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Article: A Study of Elderly Patients' Preference for "Internet + Nursing Service" Based on Discrete Choice Experiments.

Liu, Cui / Zhang, Zhixia / Chen, Qiuxia / He, Fang

Alternative therapies in health and medicine

2024

Abstract: Objective: To investigate the preference of elderly patients for "Internet + Nursing Service", so as to provide reference for accurately matching their service needs.: Methods: Based on discrete choice experiments, the elderly patients' "Internet + ... ...

Abstract	Objective: To investigate the preference of elderly patients for "Internet + Nursing Service", so as to provide reference for accurately matching their service needs. Methods: Based on discrete choice experiments, the elderly patients' "Internet + Nursing Service" choice preference questionnaire was prepared, and 410 elderly patients were interviewed face-to-face. The Conditional Logit Model was used for quantitative analysis of the experimental data. Results: The six attributes included in the study had a significant impact on the elderly patients' preference for "Internet + Nursing Service" (P < .05). Among non-economic attributes, "medical insurance reimbursement ratio -70%" has the highest utility (.263, P < .001), with "hospital size - larger (.205, P < .05)" and "medical insurance reimbursement ratio -50%" (.188, P < .05) ranking second and third, respectively. The relative importance of the attribute of medical insurance reimbursement proportion is the highest (26.44%), and the relative importance of service content is the lowest (9.78%). If the proportion of medical insurance reimbursement increases from 30% to 70%, patients are willing to pay 202.9 yuan, and the probability of choosing "Internet + Nursing Service" increases by 6.1%. Conclusion: Patients prefer to choose a higher proportion of medical insurance reimbursement, a larger medical institution, a higher level of nurses, low single service costs, a basic package, and "Internet + Nursing Service" led by the government and hospitals. Improvement of the price and medical insurance payment policy is recommended, along with the enhancement of the ability of primary nursing services, strengthening of the management of Internet enterprise platforms, and scientific assessment of the needs of patients for personalized nursing services.
Language	English
Publishing date	2024-01-01
Publishing country	United States
Document type	Journal Article
ZDB-ID	1225073-9
ISSN	1078-6791
ISSN	1078-6791
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Article ; Online: The contribution and interactive relationship of tourism industry development and technological innovation to the informatization level

Guo Zimeng / Yang Wei / Chen Qiuxia / Huang Xiaoting

Frontiers in Environmental Science, Vol

Based on the context of low-carbon development

2023 Volume 11

Abstract: Research background: Informatization is a new economic form arising from a new round of technological and industrial changes. Information technology has been used to promote the integrated development of the tourism industry and propel technological ... ...

Abstract	Research background: Informatization is a new economic form arising from a new round of technological and industrial changes. Information technology has been used to promote the integrated development of the tourism industry and propel technological innovation, which will help accelerate the achievement of the strategic goals of carbon emission peaking and carbon neutrality. China’s informatization level has improved to a certain extent due to the concentration of capital and technological innovation brought about by the government-led model, and also owing to the consumer dynamics released by the industry-side reform.Research contents and methods: This study constructs a panel vector auto-regression model to investigate the impact of tourism industry development and technological innovation on informatization based on Chinese provincial statistics from 2010 to 2019. This study adopts the entropy method, Monte Carlo simulation, variance decomposition, and pulse response to investigate the impact, characteristics, and trends of their interactions.Results: First, tourism industry development, technological innovation, and informatization all experience inertia development and have self-reinforcing mechanisms during the research period. Second, tourism industry development and technological innovation have a significantly positive impact on the enhancement of informatization, and their influence presents a trend, from upward to downward. Third, tourism industry development has a positive impact on technological innovation, and the response trend presents a curve approximately inverted U-shape. Fourth, from the results of variance decomposition, the contribution of technological innovation to the improvement of informatization level increases rapidly and reaches 18.5% and then levels off. The contribution rate of tourism industry development to the improvement of informatization level gradually rises and reaches 5.1%, finally tending to be stable.Contribution: This study reveals that tourism industry development and ...
Keywords	informatization ; tourism industry ; technological innovation ; panel vector auto-regression ; pulse response ; low-carbon economic development ; Environmental sciences ; GE1-350
Subject code	910
Language	English
Publishing date	2023-04-01T00:00:00Z
Publisher	Frontiers Media S.A.
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Target Protein Design and Preselection Analysis.

Chen, Qiuxia / Israel, David I

Methods in molecular biology (Clifton, N.J.)

2022 Volume 2541, Page(s) 143–154

Abstract: DNA-encoded library (DEL) technology utilizes affinity-based selection methods to screen chemical libraries. DEL technology possesses some unique features compared to other small molecule screening technologies, such as the use of DNA identification tags ...

Abstract	DNA-encoded library (DEL) technology utilizes affinity-based selection methods to screen chemical libraries. DEL technology possesses some unique features compared to other small molecule screening technologies, such as the use of DNA identification tags and use of target protein immobilization in the standard library screening process. Therefore, it is of great importance to ensure the target protein is properly designed for DEL selections, that the protein is of high quality, and that ligand binding sites are accessible under DEL selection conditions. Here we describe general considerations for target protein design and expression and experiments that are conducted before initiating selections to assess protein quality and validate methods that will be used for the DEL selection.
MeSH term(s)	DNA/chemistry ; Gene Library ; Ligands ; Small Molecule Libraries/chemistry
Chemical Substances	Ligands ; Small Molecule Libraries ; DNA (9007-49-2)
Language	English
Publishing date	2022-09-09
Publishing country	United States
Document type	Journal Article
ISSN	1940-6029
ISSN (online)	1940-6029
DOI	10.1007/978-1-0716-2545-3_18
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Article ; Online: DEL Selections Against a Soluble Protein Target.

Chen, Qiuxia / Zhu, Junyang

Methods in molecular biology (Clifton, N.J.)

2022 Volume 2541, Page(s) 155–164

Abstract: Affinity-based DNA-encoded library (DEL) selection is considered a powerful tool for small molecule drug discovery. Such selections are a multi-round process that involves incubation of a target protein with the DEL, capture of the protein and associated ...

Abstract	Affinity-based DNA-encoded library (DEL) selection is considered a powerful tool for small molecule drug discovery. Such selections are a multi-round process that involves incubation of a target protein with the DEL, capture of the protein and associated DEL compounds on a solid support, separation of bound molecules from the bulk DEL that is unbound, and recovery of bound DEL molecules. Each step is of great importance in order to achieve successful selections. Here we describe the selection process against a soluble target protein in both the immobilized and in-solution modes.
MeSH term(s)	DNA ; Drug Discovery ; Small Molecule Libraries/metabolism ; Small Molecule Libraries/pharmacology
Chemical Substances	Small Molecule Libraries ; DNA (9007-49-2)
Language	English
Publishing date	2022-09-09
Publishing country	United States
Document type	Journal Article
ISSN	1940-6029
ISSN (online)	1940-6029
DOI	10.1007/978-1-0716-2545-3_19
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Exploring the role of psychological assistance hotlines in improving mental health problems among Chinese adult women: A perspective based on social expectations and gender roles.

Wei, Yating / Chen, Qiuxia / Wu, Deyuan / Fu, Xiaonv / Song, Haidong

Asian journal of psychiatry

2024 Volume 96, Page(s) 104026

Abstract: This paper looks at how social expectations and gender roles affect the mental health of Chinese women. Traditional Chinese culture, influenced by Confucianism and patriarchy, still has a negative impact on women's mental well-being, despite efforts for ... ...

Abstract	This paper looks at how social expectations and gender roles affect the mental health of Chinese women. Traditional Chinese culture, influenced by Confucianism and patriarchy, still has a negative impact on women's mental well-being, despite efforts for gender equality. Women's mental health is vital for both individuals and society, and this study aims to understand these issues better to help shape policies and interventions.
Language	English
Publishing date	2024-03-22
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2456678-0
ISSN	1876-2026 ; 1876-2018
ISSN (online)	1876-2026
ISSN	1876-2018
DOI	10.1016/j.ajp.2024.104026
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Article ; Online: Towards Sustainable Development: How Digitalization, Technological Innovation, and Green Economic Development Interact with Each Other.

Yang, Wei / Chen, Qiuxia / Guo, Qiuqi / Huang, Xiaoting

International journal of environmental research and public health

2022 Volume 19, Issue 19

Abstract: Green technological innovation is one of the endogenous drivers of green economic growth, and digitalization can promote green economic development in the form of industrial empowerment. The interactive relationship and the degree of influence between ... ...

Abstract	Green technological innovation is one of the endogenous drivers of green economic growth, and digitalization can promote green economic development in the form of industrial empowerment. The interactive relationship and the degree of influence between digitalization, technological innovation, and green economic development is thus an urgent issue to be addressed. Based on the panel data of 30 Chinese provinces from 2011 to 2019, we measured digitalization, technological innovation, and green economic development for the first time using the entropy method and included them in the same analytical framework by constructing a PVAR model to empirically test their interrelationship and degree of influence. Our findings suggest that: (1) There is an inertial development and self-reinforcing mechanism among the three variables. (2) The impact of digitalization on green economic development has a positive promotion effect, while the impact of technological innovation on green economic development is not significant. (3) The impact of green economic development on technological innovation has a positive promotion effect in the short term, but this effect gradually declines and tends to zero in the long term. Finally, based on the findings, several practical suggestions are made.
MeSH term(s)	China ; Economic Development ; Entropy ; Industry ; Inventions
Language	English
Publishing date	2022-09-27
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2175195-X
ISSN	1660-4601 ; 1661-7827
ISSN (online)	1660-4601
ISSN	1661-7827
DOI	10.3390/ijerph191912273
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Article ; Online: Effect of Prenatal Perineal Massage on Postpartum Perineal Injury and Postpartum Complications: A Meta-Analysis.

Chen, Qiuxia / Qiu, Xiaocui / Fu, Aizhen / Han, Yanmei

Computational and mathematical methods in medicine

2022 Volume 2022, Page(s) 3315638

Abstract: Background: The efficacy of perineal massage is controversial. The study was aimed at comparing the effects of perineal massage on perineal injury and complications.: Methods: PubMed, Embase, the Cochrane Library, and ISI Web of Science were searched ...

Abstract	Background: The efficacy of perineal massage is controversial. The study was aimed at comparing the effects of perineal massage on perineal injury and complications. Methods: PubMed, Embase, the Cochrane Library, and ISI Web of Science were searched for literature on the relationship between prenatal perineal massage and postpartum perineal injury and complications until April 2022. Indicators included postpartum perineal tears, perineotomy, postpartum perineal pain, natural labour, and postpartum incontinence. Finally, RevMan5.4 software was used to analyze the extracted data. Results: A total of 6487 subjects in 16 studies were included, with 3211 who received perineal massage and 3276 did not. There was no significant difference in 1-2 degree perineal tearing between the intervention group and the control group (RR = 0.96, 95% CI [0.90, 1.03], Conclusion: Compared with no prenatal perineal massage, prenatal perineal massage can reduce the risk of perineal injury, the incidence of lateral perineal resection, and the incidence of long-term pain.
MeSH term(s)	Female ; Humans ; Lacerations/epidemiology ; Lacerations/etiology ; Lacerations/prevention & control ; Massage ; Obstetric Labor Complications/epidemiology ; Obstetric Labor Complications/prevention & control ; Pain/complications ; Pain/prevention & control ; Perineum/injuries ; Postpartum Period ; Pregnancy
Language	English
Publishing date	2022-07-14
Publishing country	United States
Document type	Journal Article ; Meta-Analysis
ZDB-ID	2252430-7
ISSN	1748-6718 ; 1748-670X ; 1027-3662
ISSN (online)	1748-6718
ISSN	1748-670X ; 1027-3662
DOI	10.1155/2022/3315638
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Article: How do aesthetics and tourist involvement influence cultural identity in heritage tourism? The mediating role of mental experience.

Yang, Wei / Chen, Qiuxia / Huang, Xiaoting / Xie, Mei / Guo, Qiuqi

Frontiers in psychology

2022 Volume 13, Page(s) 990030

Abstract: As heritage is the precious treasure of human society, heritage also carries the genes of culture. It is of vital importance to effectively develop heritage tourism resources and explore the mechanisms that influence tourists' cultural identity. This ... ...

Abstract	As heritage is the precious treasure of human society, heritage also carries the genes of culture. It is of vital importance to effectively develop heritage tourism resources and explore the mechanisms that influence tourists' cultural identity. This study has integrated the stimulus-organism-response (SOR) framework with the attitude-behavior-context (ABC) theory to construct a hypothetical model of heritage tourism aesthetics, tourist involvement, mental experience, and cultural identity so as to figure out their relationships. The questionnaires were collected to investigate the impact paths and mechanisms between heritage aesthetics, tourist involvement, mental experience, and cultural identity. The structural equation model was used to examine the relationship between heritage tourism aesthetics, tourist involvement, mental experience, and cultural identity. The main findings include: (1) the positive impact of aesthetics driving mental experience and cultural identity is significant; (2) the impact of tourist involvement on mental experience and cultural identity is also significant; (3) the impact of aesthetics on cultural identity is not significant, but mental experience mediates the relationship between aesthetics and cultural identity in heritage tourism. This study provides a new research framework and perspective for the aesthetics, tourist involvement, mental experience, and cultural identity of tourists in heritage tourism. This study also provides practical implications for government culture sectors to propagandize culture and for heritage destination managers to better manage heritage sites.
Language	English
Publishing date	2022-10-28
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2563826-9
ISSN	1664-1078
ISSN	1664-1078
DOI	10.3389/fpsyg.2022.990030
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Article ; Online: Ecological Civilization and High-Quality Development: Do Tourism Industry and Technological Progress Affect Ecological Economy Development?

Yang, Wei / Chen, Qiuxia / Dao, Yanyue / Huang, Xiaoting / Shao, Weifang

International journal of environmental research and public health

2022 Volume 20, Issue 1

Abstract: The tourism industry is considered a smokeless industry or green economy. Under the circumstances of carbon peaking and carbon neutrality, it is essential and urgent to explore whether the tourism industry and technological progress can promote ... ...

Abstract	The tourism industry is considered a smokeless industry or green economy. Under the circumstances of carbon peaking and carbon neutrality, it is essential and urgent to explore whether the tourism industry and technological progress can promote ecological economy development. Based on the panel data of 30 provinces in mainland China from 2007-2019, this paper, for the first time, incorporates the tourism industry, technological progress, and ecological economy development into the analytical framework by constructing a PVAR model. In addition, this paper calculates the indicator weights of each variable using the entropy weighting method. This paper utilizes GMM tests, impulse response analysis, Monte Carlo simulation, and variance decomposition to empirically investigate the dynamic impact mechanism of variables interacting with each other. The conclusions are as follows. First, the tourism industry always contributes positively to ecological economy development, while technological progress can facilitate ecological economy development in the long run rather than in the short term. Second, the tourism industry also positively contributes to technological progress. Third, ecological economy development has a "crowding out effect" on the tourism industry. Fourth, the tourism industry in developed eastern regions has a more powerful impact on ecological economy development than in underdeveloped middle and western regions. Based on the empirical results, we provide practical implications: first, the assessment system of the regional economy should include ecological development indicators; second, the tourism industry should accelerate the use of clean energy and the transformation of green technological innovation.
MeSH term(s)	Tourism ; Technology ; Inventions ; Economic Development ; China ; Carbon
Chemical Substances	Carbon (7440-44-0)
Language	English
Publishing date	2022-12-31
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2175195-X
ISSN	1660-4601 ; 1661-7827
ISSN (online)	1660-4601
ISSN	1661-7827
DOI	10.3390/ijerph20010783
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Article: A prognostic model based on DNA methylation-related gene expression for predicting overall survival in hepatocellular carcinoma.

Luo, Jin / Zhu, Wan-Cui / Chen, Qiu-Xia / Yang, Chang-Fu / Huang, Bi-Jun / Zhang, Shi-Jun

Frontiers in oncology

2024 Volume 13, Page(s) 1171932

Abstract: Background: Hepatocellular carcinoma (HCC) continues to increase in morbidity and mortality among all types of cancer. DNA methylation, an important epigenetic modification, is associated with cancer occurrence and progression. The objective of this ... ...

Abstract	Background: Hepatocellular carcinoma (HCC) continues to increase in morbidity and mortality among all types of cancer. DNA methylation, an important epigenetic modification, is associated with cancer occurrence and progression. The objective of this study was to establish a model based on DNA methylation risk scores for identifying new potential therapeutic targets in HCC and preventing cancer progression. Methods: Transcriptomic, clinical, and DNA methylation data on 374 tumor tissues and 50 adjacent normal tissues were downloaded from The Cancer Genome Atlas-Liver Hepatocellular Carcinoma database. The gene expression profiles of the GSE54236 liver cancer dataset, which contains data on 161 liver tissue samples, were obtained from the Gene Expression Omnibus database. We analyzed the relationship between DNA methylation and gene expression levels after identifying the differentially methylated and expressed genes. Then, we developed and validated a risk score model based on the DNA methylation-driven genes. A tissue array consisting of 30 human hepatocellular carcinoma samples and adjacent normal tissues was used to assess the protein and mRNA expression levels of the marker genes by immunohistochemistry and qRT-PCR, respectively. Results: Three methylation-related differential genes were identified in our study: GLS, MEX3B, and GNA14. The results revealed that their DNA methylation levels were negatively correlated with local gene expression regulation. The gene methylation levels correlated strongly with the prognosis of patients with liver cancer. This was confirmed by qRT-PCR and immunohistochemical verification of the expression of these genes or proteins in tumors and adjacent tissues. These results revealed the relationship between the level of relevant gene methylation and the prognosis of patients with liver cancer as well as the underlying cellular and biological mechanisms. This allows our gene signature to provide more accurate and appropriate predictions for clinical applications. Conclusion: Through bioinformatics analysis and experimental validation, we obtained three DNA methylation marker: GLS, MEX3B, and GNA14. This helps to predict the prognosis and may be a potential therapeutic target for HCC patients.
Language	English
Publishing date	2024-01-18
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2649216-7
ISSN	2234-943X
ISSN	2234-943X
DOI	10.3389/fonc.2023.1171932
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