LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 6 of total 6

Search options

  1. Article ; Online: Total Synthesis of the Racemate of Laurolitsine.

    Cao, Mingyu / Wang, Yiming / Zhang, Yong / Zhang, Caiyun / Chen, Niangen / Zhang, Xiaopo

    Molecules (Basel, Switzerland)

    2024  Volume 29, Issue 3

    Abstract: The total synthesis of laurolitsine was achieved for the first time. This reaction was accomplished in 14 steps with a 2.3% yield (this was calculated using 3-hydroxy-4-methoxybenzaldehyde as the starting material) starting from two simple materials, 3- ... ...

    Abstract The total synthesis of laurolitsine was achieved for the first time. This reaction was accomplished in 14 steps with a 2.3% yield (this was calculated using 3-hydroxy-4-methoxybenzaldehyde as the starting material) starting from two simple materials, 3-hydroxy-4-methoxybenzaldehyde and 2-(3-hydroxy-4-methoxyphenyl)acetic acid, and the longest linear sequence consisted of 11 steps. The key steps included an electrophilic addition reaction in which a nitro group was reduced to an amino group using lithium tetrahydroaluminum and a Pd-catalyzed direct biaryl coupling reaction. In this paper, many of the experimental steps were optimized, and an innovative postprocessing method in which 2-(3-(benzyloxy)-4-methoxyphenyl)ethanamine is salted with oxalic acid was proposed.
    Language English
    Publishing date 2024-02-05
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 1413402-0
    ISSN 1420-3049 ; 1431-5165 ; 1420-3049
    ISSN (online) 1420-3049
    ISSN 1431-5165 ; 1420-3049
    DOI 10.3390/molecules29030745
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.MO 81: Show issues

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  2. Article ; Online: Multiple Beneficial Effects of Aloesone from

    Wang, Yan / Xiong, Zhongyv / Li, Chang / Liu, Dong / Li, Xiaogang / Xu, Junyv / Chen, Niangen / Wang, Xuesong / Li, Qifu / Li, Youbin

    Molecules (Basel, Switzerland)

    2023  Volume 28, Issue 4

    Abstract: Aloesone is a major metabolic compound ... ...

    Abstract Aloesone is a major metabolic compound in
    MeSH term(s) Mice ; Animals ; Lipopolysaccharides/pharmacology ; Aloe/metabolism ; Reactive Oxygen Species/metabolism ; RAW 264.7 Cells ; Inflammation/drug therapy ; Oxidative Stress ; Apoptosis ; TOR Serine-Threonine Kinases/metabolism ; Cytokines/metabolism ; Focal Adhesion Kinase 2/metabolism
    Chemical Substances Lipopolysaccharides ; aloesone ; Reactive Oxygen Species ; TOR Serine-Threonine Kinases (EC 2.7.11.1) ; Cytokines ; Ptk2b protein, mouse (EC 2.7.10.2) ; Focal Adhesion Kinase 2 (EC 2.7.10.2)
    Language English
    Publishing date 2023-02-08
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 1413402-0
    ISSN 1420-3049 ; 1431-5165 ; 1420-3049
    ISSN (online) 1420-3049
    ISSN 1431-5165 ; 1420-3049
    DOI 10.3390/molecules28041617
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.MO 81: Show issues

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  3. Article: The Synthesis of 5-Hydroxybenzofurans via Tandem In Situ Oxidative Coupling and Cyclization

    Lin, Zhongren / Tong, Lingfeng / Qiu, Hong / Li, Zheyao / Shen, Lunhua / Chen, Niangen / Yu, Xinhong

    SynOpen

    2022  Volume 06, Issue 03, Page(s) 158–163

    Abstract: A series of 5-hydroxybenzofurans have been prepared by PIDA-mediated oxidation and coupling cyclization of β-dicarbonyl compounds and hydroquinones. The reaction functionalizes C(sp 2 )–H of hydroquinones directly with yields of target molecules up to 96% ...

    Abstract A series of 5-hydroxybenzofurans have been prepared by PIDA-mediated oxidation and coupling cyclization of β-dicarbonyl compounds and hydroquinones. The reaction functionalizes C(sp 2 )–H of hydroquinones directly with yields of target molecules up to 96%.
    Keywords 5-hydroxybenzofurans ; oxidation ; dearomatization ; aromatic C(sp ; )–H functionalization ; one-pot reaction
    Language English
    Publishing date 2022-05-04
    Publisher Georg Thieme Verlag KG
    Publishing place Stuttgart ; New York
    Document type Article
    ISSN 2509-9396
    ISSN (online) 2509-9396
    DOI 10.1055/a-1843-6641
    Database Thieme publisher's database

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  4. Article: Palladium/Norbornene-Cocatalyzed Three-Component Synthesis of ortho-Acylated Benzonitriles

    Wang, Liqin / Song, Guangjun / Wu, Qiufang / Qin, Jiaxin / Yu, Xinhong / Chen, Niangen / Li, Cuiqing

    Synthesis

    2022  Volume 54, Issue 19, Page(s) 4329–4338

    Abstract: A palladium/norbornene-cocatalyzed Catellani-type ortho -C–H-acylation/ ipso -cyanation of iodoarenes is developed via a three-component approach using safe and low-toxic sodium carboxylates as the acyl sources and CuCN as the CN source, affording the ... ...

    Abstract A palladium/norbornene-cocatalyzed Catellani-type ortho -C–H-acylation/ ipso -cyanation of iodoarenes is developed via a three-component approach using safe and low-toxic sodium carboxylates as the acyl sources and CuCN as the CN source, affording the desired products in yields of 50–94%. Without introducing a directing group on the substrate, a catalytic amount of norbornene and palladium can regioselectively activate the ortho -C–H bonds of iodoarenes. The reaction exhibits good functional group tolerance and works well on gram-scale. In addition, this transformation allows rapid and convenient access toward isoindolinones, 1,4-dicarbonyl compounds and ortho -aminated benzonitriles by manipulation of the cyano and carbonyl groups.
    Keywords palladium ; C–H activation ; acylation ; arenes ; synthetic methods
    Language English
    Publishing date 2022-06-01
    Publisher Georg Thieme Verlag KG
    Publishing place Stuttgart ; New York
    Document type Article
    ZDB-ID 2033062-5
    ISSN 1437-210X ; 0039-7881
    ISSN (online) 1437-210X
    ISSN 0039-7881
    DOI 10.1055/a-1866-7737
    Database Thieme publisher's database

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  5. Article: Up-and-coming anti-epileptic effect of aloesone in

    Wang, Yan / Li, Chang / Xiong, Zhongyv / Chen, Niangen / Wang, Xuesong / Xu, Junyv / Wang, Yuemei / Liu, Longfeng / Wu, Hang / Huang, Caihui / Huang, Aiqin / Tan, Jiajia / Li, Youbin / Li, Qifu

    Frontiers in pharmacology

    2022  Volume 13, Page(s) 962223

    Abstract: Background: ...

    Abstract Background:
    Language English
    Publishing date 2022-08-12
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2587355-6
    ISSN 1663-9812
    ISSN 1663-9812
    DOI 10.3389/fphar.2022.962223
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  6. Article ; Online: Regioselective synthesis of novel N2- and N4-substituted 7-methylpyrazolo[4,5-e][1,2,4]thiadiazines.

    Liu, Xinyong / Yan, Renzhang / Chen, Niangen / Xu, Wenfang / Molina, Maria Teresa / Vega, Salvador

    Molecules (Basel, Switzerland)

    2006  Volume 11, Issue 11, Page(s) 827–836

    Abstract: The new compound 7-methylpyrazolo[4,5-e][1,2,4]thiadiazin-3(2H,4H)-one1,1-dioxide (5) was synthesized and its novel mono N2- or N4-substituted derivatives 6 and 7 were prepared by regioselective N-alkylation of 5 with different molar ratios of NaH and ... ...

    Abstract The new compound 7-methylpyrazolo[4,5-e][1,2,4]thiadiazin-3(2H,4H)-one1,1-dioxide (5) was synthesized and its novel mono N2- or N4-substituted derivatives 6 and 7 were prepared by regioselective N-alkylation of 5 with different molar ratios of NaH and alkyl halides. Based on the regioselective alkylation conditions found a facile one-pot synthesis of N2,N4-disubstituted pyrazolo[4,5-e][1,2,4] thiadiazines 8 was developed. The structures of the newly synthesized compounds were confirmed by IR,(1)H-NMR, (13)C-NMR and MS spectral analysis.
    MeSH term(s) Alkylation ; Pyrazoles/chemical synthesis ; Pyrazoles/chemistry ; Stereoisomerism ; Thiadiazines/chemical synthesis ; Thiadiazines/chemistry
    Chemical Substances Pyrazoles ; Thiadiazines
    Language English
    Publishing date 2006-11-01
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1413402-0
    ISSN 1420-3049 ; 1431-5165 ; 1420-3049
    ISSN (online) 1420-3049
    ISSN 1431-5165 ; 1420-3049
    DOI 10.3390/11110827
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.MO 81: Show issues

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

To top