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Article ; Online: A Low Dose of Rapamycin Promotes Hair Cell Differentiation by Enriching SOX2

Wu, Wenjin / Chen, Penghui / Yang, Jun / Liu, Yupeng

Journal of the Association for Research in Otolaryngology : JARO

2024 Volume 25, Issue 2, Page(s) 149–165

Abstract: Purpose: To investigate the impact of rapamycin on the differentiation of hair cells.: Methods: Murine cochlear organoids were derived from cochlear progenitor cells. Different concentrations of rapamycin were added into the culture medium at ... ...

Abstract	Purpose: To investigate the impact of rapamycin on the differentiation of hair cells. Methods: Murine cochlear organoids were derived from cochlear progenitor cells. Different concentrations of rapamycin were added into the culture medium at different proliferation and differentiation stages. Results: Rapamycin exhibited a concentration-dependent reduction in the proliferation of these inner ear organoids. Nevertheless, organoids subjected to a 10-nM dose of rapamycin demonstrated a markedly increased proportion of hair cells. Furthermore, rapamycin significantly upregulated the expression of markers associated with both hair cells and supporting cells, including ATOH1, MYO7A, and SOX2. Mechanistic studies revealed that rapamycin preferentially suppressed cells without Sox2 expression during the initial proliferation stage, thereby augmenting and refining the population of SOX2 Conclusion: Our findings underscore a practical strategy for enhancing the generation of inner ear organoids with a low dose of rapamycin, achieved by enriching SOX2
MeSH term(s)	Animals ; Mice ; Animals, Newborn ; Cell Differentiation/drug effects ; Ear, Inner/drug effects ; Organoids/drug effects ; Sirolimus/pharmacology ; SOXB1 Transcription Factors/metabolism
Chemical Substances	Sirolimus (W36ZG6FT64) ; Sox2 protein, mouse ; SOXB1 Transcription Factors
Language	English
Publishing date	2024-03-12
Publishing country	United States
Document type	Journal Article
ZDB-ID	2021417-0
ISSN	1438-7573 ; 1525-3961
ISSN (online)	1438-7573
ISSN	1525-3961
DOI	10.1007/s10162-024-00938-1
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Article ; Online: Research on Industrial Design Method Based on Shape Symbolic Language of Stacked Stone in Yangzhou Geyuan Garden

Liu Wenming / Chen Penghui

E3S Web of Conferences, Vol 275, p

2021 Volume 03041

Abstract: Stone stacking represents a high concentration and replication of natural mountain landscape, while stone stacking art serves as a significant element and a key tool in traditional Chinese landscape design. This paper presents the artistic background and ...

Abstract	Stone stacking represents a high concentration and replication of natural mountain landscape, while stone stacking art serves as a significant element and a key tool in traditional Chinese landscape design. This paper presents the artistic background and characteristics of stone stacking. Through the analysis of the form symbol and design method of “spring, summer, autumn and winter”, this paper proves that the application of cultural symbols in product design is effective and can be used as a method of auxiliary design.
Keywords	Environmental sciences ; GE1-350
Language	English
Publishing date	2021-01-01T00:00:00Z
Publisher	EDP Sciences
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Design Practice of Ceramic Tea Set Based on Aesthetic Features of Fractal Pattern

Liu Wenming / Chen Penghui

E3S Web of Conferences, Vol 179, p

2020 Volume 02107

Abstract: The unique aesthetic characteristics of the fractal pattern are analyzed and discussed, and the aesthetic features of the fractal pattern are used to practice the appearance design and decorative pattern design of the ceramic tea set. Through the ... ...

Abstract	The unique aesthetic characteristics of the fractal pattern are analyzed and discussed, and the aesthetic features of the fractal pattern are used to practice the appearance design and decorative pattern design of the ceramic tea set. Through the practice of product design based on fractal ideas, a set of effective and feasible ideas and methods for applying fractal ideas to product design were explored, which broadened product design ideas and tried new possibilities for product design.
Keywords	Environmental sciences ; GE1-350
Language	English
Publishing date	2020-01-01T00:00:00Z
Publisher	EDP Sciences
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Synergistic effect of hydrothermal sludge and food waste in the anaerobic co-digestion process: microbial shift and dewaterability.

Chen, Penghui / Wang, Enzhen / Zheng, Yonghui / Ran, Xueling / Ren, Zhengran / Guo, Jianbin / Dong, Renjie

Environmental science and pollution research international

2024 Volume 31, Issue 12, Page(s) 18723–18736

Abstract: While thermal hydrolysis technology is commonly employed for sewage sludge treatment in extensive wastewater treatment facilities, persistent challenges remain, including issues such as ammonia-induced digestive inhibition and reduced productivity ... ...

Abstract	While thermal hydrolysis technology is commonly employed for sewage sludge treatment in extensive wastewater treatment facilities, persistent challenges remain, including issues such as ammonia-induced digestive inhibition and reduced productivity stemming from nutrient deficiency within the hydrothermal sludge. In this study, the effects of hydrothermal sludge-to-food waste mixing ratios and fermentation temperatures on anaerobic co-digestion were systematically investigated through a semi-continuous experiment lasting approximately 100 days. The results indicated that anaerobic co-digestion of hydrothermal sludge and food waste proceeded synergistically at any mixing ratio, and the synergistic effect is mainly attributed to the improvement of carbohydrate removal and digestive system stability. However, thermophilic digestion did not improve the anaerobic performance and methane yield. On the contrary, mesophilic digestion performed better in terms of organic matter removal, especially in the utilization of soluble carbohydrates, soluble proteins, and VFAs. Microbial community analysis revealed that the transition from mesophilic to thermophilic anaerobic co-digestion prompts changes in the methane-producing pathways. Specifically, the transition entails a gradual shift from pathways involving acetoclastic and hydrogenotrophic methanogenesis to a singular hydrogenotrophic methanogenesis pathway. This shift is driven by thermodynamic tendencies, as reflected in Gibbs free energy, as well as environmental factors like ammonia nitrogen and volatile fatty acids. Lastly, it is worth noting that the introduction of food waste did lead to a reduction in cake solids following dewatering. Nevertheless, it was observed that thermophilic digestion had a positive impact on dewatering performance.
MeSH term(s)	Sewage ; Food Loss and Waste ; Anaerobiosis ; Food ; Ammonia ; Refuse Disposal ; Methane/metabolism ; Digestion ; Bioreactors
Chemical Substances	Sewage ; Food Loss and Waste ; Ammonia (7664-41-7) ; Methane (OP0UW79H66)
Language	English
Publishing date	2024-02-13
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1178791-0
ISSN	1614-7499 ; 0944-1344
ISSN (online)	1614-7499
ISSN	0944-1344
DOI	10.1007/s11356-024-32282-5
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Article ; Online: Notch1 signaling modulates hypoxia-induced multidrug resistance in human laryngeal cancer cells.

Li, Dawei / Xu, Dan / Chen, Penghui / Xie, Jin

Molecular biology reports

2022 Volume 49, Issue 7, Page(s) 6235–6240

Abstract: Background: Laryngeal carcinoma is one of the common malignant tumors of the head and neck. Multidrug resistance (MDR) remains a critical problem in the chemotherapy of patients with laryngeal cancer. This study aims to clarify the role and mechanisms ... ...

Abstract	Background: Laryngeal carcinoma is one of the common malignant tumors of the head and neck. Multidrug resistance (MDR) remains a critical problem in the chemotherapy of patients with laryngeal cancer. This study aims to clarify the role and mechanisms of Notch1 signaling in MDR induced by hypoxia in laryngeal cancer cells. Methods and results: Laryngeal carcinoma cells were cultured under normoxia or hypoxia. Notch1 expression was inhibited by small interfering RNA (siRNA). The mRNA expression of Notch1, Hes1, Hey1, MDR1 and survivin was analyzed by real-time PCR. The protein expression of Notch1, the Notch1 intracellular domain (N1ICD), MDR1/P-gp and survivin was analyzed by Western blotting. Current research has shown that hypoxia can upregulate Notch1 expression and Notch1 signaling activity. Furthermore, suppression of Notch1 expression effectively downregulated Notch1 signaling activity and the expression of the MDR and survivin genes in laryngeal cancer cells under hypoxic conditions (P < 0.05). The Cell Counting Kit-8 (CCK-8) assay results confirmed that the sensitivity of hypoxic laryngeal cancer cells to a variety of drugs could be upregulated by suppressing Notch1 expression (P < 0.05). Additionally, flow cytometry (FCM) showed that suppression of Notch1 expression significantly increased drug-induced apoptosis and intracellular rhodamine 123 (Rh123) accumulation in hypoxic laryngeal carcinoma cells (P < 0.05). Conclusions: Notch1 signalling could be regarded as a pivotal regulator of hypoxia-induced MDR in laryngeal cancer cells through the regulation of survivin-mediated apoptosis resistance and MDR1/P-gp-mediated drug transport.
MeSH term(s)	Carcinoma ; Cell Line, Tumor ; Drug Resistance, Multiple/genetics ; Drug Resistance, Neoplasm/genetics ; Humans ; Hypoxia ; Laryngeal Neoplasms/genetics ; RNA, Small Interfering/genetics ; Receptor, Notch1/genetics ; Survivin/genetics
Chemical Substances	NOTCH1 protein, human ; RNA, Small Interfering ; Receptor, Notch1 ; Survivin
Language	English
Publishing date	2022-05-08
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	186544-4
ISSN	1573-4978 ; 0301-4851
ISSN (online)	1573-4978
ISSN	0301-4851
DOI	10.1007/s11033-022-07421-1
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Article: Notch1 signaling modulates hypoxia-induced multidrug resistance in human laryngeal cancer cells

Li, Dawei / Xu, Dan / Chen, Penghui / Xie, Jin

Molecular biology reports. 2022 July, v. 49, no. 7

2022

Abstract: BACKGROUND: Laryngeal carcinoma is one of the common malignant tumors of the head and neck. Multidrug resistance (MDR) remains a critical problem in the chemotherapy of patients with laryngeal cancer. This study aims to clarify the role and mechanisms of ...

Abstract	BACKGROUND: Laryngeal carcinoma is one of the common malignant tumors of the head and neck. Multidrug resistance (MDR) remains a critical problem in the chemotherapy of patients with laryngeal cancer. This study aims to clarify the role and mechanisms of Notch1 signaling in MDR induced by hypoxia in laryngeal cancer cells. METHODS AND RESULTS: Laryngeal carcinoma cells were cultured under normoxia or hypoxia. Notch1 expression was inhibited by small interfering RNA (siRNA). The mRNA expression of Notch1, Hes1, Hey1, MDR1 and survivin was analyzed by real-time PCR. The protein expression of Notch1, the Notch1 intracellular domain (N1ICD), MDR1/P-gp and survivin was analyzed by Western blotting. Current research has shown that hypoxia can upregulate Notch1 expression and Notch1 signaling activity. Furthermore, suppression of Notch1 expression effectively downregulated Notch1 signaling activity and the expression of the MDR and survivin genes in laryngeal cancer cells under hypoxic conditions (P < 0.05). The Cell Counting Kit-8 (CCK-8) assay results confirmed that the sensitivity of hypoxic laryngeal cancer cells to a variety of drugs could be upregulated by suppressing Notch1 expression (P < 0.05). Additionally, flow cytometry (FCM) showed that suppression of Notch1 expression significantly increased drug-induced apoptosis and intracellular rhodamine 123 (Rh123) accumulation in hypoxic laryngeal carcinoma cells (P < 0.05). CONCLUSIONS: Notch1 signalling could be regarded as a pivotal regulator of hypoxia-induced MDR in laryngeal cancer cells through the regulation of survivin-mediated apoptosis resistance and MDR1/P-gp-mediated drug transport.
Keywords	apoptosis ; carcinoma ; drug therapy ; drugs ; flow cytometry ; gene expression ; head ; humans ; hypoxia ; laryngeal neoplasms ; larynx ; molecular biology ; multiple drug resistance ; neck ; normoxia ; pro-apoptotic proteins ; protein synthesis ; quantitative polymerase chain reaction ; rhodamines
Language	English
Dates of publication	2022-07
Size	p. 6235-6240.
Publishing place	Springer Netherlands
Document type	Article
ZDB-ID	186544-4
ISSN	1573-4978 ; 0301-4851
ISSN (online)	1573-4978
ISSN	0301-4851
DOI	10.1007/s11033-022-07421-1
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Two-step anaerobic digestion of rice straw with nanobubble water

Wang, Enzhen / Sun, Hui / Chen, Penghui / Zheng, Yonghui / Guo, Jianbin / Dong, Renjie

Bioresource Technology. 2023 May, v. 376 p.128928-

2023

Abstract: Lignocellulose usually requires pretreatment to improve biogas production. To enhance lignocellulose biodegradability and improve anaerobic digestion (AD) efficiency, different types (N₂, CO₂, and O₂) of nanobubble water (NW) were applied in this study ... ...

Abstract	Lignocellulose usually requires pretreatment to improve biogas production. To enhance lignocellulose biodegradability and improve anaerobic digestion (AD) efficiency, different types (N₂, CO₂, and O₂) of nanobubble water (NW) were applied in this study as soaking agent and AD accelerant to increase the biogas yield of rice straw. The results showed that the cumulative methane yields of treating with NW in two-step AD increased by 11.0%–21.4% compared with untreated straw. The maximum cumulative methane yield was 313.9±1.7 mL/gVS in straw treated with CO₂-NW as soaking agent and AD accelerant (PCO₂-MCO₂). The application of CO₂-NW and O₂-NW as AD accelerants increased bacterial diversity and relative abundance of Methanosaeta. This study suggested that using NW could enhance soaking pretreatment and methane production of rice straw in two-step AD; however, combined treatment with inoculum and NW or microbubble water in the pretreatment needs to compare in future.
Keywords	Methanosaeta ; anaerobic digestion ; biodegradability ; biogas ; carbon dioxide ; gas production (biological) ; inoculum ; lignocellulose ; methane ; methane production ; microbubbles ; nanobubbles ; rice straw ; Nanobubble water ; Soaking pretreatment ; Accelerant ; Microbial community
Language	English
Dates of publication	2023-05
Publishing place	Elsevier Ltd
Document type	Article ; Online
ZDB-ID	1065195-0
ISSN	1873-2976 ; 0960-8524
ISSN (online)	1873-2976
ISSN	0960-8524
DOI	10.1016/j.biortech.2023.128928
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Effect of Notch1 signaling on cellular proliferation and apoptosis in human laryngeal carcinoma.

Li, Dawei / Xu, Dan / Zhang, Yifei / Chen, Penghui / Xie, Jin

World journal of surgical oncology

2022 Volume 20, Issue 1, Page(s) 262

Abstract: Background: The occurrence and development of malignancies include excessive proliferation and apoptosis resistance in tumor cells. This study aimed to identify the effects of Notch1 signaling on proliferation and apoptosis of laryngeal cancer cells in ... ...

Abstract	Background: The occurrence and development of malignancies include excessive proliferation and apoptosis resistance in tumor cells. This study aimed to identify the effects of Notch1 signaling on proliferation and apoptosis of laryngeal cancer cells in a hypoxic microenvironment. Methods: Notch1 and Ki-67 expression in laryngeal squamous cell carcinoma (LSCC) tissues was detected by immunohistochemistry. The apoptotic index (AI) of LSCC was evaluated by the TUNEL method. Small interfering RNA (siRNA) was used to inhibit Notch1 expression in laryngeal cancer cells. Real-time PCR was used to measure Notch1, Hes1, and Hey1 mRNA expression, and Western blotting was used to measure Notch1 and Notch1 intracellular domain (N1ICD) protein expression. Annexin V-FITC/propidium iodide staining and Cell Counting Kit-8 assays were used to measure cell apoptosis and proliferation, respectively. Results: Notch1 expression was significantly related to the proliferation index (PI) and AI in LSCC tissues. Hypoxia could induce proliferation and inhibit apoptosis in cancer cells. Notch1 expression and Notch1 signaling activity could be upregulated by hypoxia. Suppressing Notch1 signaling activity in hypoxic cells could decrease proliferation and increase apoptosis. Conclusions: Our study has demonstrated that hypoxia may promote proliferation and inhibit apoptosis of laryngeal cancer cells. Notch1 signaling may play a pivotal role in regulating the proliferation and apoptosis resistance of laryngeal cancer cells under hypoxic conditions.
MeSH term(s)	Apoptosis ; Cell Line, Tumor ; Cell Proliferation ; Gene Expression Regulation, Neoplastic ; Humans ; Laryngeal Neoplasms/genetics ; Laryngeal Neoplasms/pathology ; RNA, Small Interfering/genetics ; Receptor, Notch1/genetics ; Receptor, Notch1/metabolism ; Squamous Cell Carcinoma of Head and Neck/genetics ; Squamous Cell Carcinoma of Head and Neck/pathology ; Tumor Hypoxia ; Tumor Microenvironment
Chemical Substances	NOTCH1 protein, human ; RNA, Small Interfering ; Receptor, Notch1
Language	English
Publishing date	2022-08-19
Publishing country	England
Document type	Journal Article
ZDB-ID	2118383-1
ISSN	1477-7819 ; 1477-7819
ISSN (online)	1477-7819
ISSN	1477-7819
DOI	10.1186/s12957-022-02728-6
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Article ; Online: A Novel Unsupervised Video Anomaly Detection Framework Based on Optical Flow Reconstruction and Erased Frame Prediction.

Huang, Heqing / Zhao, Bing / Gao, Fei / Chen, Penghui / Wang, Jun / Hussain, Amir

Sensors (Basel, Switzerland)

2023 Volume 23, Issue 10

Abstract: Reconstruction-based and prediction-based approaches are widely used for video anomaly detection (VAD) in smart city surveillance applications. However, neither of these approaches can effectively utilize the rich contextual information that exists in ... ...

Abstract	Reconstruction-based and prediction-based approaches are widely used for video anomaly detection (VAD) in smart city surveillance applications. However, neither of these approaches can effectively utilize the rich contextual information that exists in videos, which makes it difficult to accurately perceive anomalous activities. In this paper, we exploit the idea of a training model based on the "Cloze Test" strategy in natural language processing (NLP) and introduce a novel unsupervised learning framework to encode both motion and appearance information at an object level. Specifically, to store the normal modes of video activity reconstructions, we first design an optical stream memory network with skip connections. Secondly, we build a space-time cube (STC) for use as the basic processing unit of the model and erase a patch in the STC to form the frame to be reconstructed. This enables a so-called "incomplete event (IE)" to be completed. On this basis, a conditional autoencoder is utilized to capture the high correspondence between optical flow and STC. The model predicts erased patches in IEs based on the context of the front and back frames. Finally, we employ a generating adversarial network (GAN)-based training method to improve the performance of VAD. By distinguishing the predicted erased optical flow and erased video frame, the anomaly detection results are shown to be more reliable with our proposed method which can help reconstruct the original video in IE. Comparative experiments conducted on the benchmark UCSD Ped2, CUHK Avenue, and ShanghaiTech datasets demonstrate AUROC scores reaching 97.7%, 89.7%, and 75.8%, respectively.
Language	English
Publishing date	2023-05-17
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2052857-7
ISSN	1424-8220 ; 1424-8220
ISSN (online)	1424-8220
ISSN	1424-8220
DOI	10.3390/s23104828
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Exploration and identification of six novel ferroptosis-related hub genes as potential gene signatures for peripheral nerve injury.

Zhang, Yifei / Chen, Chun / Li, Dawei / Chen, Penghui / Hang, Lei / Yang, Jun / Xie, Jin

Frontiers in genetics

2023 Volume 14, Page(s) 1156467

Abstract: Specific biomarkers of ferroptosis after peripheral nerve injury (PNI) are still under debate. In this study, 52 differentially expressed ferroptosis-related genes (DE-FRGs) were retrieved from publicly accessible sequencing data of intact and injured ... ...

Abstract	Specific biomarkers of ferroptosis after peripheral nerve injury (PNI) are still under debate. In this study, 52 differentially expressed ferroptosis-related genes (DE-FRGs) were retrieved from publicly accessible sequencing data of intact and injured samples of rats with sciatic nerve crush injury. Functional enrichment analyses revealed that adipogenesis, mitochondrial gene sets, and pathways of MAPK, p53, and CD28 family were predominantly engaged in ferroptosis after PNI. Next, Cdkn1a, Cdh1, Hif1a, Hmox1, Nfe2l2, and Tgfb1 were investigated as new ferroptosis-associated hub genes after PNI. Subsequently, clustering correlation heatmap shows six hub genes are linked to mitochondria. The immunofluorescence assay at 0, 1, 4, 7, and 14 days indicated the temporal expression patterns of Tgfb1, Hmox1, and Hif1a after PNI were consistent with ferroptosis validated by PI and ROS staining, while Cdh1, Cdkn1a, and Nfe2l2 were the opposite. In summary, this study identified six hub genes as possible ferroptosis-related biomarkers for PNI, which may offer therapeutic targets for peripheral nerve regeneration and provide a therapeutic window for ferroptosis.
Language	English
Publishing date	2023-04-06
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2606823-0
ISSN	1664-8021
ISSN	1664-8021
DOI	10.3389/fgene.2023.1156467
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