaneous postoperative endophthalmitis: review of cases reported over the past 50 years.

    Chen, Mike Yuan / Qi, Susan Ruyu / Arshinoff, Steve A

    Journal of cataract and refractive surgery

    2021  Volume 48, Issue 7, Page(s) 850–854

    Abstract: A detailed retrospective analysis and literature review were conducted for all previously published reports of bilateral simultaneous postoperative endophthalmitis (BSPOE) since 1970. There have been 7 (9, with 2 currently being reported elsewhere) cases ...

    Abstract A detailed retrospective analysis and literature review were conducted for all previously published reports of bilateral simultaneous postoperative endophthalmitis (BSPOE) since 1970. There have been 7 (9, with 2 currently being reported elsewhere) cases of BSPOE after immediately sequential bilateral cataract surgery (ISBCS) reported over 50 years. Generally, in these cases, the surgical protocol recommended by the International Society of Bilateral Cataract Surgeons ( i SBCS) was breached or uncertain. Bacterial causes were Pseudomonas aeruginosa (3), Staphylococcus epidermidis (3), and Burkholderia cepacia complex (1). One case showed negative results for bacterial infection and 1 was not determined. Visual recovery was light perception, or worse, for Pseudomonas cases, generally good for Staphylococcus and Burkholderia cases, and mixed in cases of unknown etiology. Therefore, BSPOE is rare and causes vary. Strict adherence to the i SBCS General Principles of Excellence in ISBCS 2009 surgical protocol and care with operating room construction seem to considerably lessen the risk.
    MeSH term(s) Cataract ; Cataract Extraction/adverse effects ; Cataract Extraction/methods ; Endophthalmitis/diagnosis ; Humans ; Postoperative Complications ; Retrospective Studies
    Language English
    Publishing date 2021-12-10
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 632744-8
    ISSN 1873-4502 ; 0886-3350
    ISSN (online) 1873-4502
    ISSN 0886-3350
    DOI 10.1097/j.jcrs.0000000000000875
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1806: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  10. Article ; Online: Human induced pluripotent stem cell-derived platelets loaded with lapatinib effectively target HER2+ breast cancer metastasis to the brain.

    Bhan, Arunoday / Ansari, Khairul / Chen, Mike Y / Jandial, Rahul

    publication RETRACTED

    Scientific reports

    2021  Volume 11, Issue 1, Page(s) 16866

    Abstract: Prognosis of patients with HER2+ breast-to-brain-metastasis (BBM) is dismal even after current standard-of-care treatments, including surgical resection, whole-brain radiation, and systemic chemotherapy. Radiation and systemic chemotherapies can also ... ...

    Abstract Prognosis of patients with HER2+ breast-to-brain-metastasis (BBM) is dismal even after current standard-of-care treatments, including surgical resection, whole-brain radiation, and systemic chemotherapy. Radiation and systemic chemotherapies can also induce cytotoxicity, leading to significant side effects. Studies indicate that donor-derived platelets can serve as immune-compatible drug carriers that interact with and deliver drugs to cancer cells with fewer side effects, making them a promising therapeutic option with enhanced antitumor activity. Moreover, human induced pluripotent stem cells (hiPSCs) provide a potentially renewable source of clinical-grade transfusable platelets that can be drug-loaded to complement the supply of donor-derived platelets. Here, we describe methods for ex vivo generation of megakaryocytes (MKs) and functional platelets from hiPSCs (hiPSC-platelets) in a scalable fashion. We then loaded hiPSC-platelets with lapatinib and infused them into BBM tumor-bearing NOD/SCID mouse models. Such treatment significantly increased intracellular lapatinib accumulation in BBMs in vivo, potentially via tumor cell-induced activation/aggregation. Lapatinib-loaded hiPSC-platelets exhibited normal morphology and function and released lapatinib pH-dependently. Importantly, lapatinib delivery to BBM cells via hiPSC-platelets inhibited tumor growth and prolonged survival of tumor-bearing mice. Overall, use of lapatinib-loaded hiPSC-platelets effectively reduced adverse effects of free lapatinib and enhanced its therapeutic efficacy, suggesting that they represent a novel means to deliver chemotherapeutic drugs as treatment for BBM.
    MeSH term(s) Animals ; Antineoplastic Agents/pharmacology ; Brain Neoplasms/drug therapy ; Brain Neoplasms/secondary ; Breast Neoplasms/drug therapy ; Breast Neoplasms/pathology ; Drug Carriers/pharmacology ; Humans ; Induced Pluripotent Stem Cells/cytology ; Induced Pluripotent Stem Cells/drug effects ; Lapatinib/pharmacology ; Mice, Inbred NOD ; Mice, SCID ; Neoplasm Metastasis/pathology ; Quinazolines/pharmacology ; Receptor, ErbB-2/drug effects ; Receptor, ErbB-2/metabolism ; Mice
    Chemical Substances Antineoplastic Agents ; Drug Carriers ; Quinazolines ; Lapatinib (0VUA21238F) ; Receptor, ErbB-2 (EC 2.7.10.1)
    Language English
    Publishing date 2021-10-15
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S. ; Retracted Publication
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-021-96351-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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