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Article ; Online: Exploration of Inflammatory Biomarkers and Psychological Cardiovascular Disease Risk Factors Among Community Dwelling Adults: A Gender Comparison Study.

Hung, Hsuan-Man / Chen, Ming-Fu / Lee, Huan-Fang / Wang, Hui-Ling

2023 Volume 26, Issue 1, Page(s) 139–149

Abstract: Patients with rheumatic disease (RD) are at high risk for cardiovascular disease (CVD), which is the leading non-communicable chronic disease cause of death worldwide. Inflammatory biomarkers and psychological health status are reliable predictors of CVD ...

Abstract	Patients with rheumatic disease (RD) are at high risk for cardiovascular disease (CVD), which is the leading non-communicable chronic disease cause of death worldwide. Inflammatory biomarkers and psychological health status are reliable predictors of CVD in patients with RD. The primary aim of this study was to compare the inflammatory biomarkers and psychological CVD risk factors (CRFs) between a group of community-dwelling adults with RD and CRFs and a group of their peers with CRFs only. The secondary aim of this study was to analyze and compare the collected data by gender in the RD group. Data were collected and analyzed from 355 participants, with the 135 participants with physician-diagnosed RD assigned to the RD group and the remainder (
MeSH term(s)	Humans ; Adult ; Male ; Female ; Cardiovascular Diseases ; Independent Living ; C-Reactive Protein/analysis ; Biomarkers ; Risk Factors
Chemical Substances	C-Reactive Protein (9007-41-4) ; Biomarkers
Language	English
Publishing date	2023-08-21
Publishing country	United States
Document type	Journal Article ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	2145107-2
ISSN	1552-4175 ; 1099-8004
ISSN (online)	1552-4175
ISSN	1099-8004
DOI	10.1177/10998004231197845
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Article ; Online: Design, fabrication, and validation of an aberration-free integral imaging system for 3D reconstruction.

Lin, Chih-Hao / Lin, Po-Ming / Chen, Chih-Wen / Chen, Ming-Fu

Applied optics

2022 Volume 61, Issue 27, Page(s) 7883–7888

Abstract: Optical design for reducing aberrations of the micro-lens-array-based integral imaging system is challenging. A design process combining the sequential and non-sequential modes of optical design software is proposed. The process is verified by a system ... ...

Abstract	Optical design for reducing aberrations of the micro-lens-array-based integral imaging system is challenging. A design process combining the sequential and non-sequential modes of optical design software is proposed. The process is verified by a system assembled on a coordinate measuring machine with errors of several micrometers. Differences in the modulation transfer function, measured by the slanted-edge method, are less than 0.02 between the paraxial and off-axial regions. Reconstructed images of a U.S. quarter-dollar coin with different refocusing depths show the synthesized defocusing. The estimated depth map and depth-based reconstructed image show the rough shape of the coin.
Language	English
Publishing date	2022-10-03
Publishing country	United States
Document type	Journal Article
ISSN	1539-4522
ISSN (online)	1539-4522
DOI	10.1364/AO.466173
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Article ; Online: Impacts of Fatigue, Stress, and Perceived Health Status on Women With Rheumatic Diseases: A Comparison Study.

Hung, Hsuan-Man / Chen, Ming-Fu / Chen, Chung-Hey

The journal of nursing research : JNR

2019 Volume 28, Issue 3, Page(s) e89

Abstract: Background: Rheumatic conditions, which increase in prevalence as populations age, are a growing public health problem that disproportionately affects women. Understanding the influences of rheumatic diseases (RDs) on fatigue, stress, and perceived ... ...

Abstract	Background: Rheumatic conditions, which increase in prevalence as populations age, are a growing public health problem that disproportionately affects women. Understanding the influences of rheumatic diseases (RDs) on fatigue, stress, and perceived health status is deemed important to the improvement of physical and mental health for women with RDs. Purpose: This study was designed to compare the fatigue, stress, and perceived physical and mental health status of women with RDs (RD group) with those of peers who did not have chronic illnesses (comparison group). Methods: A cross-sectional, purposive sample and comparative design was used. Four hundred forty-three women with a mean age of 46.2 years participated in this study. Those with physician-diagnosed RDs (n = 212) were enrolled in the RD group, and those without chronic disease were enrolled in the comparison group (n = 231). Measures used included a demographic datasheet, Fatigue Severity Scale, Perceived Stress Scale, and Short Form-12 Items Health Survey. Analysis of covariance was used to examine the intergroup differences for major variables based on demographic covariates. Results: The RD group reported significantly more fatigue and stress than the comparison group. Moreover, the RD group reported significantly poorer perceived physical health status, significantly poorer physical functioning and general health, and greater bodily pain compared with the comparison group. Conversely, the RD group reported significantly better perceived mental health status, significantly lower vitality, and better role emotional status than the comparison group. Conclusions/implications for practice: The findings support the theory that RDs have a negative impact on perceived stress and fatigue in women. Physical function, bodily pain, and general health may be the most significantly affected domains of perceived physical health in women with RDs. Of note, with the exception of the vitality subscale, RDs did not adversely affect the perceived mental health of participants with RD in this study. Healthcare professionals should cooperate with clinical rheumatologists, psychologists, and physiotherapists to provide comprehensive care that includes long-term education to help patients with RD self-manage stress, restore vitality, relieve pain, and increase physical function.
MeSH term(s)	Adult ; Aged ; Aged, 80 and over ; Cross-Sectional Studies ; Fatigue/etiology ; Fatigue/psychology ; Female ; Health Status ; Humans ; Middle Aged ; Pain/etiology ; Pain/psychology ; Perception ; Psychometrics/instrumentation ; Psychometrics/methods ; Rheumatic Diseases/complications ; Rheumatic Diseases/psychology ; Severity of Illness Index ; Stress, Psychological/etiology ; Stress, Psychological/psychology ; Surveys and Questionnaires ; Taiwan
Language	English
Publishing date	2019-11-05
Publishing country	China (Republic : 1949- )
Document type	Journal Article
ZDB-ID	2277010-0
ISSN	1948-965X ; 1682-3141
ISSN (online)	1948-965X
ISSN	1682-3141
DOI	10.1097/JNR.0000000000000354
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Article ; Online: The clinically crucial predictors of depression in women with systemic autoimmune diseases.

Hung, Hsuan-Man / Chen, Ming-Fu / Chen, Chung-Hey

Health care for women international

2019 Volume 41, Issue 3, Page(s) 293–307

Abstract: The researchers' aim of this study was to identify and quantify the useful, clinically crucial predictors of depression in Taiwanese women with systemic autoimmune diseases (SADs). We used a cross-sectional method. A total of 241 Taiwanese women with ... ...

Abstract	The researchers' aim of this study was to identify and quantify the useful, clinically crucial predictors of depression in Taiwanese women with systemic autoimmune diseases (SADs). We used a cross-sectional method. A total of 241 Taiwanese women with SADs between 21 and 85 years of age participated in the study. Analysis revealed that the strongest predictors of depression in participants were: perceived stress, fatigue, mental health, physical health, chronic-disease-related comorbidities, self-perceived SAD severity, and social support. The model used in the present study explained 70.9% of the variance in the depression.
MeSH term(s)	Adult ; Aged ; Aged, 80 and over ; Autoimmune Diseases/diagnosis ; Autoimmune Diseases/epidemiology ; Autoimmune Diseases/psychology ; Comorbidity ; Cross-Sectional Studies ; Depression/epidemiology ; Depression/psychology ; Depressive Disorder/diagnosis ; Depressive Disorder/epidemiology ; Fatigue/epidemiology ; Fatigue/psychology ; Female ; Humans ; Mental Health ; Middle Aged ; Predictive Value of Tests ; Severity of Illness Index ; Sickness Impact Profile ; Social Support ; Stress, Psychological/epidemiology ; Stress, Psychological/psychology ; Taiwan/epidemiology ; Young Adult
Language	English
Publishing date	2019-06-27
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	632677-8
ISSN	1096-4665 ; 0739-9332
ISSN (online)	1096-4665
ISSN	0739-9332
DOI	10.1080/07399332.2019.1623796
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Article: WIPI2 enhances the vulnerability of colorectal cancer cells to erastin via bioinformatics analysis and experimental verification.

Yu, Liying / Luo, Yan / Ding, Xile / Tang, Miaomiao / Gao, Huan / Zhang, Renfang / Chen, Mingfu / Liu, Yuchen / Chen, Qiongxia / Ouyang, Yanli / Wang, Xiang / Zhen, Hongyan

Frontiers in oncology

2023 Volume 13, Page(s) 1146617

Abstract: Introduction: WD Repeat Domain Phosphoinositide Interacting 2 (WIPI2) is a WD repeat protein that interacts with phosphatidylinositol and regulates multiprotein complexes by providing a b-propeller platform for synchronous and reversible protein-protein ...

Abstract	Introduction: WD Repeat Domain Phosphoinositide Interacting 2 (WIPI2) is a WD repeat protein that interacts with phosphatidylinositol and regulates multiprotein complexes by providing a b-propeller platform for synchronous and reversible protein-protein interactions assembled proteins. Ferroptosis is a novel iron-dependent form of cell death. It is usually accompanied with the accumulation of membrane lipid peroxides. Our study is to focus on investigating the effect of WIPI2 on the growth and ferroptosis of colorectal cancer (CRC) cells and its potential mechanism. Methods: We analyzed the expression of WIPI2 in colorectal cancer versus normal tissues through The Cancer Genome Atlas (TCGA), and the relationship between clinical traits and WIPI2 expression and prognosis was assessed by univariate and multifactorial cox analysis. Next, we constructed the siRNAs targeting the WIPI2 sequence si-WIPI2 to further investigate the mechanism of WIPI2 in CRC cells through vitro experiments. Results: Public data from the TCGA platform showed that WIPI2 expression was significantly elevated in colorectal cancer tissues compared to paracancerous tissues, and high WIPI2 expressionpredicted poor prognosis for CRC patients. Moreover, we found that the knockdown of WIPI2 expression could inhibit the growth and proliferation of HCT116 and HT29 cells. Furthermore, we found that the expression level of ACSL4 decreased and that of GPX4 increased when WIPI2 was knocked down, suggesting that WIPI2 can potentially positively regulate CRC ferroptosis. Meanwhile, both NC and si groups were able to further inhibit cell growth activity, as well as increase WIPI2 and decrease GPX4 expression when treated with Erastin, but the rate of cell viability inhibition and the trend of protein changes were more significantly in the NC group than si groups, which indicated that Erastin induced CRC ferroptosis through the WIPI2/GPX4 pathway thereby enhancing the sensitivity of colorectal cancer cells to Erastin. Conclusions: Our study suggested that WIPI2 had a promotional effect on the growth of colorectal cancer cells, and it also played an important role in the ferroptosis pathway.
Language	English
Publishing date	2023-05-03
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2649216-7
ISSN	2234-943X
ISSN	2234-943X
DOI	10.3389/fonc.2023.1146617
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Article ; Online: A Synthetic Bioinspired Carbohydrate Polymer with Mucoadhesive Properties.

Balijepalli, Anant S / Sabatelle, Robert C / Chen, Mingfu / Suki, Bela / Grinstaff, Mark W

Angewandte Chemie (International ed. in English)

2019 Volume 59, Issue 2, Page(s) 704–710

Abstract: Mucoadhesive polymers are of significant interest to the pharmaceutical, medical device, and cosmetic industries. Polysaccharides possessing charged functional groups, such as chitosan, are known for mucoadhesive properties but suffer from poor chemical ... ...

Abstract	Mucoadhesive polymers are of significant interest to the pharmaceutical, medical device, and cosmetic industries. Polysaccharides possessing charged functional groups, such as chitosan, are known for mucoadhesive properties but suffer from poor chemical definition and solubility, while the chemical synthesis of polysaccharides is challenging with few reported examples of synthetic carbohydrate polymers with engineered-in ionic functionality. We report the design, synthesis, and evaluation of a synthetic, cationic, enantiopure carbohydrate polymer inspired by the structure of chitosan. These water-soluble, cytocompatible polymers are prepared via an anionic ring-opening polymerization of a bicyclic β-lactam sugar monomer. The synthetic method provides control over the site of amine functionalization and the length of the polymer while providing narrow dispersities. These well-defined polymers are mucoadhesive as documented in single-molecule scale (AFM), bulk solution phase (FRAP), and ex vivo tissue experiments. Polymer length and functionality affects bioactivity as long, charged polymers display higher mucoadhesivity than long, neutral polymers or short, charged polymers.
MeSH term(s)	Carbohydrates/chemistry ; Chitosan/chemistry ; Humans ; Polymerization ; Polymers/chemistry
Chemical Substances	Carbohydrates ; Polymers ; Chitosan (9012-76-4)
Language	English
Publishing date	2019-11-27
Publishing country	Germany
Document type	Journal Article ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	2011836-3
ISSN	1521-3773 ; 1433-7851
ISSN (online)	1521-3773
ISSN	1433-7851
DOI	10.1002/anie.201911720
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Article: Dexmedetomidine inhibits inflammation in microglia cells under stimulation of LPS and ATP by c-Fos/NLRP3/caspase-1 cascades.

Li, Hu / Zhang, Xueping / Chen, Mingfu / Chen, Jianyan / Gao, Tao / Yao, Shanglong

EXCLI journal

2018 Volume 17, Page(s) 302–311

Abstract: NOD-like receptor 3 (NLRP3) plays critical roles in the initiation of inflammasome-mediated inflammation in microglia, thus becomes an important therapeutic target of Alzheimer's disease (AD). Dexmedetomidine (Dex), a new type of clinical anesthetic ... ...

Abstract	NOD-like receptor 3 (NLRP3) plays critical roles in the initiation of inflammasome-mediated inflammation in microglia, thus becomes an important therapeutic target of Alzheimer's disease (AD). Dexmedetomidine (Dex), a new type of clinical anesthetic agent, shows anti-inflammatory properties and inhibits postoperative cognitive dysfunction in AD patients. The present study was aimed to investigate effect of Dex on NLRP3 activity in activated microglia and reveal the underlying mechanisms. The human microglia clone 3 (HMC3) cells were exposed to 100 ng/ml LPS and 5 mM ATP, in the presence and absence of doses of Dex. Data from ELISA and Western blot assays showed that Dex abrogated the promoting effects of LPS/ATP on the release of pro-inflammatory cytokines including IL-1β and IL-18 in the cell medium and the expression of NLRP3 and its downstream target caspase-1 in HMC3 cells. Furthermore, the present study found that exposure of HMC3 cells to LPS/ATP increased nuclear protein levels of transcription factor c-Fos, but treatment with Dex reversed the increase in c-Fos, as indicated by Western blot and immunofluorescence measures. Luciferase reported assay revealed that c-Fos can bind to the promoter region of
Language	English
Publishing date	2018-03-22
Publishing country	Germany
Document type	Journal Article
ISSN	1611-2156
ISSN	1611-2156
DOI	10.17179/excli2017-1018
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Article: Amiodarone for the Successful Management of Caowu Poisoning - Induced Cardiac Arrhythmia.

Chen, Ming-Fu / Ho, Cheng-Hsuan / Tsai, Tsung-Neng / Chen, Pai-Shan / Chen, Sy-Jou

Acta Cardiologica Sinica

2018 Volume 34, Issue 2, Page(s) 189–191

Language	English
Publishing date	2018-03-28
Publishing country	China (Republic : 1949- )
Document type	Journal Article
ZDB-ID	1051394-2
ISSN	1011-6842
ISSN	1011-6842
DOI	10.6515/ACS.201803_34(2).20171120A
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Article ; Online: Contemporary approaches for nonviral gene therapy.

Jones, Charles H / Hill, Andrew / Chen, Mingfu / Pfeifer, Blaine A

Discovery medicine

2015 Volume 19, Issue 107, Page(s) 447–454

Abstract: Gene therapy is the manipulation of gene expression patterns in specific cells to treat genetic and pathological diseases. This manipulation is accomplished by the controlled introduction of exogenous nucleic acids into target cells. Given the size and ... ...

Abstract	Gene therapy is the manipulation of gene expression patterns in specific cells to treat genetic and pathological diseases. This manipulation is accomplished by the controlled introduction of exogenous nucleic acids into target cells. Given the size and negative charge of these biomacromolecules, the delivery process is driven by the carrier vector, of which the usage of viral vectors dominates. Taking into account the limitations of viral vectors, nonviral alternatives have gained significant attention due to their flexible design, low cytotoxicity and immunogenicity, and their gene delivery efficacy. That stated, the field of nonviral vectors has been dominated by research dedicated to overcoming barriers in gene transfer. Unfortunately, these traditional nonviral vectors have failed to completely overcome the barriers required for clinical translation and thus, have failed to match the delivery outcomes of viral vector. This has consequently encouraged the development of new, more radical approaches that have the potential for higher clinical translation. In this review, we discuss recent advances in vector technology and nucleic acid chemistry that have challenged the current understanding of nonviral systems. The diversity of these approaches highlights the numerous alternative avenues for overcoming innate and technical barriers associated with gene delivery.
MeSH term(s)	Animals ; Gene Transfer Techniques ; Genetic Therapy/methods ; Genetic Vectors/genetics ; Genetic Vectors/therapeutic use ; Humans
Language	English
Publishing date	2015-07-29
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	2415544-5
ISSN	1944-7930 ; 1944-7930
ISSN (online)	1944-7930
ISSN	1944-7930
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Article: Hydrogel-Embedded Quantum Dot–Transcription Factor Sensors for Quantitative Progesterone Detection

Chen, Mingfu / Grazon, Chloé / Sensharma, Prerana / Nguyen, Thuy T / Feng, Yunpeng / Chern, Margaret / Baer, R. C / Varongchayakul, Nitinun / Cook, Katherine / Lecommandoux, Sébastien / Klapperich, Catherine M / Galagan, James E / Dennis, Allison M / Grinstaff, Mark W

ACS applied materials & interfaces. 2020 Sept. 07, v. 12, no. 39

2020

Abstract: Immobilization of biosensors in or on a functional material is critical for subsequent device development and translation to wearable technology. Here, we present the development and assessment of an immobilized quantum dot–transcription factor–nucleic ... ...

Abstract	Immobilization of biosensors in or on a functional material is critical for subsequent device development and translation to wearable technology. Here, we present the development and assessment of an immobilized quantum dot–transcription factor–nucleic acid complex for progesterone detection as a first step toward such device integration. The sensor, composed of a polyhistidine-tagged transcription factor linked to a quantum dot and a fluorophore-modified cognate DNA, is embedded within a hydrogel as an immobilization matrix. The hydrogel is optically transparent, soft, and flexible as well as traps the quantum dot–transcription factor DNA assembly but allows free passage of the analyte, progesterone. Upon progesterone exposure, DNA dissociates from the quantum dot–transcription factor DNA assembly resulting in an attenuated ratiometric fluorescence output via Förster resonance energy transfer. The sensor performs in a dose-dependent manner with a limit of detection of 55 nM. Repeated analyte measurements are similarly successful. Our approach combines a systematically characterized hydrogel as an immobilization matrix and a transcription factor–DNA assembly as a recognition/transduction element, offering a promising framework for future biosensor devices.
Keywords	DNA ; DNA assembly ; biosensors ; detection limit ; dose response ; energy transfer ; fluorescence ; hydrogels ; progesterone ; quantum dots ; transcription factors
Language	English
Dates of publication	2020-0907
Size	p. 43513-43521.
Publishing place	American Chemical Society
Document type	Article
Note	NAL-AP-2-clean
ISSN	1944-8252
DOI	10.1021/acsami.0c13489
Database	NAL-Catalogue (AGRICOLA)

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