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  1. Article: Stevens-Johnson syndrome/toxic epidermal necrolysis successfully treated with Chinese herbal medicine Pi-Yan-Ning: A case report.

    Chen, Shu-Yi / Chen, Qun-Wei / Shou, Liu-Mei / Pan, Hong / Ruan, Shan-Ming / Liang, Zhe-Hao / Shu, Qi-Jin

    Journal of integrative medicine

    2021  Volume 19, Issue 6, Page(s) 555–560

    Abstract: Stevens-Johnson syndrome/toxic epidermal necrolysis (SJS/TEN) is a rare adverse cutaneous reaction with a low incidence and high mortality. Despite posing a serious threat to patients' health and lives, there is no high-quality evidence for a standard ... ...

    Abstract Stevens-Johnson syndrome/toxic epidermal necrolysis (SJS/TEN) is a rare adverse cutaneous reaction with a low incidence and high mortality. Despite posing a serious threat to patients' health and lives, there is no high-quality evidence for a standard treatment regimen. Here we report the case of a 62-year-old man with stage IV pancreatic cancer who experienced immunotherapy-induced SJS/TEN. After consensus-based regular treatments at a local hospital, his symptoms became worse. Thus, he consented to receive Chinese herbal medicine (CHM) therapy. The affected parts of the patient were treated with the CHM Pi-Yan-Ning which was applied externally for 20 min twice a day. After 7 days of treatment, the dead skin began peeling away from the former lesions that had covered his hands, feet, and lips, indicating that skin had regenerated. After 12 days of treatment, the patient's skin was completely recovered. In this case, SJS/TEN was successfully treated with Pi-Yan-Ning, suggesting that there might be tremendous potential for the use of Pi-Yan-Ning in the treatment of severe skin reactions to drug treatments. Further basic investigations and clinical trials to explore the mechanism and efficacy are needed.
    MeSH term(s) Drugs, Chinese Herbal/therapeutic use ; Humans ; Immunologic Factors ; Incidence ; Male ; Middle Aged ; Skin ; Stevens-Johnson Syndrome/drug therapy ; Stevens-Johnson Syndrome/etiology
    Chemical Substances Drugs, Chinese Herbal ; Immunologic Factors
    Language English
    Publishing date 2021-10-11
    Publishing country Netherlands
    Document type Case Reports
    ZDB-ID 2705612-0
    ISSN 2095-4964
    ISSN 2095-4964
    DOI 10.1016/j.joim.2021.10.001
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: [Analysis of nosocomial infections in 110 death cases with viral hepatitis].

    Zhao, Guo-gen / Chen, Qun-wei / Pan, Xiao-cheng / Zhang, Lin

    Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology

    2004  Volume 12, Issue 6, Page(s) 379

    MeSH term(s) Adolescent ; Adult ; Aged ; Aged, 80 and over ; Cause of Death ; Child ; Cross Infection/epidemiology ; Female ; Hepatitis, Viral, Human/complications ; Humans ; Liver Cirrhosis/complications ; Male ; Middle Aged ; Peritonitis/complications ; Peritonitis/epidemiology ; Pneumonia/complications ; Pneumonia/epidemiology
    Language Chinese
    Publishing date 2004-06
    Publishing country China
    Document type Journal Article
    ISSN 1007-3418
    ISSN 1007-3418
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: [Determination of ascitic bacterial 16S rRNA gene in the rapid diagnosis of spontaneous bacterial peritonitis].

    Pan, Hong-ying / Sun, Hong-yun / Chen, Cui-rong / Chen, Qun-wei / Xu, Jing / Ye, Rong-xia / Lou, Guo-qiang / Lu, De-rong

    Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae

    2010  Volume 32, Issue 5, Page(s) 557–560

    Abstract: Objective: To evaluate the value of ascitic bacterial 16S rRNA gene determination in the rapid diagnosis of spontaneous bacterial peritonitis (SBP).: Methods: 16S rRNA gene from bacterial DNA in ascites was determined by quantitative fluorescent ... ...

    Abstract Objective: To evaluate the value of ascitic bacterial 16S rRNA gene determination in the rapid diagnosis of spontaneous bacterial peritonitis (SBP).
    Methods: 16S rRNA gene from bacterial DNA in ascites was determined by quantitative fluorescent polymerase chain reaction (PCR) in 76 patients with suspected SBP and 6 patients with non-infectious ascites. The results were compared with those obtained from bacterial culture.
    Results: The positive rate of SBP was 22.4% among patients detected with ascitic bacterial 16S rRNA gene determination-based quantitative fluorescent PCR, which was significantly higher than that (7.9%) in patients only received bacterial culture (P<0.05). In addition,in 6 patients with non-infectious ascites,both the 16S rRNA gene determination-based quantitative fluorescent PCR and bacterial culture showed negative results.
    Conclusions: 16S rRNA gene determination-based quantitative fluorescent PCR can be an effective tool for the rapid diagnosis of SBP. It is more sensitive than the bacterial culture.
    MeSH term(s) Adult ; Aged ; Ascitic Fluid/microbiology ; Bacterial Infections/diagnosis ; DNA, Bacterial/analysis ; Female ; Humans ; Male ; Middle Aged ; Peritonitis/diagnosis ; Peritonitis/microbiology ; RNA, Ribosomal, 16S
    Chemical Substances DNA, Bacterial ; RNA, Ribosomal, 16S
    Language Chinese
    Publishing date 2010-10
    Publishing country China
    Document type English Abstract ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 604853-5
    ISSN 1000-503X
    ISSN 1000-503X
    DOI 10.3881/j.issn.1000-503X.2010.05.017
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.B 2554: Show issues Location:
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  4. Article: [The expression of B7 and CD28 in peripheral blood mononuclear cells of chronic severe hepatitis B patients and its clinical significance].

    Liu, Cui-xue / Chen, Qun-wei / Zhao, Guo-gen / Zhang, Song-ping / Lou, Guo-qiang

    Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology

    2005  Volume 13, Issue 12, Page(s) 943–944

    MeSH term(s) Adult ; Aged ; Antigens, CD/biosynthesis ; Antigens, CD/genetics ; B7-H1 Antigen ; CD28 Antigens/biosynthesis ; CD28 Antigens/genetics ; Female ; Hepatitis B, Chronic/immunology ; Humans ; Leukocytes, Mononuclear/immunology ; Male ; Middle Aged
    Chemical Substances Antigens, CD ; B7-H1 Antigen ; CD274 protein, human ; CD28 Antigens
    Language Chinese
    Publishing date 2005-12
    Publishing country China
    Document type Journal Article
    ISSN 1007-3418
    ISSN 1007-3418
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: [Level of serum and liver tissue TGF-beta1 in patients with liver fibrosis due to chronic hepatitis B].

    Guo, Jian-chun / Bao, Jian-feng / Chen, Qun-wei / Li, Xiao-ou / Shi, Jun-ping / Lou, Guo-qiang / Shi, Wei-zhen / Xun, Yun-hao

    Zhonghua shi yan he lin chuang bing du xue za zhi = Zhonghua shiyan he linchuang bingduxue zazhi = Chinese journal of experimental and clinical virology

    2008  Volume 22, Issue 5, Page(s) 354–357

    Abstract: Objective: To detect the level of serum and liver tissue TGF-beta1 in patients with chronic hepatitis B, to study their relation to liver fibrosis and gain the evidence for diagnosis of liver fibrosis.: Methods: The liver fibrosis grades (S0-S4) of ... ...

    Abstract Objective: To detect the level of serum and liver tissue TGF-beta1 in patients with chronic hepatitis B, to study their relation to liver fibrosis and gain the evidence for diagnosis of liver fibrosis.
    Methods: The liver fibrosis grades (S0-S4) of 131 cases with chronic HBV infection were diagnosed after liver biopsy. Serum TGF-beta1 was detected by enzyme-linked immunosorbent assay, and the semiquantitative analysis was applied after detecting the expression of TGF-beta1 in liver tissue with immunohistochemistry. Their relations to liver fibrosis were analyzed.
    Results: Serum and tissue level of TGF-beta1 increased significantly with the development of fibrosis, and the same result was obtained between themselves (P < 0.01). There was very significant difference for serum level of TGF-beta1 among the groups with different fibrosis grades (P < 0.01). Serum levels of TGF-beta1 were decreased significantly comparing the Group S0 or S1 to S4 (P < 0.005). There were significant difference for serum level of TGF-beta1 among S0 and the others (P < 0.005). And there was significant difference between S1 and S3 (P < 0.005). The expression level of TGF-beta1 in liver tissue has no significant difference between group S3 and S4 (P > 0.05). However, the differences were significantly among the other comparisons (P < 0.01).
    Conclusion: There is close relation between the level of TGF-beta1 and the different liver fibrosis grades due to chronic hepatitis B. The serum level of TGF-beta1 is a potential noninvasive maker for diagnosis of liver fibrosis.
    MeSH term(s) Adult ; Female ; Hepatitis B/complications ; Hepatitis B/drug therapy ; Hepatitis B/metabolism ; Hepatitis B/pathology ; Hepatitis B virus/genetics ; Hepatitis B virus/metabolism ; Hepatitis B, Chronic/complications ; Hepatitis B, Chronic/metabolism ; Humans ; Liver Cirrhosis/etiology ; Male ; Transforming Growth Factor beta1/blood ; Transforming Growth Factor beta1/metabolism
    Chemical Substances Transforming Growth Factor beta1
    Language Chinese
    Publishing date 2008-10
    Publishing country China
    Document type English Abstract ; Journal Article
    ISSN 1003-9279
    ISSN 1003-9279
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: [Determination of ascitic bacterial 16S rRNA by quantitative PCR-microarray in the diagnosis of spontaneous bacterial peritonitis].

    Pan, Hong-ying / Chen, Cui-rong / Shang, Shi-qiang / Sun, Hong-yun / Chen, Qun-wei / Xu, Jing / Ye, Rong-xia / Lou, Guo-qiang / Lu, De-rong

    Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology

    2011  Volume 19, Issue 4, Page(s) 297–300

    Abstract: Objective: To evaluate the significance of determining ascitic bacterial 16S rRNA by quantitative PCR combined with microarray (PCR-microarray) in the diagnosis of spontaneous bacterial peritonitis (SBP).: Methods: Ascitic bacterial 16SrRNA was ... ...

    Abstract Objective: To evaluate the significance of determining ascitic bacterial 16S rRNA by quantitative PCR combined with microarray (PCR-microarray) in the diagnosis of spontaneous bacterial peritonitis (SBP).
    Methods: Ascitic bacterial 16SrRNA was determined by real time fluorescent quantitative PCR-microarray in 76 cases of suspected SBP and 6 cases of non-infectious ascites with chronic liver diseases. The results were compared with ascitic bacterial culture simultaneously.
    Results: Of 76 ascitic samples, 17 were detected bacteria positive by PCR-microarray, including 8 Grams positive(G+) and 9 Grams negative(G-), which was higher than that by bacterial culture which had only 6 ascitic samples detected positive (all G-); the positive rates were 22.4% vs 7.9%, respectively (P < 0.01). The bacterial strains detected by both methods in 6 cases had a consistency with each other. No bacteria were detected in another 6 cases of non-infectious ascites with chronic liver diseases.
    Conclusions: Determination of ascitic bacteria 16S rRNA by PCR-microarray has a higher specificity and sensitivity in the diagnosis of SBP as compared with the bacteria culture. Application of this novel method can not only accelerate SBP diagnosis but also stratify the different pathogens.
    MeSH term(s) Adult ; Aged ; Ascitic Fluid/microbiology ; Bacterial Infections/diagnosis ; Bacterial Infections/microbiology ; Female ; Humans ; Liver Cirrhosis/diagnosis ; Liver Cirrhosis/microbiology ; Male ; Middle Aged ; Oligonucleotide Array Sequence Analysis ; Peritonitis/diagnosis ; Peritonitis/microbiology ; Polymerase Chain Reaction/methods ; RNA, Bacterial/isolation & purification ; RNA, Ribosomal, 16S/isolation & purification
    Chemical Substances RNA, Bacterial ; RNA, Ribosomal, 16S
    Language Chinese
    Publishing date 2011-04
    Publishing country China
    Document type Comparative Study ; English Abstract ; Evaluation Studies ; Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 1007-3418
    ISSN 1007-3418
    DOI 10.3760/cma.j.issn.1007-3418.2011.04.015
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: [Expression of Bcl-2 and Bax proteins in rat liver fibrosis model and the role of IFN-gamma].

    Tao, Jun / Cai, Wei-min / Lu, Liang-wei / Chen, Qun-wei / Weng, Hong-lei / Zhang, Yong-sheng

    Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology

    2003  Volume 11, Issue 11, Page(s) 669–672

    Abstract: Objective: To study the expression of Bcl-2 and Bax in rat liver fibrosis model induced by CCl4 and the role of IFN-gamma.: Methods: Liver fibrosis was induced in rats by subcutaneous injection of CCl4. The rats were divided into fibrosis model group, ...

    Abstract Objective: To study the expression of Bcl-2 and Bax in rat liver fibrosis model induced by CCl4 and the role of IFN-gamma.
    Methods: Liver fibrosis was induced in rats by subcutaneous injection of CCl4. The rats were divided into fibrosis model group, Bie-Jia-Ruan-Gan-Tablet treatment group and IFN-gamma treatment group (0.2 MU.kg.d, i. m. for 12 weeks), and another 10 rats without any treatment were used as normal control. Bcl-2 and Bax proteins expression were detected by immunohistochemistry.
    Results: Bcl-2 was expressed weakly in the homogenate of hepatocytes and hepatic sinusoid in normal control rats, and it was expressed stronger in fibrous septae, portal area, hepatic sinusoid, the homogenate and membrane of hepatocytes and central vein in fibrosis model rats (3.87%+/-2.37% vs 9.46%+/-4.29%, t=2.83, P<0.05). Bax was expressed slightly in central vein and the hepatic sinusoid around, and it was expressed stronger in the homogenate of hepatocytes, hepatic sinusoid, fibrous septae, membrane of hepatocytes and epithelial cells of bile duct (3.50%+/-1.88% vs 9.80%+/-3.75%, t=3.72, P<0.01). Compared with that in fibrosis model rats, the expression of Bax was significantly lower in rats treated with IFN-gamma (9.80%+/-3.75% vs 5.85%+/-2.35%, t=2.98, P<0.01), but the expression of Bcl-2 was not significantly different (t=1.49, P>0.05), however it was significantly lower in fibrous septae in IFN-gamma-treated group than in model group (6.58%+/-4.13% vs 9.46%+/-4.29%, t=2.80, P<0.05).
    Conclusion: The expression of Bcl-2 and Bax increases in liver fibrosis model rats, and IFN-gamma can promote myofibroblasts apoptosis
    MeSH term(s) Animals ; Apoptosis ; Disease Models, Animal ; Female ; Gene Expression ; Interferon-gamma/pharmacology ; Liver Cirrhosis/metabolism ; Male ; Proto-Oncogene Proteins/metabolism ; Proto-Oncogene Proteins c-bcl-2/metabolism ; Rats ; Rats, Sprague-Dawley ; Recombinant Proteins/pharmacology ; bcl-2-Associated X Protein
    Chemical Substances Bax protein, rat ; Proto-Oncogene Proteins ; Proto-Oncogene Proteins c-bcl-2 ; Recombinant Proteins ; bcl-2-Associated X Protein ; Interferon-gamma (82115-62-6)
    Language Chinese
    Publishing date 2003-11
    Publishing country China
    Document type English Abstract ; Journal Article
    ISSN 1007-3418
    ISSN 1007-3418
    Database MEDical Literature Analysis and Retrieval System OnLINE

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