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  1. Article ; Online: Research progress on carotenoid production by Rhodosporidium toruloides.

    Xie, Zhuo-Ting / Mi, Bing-Qian / Lu, Yong-Jun / Chen, Mou-Tong / Ye, Zhi-Wei

    Applied microbiology and biotechnology

    2024  Volume 108, Issue 1, Page(s) 7

    Abstract: Carotenoids are natural lipophilic pigments, which have been proven to provide significant health benefits to humans, relying on their capacity to efficiently scavenge singlet oxygen and peroxyl radicals as antioxidants. Strains belonging to the genus ... ...

    Abstract Carotenoids are natural lipophilic pigments, which have been proven to provide significant health benefits to humans, relying on their capacity to efficiently scavenge singlet oxygen and peroxyl radicals as antioxidants. Strains belonging to the genus Rhodosporidium represent a heterogeneous group known for a number of phenotypic traits including accumulation of carotenoids and lipids and tolerance to heavy metals and oxidative stress. As a representative of these yeasts, Rhodosporidium toruloides naturally produces carotenoids with high antioxidant activity and grows on a wide variety of carbon sources. As a result, R. toruloides is a promising host for the efficient production of more value-added lipophilic compound carotenoids, e.g., torulene and torularhodin. This review provides a comprehensive summary of the research progress on carotenoid biosynthesis in R. toruloides, focusing on the understanding of biosynthetic pathways and the regulation of key enzymes and genes involved in the process. Moreover, the relationship between the accumulation of carotenoids and lipid biosynthesis, as well as the stress from diverse abiotic factors, has also been discussed for the first time. Finally, several feasible strategies have been proposed to promote carotenoid production by R. toruloides. It is possible that R. toruloides may become a critical strain in the production of carotenoids or high-value terpenoids by genetic technologies and optimal fermentation processes. KEY POINTS: • Biosynthetic pathway and its regulation of carotenoids in Rhodosporidium toruloides were concluded • Stimulation of abiotic factors for carotenoid biosynthesis in R. toruloides was summarized • Feasible strategies for increasing carotenoid production by R. toruloides were proposed.
    MeSH term(s) Humans ; Carotenoids/metabolism ; Rhodotorula/genetics ; Yeasts/metabolism ; Biosynthetic Pathways
    Chemical Substances Carotenoids (36-88-4)
    Language English
    Publishing date 2024-01-03
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 392453-1
    ISSN 1432-0614 ; 0171-1741 ; 0175-7598
    ISSN (online) 1432-0614
    ISSN 0171-1741 ; 0175-7598
    DOI 10.1007/s00253-023-12943-0
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2229: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: Microbiologic risk factors of recurrent choledocholithiasis post-endoscopic sphincterotomy.

    Li, Ying / Tan, Wen-Hui / Wu, Jia-Chuan / Huang, Zhi-Xin / Shang, Yan-Yan / Liang, Biao / Chen, Jian-Hui / Pang, Rui / Xie, Xin-Qiang / Zhang, Ju-Mei / Ding, Yu / Xue, Liang / Chen, Mou-Tong / Wang, Juan / Wu, Qing-Ping

    World journal of gastroenterology

    2021  Volume 28, Issue 12, Page(s) 1257–1271

    Abstract: Background: Choledocholithiasis is a severe disorder that affects a significant portion of the world's population. Treatment using endoscopic sphincterotomy (EST) has become widespread; however, recurrence post-EST is relatively common. The bile ... ...

    Abstract Background: Choledocholithiasis is a severe disorder that affects a significant portion of the world's population. Treatment using endoscopic sphincterotomy (EST) has become widespread; however, recurrence post-EST is relatively common. The bile microbiome has a profound influence on the recurrence of choledocholithiasis in patients after EST; however, the key pathogens and their functions in the biliary tract remain unclear.
    Aim: To investigate the biliary microbial characteristics of patients with recurrent choledocholithiasis post-EST, using next-generation sequencing.
    Methods: This cohort study included 43 patients, who presented with choledocholithiasis at the Guangdong Second Provincial General Hospital between May and June 2020. The patients had undergone EST or endoscopic papillary balloon dilation and were followed up for over a year. They were divided into either the stable or recurrent groups. We collected bile samples and extracted microbial DNA for analysis through next-generation sequencing. Resulting sequences were analyzed for core microbiome and statistical differences between the diagnosis groups; they were examined using the Kyoto Encyclopedia of Genes and Genomes pathway hierarchy level using analysis of variance. Correlation between the key genera and metabolic pathways in bile, were analyzed using Pearson's correlation test.
    Results: The results revealed distinct clustering of biliary microbiota in recurrent choledocholithiasis. Higher relative abundances (RAs) of
    Conclusion: We demonstrated differences in the bile microbiome of patients with recurrent choledocholithiasis compared to that in patients with stable disease, thereby adding to the current knowledge on its microbiologic etiology.
    MeSH term(s) Cholangiopancreatography, Endoscopic Retrograde/adverse effects ; Choledocholithiasis/surgery ; Cohort Studies ; Humans ; Risk Factors ; Sphincterotomy, Endoscopic/adverse effects ; Sphincterotomy, Endoscopic/methods ; Treatment Outcome
    Language English
    Publishing date 2021-11-23
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2185929-2
    ISSN 2219-2840 ; 1007-9327
    ISSN (online) 2219-2840
    ISSN 1007-9327
    DOI 10.3748/wjg.v28.i12.1257
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6039: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  3. Article ; Online: Proteomics analysis of Listeria monocytogenes ATCC 19115 in response to simultaneous triple stresses.

    He, Lei / Deng, Qing-Li / Chen, Mou-Tong / Wu, Qing-Ping / Lu, Yong-Jun

    Archives of microbiology

    2015  Volume 197, Issue 6, Page(s) 833–841

    Abstract: Listeria monocytogenes can cause listeriosis in humans through consumption of contaminated food. L. monocytogenes can adapt and grow in a vast array of physiochemical stresses in the food production environment. In this study, we performed a proteomics ... ...

    Abstract Listeria monocytogenes can cause listeriosis in humans through consumption of contaminated food. L. monocytogenes can adapt and grow in a vast array of physiochemical stresses in the food production environment. In this study, we performed a proteomics strategy in order to investigate how L. monocytogenes survives with a simultaneous exposure to low pH, high salinity and low temperature. The results showed that the adaptation processes mainly affected the biochemical pathways related to protein synthesis, oxidative stress, cell wall and nucleotide metabolism. Interestingly, enzymes involved in the carbohydrate metabolism of energy, such as glycolysis and pentose phosphate pathway, were derepressed due to the down-regulation of CodY, a global transcriptional repressor. The down-regulation of CodY, together with the up-regulation of carbohydrate metabolism enzymes, likely leads to the accumulation of pyruvate and further to the activation of fatty acid synthesis pathway. Proteomics profiling offered a better understanding of the physiological responses of this pathogen to adapt to harsh environment and would hopefully contribute to improving the food-processing and storage methods.
    MeSH term(s) Adaptation, Physiological/genetics ; Bacterial Proteins/metabolism ; Cell Wall/metabolism ; Cold Temperature ; Energy Metabolism/physiology ; Fatty Acids/metabolism ; Gene Expression Profiling ; Gene Expression Regulation/physiology ; Hydrogen-Ion Concentration ; Listeria monocytogenes/metabolism ; Listeria monocytogenes/physiology ; Nucleotides/metabolism ; Oxidative Stress/genetics ; Oxidative Stress/physiology ; Proteomics ; Salinity
    Chemical Substances Bacterial Proteins ; Fatty Acids ; Nucleotides
    Language English
    Publishing date 2015-08
    Publishing country Germany
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 124824-8
    ISSN 1432-072X ; 0302-8933
    ISSN (online) 1432-072X
    ISSN 0302-8933
    DOI 10.1007/s00203-015-1116-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 805: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  4. Article: Trichloroethylene induces biphasic concentration-dependent changes in cell proliferation and the expression of SET-associated proteins in human hepatic L-02 cells.

    Hong, Wen Xu / Ye, Jin Bo / Chen, Mou Tong / Yan, Yan / Zhou, Gui Feng / Yang, Xi Fei / Yang, Liang / Ren, Xiao Hu / Huang, Hai Yan / Zhou, Li / Huang, Xin Feng / Zhuang, Zhi Xiong / Liu, Jian Jun

    Biomedical and environmental sciences : BES

    2013  Volume 26, Issue 7, Page(s) 618–621

    MeSH term(s) Cell Line ; Cell Proliferation/drug effects ; Dose-Response Relationship, Drug ; Histone Chaperones/metabolism ; Humans ; Liver/cytology ; Protein Interaction Maps ; Solvents/administration & dosage ; Solvents/toxicity ; Transcription Factors/metabolism ; Trichloroethylene/administration & dosage ; Trichloroethylene/toxicity
    Chemical Substances Histone Chaperones ; SET protein, human ; Solvents ; Transcription Factors ; Trichloroethylene (290YE8AR51)
    Language English
    Publishing date 2013-07
    Publishing country Netherlands
    Document type Letter ; Research Support, Non-U.S. Gov't
    ZDB-ID 645083-0
    ISSN 0895-3988
    ISSN 0895-3988
    DOI 10.3967/0895-3988.2013.07.016
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 2459: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  5. Article: Proteomics analysis of Listeria monocytogenes ATCC 19115 in response to simultaneous triple stresses

    He, Lei / Deng, Qing-Li / Chen, Mou-tong / Wu, Qing-ping / Lu, Yong-Jun

    Archives of microbiology

    Volume v. 197,, Issue no. 6

    Abstract: Listeria monocytogenes can cause listeriosis in humans through consumption of contaminated food. L. monocytogenes can adapt and grow in a vast array of physiochemical stresses in the food production environment. In this study, we performed a proteomics ... ...

    Abstract Listeria monocytogenes can cause listeriosis in humans through consumption of contaminated food. L. monocytogenes can adapt and grow in a vast array of physiochemical stresses in the food production environment. In this study, we performed a proteomics strategy in order to investigate how L. monocytogenes survives with a simultaneous exposure to low pH, high salinity and low temperature. The results showed that the adaptation processes mainly affected the biochemical pathways related to protein synthesis, oxidative stress, cell wall and nucleotide metabolism. Interestingly, enzymes involved in the carbohydrate metabolism of energy, such as glycolysis and pentose phosphate pathway, were derepressed due to the down-regulation of CodY, a global transcriptional repressor. The down-regulation of CodY, together with the up-regulation of carbohydrate metabolism enzymes, likely leads to the accumulation of pyruvate and further to the activation of fatty acid synthesis pathway. Proteomics profiling offered a better understanding of the physiological responses of this pathogen to adapt to harsh environment and would hopefully contribute to improving the food-processing and storage methods.
    Keywords Listeria monocytogenes ; repressor proteins ; glycolysis ; fatty acids ; humans ; salinity ; cell walls ; pathogens ; enzymes ; oxidative stress ; temperature ; food processing ; pyruvic acid ; food contamination ; protein synthesis ; listeriosis ; proteomics ; food production ; pentose phosphate cycle ; pH ; physiological response
    Language English
    Document type Article
    ISSN 0302-8933
    Database AGRIS - International Information System for the Agricultural Sciences and Technology

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