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Article ; Online: Antimicrobial polysaccharide hydrogels embedded with methyl-β-cyclodextrin/thyme oil inclusion complexes for exceptional mechanical performance and chilled chicken breast preservation.

Chen, Mingshan / Hu, Zhiyu / Zheng, Haoyuan / Wang, Jiesheng / Xu, Xiaowen

International journal of biological macromolecules

2024 Volume 267, Issue Pt 2, Page(s) 131586

Abstract: While hydrogels have potential for food packaging, limited research on hydrogels with excellent mechanical performance and antibacterial activity for preserving chicken breasts. Herein, we created antibacterial hydrogels by embedding methyl-β- ... ...

Abstract	While hydrogels have potential for food packaging, limited research on hydrogels with excellent mechanical performance and antibacterial activity for preserving chicken breasts. Herein, we created antibacterial hydrogels by embedding methyl-β-cyclodextrin/thyme oil inclusion complexes (MCD/TO-ICs) into a polyvinyl alcohol matrix containing dendrobium polysaccharides and guar gum in varying ratios using freeze-thaw cycling method. The resulting hydrogels exhibited a more compact structure than those without MCD/TO-ICs, enhancing thermal stability and increasing glass transition temperature due to additional intermolecular interactions between polymer chains that inhibited chain movement. XRD analysis showed no significant changes in crystalline phase, enabling formation of a 3D network through abundant hydrogen bonding. Moreover, the hydrogel demonstrated exceptional durability, with a toughness of 350 ± 25 kJ/m
MeSH term(s)	Animals ; Hydrogels/chemistry ; Hydrogels/pharmacology ; Chickens ; Polysaccharides/chemistry ; Polysaccharides/pharmacology ; Food Preservation/methods ; beta-Cyclodextrins/chemistry ; Food Packaging/methods ; Galactans/chemistry ; Galactans/pharmacology ; Anti-Infective Agents/pharmacology ; Anti-Infective Agents/chemistry ; Anti-Bacterial Agents/pharmacology ; Anti-Bacterial Agents/chemistry ; Antioxidants/pharmacology ; Antioxidants/chemistry ; Oils, Volatile/chemistry ; Oils, Volatile/pharmacology ; Mannans ; Plant Gums
Chemical Substances	Hydrogels ; Polysaccharides ; beta-Cyclodextrins ; Galactans ; Anti-Infective Agents ; Anti-Bacterial Agents ; Antioxidants ; Oils, Volatile ; guar gum (E89I1637KE) ; Mannans ; Plant Gums
Language	English
Publishing date	2024-04-13
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	282732-3
ISSN	1879-0003 ; 0141-8130
ISSN (online)	1879-0003
ISSN	0141-8130
DOI	10.1016/j.ijbiomac.2024.131586
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Zs.B 2374: Show issues

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Article ; Online: Modulation of secretory factors by lipofundin contributes to its anti‑neuroinflammatory effects.

Chen, Ming-Shan / Hu, Chia-Lin / Jiang, Shin-Kuang / Chong, Zhi-Yong / Chen, Jui-Chieh

Experimental and therapeutic medicine

2024 Volume 27, Issue 4, Page(s) 169

Abstract: As the global population ages, the prevalence of neuroinflammatory diseases such as Alzheimer's disease, Parkinson's disease and stroke continues to increase. Therefore, it is necessary to develop preventive and therapeutic methods against ... ...

Abstract	As the global population ages, the prevalence of neuroinflammatory diseases such as Alzheimer's disease, Parkinson's disease and stroke continues to increase. Therefore, it is necessary to develop preventive and therapeutic methods against neuroinflammatory diseases. Lipofundin is a lipid emulsion commonly used in clinical anesthetic solvents and nutritional supplements. Lipid emulsions have been shown to possess anti-inflammatory properties. However, the potential beneficial effect of lipofundin against neuroinflammation requires elucidation. In the present study, two cell models were used to investigate the efficacy of lipofundin against neuroinflammation. In the first model, BV2 mouse microglial cells were treated with lipopolysaccharide (LPS) to induce nitric oxide (NO) production as a model of neuroinflammation. In the second model, HMC3 human microglial were activated by LPS, and changes in the secretion of factors associated with inflammation were analyzed using Luminex xMAP
Language	English
Publishing date	2024-02-27
Publishing country	Greece
Document type	Journal Article
ZDB-ID	2683844-8
ISSN	1792-1015 ; 1792-0981
ISSN (online)	1792-1015
ISSN	1792-0981
DOI	10.3892/etm.2024.12456
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Article ; Online: Multi-Staged Surgeries for Coexisting Facial Asymmetry and Strabismus in Parry-Romberg Syndrome.

Fang, Chien-Liang / Tsai, Chong-Bin / Chen, Ming-Shan

The Journal of craniofacial surgery

2022 Volume 33, Issue 5, Page(s) e495–e497

Abstract: Abstract: Parry-Romberg syndrome (PRS) is a rare disorder resulting in disfiguring facial asymmetry. Ocular manifestations can result in complex strabismus. There were limited reports on the treatment of PRS with coexisting strabismus. We present a ... ...

Abstract	Abstract: Parry-Romberg syndrome (PRS) is a rare disorder resulting in disfiguring facial asymmetry. Ocular manifestations can result in complex strabismus. There were limited reports on the treatment of PRS with coexisting strabismus. We present a multistaged surgical approach to manage the facial asymmetry and strabismus.
MeSH term(s)	Adolescent ; Face ; Facial Asymmetry/etiology ; Facial Asymmetry/surgery ; Facial Hemiatrophy/complications ; Facial Hemiatrophy/surgery ; Female ; Humans ; Strabismus/complications ; Strabismus/surgery
Language	English
Publishing date	2022-06-27
Publishing country	United States
Document type	Case Reports ; Journal Article
ZDB-ID	1159501-2
ISSN	1536-3732 ; 1049-2275
ISSN (online)	1536-3732
ISSN	1049-2275
DOI	10.1097/SCS.0000000000008400
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Zs.A 3761: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 175: Show issues

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Article ; Online: Oncolytic viruses-modulated immunogenic cell death, apoptosis and autophagy linking to virotherapy and cancer immune response.

Wu, Yi-Ying / Sun, Te-Kai / Chen, Ming-Shan / Munir, Muhammad / Liu, Hung-Jen

Frontiers in cellular and infection microbiology

2023 Volume 13, Page(s) 1142172

Abstract: Recent reports have revealed that oncolytic viruses (OVs) play a significant role in cancer therapy. The infection of OVs such as oncolytic vaccinia virus (OVV), vesicular stomatitis virus (VSV), parvovirus, mammalian reovirus (MRV), human adenovirus, ... ...

Abstract	Recent reports have revealed that oncolytic viruses (OVs) play a significant role in cancer therapy. The infection of OVs such as oncolytic vaccinia virus (OVV), vesicular stomatitis virus (VSV), parvovirus, mammalian reovirus (MRV), human adenovirus, Newcastle disease virus (NDV), herpes simplex virus (HSV), avian reovirus (ARV), Orf virus (ORFV), inactivated Sendai virus (ISV), enterovirus, and coxsackievirus offer unique opportunities in immunotherapy through diverse and dynamic pathways. This mini-review focuses on the mechanisms of OVs-mediated virotherapy and their effects on immunogenic cell death (ICD), apoptosis, autophagy and regulation of the immune system.
MeSH term(s)	Animals ; Humans ; Oncolytic Viruses ; Immunogenic Cell Death ; Neoplasms/therapy ; Apoptosis ; Immunity ; Autophagy ; Mammals
Language	English
Publishing date	2023-03-15
Publishing country	Switzerland
Document type	Journal Article ; Review ; Research Support, Non-U.S. Gov't
ZDB-ID	2619676-1
ISSN	2235-2988 ; 2235-2988
ISSN (online)	2235-2988
ISSN	2235-2988
DOI	10.3389/fcimb.2023.1142172
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Article ; Online: Lidocaine attenuates TMZ resistance and inhibits cell migration by modulating the MET pathway in glioblastoma cells.

Chen, Ming-Shan / Chong, Zhi-Yong / Huang, Cheng / Huang, Hsiu-Chen / Su, Pin-Hsuan / Chen, Jui-Chieh

Oncology reports

2024 Volume 51, Issue 5

Abstract: Glioblastoma multiforme (GBM) is the most aggressive type of malignant brain tumor. Currently, the predominant clinical treatment is the combination of surgical resection with concurrent radiotherapy and chemotherapy, using temozolomide (TMZ) as the ... ...

Abstract	Glioblastoma multiforme (GBM) is the most aggressive type of malignant brain tumor. Currently, the predominant clinical treatment is the combination of surgical resection with concurrent radiotherapy and chemotherapy, using temozolomide (TMZ) as the primary chemotherapy drug. Lidocaine, a widely used amide‑based local anesthetic, has been found to have a significant anticancer effect. It has been reported that aberrant hepatocyte growth factor (HGF)/mesenchymal‑epithelial transition factor (MET) signaling plays a role in the progression of brain tumors. However, it remains unclear whether lidocaine can regulate the MET pathway in GBM. In the present study, the clinical importance of the HGF/MET pathway was analyzed using bioinformatics. By establishing TMZ‑resistant cell lines, the impact of combined treatment with lidocaine and TMZ was investigated. Additionally, the effects of lidocaine on cellular function were also examined and confirmed using knockdown techniques. The current findings revealed that the HGF/MET pathway played a key role in brain cancer, and its activation in GBM was associated with increased malignancy and poorer patient outcomes. Elevated HGF levels and activation of its receptor were found to be associated with TMZ resistance in GBM cells. Lidocaine effectively suppressed the HGF/MET pathway, thereby restoring TMZ sensitivity in TMZ‑resistant cells. Furthermore, lidocaine also inhibited cell migration. Overall, these results indicated that inhibiting the HGF/MET pathway using lidocaine can enhance the sensitivity of GBM cells to TMZ and reduce cell migration, providing a potential basis for developing novel therapeutic strategies for GBM.
MeSH term(s)	Humans ; Antineoplastic Agents, Alkylating/pharmacology ; Brain Neoplasms/drug therapy ; Brain Neoplasms/genetics ; Brain Neoplasms/metabolism ; Cell Line, Tumor ; Cell Movement ; Drug Resistance, Neoplasm ; Glioblastoma/drug therapy ; Glioblastoma/genetics ; Glioblastoma/metabolism ; Lidocaine/pharmacology ; Lidocaine/therapeutic use ; Signal Transduction ; Temozolomide/therapeutic use
Chemical Substances	Antineoplastic Agents, Alkylating ; Lidocaine (98PI200987) ; Temozolomide (YF1K15M17Y)
Language	English
Publishing date	2024-04-12
Publishing country	Greece
Document type	Journal Article
ZDB-ID	1222484-4
ISSN	1791-2431 ; 1021-335X
ISSN (online)	1791-2431
ISSN	1021-335X
DOI	10.3892/or.2024.8731
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Zs.A 4213: Show issues

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Article ; Online: Novel Role of Hemeoxygenase-1 in Phthalate-Induced Renal Proximal Tubule Cell Ferroptosis.

Chen, Ming-Shan / Wang, Jia-Xin / Zhang, Hao / Cui, Jia-Gen / Zhao, Yi / Li, Jin-Long

Journal of agricultural and food chemistry

2023 Volume 71, Issue 5, Page(s) 2579–2589

Abstract: Phthalates are widely used to improve the flexibility of poly(vinyl chloride) (PVC) polymer agriculture products. Di(2-ethylhexyl) phthalate (DEHP) is a type of addition to plastic and can lead to many health problems. Hemeoxygenase-1 (HO-1) is an ... ...

Abstract	Phthalates are widely used to improve the flexibility of poly(vinyl chloride) (PVC) polymer agriculture products. Di(2-ethylhexyl) phthalate (DEHP) is a type of addition to plastic and can lead to many health problems. Hemeoxygenase-1 (HO-1) is an extremely important molecule that releases enzymatic products to promote ferroptosis. This research aimed to explore the function of HO-1 in DEHP-induced renal proximal tubule cell ferroptosis. In the experiment, ICR male mice are exposed to (0, 50, 200, and 500 mg/kg BW/day) DEHP for 28 days. Here, we observed that DEHP induced glomeruli atrophy and the tubules swell. Furthermore, DEHP exposure could increase ferrous iron content and decrease antioxidant activity. We also found that DEHP exposure increased the expression of nuclear factor-erythroid 2 p45-related factor 2 (NFE2L2) in the nucleus. In particular, the expression of (HO-1) is significantly increased both in protein and mRNA levels. Glutathione peroxidase 4 (GPX4) as an endogenous control of ferroptosis was downregulated, which proved the occurrence of ferroptosis. In the study, exposure to DEHP activated the NFE2L2/HO-1 signaling pathway and resulted in ferroptosis of the proximal tubule. This research connects ferroptosis with HO-1, providing new insights into the potential roles of phthalates in nephrotoxicity.
MeSH term(s)	Animals ; Male ; Mice ; Diethylhexyl Phthalate/toxicity ; Ferroptosis ; Mice, Inbred ICR ; Phthalic Acids ; Heme Oxygenase-1
Chemical Substances	Diethylhexyl Phthalate (C42K0PH13C) ; phthalic acid (6O7F7IX66E) ; Phthalic Acids ; Heme Oxygenase-1 (EC 1.14.14.18)
Language	English
Publishing date	2023-01-25
Publishing country	United States
Document type	Journal Article
ZDB-ID	241619-0
ISSN	1520-5118 ; 0021-8561
ISSN (online)	1520-5118
ISSN	0021-8561
DOI	10.1021/acs.jafc.2c07762
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Zs.A 1172: Show issues

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Article ; Online: Abducens nerve palsy treated by tethering the globe to the lateral orbital rim with a bone screw.

Tsai, Chong-Bin / Fang, Chien-Liang / Chen, Ming-Shan

Journal of AAPOS : the official publication of the American Association for Pediatric Ophthalmology and Strabismus

2021 Volume 25, Issue 2, Page(s) 123–125

Abstract: We report the case of a 38-year-old man with abducens palsy following a traumatic skull injury who failed multiple strabismus surgeries. A suture-armed 5 mm micro bone screw was placed on the anterior face of the lateral orbital rim and used to tether ... ...

Abstract	We report the case of a 38-year-old man with abducens palsy following a traumatic skull injury who failed multiple strabismus surgeries. A suture-armed 5 mm micro bone screw was placed on the anterior face of the lateral orbital rim and used to tether and abduct the globe. The patient remained orthotropic in primary position 12 months postoperatively.
MeSH term(s)	Abducens Nerve Diseases/etiology ; Abducens Nerve Diseases/surgery ; Adult ; Bone Screws ; Humans ; Male ; Oculomotor Muscles ; Skull ; Sutures
Language	English
Publishing date	2021-02-27
Publishing country	United States
Document type	Case Reports ; Journal Article
ZDB-ID	1412476-2
ISSN	1528-3933 ; 1091-8531
ISSN (online)	1528-3933
ISSN	1091-8531
DOI	10.1016/j.jaapos.2020.11.013
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Zs.A 5188: Show issues

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Article ; Online: Heme-oxygenase-1 as a target for phthalate-induced cardiomyocytes ferroptosis.

Wang, Jia-Xin / Zhao, Yi / Chen, Ming-Shan / Zhang, Hao / Cui, Jia-Gen / Li, Jin-Long

Environmental pollution (Barking, Essex : 1987)

2022 Volume 317, Page(s) 120717

Abstract: Phthalates as a large group of environmental pollutants are used primarily as plasticizers and solvents, which have become a growing problem worldwide. Epidemiological results show that severity of heart disease is related to degree of environmental ... ...

Abstract	Phthalates as a large group of environmental pollutants are used primarily as plasticizers and solvents, which have become a growing problem worldwide. Epidemiological results show that severity of heart disease is related to degree of environmental contamination. As the most usually used phthalate, di(2-ethylhexyl) phthalate (DEHP) has toxic effects on organism health and is also a major cause of heart damage. Ingestion of food, liquid, or dust contaminated with DEHP are major routes of exposure. The purpose of the present research was to determine the mechanism of cardiotoxicity in mice after exposure to DEHP. Here, male mice were treated by gavage with three different doses of (50, 200 and 500 mg/kg b.w.) DEHP for 28 days. Our research showed that DEHP brought about histopathological changes involving cardiomyocyte lysis and rupture, and ultrastructural damage such as dissolution and loss of mitochondrial cristae. Furthermore, DEHP induced oxidative stress and a significant decline in the antioxidant function, which activates nuclear factor E2-related factor 2 (Nrf2)/heme-oxygense-1 (HO-1) signaling pathways. Interestingly, DEHP resulted in lipid peroxidation and increased ferrous ion content, suggesting that ferroptosis occurred in mouse hearts. Therefore, our findings demonstrated that DEHP could induce cardiac ferroptosis via upregulation of HO-1. The present study provides novel evidence of HO-1 as a target for DEHP-induced cardiotoxicity.
Language	English
Publishing date	2022-11-21
Publishing country	England
Document type	Journal Article
ZDB-ID	280652-6
ISSN	1873-6424 ; 0013-9327 ; 0269-7491
ISSN (online)	1873-6424
ISSN	0013-9327 ; 0269-7491
DOI	10.1016/j.envpol.2022.120717
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Zs.A 2599: Show issues

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Article ; Online: In Utero Cell Treatment of Hemophilia A Mice via Human Amniotic Fluid Mesenchymal Stromal Cell Engraftment.

Kao, Yung-Tsung / Yen, Chih-Ching / Fan, Hueng-Chuen / Chen, Jen-Kun / Chen, Ming-Shan / Lan, Ying-Wei / Yang, Shang-Hsun / Chen, Chuan-Mu

International journal of molecular sciences

2023 Volume 24, Issue 22

Abstract: Hemophilia is a genetic disorder linked to the sex chromosomes, resulting in impaired blood clotting due to insufficient intrinsic coagulation factors. There are approximately one million individuals worldwide with hemophilia, with hemophilia A being the ...

Abstract	Hemophilia is a genetic disorder linked to the sex chromosomes, resulting in impaired blood clotting due to insufficient intrinsic coagulation factors. There are approximately one million individuals worldwide with hemophilia, with hemophilia A being the most prevalent form. The current treatment for hemophilia A involves the administration of clotting factor VIII (FVIII) through regular and costly injections, which only provide temporary relief and pose inconveniences to patients. In utero transplantation (IUT) is an innovative method for addressing genetic disorders, taking advantage of the underdeveloped immune system of the fetus. This allows mesenchymal stromal cells to play a role in fetal development and potentially correct genetic abnormalities. The objective of this study was to assess the potential recovery of coagulation disorders in FVIII knockout hemophilia A mice through the administration of human amniotic fluid mesenchymal stromal cells (hAFMSCs) via IUT at the D14.5 fetal stage. The findings revealed that the transplanted human cells exhibited fusion with the recipient liver, with a ratio of approximately one human cell per 10,000 mouse cells and produced human FVIII protein in the livers of IUT-treated mice. Hemophilia A pups born to IUT recipients demonstrated substantial improvement in their coagulation issues from birth throughout the growth period of up to 12 weeks of age. Moreover, FVIII activity reached its peak at 6 weeks of age, while the levels of FVIII inhibitors remained relatively low during the 12-week testing period in mice with hemophilia. In conclusion, the results indicated that prenatal intrahepatic therapy using hAFMSCs has the potential to improve clotting issues in FVIII knockout mice, suggesting it as a potential clinical treatment for individuals with hemophilia A.
MeSH term(s)	Pregnancy ; Female ; Humans ; Mice ; Animals ; Infant ; Hemophilia A/genetics ; Hemophilia A/therapy ; Amniotic Fluid/metabolism ; Factor VIII/genetics ; Factor VIII/metabolism ; Hemostatics/metabolism ; Mice, Knockout ; Mesenchymal Stem Cells/metabolism
Chemical Substances	Factor VIII (9001-27-8) ; Hemostatics
Language	English
Publishing date	2023-11-16
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms242216411
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Article ; Online: Factors Affecting Postoperative Complications of Suction-Curettage by Arthroscopic Shaver for Bromhidrosis.

Chen, Kun-Han / Changchien, Chih-Hsuan / Fang, Chien-Liang / Yang, Cheng-San / Tsai, Chong-Bin / Chen, Ming-Shan / Yang, Hsin-Yi

Annals of plastic surgery

2023 Volume 90, Issue 5, Page(s) 471–477

Abstract: Background: Suction-curettage by arthroscopic shaver is the most effective treatment for bromhidrosis; however, postoperative complications require wound management and exhibit a high risk of hypertrophic scarring. We investigated factors affecting ... ...

Abstract	Background: Suction-curettage by arthroscopic shaver is the most effective treatment for bromhidrosis; however, postoperative complications require wound management and exhibit a high risk of hypertrophic scarring. We investigated factors affecting postoperative complications. Methods: We retrospectively evaluated data for 215 patients (430 axillae) with bromhidrosis treated with suction-curettage by arthroscopic shaver between 2011 and 2019. Cases followed for less than 1 year were excluded. Complications of hematoma or seroma, epidermis decortication, skin necrosis, and infection were recorded. Multinomial logistic analysis was used to calculate odds ratios and corresponding 95% confidence intervals for the complication of the surgery, adjusting for relevant statistically significant variables. Results: Complications occurred in 52 axillae (12.1%). Epidermis decortication occurred in 24 axillae (5.6%), with a significant difference for age (P < 0.001). Hematoma occurred in 10 axillae (2.3%) with a significant difference in tumescent infiltration use (P = 0.039). Skin necrosis occurred in 16 axillae (3.7%) with a significant difference for age (P = 0.001). Infection occurred in 2 axillae (0.5%). Severe scarring occurred in 15 axillae (3.5%), with complications related to more severe skin scarring (P < 0.05). Conclusion: Older age was a risk factor for complications. Use of tumescent infiltration resulted in good postoperative pain control and less hematoma. Patients with complications presented with more severe skin scarring, but none experienced limited range of motion after massage.
MeSH term(s)	Humans ; Hyperhidrosis/surgery ; Body Odor ; Suction/methods ; Retrospective Studies ; Curettage/adverse effects ; Curettage/methods ; Postoperative Complications/epidemiology ; Postoperative Complications/etiology ; Postoperative Complications/surgery ; Cicatrix, Hypertrophic/etiology ; Hematoma/etiology ; Necrosis/etiology ; Necrosis/surgery
Language	English
Publishing date	2023-03-08
Publishing country	United States
Document type	Journal Article
ZDB-ID	423835-7
ISSN	1536-3708 ; 0148-7043
ISSN (online)	1536-3708
ISSN	0148-7043
DOI	10.1097/SAP.0000000000003541
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