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  1. Article: Review on article of effects of tenofovir alafenamide and entecavir in chronic hepatitis B virus patients.

    Sun, Yu-Tong / Chen, Qian-Qian

    World journal of hepatology

    2024  Volume 16, Issue 1, Page(s) 109–111

    Abstract: This letter comments on the article which reported that tenofovir alafenamide may increase blood lipid levels compared with entecavir in patients with chronic hepatitis B published ... ...

    Abstract This letter comments on the article which reported that tenofovir alafenamide may increase blood lipid levels compared with entecavir in patients with chronic hepatitis B published on
    Language English
    Publishing date 2024-01-18
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2573703-X
    ISSN 1948-5182
    ISSN 1948-5182
    DOI 10.4254/wjh.v16.i1.109
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  2. Article: Reveal more mechanisms of precondition mesenchymal stem cells inhibiting inflammation.

    Li, Yi / Chen, Qian-Qian / Linghu, En-Qiang

    World journal of stem cells

    2024  Volume 16, Issue 4, Page(s) 459–461

    Abstract: Hypoxia can get more ability to inhibit inflammation. But how it impact on survival time of mesenchymal stem cells (MSCs) is confusing and how preconditioned MSCs inhibiting inflammation are partially known. Those issues decided the value of ... ...

    Abstract Hypoxia can get more ability to inhibit inflammation. But how it impact on survival time of mesenchymal stem cells (MSCs) is confusing and how preconditioned MSCs inhibiting inflammation are partially known. Those issues decided the value of preconditioned MSCs by hypoxia.
    Language English
    Publishing date 2024-04-16
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2583482-4
    ISSN 1948-0210
    ISSN 1948-0210
    DOI 10.4252/wjsc.v16.i4.459
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  3. Article ; Online: Histopathological and Immunohistochemical Mechanisms of Bone Marrow-Derived Mesenchymal Stem Cells in Reversion of Gastric Precancerous Lesions.

    Chen, Qian-Qian / Wang, Cong / Wang, Wei-Hua / Gong, Yuan / Chen, Hai-Xu

    Frontiers in bioscience (Landmark edition)

    2024  Volume 29, Issue 3, Page(s) 127

    Abstract: Background: Gastric cancer (GC) stands as one of the most prevalent cancer types worldwide, holding the position of the second leading cause of cancer-related deaths. Gastric lesions represent pathological alterations to the gastric mucosa, with an ... ...

    Abstract Background: Gastric cancer (GC) stands as one of the most prevalent cancer types worldwide, holding the position of the second leading cause of cancer-related deaths. Gastric lesions represent pathological alterations to the gastric mucosa, with an elevated propensity to advance to gastric cancer. Limited research has explored the potential of stem cells in the treatment of gastric lesions.
    Methods: This study aimed to explore the potential of intravenous transplantation of labeled bone marrow-derived mesenchymal stem cells (BMMSCs) to inhibit the progression of precancerous gastric lesions.
    Results: In the gastric lesion disease model group, the rat tissue exhibited noteworthy mucosal atrophy, intestinal metaplasia, dysplasia, and inflammatory cell infiltration. Following the infusion of BMMSCs, a notable decrease in gastric lesions was found, with atrophic gastritis being the sole remaining lesion, which was confirmed by morphological and histological examinations. BMMSCs that were colonized at gastric lesions could differentiate into epithelial and stromal cells, as determined by the expression of pan-keratin or vimentin. The expression of vascular endothelial growth factor was significantly elevated following BMMSC transplantation. BMMSCs could also upregulate the production of humoral immune response cytokines, including interleukin (IL)-4 and IL-10, and downregulate the production of IL-17 and interferon-gamma, which could be highly associated with the cellular immune response and inflammation severity of the lesions.
    Conclusions: BMMSC transplantation significantly reduced inflammation and reversed gastric lesion progression.
    MeSH term(s) Rats ; Animals ; Stomach Neoplasms/metabolism ; Vascular Endothelial Growth Factor A/metabolism ; Bone Marrow/pathology ; Gastric Mucosa/metabolism ; Gastric Mucosa/pathology ; Mesenchymal Stem Cells/metabolism ; Inflammation/metabolism ; Precancerous Conditions/therapy ; Precancerous Conditions/metabolism ; Precancerous Conditions/pathology
    Chemical Substances Vascular Endothelial Growth Factor A
    Language English
    Publishing date 2024-03-25
    Publishing country Singapore
    Document type Journal Article
    ZDB-ID 2704569-9
    ISSN 2768-6698 ; 2768-6698
    ISSN (online) 2768-6698
    ISSN 2768-6698
    DOI 10.31083/j.fbl2903127
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  4. Article: (C

    Chen, Qian-Qian / Hu, Chun-Li / Zhang, Ming-Zhi / Mao, Jiang-Gao

    Chemical science

    2023  Volume 14, Issue 48, Page(s) 14302–14307

    Abstract: Birefringent crystals can manipulate the polarization state of lasers and have vital application in polarizers, optical isolators, phase compensators, ...

    Abstract Birefringent crystals can manipulate the polarization state of lasers and have vital application in polarizers, optical isolators, phase compensators,
    Language English
    Publishing date 2023-11-27
    Publishing country England
    Document type Journal Article
    ZDB-ID 2559110-1
    ISSN 2041-6539 ; 2041-6520
    ISSN (online) 2041-6539
    ISSN 2041-6520
    DOI 10.1039/d3sc05770d
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  5. Article ; Online: α- and β-(C

    Chen, Qian-Qian / Hu, Chun-Li / Zhang, Ming-Zhi / Li, Bing-Xuan / Mao, Jiang-Gao

    Inorganic chemistry

    2023  Volume 62, Issue 32, Page(s) 12613–12619

    Abstract: Organic-inorganic hybrid nonlinear optical (NLO) materials are highly anticipated because of the integration of both merits of the organic and inorganic moieties. Herein, the 2-pyrimidinone cation ( ... ...

    Abstract Organic-inorganic hybrid nonlinear optical (NLO) materials are highly anticipated because of the integration of both merits of the organic and inorganic moieties. Herein, the 2-pyrimidinone cation (C
    Language English
    Publishing date 2023-08-11
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1484438-2
    ISSN 1520-510X ; 0020-1669
    ISSN (online) 1520-510X
    ISSN 0020-1669
    DOI 10.1021/acs.inorgchem.3c02207
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  6. Article: Effect of polyene phosphatidylcholine/ursodeoxycholic acid/ademetionine on pregnancy outcomes in intrahepatic cholestasis.

    Dong, Xiao-Rui / Chen, Qian-Qian / Xue, Meng-Ling / Wang, Ling / Wu, Qin / Luo, Teng-Fei

    World journal of clinical cases

    2023  Volume 11, Issue 27, Page(s) 6431–6439

    Abstract: Background: Intrahepatic cholestasis of pregnancy (ICP) is a liver disorder that occurs in pregnant women and can lead to a range of adverse pregnancy outcomes. The condition is typically marked by pruritus (itching) and elevated levels of liver enzymes ...

    Abstract Background: Intrahepatic cholestasis of pregnancy (ICP) is a liver disorder that occurs in pregnant women and can lead to a range of adverse pregnancy outcomes. The condition is typically marked by pruritus (itching) and elevated levels of liver enzymes and bile acids. The standard treatment for ICP has generally been ursodeoxycholic acid and ademetionine 1,4-butanedisulfonate, but the efficacy of this approach remains less than optimal. Recently, polyene phosphatidylcholine has emerged as a promising new therapeutic agent for ICP due to its potential hepatoprotective effects.
    Aim: To evaluate the effect of polyene phosphatidylcholine/ursodeoxycholic acid/ ademetionine 1,4-butanedisulfonate on bile acid levels, liver enzyme indices, and pregnancy outcomes in patients with ICP.
    Methods: From June 2020 to June 2021, 600 patients with ICP who were diagnosed and treated at our hospital were recruited and assigned at a ratio of 1:1
    Results: Prior to treatment, no significant differences were observed between the two groups (
    Conclusion: Polyene phosphatidylcholine/ursodeoxycholic acid/ademetionine 1,4-butanedisulfonate effectively relieves pruritus and reduces bile acid levels and liver enzyme indices in patients with ICP, providing a positive impact on pregnancy outcome and a high safety profile. Further clinical trials are required prior to clinical application.
    Language English
    Publishing date 2023-10-25
    Publishing country United States
    Document type Journal Article
    ISSN 2307-8960
    ISSN 2307-8960
    DOI 10.12998/wjcc.v11.i27.6431
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  7. Article ; Online: [Risk analysis of serum chemical residues for metabolic associated fatty liver disease based on exposome-lipidome wide association study].

    Chen, Qian-Qian / You, Lei / Guan, Peng-Wei / Fang, Cheng-Nan / Qin, Wang-Shu / Liu, Xin-Yu / Xu, Guo-Wang

    Se pu = Chinese journal of chromatography

    2024  Volume 42, Issue 2, Page(s) 164–175

    Abstract: Metabolic associated fatty liver disease (MAFLD) is a common liver disease with a prevalence of up to 25%; it not only adversely affects human health but also aggravates the economic burden of society. An increasing number of studies have suggested that ... ...

    Abstract Metabolic associated fatty liver disease (MAFLD) is a common liver disease with a prevalence of up to 25%; it not only adversely affects human health but also aggravates the economic burden of society. An increasing number of studies have suggested that the occurrence of chronic noncommunicable diseases is affected by both environmental exposures and genetic factors. Research has also shown that environmental pollution may increase the risk of MAFLD and promote its occurrence and development. However, the relationship between these concepts, as well as the underlying exposure effects and mechanism, remains incompletely understood. Lipidomics, a branch of metabolomics that studies lipid disorders, can help researchers investigate abnormal lipid metabolites in various disease states. Lipidome-exposome wide association studies are a promising paradigm for investigating the health effects of cumulative environmental exposures on biological responses, and could provide new ideas for determining the associations between metabolic and lipid changes and disease risk caused by chemical-pollutant exposure. Hence, in this study, targeted exposomics and nontargeted lipidomics studies based on ultra-high performance liquid chromatography-tandem mass spectrometry (UHPLC-MS/MS) and ultra-high performance liquid chromatography-high resolution mass spectrometry (UHPLC-HRMS) were used to characterize exogenous chemical pollutants and endogenous lipid metabolites in the sera of patients with MAFLD and healthy subjects. The results demonstrated that fipronil sulfone, malathion dicarboxylic acid, and monocyclohexyl phthalate may be positively associated with the disease risk of patients diagnosed as simple fatty liver disease (hereafter referred to as MAFLD(0)). Moreover, fipronil sulfone, acesulfame potassium, perfluorooctanoic acid (PFOA), perfluorononanoic acid (PFNA), perfluoroundecanoic acid (PFUnDA), 4-hydroxybenzophenone, and 3,5-di-tert-butyl-4-hydroxybenzoic acid (DBPOB) may be positively associated with the disease risk of patients diagnosed as fatty liver complicated by single or multiple metabolic disorders. Association analysis was carried out to explore the lipid metabolites induced by chemical residues. Triglyceride (TG) and diglyceride (DG) were significantly increased in MAFLD and MAFLD(0). The numbers of carbons of significantly changed DGs and TGs were mainly in the ranges of 32-40 and 35-60, respectively, and both were mainly characterized by changes in polyunsaturated lipids. Most of the lipid-effect markers were positively correlated with chemical residues and associated with increased disease risk. Our research provides a scientific basis for studies on the association and mechanism between serum chemical-pollutant residues and disease outcomes.
    MeSH term(s) Humans ; Environmental Pollutants/adverse effects ; Exposome ; Lipidomics ; Risk Assessment ; Tandem Mass Spectrometry
    Chemical Substances Environmental Pollutants ; 3,5-di-tert-butyl-4-hydroxybenzoic acid (9F0I7YAG34)
    Language Chinese
    Publishing date 2024-02-28
    Publishing country China
    Document type English Abstract ; Journal Article
    ISSN 1872-2059
    ISSN (online) 1872-2059
    DOI 10.3724/SP.J.1123.2023.12014
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  8. Article ; Online: Immunoglobulin G-mediated food intolerance and metabolic syndrome influence the occurrence of reflux esophagitis in

    Wang, Li-Hui / Su, Bin-Bin / Wang, Sheng-Shu / Sun, Guan-Chao / Lv, Kun-Ming / Li, Yi / Shi, Hui / Chen, Qian-Qian

    World journal of gastroenterology

    2024  Volume 30, Issue 8, Page(s) 855–862

    Abstract: Background: Reflux esophagitis has an increasing prevalence and complex and diverse symptoms. Identifying its risk factors is crucial to understanding the etiology, prevention, and management of the disease. The occurrence of reflux esophagitis may be ... ...

    Abstract Background: Reflux esophagitis has an increasing prevalence and complex and diverse symptoms. Identifying its risk factors is crucial to understanding the etiology, prevention, and management of the disease. The occurrence of reflux esophagitis may be associated with food reactions,
    Aim: To investigate the risk factors for reflux esophagitis and analyze the effects of immunoglobulin (Ig) G-mediated food intolerance,
    Methods: Outpatients attending the Second Medical Center of the PLA General Hospital between 2017 and 2021 were retrospectively enrolled. The patients' basic information, test results, gastroscopy results,
    Results: A total of 7954 outpatients were included; the prevalence of reflux esophagitis, IgG-mediated food intolerance,
    Conclusion: Patients with IgG-mediated food intolerance and metabolic syndrome were at higher risk of developing reflux esophagitis, while patients with
    MeSH term(s) Humans ; Esophagitis, Peptic/pathology ; Helicobacter pylori ; Metabolic Syndrome/epidemiology ; Metabolic Syndrome/complications ; Immunoglobulin G ; Food Intolerance/complications ; Retrospective Studies ; Helicobacter Infections/complications ; Helicobacter Infections/epidemiology ; Helicobacter Infections/diagnosis
    Chemical Substances Immunoglobulin G
    Language English
    Publishing date 2024-03-14
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2185929-2
    ISSN 2219-2840 ; 1007-9327
    ISSN (online) 2219-2840
    ISSN 1007-9327
    DOI 10.3748/wjg.v30.i8.855
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  9. Article ; Online: Diagnostic performance of contrast-enhanced mammography for suspicious findings in dense breasts: A systematic review and meta-analysis.

    Lin, Shu-Ting / Li, Hong-Jiang / Li, Yi-Zhong / Chen, Qian-Qian / Ye, Jia-Yi / Lin, Shu / Cai, Si-Qing / Sun, Jian-Guo

    Cancer medicine

    2024  Volume 13, Issue 8, Page(s) e7128

    Abstract: Purpose: Contrast-enhanced spectral imaging (CEM) is a new mammography technique, but its diagnostic value in dense breasts is still inconclusive. We did a systematic review and meta-analysis of studies evaluating the diagnostic performance of CEM for ... ...

    Abstract Purpose: Contrast-enhanced spectral imaging (CEM) is a new mammography technique, but its diagnostic value in dense breasts is still inconclusive. We did a systematic review and meta-analysis of studies evaluating the diagnostic performance of CEM for suspicious findings in dense breasts.
    Materials and methods: The PubMed, Embase, and Cochrane Library databases were searched systematically until August 6, 2023. Prospective and retrospective studies were included to evaluate the diagnostic performance of CEM for suspicious findings in dense breasts. The QUADAS-2 tool was used to evaluate the quality and risk of bias of the included studies. STATA V.16.0 and Review Manager V.5.3 were used to meta-analyze the included studies.
    Results: A total of 10 studies (827 patients, 958 lesions) were included. These 10 studies reported the diagnostic performance of CEM for the workup of suspicious lesions in patients with dense breasts. The summary sensitivity and summary specificity were 0.95 (95% CI, 0.92-0.97) and 0.81 (95% CI, 0.70-0.89), respectively. Enhanced lesions, circumscribed margins, and malignancy were statistically correlated. The relative malignancy OR value of the enhanced lesions was 28.11 (95% CI, 6.84-115.48). The relative malignancy OR value of circumscribed margins was 0.17 (95% CI, 0.07-0.45).
    Conclusion: CEM has high diagnostic performance in the workup of suspicious findings in dense breasts, and when lesions are enhanced and have irregular margins, they are often malignant.
    MeSH term(s) Female ; Humans ; Breast/diagnostic imaging ; Breast/pathology ; Breast Density ; Breast Neoplasms/diagnostic imaging ; Breast Neoplasms/pathology ; Contrast Media ; Mammography/methods ; Sensitivity and Specificity
    Chemical Substances Contrast Media
    Language English
    Publishing date 2024-04-30
    Publishing country United States
    Document type Journal Article ; Meta-Analysis ; Research Support, Non-U.S. Gov't ; Systematic Review
    ZDB-ID 2659751-2
    ISSN 2045-7634 ; 2045-7634
    ISSN (online) 2045-7634
    ISSN 2045-7634
    DOI 10.1002/cam4.7128
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  10. Article: A Prebiotic Ribosylation of Pyrimidine Nucleobases Enabled by Metal Cations and Clay Minerals.

    Chen, Qian-Qian / Zhao, Ze-Run / Wang, Xiao

    Life (Basel, Switzerland)

    2021  Volume 11, Issue 12

    Abstract: We report a prebiotically relevant solution to ... ...

    Abstract We report a prebiotically relevant solution to the
    Language English
    Publishing date 2021-12-10
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662250-6
    ISSN 2075-1729
    ISSN 2075-1729
    DOI 10.3390/life11121381
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