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Article ; Online: Female showed favorable left ventricle hypertrophy regression during post-TAVR follow-up.

Chiu, Cheng-An / Chen, Pin-Rong / Li, Yu-Ju / Hsieh, Chong-Chao / Yu, Hui-Chen / Chiu, Chaw-Chi / Huang, Jiann-Woei / Chu, Chun-Yuan / Lin, Tsung-Hsien / Lee, Hsiang-Chun

The Kaohsiung journal of medical sciences

2024 Volume 40, Issue 4, Page(s) 384–394

Abstract: Transcatheter aortic valve replacement (TAVR) is a well-established procedure using a catheter-introduced valve prosthesis for patients with severe aortic stenosis (AS). This retrospective study investigated sex-related differences in pre- and post-TAVR ... ...

Abstract	Transcatheter aortic valve replacement (TAVR) is a well-established procedure using a catheter-introduced valve prosthesis for patients with severe aortic stenosis (AS). This retrospective study investigated sex-related differences in pre- and post-TAVR clinical and hemodynamic outcomes and analyzed data of the first 100 cases at Kaohsiung Medical University Chung-Ho Memorial Hospital (KMUH) between December 2013 and December 2021. Baseline characteristics, procedural outcomes, mortality rates, and echocardiographic parameters were analyzed and compared between sexes. Among the 100 patients, male (46%) and female (54%) were of similar age (mean age, male 86.0 years vs. female 84.5 years) and of the same severity of AS (mean pressure gradient, male 47.5 mmHg vs. female 45.7 mmHg) at the time receiving the TAVR procedure. Women had smaller aortic valve areas calculated by continuity equation (0.8 ± 0.3 cm
MeSH term(s)	Humans ; Male ; Female ; Aged, 80 and over ; Transcatheter Aortic Valve Replacement/methods ; Follow-Up Studies ; Retrospective Studies ; Aortic Valve Stenosis/surgery ; Heart Ventricles/diagnostic imaging ; Treatment Outcome ; Hypertrophy/surgery ; Aortic Valve/diagnostic imaging ; Aortic Valve/surgery ; Severity of Illness Index
Language	English
Publishing date	2024-02-08
Publishing country	China (Republic : 1949- )
Document type	Journal Article
ZDB-ID	639302-0
ISSN	2410-8650 ; 0257-5655
ISSN (online)	2410-8650
ISSN	0257-5655
DOI	10.1002/kjm2.12808
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Article ; Online: An investigation of the influence of reactive oxygen species produced from riboflavin-5'-phosphate by blue or violet light on the inhibition of WiDr colon cancer cells.

Chiu, Chi-Ming / Lee, Shwu-Yuan / Chen, Pin-Rong / Zhan, Shao-Qi / Yuann, Jeu-Ming P / Huang, Shiuh-Tsuen / Wu, Ming-Fang / Cheng, Chien-Wei / Chang, Yu-Chung / Liang, Ji-Yuan

Photodiagnosis and photodynamic therapy

2023 Volume 44, Page(s) 103810

Abstract: Riboflavin-5'-phosphate (FMN), an innocuous product of riboflavin (RF) phosphorylation, is vital for humans. FMN is sensitive to light illumination, as indicated by reactive oxygen species (ROS) formation. This investigation was undertaken to evaluate ... ...

Abstract	Riboflavin-5'-phosphate (FMN), an innocuous product of riboflavin (RF) phosphorylation, is vital for humans. FMN is sensitive to light illumination, as indicated by reactive oxygen species (ROS) formation. This investigation was undertaken to evaluate the influence of blue light illumination (BLI) and violet light illumination (VLI) upon FMN to develop a method to inhibit WiDr colon cancer cells by FMN photolysis. When FMN is subjected to BLI and VLI, it inhibits WiDr colon cancer cells by generating superoxide radical anions (O
MeSH term(s)	Humans ; Reactive Oxygen Species/metabolism ; Light ; Photochemotherapy/methods ; Photosensitizing Agents/pharmacology ; Riboflavin/pharmacology ; Colonic Neoplasms/drug therapy ; Phosphates
Chemical Substances	Reactive Oxygen Species ; Photosensitizing Agents ; Riboflavin (TLM2976OFR) ; Phosphates
Language	English
Publishing date	2023-09-23
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2149918-4
ISSN	1873-1597 ; 1572-1000
ISSN (online)	1873-1597
ISSN	1572-1000
DOI	10.1016/j.pdpdt.2023.103810
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Article ; Online: A flexible liposomal polymer complex as a platform of specific and regulable immune regulation for individual cancer immunotherapy.

Chen, Chia-Hung / Weng, Tzu-Han / Huang, Hsiao-Hsuan / Huang, Ling-Ya / Huang, Kai-Yao / Chen, Pin-Rong / Yeh, Kuang-Yu / Huang, Chi-Ting / Chien, Yu-Tzu / Chuang, Po-Ya / Lin, Yu-Ling / Tsai, Nu-Man / Liu, Shih-Jen / Su, Yu-Cheng / Weng, Shun-Long / Liao, Kuang-Wen

Journal of experimental & clinical cancer research : CR

2023 Volume 42, Issue 1, Page(s) 29

Abstract: Background: The applicability and therapeutic efficacy of specific personalized immunotherapy for cancer patients is limited by the genetic diversity of the host or the tumor. Side-effects such as immune-related adverse events (IRAEs) derived from the ... ...

Abstract	Background: The applicability and therapeutic efficacy of specific personalized immunotherapy for cancer patients is limited by the genetic diversity of the host or the tumor. Side-effects such as immune-related adverse events (IRAEs) derived from the administration of immunotherapy have also been observed. Therefore, regulatory immunotherapy is required for cancer patients and should be developed. Methods: The cationic lipo-PEG-PEI complex (LPPC) can stably and irreplaceably adsorb various proteins on its surface without covalent linkage, and the bound proteins maintain their original functions. In this study, LPPC was developed as an immunoregulatory platform for personalized immunotherapy for tumors to address the barriers related to the heterogenetic characteristics of MHC molecules or tumor associated antigens (TAAs) in the patient population. Here, the immune-suppressive and highly metastatic melanoma, B16F10 cells were used to examine the effects of this platform. Adsorption of anti-CD3 antibodies, HLA-A2/peptide, or dendritic cells' membrane proteins (MP) could flexibly provide pan-T-cell responses, specific Th1 responses, or specific Th1 and Th2 responses, depending on the host needs. Furthermore, with regulatory antibodies, the immuno-LPPC complex properly mediated immune responses by adsorbing positive or negative antibodies, such as anti-CD28 or anti-CTLA4 antibodies. Results: The results clearly showed that treatment with LPPC/MP/CD28 complexes activated specific Th1 and Th2 responses, including cytokine release, CTL and prevented T-cell apoptosis. Moreover, LPPC/MP/CD28 complexes could eliminate metastatic B16F10 melanoma cells in the lung more efficiently than LPPC/MP. Interestingly, the melanoma resistance of mice treated with LPPC/MP/CD28 complexes would be reversed to susceptible after administration with LPPC/MP/CTLA4 complexes. NGS data revealed that LPPC/MP/CD28 complexes could enhance the gene expression of cytokine and chemokine pathways to strengthen immune activation than LPPC/MP, and that LPPC/MP/CTLA4 could abolish the LPPC/MP complex-mediated gene expression back to un-treatment. Conclusions: Overall, we proved a convenient and flexible immunotherapy platform for developing personalized cancer therapy.
MeSH term(s)	Animals ; Mice ; Cytokines/metabolism ; Immunotherapy ; Liposomes/chemistry ; Melanoma ; Polymers
Chemical Substances	Cytokines ; Liposomes ; poly(ethylene glycol)-co-poly(ethyleneimine) ; Polymers
Language	English
Publishing date	2023-01-23
Publishing country	England
Document type	Journal Article
ZDB-ID	803138-1
ISSN	1756-9966 ; 0392-9078
ISSN (online)	1756-9966
ISSN	0392-9078
DOI	10.1186/s13046-023-02601-8
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Article ; Online: Kurarinone exerts anti-inflammatory effect via reducing ROS production, suppressing NLRP3 inflammasome, and protecting against LPS-induced sepsis.

Yazal, Taha / Lee, Po-Yen / Chen, Pin-Rong / Chen, I-Chen / Liu, Po-Len / Chen, Yuan-Ru / Lin, Tzu-Chieh / Chen, Yi-Ting / Huang, Shu-Pin / Yeh, Hsin-Chih / Liu, Ching-Chih / Lo, Jung / Wu, Hsin-En / Wang, Shu-Chi / Li, Chia-Yang

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

2023 Volume 167, Page(s) 115619

Abstract: Kurarinone, a major lavandulyl flavanone found in the roots of Sophora flavescens aiton, has been reported to exhibit anti-inflammatory and anti-oxidative activities in lipopolysaccharide (LPS)-induced macrophages; however, the effects of kurarinone on ... ...

Abstract	Kurarinone, a major lavandulyl flavanone found in the roots of Sophora flavescens aiton, has been reported to exhibit anti-inflammatory and anti-oxidative activities in lipopolysaccharide (LPS)-induced macrophages; however, the effects of kurarinone on the activation of NLRP3 inflammasome and the protective effects against sepsis have not been well investigated. In this study, we aimed to investigate the impacts of kurarinone on NLRP3 inflammasome activation in lipopolysaccharide (LPS)-induced macrophages and its protective effects against sepsis in vivo. Secretion of pro-inflammatory cytokines, activation of MAPKs and NF-κB signaling pathways, formation of NLRP3 inflammasome, and production of reactive oxygen species (ROS) by LPS-induced macrophages were examined; additionally, in vivo LPS-induced endotoxemia model was used to investigate the protective effects of kurarinone in sepsis-induced damages. Our experimental results demonstrated that kurarinone inhibited the expression of iNOS and COX-2, suppressed the phosphorylation of MAPKs, attenuated the production of TNF-α, IL-6, nitric oxide (NO) and ROS, repressed the activation of the NLRP3 inflammasome, and impeded the maturation and secretion of IL-1β and caspase-1. Furthermore, the administration of kurarinone attenuated the infiltration of neutrophils in the lung, kidneys and liver, reduced the expression of organ damage markers, and increased the survival rate in LPS-challenged mice. Collectively, our study demonstrated that kurarinone can protect against LPS-induced sepsis damage and exert anti-inflammatory effects via inhibiting MAPK/NF-κB pathways, attenuating NLRP3 inflammasome formation, and preventing intracellular ROS accumulation, suggesting that kurarinone might have potential for treating sepsis and inflammation-related diseases.
MeSH term(s)	Mice ; Animals ; Inflammasomes/metabolism ; NLR Family, Pyrin Domain-Containing 3 Protein/metabolism ; Lipopolysaccharides/toxicity ; Reactive Oxygen Species/metabolism ; NF-kappa B/metabolism ; Anti-Inflammatory Agents/pharmacology ; Anti-Inflammatory Agents/therapeutic use ; Sepsis/chemically induced ; Sepsis/drug therapy
Chemical Substances	Inflammasomes ; NLR Family, Pyrin Domain-Containing 3 Protein ; Lipopolysaccharides ; kurarinone ; Reactive Oxygen Species ; NF-kappa B ; Anti-Inflammatory Agents
Language	English
Publishing date	2023-10-05
Publishing country	France
Document type	Journal Article
ZDB-ID	392415-4
ISSN	1950-6007 ; 0753-3322 ; 0300-0893
ISSN (online)	1950-6007
ISSN	0753-3322 ; 0300-0893
DOI	10.1016/j.biopha.2023.115619
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Article ; Online: Transdermal nanolipoplex simultaneously inhibits subcutaneous melanoma growth and suppresses systemically metastatic melanoma by activating host immunity.

Chen, Chia-Hung / Weng, Tzu-Han / Chuang, Cheng-Hsun / Huang, Kai-Yao / Huang, Sih-Cheng / Chen, Pin-Rong / Huang, Hsiao-Hsuan / Huang, Ling-Ya / Shen, Pei-Chun / Chuang, Po-Ya / Huang, Hsiao-Yen / Wu, Yi-Syuan / Chang, Hao-Chiun / Weng, Shun-Long / Liao, Kuang-Wen

Nanomedicine : nanotechnology, biology, and medicine

2022 Volume 47, Page(s) 102628

Abstract: Benefit for clinical melanoma treatments, the transdermal neoadjuvant therapy could reduce surgery region and increase immunotherapy efficacy. Using lipoplex (Lipo-PEG-PEI-complex, LPPC) encapsulated doxorubicin (DOX) and carrying CpG ... ...

Abstract	Benefit for clinical melanoma treatments, the transdermal neoadjuvant therapy could reduce surgery region and increase immunotherapy efficacy. Using lipoplex (Lipo-PEG-PEI-complex, LPPC) encapsulated doxorubicin (DOX) and carrying CpG oligodeoxynucleotide; the transdermally administered nano-liposomal drug complex (LPPC-DOX-CpG) would have high cytotoxicity and immunostimulatory activity to suppress systemic metastasis of melanoma. LPPC-DOX-CpG dramatically suppressed subcutaneous melanoma growth by inducing tumor cell apoptosis and recruiting immune cells into the tumor area. Animal studies further showed that the colonization and growth of spontaneously metastatic melanoma cells in the liver and lung were suppressed by transdermal LPPC-DOX-CpG. Furthermore, NGS analysis revealed IFN-γ and NF-κB pathways were triggered to recruit and activate the antigen-presenting-cells and effecter cells, which could activate the anti-tumor responses as the major mechanism responsible for the therapeutic effect of LPPC-DOX-CpG. Finally, we have successfully proved transdermal LPPC-DOX-CpG as a promising penetrative carrier to activate systemic anti-tumor immunity against subcutaneous and metastatic tumor.
MeSH term(s)	Humans ; Melanoma/drug therapy
Language	English
Publishing date	2022-11-16
Publishing country	United States
Document type	Journal Article
ZDB-ID	2183417-9
ISSN	1549-9642 ; 1549-9634
ISSN (online)	1549-9642
ISSN	1549-9634
DOI	10.1016/j.nano.2022.102628
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Article ; Online: Lipoplex-based targeted gene therapy for the suppression of tumours with VEGFR expression by producing anti-angiogenic molecules.

Ho, Shu-Yi / Chen, Pin-Rong / Chen, Chia-Hung / Tsai, Nu-Man / Lin, Yu-Hsin / Lin, Chen-Si / Chuang, Cheng-Hsun / Huang, Xiao-Fan / Chan, Yi-Lin / Liu, Yen-Ku / Chung, Chen-Han / Weng, Shun-Long / Liao, Kuang-Wen

Journal of nanobiotechnology

2020 Volume 18, Issue 1, Page(s) 58

Abstract: Background: The anti-angiogenic fusion protein RBDV-IgG1 Fc (RBDV), which comprises the receptor-binding domain of vascular endothelial growth factor-A (VEGF-A), has shown antitumour effects by reducing angiogenesis in vivo. This study used the cationic ...

Abstract	Background: The anti-angiogenic fusion protein RBDV-IgG1 Fc (RBDV), which comprises the receptor-binding domain of vascular endothelial growth factor-A (VEGF-A), has shown antitumour effects by reducing angiogenesis in vivo. This study used the cationic lipoplex lipo-PEG-PEI-complex (LPPC) to simultaneously encapsulate both the RBDV targeting protein and the RBDV plasmid (pRBDV) without covalent bonds to assess VEGFR targeting gene therapy in mice with melanoma in vivo. Results: LPPC protected the therapeutic transgene from degradation by DNase, and the LPPC/RBDV complexes could specifically target VEGFR-positive B16-F10 cells both in vitro and in vivo. With or without RBDV protein-targeting direction, the pRBDV-expressing RBDV proteins were expressed and reached a maximal concentration on the 7th day in the sera after transfection in vivo and significantly elicited growth suppression against B16-F10 melanoma but not IgG1 control proteins. In particular, LPPC/pRBDV/RBDV treatment with the targeting molecules dramatically inhibited B16-F10 tumour growth in vivo to provide better therapeutic efficacy than the treatments with gene therapy with IgG1 protein targeting or administration of a protein drug with RBDV. Conclusions: The simultaneous combination of the LPPC complex with pRBDV gene therapy and RBDV protein targeting might be a potential tool to conveniently administer targeted gene therapy for cancer therapy.
MeSH term(s)	3T3 Cells ; Angiogenesis Inhibitors/genetics ; Animals ; Cell Line, Tumor ; Cell Proliferation ; Genetic Therapy/methods ; Immunoglobulin Fc Fragments/genetics ; Immunoglobulin Fc Fragments/metabolism ; Liposomes/chemistry ; Male ; Melanoma, Experimental/mortality ; Melanoma, Experimental/pathology ; Melanoma, Experimental/therapy ; Mice ; Mice, Inbred C57BL ; Plasmids/chemistry ; Plasmids/genetics ; Plasmids/therapeutic use ; Protein Domains/genetics ; Receptors, Vascular Endothelial Growth Factor/genetics ; Receptors, Vascular Endothelial Growth Factor/metabolism ; Recombinant Fusion Proteins/biosynthesis ; Recombinant Fusion Proteins/isolation & purification ; Survival Rate ; Transplantation, Homologous ; Vascular Endothelial Growth Factor A/genetics ; Vascular Endothelial Growth Factor A/metabolism
Chemical Substances	Angiogenesis Inhibitors ; Immunoglobulin Fc Fragments ; Liposomes ; Recombinant Fusion Proteins ; Vascular Endothelial Growth Factor A ; Receptors, Vascular Endothelial Growth Factor (EC 2.7.10.1)
Language	English
Publishing date	2020-04-09
Publishing country	England
Document type	Journal Article
ISSN	1477-3155
ISSN (online)	1477-3155
DOI	10.1186/s12951-020-00610-9
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Article ; Online: Differential protein expression in chicken spermatozoa before and after freezing-thawing treatment.

Cheng, Chuen-Yu / Chen, Pin-Rong / Chen, Chao-Jung / Wang, Shin-Han / Chen, Chih-Feng / Lee, Yen-Pai / Huang, San-Yuan

Animal reproduction science

2015 Volume 152, Page(s) 99–107

Abstract: The biological characteristics of rooster sperm that has undergone freezing treatment remain elusive. This study analyzed the change in sperm proteins after freezing-thawing treatment by using a proteomic approach. Semen from three 36-wk-old L2 strain ... ...

Abstract	The biological characteristics of rooster sperm that has undergone freezing treatment remain elusive. This study analyzed the change in sperm proteins after freezing-thawing treatment by using a proteomic approach. Semen from three 36-wk-old L2 strain Taiwan country chickens were used. A qualifying ejaculate containing more than 80% motility and volume 200μL was used for cryopreservation. The proteomic analysis explored 55 protein spots that differed significantly before and after freezing-thawing treatment (P<0.05). Among the 55 protein spots, expression levels of 19 proteins decreased after treatment. Forty-five differentially expressed protein spots were identified and belong to 33 proteins. Results of gene ontology analysis revealed that most differentially expressed proteins were involved in molecular function of the cellular metabolism process (28%) and cellular carbohydrate metabolism process (15%), and were associated with molecular function of oxidoreductase activity (19%) and protein binding (18%). The differentially expressed proteins before and after freezing-thawing treatment, including fructose-bisphosphate aldolase C, triosephosphate isomerase, aconitate hydratase, tubulin and outer dense-fiber protein, are associated with sperm energy metabolism and flagellum structure. In conclusion, freezing-thawing treatment significantly affects the expression of proteins related to sperm metabolism and structure in chicken spermatozoa. The differing levels of these proteins could be valuable for further enhancing the fertility of frozen-thawed chicken spermatozoa.
MeSH term(s)	Animals ; Chickens/physiology ; Cryopreservation/veterinary ; Freezing ; Gene Expression Regulation/physiology ; Male ; Semen Preservation/veterinary ; Spermatozoa/metabolism
Language	English
Publishing date	2015-01
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	429674-6
ISSN	1873-2232 ; 0378-4320
ISSN (online)	1873-2232
ISSN	0378-4320
DOI	10.1016/j.anireprosci.2014.11.011
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Article: Blockade of ITGA2 Induces Apoptosis and Inhibits Cell Migration in Gastric Cancer.

Chuang, Yu-Chang / Wu, Hsin-Yi / Lin, Yu-Ling / Tzou, Shey-Cherng / Chuang, Cheng-Hsun / Jian, Ting-Yan / Chen, Pin-Rong / Chang, Yuan-Ching / Lin, Chi-Hsin / Huang, Tse-Hung / Wang, Chao-Ching / Chan, Yi-Lin / Liao, Kuang-Wen

Biological procedures online

2018 Volume 20, Page(s) 10

Abstract: Background: Gastric cancer is currently the fourth leading cause of cancer-related death worldwide. Gastric cancer is often diagnosed at advanced stages and the outcome of the treatment is often poor. Therefore, identifying new therapeutic targets for ... ...

Abstract	Background: Gastric cancer is currently the fourth leading cause of cancer-related death worldwide. Gastric cancer is often diagnosed at advanced stages and the outcome of the treatment is often poor. Therefore, identifying new therapeutic targets for this cancer is urgently needed. Integrin alpha 2 (ITGA2) subunit and the beta 1 subunit form a heterodimer for a transmembrane receptor for extracellular matrix, is an important molecule involved in tumor cell proliferation, survival and migration. Integrin α2β1 is over-expressed on a variety of cancer cells, but is low or absent in most normal organs and resting endothelial cells. Results: In this report, we assessed the ITGA2 as the potential therapeutic target with the bioinformatics tools from the TCGA dataset in which composed of 375 gastric cancer tissues and 32 gastric normal tissues. According to the information from the Cancer Cell Line Encyclopedia (CCLE) database, the AGS cell line with ITGA2 high expression and the SUN-1 cell line with low expression were chosen for the further investigation. Interestingly, the anti-ITGA2 antibody (at 3 μg/ml) inhibited approximately 50% survival of the AGS cells (over-expressed ITGA2), but had no effect in SNU-1 cells (ITGA2 negative). The extents of antibody-mediated cancer inhibition positively correlated with the expression levels of the ITGA2. We further showed that the anti-ITGA2 antibody induced apoptosis by up-regulating the RhoA-p38 MAPK signaling to promote the expressions of Bim, Apaf-1 and Caspase-9, whereas the expressions of Ras and Bax/Bcl-2 were not affected. Moreover, blocking ITGA2 by the specific antibody at lower doses also inhibited cell migration of gastric cancer cells. Blockade of ITGA2 by a specific antibody down-regulated the expression of N-WASP, PAK and LIMK to impede actin organization and cell migration of gastric cancer cells. Conclusions: Here, we showed that the mRNA expression levels of ITGA2 comparing to normal tissues significantly increased. In addition, the results revealed that targeting integrin alpha 2 subunit by antibodies did not only inhibit cell migration, but also induce apoptosis effect on gastric cancer cells. Interestingly, higher expression level of ITGA2 led to significant effects on apoptosis progression during anti-ITGA2 antibody treatment, which indicated that ITGA2 expression levels directly correlate with their functionality. Our findings suggest that ITGA2 is a potential therapeutic target for gastric cancer.
Language	English
Publishing date	2018-05-01
Publishing country	England
Document type	Journal Article
ZDB-ID	2027823-8
ISSN	1480-9222
ISSN	1480-9222
DOI	10.1186/s12575-018-0073-x
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Article ; Online: The inhibitory effect of 7,7″-dimethoxyagastisflavone on the metastasis of melanoma cells via the suppression of F-actin polymerization.

Lin, Ching-Min / Lin, Yu-Ling / Ho, Shu-Yi / Chen, Pin-Rong / Tsai, Yi-Hsuan / Chung, Chen-Han / Hwang, Chia-Hsiang / Tsai, Nu-Man / Tzou, Shey-Cherng / Ke, Chun-Yen / Chang, Jung / Chan, Yi-Lin / Wang, Yu-Shan / Chi, Kwan-Hwa / Liao, Kuang-Wen

Oncotarget

2017 Volume 8, Issue 36, Page(s) 60046–60059

Abstract: 7,7″-Dimethoxyagastisflavone (DMGF), a biflavonoid isolated ... ...

Abstract	7,7″-Dimethoxyagastisflavone (DMGF), a biflavonoid isolated from
Keywords	covid19
Language	English
Publishing date	2017-09-01
Publishing country	United States
Document type	Journal Article
ZDB-ID	2560162-3
ISSN	1949-2553 ; 1949-2553
ISSN (online)	1949-2553
ISSN	1949-2553
DOI	10.18632/oncotarget.10960
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Article ; Online: miRTarBase update 2018: a resource for experimentally validated microRNA-target interactions.

Chou, Chih-Hung / Shrestha, Sirjana / Yang, Chi-Dung / Chang, Nai-Wen / Lin, Yu-Ling / Liao, Kuang-Wen / Huang, Wei-Chi / Sun, Ting-Hsuan / Tu, Siang-Jyun / Lee, Wei-Hsiang / Chiew, Men-Yee / Tai, Chun-San / Wei, Ting-Yen / Tsai, Tzi-Ren / Huang, Hsin-Tzu / Wang, Chung-Yu / Wu, Hsin-Yi / Ho, Shu-Yi / Chen, Pin-Rong /

Chuang, Cheng-Hsun / Hsieh, Pei-Jung / Wu, Yi-Shin / Chen, Wen-Liang / Li, Meng-Ju / Wu, Yu-Chun / Huang, Xin-Yi / Ng, Fung Ling / Buddhakosai, Waradee / Huang, Pei-Chun / Lan, Kuan-Chun / Huang, Chia-Yen / Weng, Shun-Long / Cheng, Yeong-Nan / Liang, Chao / Hsu, Wen-Lian / Huang, Hsien-Da

Nucleic acids research

2018 Volume 46, Issue D1, Page(s) D296–D302

Abstract: MicroRNAs (miRNAs) are small non-coding RNAs of ∼ 22 nucleotides that are involved in negative regulation of mRNA at the post-transcriptional level. Previously, we developed miRTarBase which provides information about experimentally validated miRNA- ... ...

Abstract	MicroRNAs (miRNAs) are small non-coding RNAs of ∼ 22 nucleotides that are involved in negative regulation of mRNA at the post-transcriptional level. Previously, we developed miRTarBase which provides information about experimentally validated miRNA-target interactions (MTIs). Here, we describe an updated database containing 422 517 curated MTIs from 4076 miRNAs and 23 054 target genes collected from over 8500 articles. The number of MTIs curated by strong evidence has increased ∼1.4-fold since the last update in 2016. In this updated version, target sites validated by reporter assay that are available in the literature can be downloaded. The target site sequence can extract new features for analysis via a machine learning approach which can help to evaluate the performance of miRNA-target prediction tools. Furthermore, different ways of browsing enhance user browsing specific MTIs. With these improvements, miRTarBase serves as more comprehensively annotated, experimentally validated miRNA-target interactions databases in the field of miRNA related research. miRTarBase is available at http://miRTarBase.mbc.nctu.edu.tw/.
MeSH term(s)	Data Mining ; Databases, Genetic ; Humans ; MicroRNAs/metabolism ; RNA, Messenger/chemistry ; RNA, Messenger/metabolism ; User-Computer Interface
Chemical Substances	MicroRNAs ; RNA, Messenger
Language	English
Publishing date	2018-07-03
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	186809-3
ISSN	1362-4962 ; 1362-4954 ; 0301-5610 ; 0305-1048
ISSN (online)	1362-4962 ; 1362-4954
ISSN	0301-5610 ; 0305-1048
DOI	10.1093/nar/gkx1067
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