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Article ; Online: Combined stomach and duodenal perforating injury following blunt abdominal trauma: a case report and literature review.

Lai, Chun-Chi / Huang, Hung-Chang / Chen, Ray-Jade

2020 Volume 20, Issue 1, Page(s) 217

Abstract: Background: Gastrointestinal injury following blunt abdominal trauma is uncommon; a combined stomach and duodenal perforating injury is even more rare. Because these two organs are located in different spaces in the abdomen, such injuries are difficult ... ...

Abstract	Background: Gastrointestinal injury following blunt abdominal trauma is uncommon; a combined stomach and duodenal perforating injury is even more rare. Because these two organs are located in different spaces in the abdomen, such injuries are difficult to identify. Case presentation: A young woman involved in a motor vehicle crash presented to our emergency department with concerns of severe peritonitis. Contrast-enhanced computed tomography of the abdomen revealed pneumoperitoneum and retroperitoneal hematoma in zone 1. An emergency laparotomy was performed, revealing a stomach-perforating injury, which was resolved with primary repair. No obvious injury was observed on retroperitoneal exploration. However, peritonitis presented again on the second postoperative day, and a second laparotomy was performed, revealing a duodenum-perforating injury in its third portion. We performed primary repair with multi-tube-ostomy. The patient recovered well without permanent tube placement or internal bypass. Conclusions: Assessing associated injuries in blunt abdominal trauma is crucial because they may be fatal if timely intervention is not undertaken. These types of complicated injuries require a feasible surgical strategy formulated by experienced surgeons, which gives the patient a better chance of survival.
MeSH term(s)	Abdominal Injuries/complications ; Abdominal Injuries/surgery ; Adult ; Duodenum/diagnostic imaging ; Duodenum/surgery ; Female ; Humans ; Laparotomy ; Stomach ; Wounds, Nonpenetrating/complications ; Wounds, Nonpenetrating/surgery
Language	English
Publishing date	2020-10-02
Publishing country	England
Document type	Case Reports ; Journal Article ; Review
ZDB-ID	2050442-1
ISSN	1471-2482 ; 1471-2482
ISSN (online)	1471-2482
ISSN	1471-2482
DOI	10.1186/s12893-020-00882-w
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Article ; Online: Two-vessel Occlusion Mouse Model of Cerebral Ischemia-reperfusion.

Chen, Cheng-Yu / Chen, Ray-Jade / Lee, Gilbert Aaron

Journal of visualized experiments : JoVE

2019 , Issue 145

Abstract: In this study, a middle cerebral artery (MCA) occlusion mouse model is employed to study cerebral ischemia-reperfusion. A reproducible and reliable mouse model is useful for investigating the pathophysiology of cerebral ischemia-reperfusion and ... ...

Abstract	In this study, a middle cerebral artery (MCA) occlusion mouse model is employed to study cerebral ischemia-reperfusion. A reproducible and reliable mouse model is useful for investigating the pathophysiology of cerebral ischemia-reperfusion and determining potential therapeutic strategies for patients with stroke. Variations in the anatomy of the circle of Willis of C57BL/6 mice affects their infarct volume after cerebral-ischemia-induced injury. Studies have indicated that distal MCA occlusion (MCAO) can overcome this problem and result in a stable infarct size. In this study, we establish a two-vessel occlusion mouse model of cerebral ischemia-reperfusion through the interruption of the blood flow to the right MCA. We distally ligate the right MCA and right common carotid artery (CCA) and restore blood flow after a certain period of ischemia. This ischemia-reperfusion injury induces an infarct of stable size and a behavioral deficit. Peripheral immune cells infiltrate the ischemic brain within the 24 h infiltration period. Additionally, the neuronal loss in the cortical area is less for a longer reperfusion duration. Therefore, this two-vessel occlusion model is suitable for investigating the immune response and neuronal recovery during the reperfusion period after cerebral ischemia.
MeSH term(s)	Animals ; Brain/pathology ; Brain/physiopathology ; Brain Ischemia/immunology ; Brain Ischemia/pathology ; Brain Ischemia/physiopathology ; Disease Models, Animal ; Infarction, Middle Cerebral Artery/pathology ; Infarction, Middle Cerebral Artery/physiopathology ; Male ; Mice, Inbred C57BL ; Motor Activity ; Neurons/pathology ; Reperfusion Injury/pathology ; Reperfusion Injury/physiopathology
Language	English
Publishing date	2019-03-01
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Video-Audio Media
ZDB-ID	2259946-0
ISSN	1940-087X ; 1940-087X
ISSN (online)	1940-087X
ISSN	1940-087X
DOI	10.3791/59078
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Article ; Online: Lessons learned from isolated blunt major pancreatic injury: Surgical experience in one trauma centre.

Lin, Being-Chuan / Chen, Ray-Jade / Hwang, Tsann-Long

Injury

2019 Volume 50, Issue 9, Page(s) 1522–1528

Abstract: Introduction: The aim of this study was to present our surgical experience of isolated blunt major pancreatic injury (IBMPI), and to compare its characteristic outcomes with that of multi-organ injury.: Materials and methods: From 1994-2015, 31 ... ...

Abstract	Introduction: The aim of this study was to present our surgical experience of isolated blunt major pancreatic injury (IBMPI), and to compare its characteristic outcomes with that of multi-organ injury. Materials and methods: From 1994-2015, 31 patients with IBMPI and 54 patients with multi-organ injury, who underwent surgery, were retrospectively studied. Results: Of the 31 patients with IBMPI, 22 were male and 9 were female. The median age was 30 years (interquartile range, 20-38). Twenty-one patients were classified as the American Association for the Surgery of Trauma-Organ Injury Scale Grade III, and 10 patients as Grade IV. Patients with IBMPI had significantly lower shock-at-triage rates, lower injury severity scores, longer injury-to-surgery time, and shorter length of hospital stay than those with multi-organ injury. There were no statistically significant differences in sex, age, trauma mechanism, laboratory data, surgical procedures, and complications between the two groups. Eight patients with IBMPI underwent endoscopic retrograde pancreatography, and 5 patients with complete major pancreatic duct (MPD) disruption underwent pancreatectomy eventually. The remaining 3 patients had partial MPD injury and two of them received a pancreatic duct stent for the treatment of existing postoperative pancreatic fistula. Spleen-sacrificing distal pancreatectomy (SSDP) was performed in 13 patient with IBMPI, followed by spleen-preserving distal pancreatectomy (n = 12), peripancreatic drainage (n = 4), and central pancreatectomy with Roux-en-Y reconstruction (n = 2). The overall complication rates, related to the SSDP, SPDP, peripancreatic drainage, and central pancreatectomy, were 10/13 (77%), 4/12 (33%), 3/4 (75%), and 2/2 (100%), respectively. Three patients died resulting in a 10% mortality rate, and the other 16 patients developed intra-abdominal complications resulting in a 52% morbidity rate. In the subgroup analysis of the 25 patients who underwent distal pancreatectomy, SPDP was associated with a shorter injury-to-surgery time than SSDP. Conclusions: Patients with IBMPI have longer injury-to-surgery times, compared to those with multi-organ injury. Of the distal pancreatectomy patients, the time interval from injury to surgery was a significant associated factor in preserving or sacrificing the spleen.
MeSH term(s)	Adult ; Female ; Humans ; Injury Severity Score ; Male ; Multiple Trauma/complications ; Multiple Trauma/physiopathology ; Multiple Trauma/surgery ; Pancreas/injuries ; Pancreas/surgery ; Retrospective Studies ; Spleen/injuries ; Spleen/surgery ; Time-to-Treatment/statistics & numerical data ; Trauma Centers ; Treatment Outcome ; Wounds, Nonpenetrating/complications ; Wounds, Nonpenetrating/physiopathology ; Wounds, Nonpenetrating/surgery
Language	English
Publishing date	2019-05-26
Publishing country	Netherlands
Document type	Comparative Study ; Journal Article
ZDB-ID	218778-4
ISSN	1879-0267 ; 0020-1383
ISSN (online)	1879-0267
ISSN	0020-1383
DOI	10.1016/j.injury.2019.05.027
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Article ; Online: Exploring the COVID-19 Pandemic as a Catalyst for Behavior Change Among Patient Health Record App Users in Taiwan: Development and Usability Study.

Tseng, Chinyang Henry / Chen, Ray-Jade / Tsai, Shang-Yu / Wu, Tsung-Ren / Tsaur, Woei-Jiunn / Chiu, Hung-Wen / Yang, Cheng-Yi / Lo, Yu-Sheng

Journal of medical Internet research

2022 Volume 24, Issue 1, Page(s) e33399

Abstract: Background: During the COVID-19 pandemic, personal health records (PHRs) have enabled patients to monitor and manage their medical data without visiting hospitals and, consequently, minimize their infection risk. Taiwan's National Health Insurance ... ...

Abstract	Background: During the COVID-19 pandemic, personal health records (PHRs) have enabled patients to monitor and manage their medical data without visiting hospitals and, consequently, minimize their infection risk. Taiwan's National Health Insurance Administration (NHIA) launched the My Health Bank (MHB) service, a national PHR system through which insured individuals to access their cross-hospital medical data. Furthermore, in 2019, the NHIA released the MHB software development kit (SDK), which enables development of mobile apps with which insured individuals can retrieve their MHB data. However, the NHIA MHB service has its limitations, and the participation rate among insured individuals is low. Objective: We aimed to integrate the MHB SDK with our developed blockchain-enabled PHR mobile app, which enables patients to access, store, and manage their cross-hospital PHR data. We also collected and analyzed the app's log data to examine patients' MHB use during the COVID-19 pandemic. Methods: We integrated our existing blockchain-enabled mobile app with the MHB SDK to enable NHIA MHB data retrieval. The app utilizes blockchain technology to encrypt the downloaded NHIA MHB data. Existing and new indexes can be synchronized between the app and blockchain nodes, and high security can be achieved for PHR management. Finally, we analyzed the app's access logs to compare patients' activities during high and low COVID-19 infection periods. Results: We successfully integrated the MHB SDK into our mobile app, thereby enabling patients to retrieve their cross-hospital medical data, particularly those related to COVID-19 rapid and polymerase chain reaction testing and vaccination information and progress. We retrospectively collected the app's log data for the period of July 2019 to June 2021. From January 2020, the preliminary results revealed a steady increase in the number of people who applied to create a blockchain account for access to their medical data and the number of app subscribers among patients who visited the outpatient department (OPD) and emergency department (ED). Notably, for patients who visited the OPD and ED, the peak proportions with respect to the use of the app for OPD and ED notes and laboratory test results also increased year by year. The highest proportions were 52.40% for ED notes in June 2021, 88.10% for ED laboratory test reports in May 2021, 34.61% for OPD notes in June 2021, and 41.87% for OPD laboratory test reports in June 2021. These peaks coincided with Taiwan's local COVID-19 outbreak lasting from May to June 2021. Conclusions: This study developed a blockchain-enabled mobile app, which can periodically retrieve and integrate PHRs from the NHIA MHB's cross-hospital data and the investigated hospital's self-pay medical data. Analysis of users' access logs revealed that the COVID-19 pandemic substantially increased individuals' use of PHRs and their health awareness with respect to COVID-19 prevention.
MeSH term(s)	COVID-19 ; Health Records, Personal ; Humans ; Mobile Applications ; Pandemics ; Retrospective Studies ; SARS-CoV-2 ; Taiwan/epidemiology
Language	English
Publishing date	2022-01-06
Publishing country	Canada
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2028830-X
ISSN	1438-8871 ; 1439-4456
ISSN (online)	1438-8871
ISSN	1439-4456
DOI	10.2196/33399
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Article ; Online: Association of Air Pollution and Weather Factors with Traffic Injury Severity: A Study in Taiwan.

Chan, Ta-Chien / Pai, Chih-Wei / Wu, Chia-Chieh / Hsu, Jason C / Chen, Ray-Jade / Chiu, Wen-Ta / Lam, Carlos

International journal of environmental research and public health

2022 Volume 19, Issue 12

Abstract: Exposure to air pollutants may elevate the injury severity scores (ISSs) for road traffic injuries (RTIs). This multicenter cross-sectional study aimed to investigate the associations between air pollution, weather conditions, and RTI severity. This ... ...

Abstract	Exposure to air pollutants may elevate the injury severity scores (ISSs) for road traffic injuries (RTIs). This multicenter cross-sectional study aimed to investigate the associations between air pollution, weather conditions, and RTI severity. This retrospective study was performed in Taiwan in 2018. The location of each road traffic accident (RTA) was used to determine the nearest air quality monitoring and weather station, and the time of each RTA was matched to the corresponding hourly air pollutant concentration and weather factors. Five multiple logistic regression models were used to compute the risk of sustaining severe injury (ISS ≥ 9). Of the 14,973 patients with RTIs, 2853 sustained severe injury. Moderate or unhealthy air quality index, higher exposure to particulate matter ≤2.5 μm in diameter, bicyclists or pedestrians, greater road width, nighttime, and higher temperature and relative humidity were significant risk factors for severe injury. Exposure to nitrogen oxide and ozone did not increase the risk. Auto occupants and scene-to-hospital time were the protective factors. Sensitivity analyses showed consistent results between air pollutants and the risk of severe injury. Poor air quality and hot and humid weather conditions were associated with severe RTIs. Active commuters were at higher risk of sustaining severe RTI.
MeSH term(s)	Accidents, Traffic ; Air Pollutants/analysis ; Air Pollution/adverse effects ; Air Pollution/analysis ; Cross-Sectional Studies ; Humans ; Particulate Matter/analysis ; Retrospective Studies ; Taiwan/epidemiology ; Weather
Chemical Substances	Air Pollutants ; Particulate Matter
Language	English
Publishing date	2022-06-17
Publishing country	Switzerland
Document type	Journal Article ; Multicenter Study ; Research Support, Non-U.S. Gov't
ZDB-ID	2175195-X
ISSN	1660-4601 ; 1661-7827
ISSN (online)	1660-4601
ISSN	1661-7827
DOI	10.3390/ijerph19127442
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Article: Authorship Correction: A Clinical Decision Support Engine Based on a National Medication Repository for the Detection of Potential Duplicate Medications: Design and Evaluation.

Yang, Cheng-Yi / Lo, Yu-Sheng / Chen, Ray-Jade / Liu, Chien-Tsai

JMIR medical informatics

2019 Volume 7, Issue 3, Page(s) e15063

Abstract: This corrects the article DOI: 10.2196/medinform.9064.]. ...

Abstract	[This corrects the article DOI: 10.2196/medinform.9064.].
Language	English
Publishing date	2019-07-05
Publishing country	Canada
Document type	Published Erratum
ZDB-ID	2798261-0
ISSN	2291-9694
ISSN	2291-9694
DOI	10.2196/15063
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Article ; Online: Ligustrazine improves the compensative effect of Akt survival signaling to protect liver Kupffer cells in trauma-hemorrhagic shock rats.

Chen, Ray-Jade / Chen, Ming-Cheng / Tsai, Bruce Chi-Kang / Roy, Rakesh / Chang, Yi-Ru / Wang, Tso-Fu / Kuo, Wei-Wen / Kuo, Chia-Hua / Yao, Chun-Hsu / Li, Chi-Cheng / Huang, Chih-Yang

Chemical biology & drug design

2023 Volume 102, Issue 6, Page(s) 1399–1408

Abstract: Trauma-hemorrhagic shock (THS) is a medical emergency that is encountered by physicians in the emergency department. Chuan Xiong is a traditional Chinese medicine and ligustrazine is a natural compound from it. Ligustrazine improves coronary blood flow ... ...

Abstract	Trauma-hemorrhagic shock (THS) is a medical emergency that is encountered by physicians in the emergency department. Chuan Xiong is a traditional Chinese medicine and ligustrazine is a natural compound from it. Ligustrazine improves coronary blood flow and reduces cardiac ischemia in animals through Ca
MeSH term(s)	Rats ; Animals ; Proto-Oncogene Proteins c-akt/metabolism ; Shock, Hemorrhagic/drug therapy ; Kupffer Cells/metabolism ; Liver/metabolism ; Inflammation/drug therapy
Chemical Substances	Proto-Oncogene Proteins c-akt (EC 2.7.11.1) ; tetramethylpyrazine (V80F4IA5XG)
Language	English
Publishing date	2023-08-23
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2216600-2
ISSN	1747-0285 ; 1747-0277
ISSN (online)	1747-0285
ISSN	1747-0277
DOI	10.1111/cbdd.14327
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Article ; Online: Epithelioid Angiomyolipoma of the Liver.

Huang, Yu-Min / Wei, Po-Li / Chen, Ray-Jade

Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract

2017 Volume 22, Issue 1, Page(s) 175–176

Language	English
Publishing date	2017-11-06
Publishing country	United States
Document type	Journal Article
ZDB-ID	2012365-6
ISSN	1873-4626 ; 1934-3213 ; 1091-255X
ISSN (online)	1873-4626 ; 1934-3213
ISSN	1091-255X
DOI	10.1007/s11605-017-3616-6
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Zs.A 5207: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Impact of Beta-Blocker Initiation Timing on Mortality Risk in Patients With Diabetes Mellitus Undergoing Noncardiac Surgery: A Nationwide Population-Based Cohort Study.

Chen, Ray-Jade / Chu, Hsi / Tsai, Lung-Wen

Journal of the American Heart Association

2017 Volume 6, Issue 1

Abstract: Background: Relevant clinical studies have been small and have not convincingly demonstrated whether the perioperative initiation of beta-blockers should be considered in patients with diabetes mellitus undergoing noncardiac surgery.: Methods and ... ...

Abstract	Background: Relevant clinical studies have been small and have not convincingly demonstrated whether the perioperative initiation of beta-blockers should be considered in patients with diabetes mellitus undergoing noncardiac surgery. Methods and results: In this nationwide propensity score-matched study, we included patients with diabetes mellitus undergoing noncardiac surgery between 2000 and 2011 from Taiwan's National Health Insurance Research Database. Patients were classified as beta-blocker and non-beta-blocker cohorts. We further stratified beta-blocker users into cardioprotective beta-blocker (atenolol, bisoprolol, metoprolol, or carvedilol) and other beta-blocker users. To investigate time of initiation of beta-blocker use, initiation time was stratified into 2 periods (>30 and ≤30 days preoperatively). The outcomes of interest were in-hospital and 30-day mortality. After propensity score matching, we identified 50 952 beta-blocker users and 50 952 matched controls. Compared with non-beta-blocker users, cardioprotective beta-blocker users were associated with lower risks of in-hospital (odds ratio 0.75, 95% CI 0.68-0.82) and 30-day (odds ratio 0.75, 95% CI 0.70-0.81) mortality. Among initiation times, only the use of cardioprotective beta-blockers for >30 days was associated with decreased risk of in-hospital (odds ratio 0.72, 95% CI 0.65-0.78) and 30-day (odds ratio 0.72, 95% CI 0.66-0.78) mortality. Of note, use of other beta-blockers for ≤30 days before surgery was associated with increased risk of both in-hospital and 30-day mortality. Conclusions: The use of cardioprotective beta-blockers for >30 days before surgery was associated with reduced mortality risk, whereas short-term use of beta-blockers was not associated with differences in mortality in patients with diabetes mellitus.
MeSH term(s)	Adrenergic beta-Antagonists/therapeutic use ; Aged ; Atenolol/therapeutic use ; Bisoprolol/therapeutic use ; Carbazoles/therapeutic use ; Carvedilol ; Cohort Studies ; Databases, Factual ; Diabetes Mellitus, Type 2 ; Female ; Hospital Mortality ; Humans ; Male ; Metoprolol/therapeutic use ; Middle Aged ; Mortality ; Odds Ratio ; Perioperative Care/methods ; Propanolamines/therapeutic use ; Propensity Score ; Protective Factors ; Risk Factors ; Surgical Procedures, Operative ; Taiwan/epidemiology ; Time Factors
Chemical Substances	Adrenergic beta-Antagonists ; Carbazoles ; Propanolamines ; Carvedilol (0K47UL67F2) ; Atenolol (50VV3VW0TI) ; Metoprolol (GEB06NHM23) ; Bisoprolol (Y41JS2NL6U)
Language	English
Publishing date	2017-01-10
Publishing country	England
Document type	Journal Article ; Observational Study
ZDB-ID	2653953-6
ISSN	2047-9980 ; 2047-9980
ISSN (online)	2047-9980
ISSN	2047-9980
DOI	10.1161/JAHA.116.004392
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Article ; Online: Paclitaxel exerts antiplatelet and antithrombotic activities: Additional benefit from use of paclitaxel-coated balloons and -eluting stents in coronary revascularization and prevention of in-stent restenosis.

Lin, Kuan-Hung / Li, Jiun-Yi / Chen, Ray-Jade / Chen, Ting-Yu / Hsu, Shao-Hsuan / Wang, Hsueh-Hsiao / Peng, Hsien-Yu / Sun, Yu-Yo / Lu, Wan-Jung

Thrombosis research

2023 Volume 225, Page(s) 63–72

Abstract: Introduction: Paclitaxel is a microtubule-stabilizing drug used to treat several types of cancer, including ovarian and breast cancer. Because of its antiproliferative effect on vascular smooth muscle cells, balloons and stents are coated with ... ...

Abstract	Introduction: Paclitaxel is a microtubule-stabilizing drug used to treat several types of cancer, including ovarian and breast cancer. Because of its antiproliferative effect on vascular smooth muscle cells, balloons and stents are coated with paclitaxel for use in coronary revascularization and prevention of in-stent restenosis (ISR). However, mechanisms underlying ISR are complicated. Platelet activation is one of the major causes of ISR after percutaneous coronary intervention. Although the antiplatelet activity of paclitaxel was noted in rabbit platelets, the effect of paclitaxel on platelets remains unclear. This study investigated whether paclitaxel exhibits antiplatelet activity in human platelets. Methods and results: Paclitaxel inhibited platelet aggregation induced by collagen but not that induced by thrombin, arachidonic acid, or U46619, suggesting that paclitaxel is more sensitive to the inhibition of collagen-induced platelet activation. Moreover, paclitaxel blocked collagen receptor glycoprotein (GP) VI downstream signaling molecules, including Lyn, Fyn, PLCγ2, PKC, Akt, and MAPKs. However, paclitaxel did not directly bind to GPVI and cause GPVI shedding, as detected by surface plasmon resonance and flow cytometry, respectively, indicating that paclitaxel may interfere with GPVI downstream signaling molecules, such as Lyn and Fyn. Paclitaxel also prevented granule release and GPIIbIIIa activation induced by collagen and low convulxin doses. Moreover, paclitaxel attenuated pulmonary thrombosis and delayed platelet thrombus formation in mesenteric microvessels without significantly affecting hemostasis. Conclusion: Paclitaxel exerts antiplatelet and antithrombotic effects. Thus, paclitaxel may provide additional benefits beyond its antiproliferative effect when used in drug-coated balloons and drug-eluting stents for coronary revascularization and prevention of ISR.
MeSH term(s)	Animals ; Humans ; Rabbits ; Paclitaxel/pharmacology ; Paclitaxel/therapeutic use ; Drug-Eluting Stents/adverse effects ; Fibrinolytic Agents ; Coronary Restenosis/etiology ; Coronary Restenosis/therapy ; Treatment Outcome ; Stents/adverse effects ; Percutaneous Coronary Intervention/adverse effects ; Collagen ; Coronary Angiography/adverse effects
Chemical Substances	Paclitaxel (P88XT4IS4D) ; Fibrinolytic Agents ; Collagen (9007-34-5)
Language	English
Publishing date	2023-03-31
Publishing country	United States
Document type	Journal Article
ZDB-ID	121852-9
ISSN	1879-2472 ; 0049-3848
ISSN (online)	1879-2472
ISSN	0049-3848
DOI	10.1016/j.thromres.2023.03.017
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