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  1. Book ; Online ; E-Book: COVID-19

    Qu, Jie-Ming / Cao, Bin / Chen, Rong-Chang

    the essentials of prevention and treatment

    2021  

    Author's details Jie-Ming Qu, Bin Cao, Rong-Chang Chen
    Keywords COVID-19 (Disease)/Treatment ; COVID-19 (Disease)/Prevention
    Subject code 616.2414
    Language English
    Size 1 Online-Ressource (x, 103 Seiten), Illustrationen, Diagramme
    Publisher Elsevier
    Publishing place Amsterdam
    Publishing country Netherlands
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    HBZ-ID HT020626889
    ISBN 978-0-12-824251-3 ; 9780128240038 ; 0-12-824251-5 ; 0128240032
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Article ; Online: Triple therapy in chronic obstructive pulmonary disease: consideration under new evidence.

    Gao, Yong-Hua / Chen, Rong-Chang

    Chinese medical journal

    2021  Volume 134, Issue 13, Page(s) 1513

    MeSH term(s) Administration, Inhalation ; Adrenal Cortex Hormones/therapeutic use ; Adrenergic beta-2 Receptor Agonists ; Bronchodilator Agents/therapeutic use ; Drug Therapy, Combination ; Humans ; Pulmonary Disease, Chronic Obstructive/drug therapy
    Chemical Substances Adrenal Cortex Hormones ; Adrenergic beta-2 Receptor Agonists ; Bronchodilator Agents
    Language English
    Publishing date 2021-02-15
    Publishing country China
    Document type Editorial
    ZDB-ID 127089-8
    ISSN 2542-5641 ; 0366-6999 ; 1002-0187
    ISSN (online) 2542-5641
    ISSN 0366-6999 ; 1002-0187
    DOI 10.1097/CM9.0000000000001340
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Strategies for the prevention and management of coronavirus disease 2019.

    Guan, Wei-Jie / Chen, Rong-Chang / Zhong, Nan-Shan

    The European respiratory journal

    2020  Volume 55, Issue 4

    MeSH term(s) Betacoronavirus ; COVID-19 ; Communicable Disease Control/organization & administration ; Coronavirus Infections/diagnosis ; Coronavirus Infections/epidemiology ; Coronavirus Infections/therapy ; Humans ; Pandemics ; Pneumonia, Viral/diagnosis ; Pneumonia, Viral/epidemiology ; Pneumonia, Viral/therapy ; SARS-CoV-2
    Keywords covid19
    Language English
    Publishing date 2020-04-16
    Publishing country England
    Document type Editorial
    ZDB-ID 639359-7
    ISSN 1399-3003 ; 0903-1936
    ISSN (online) 1399-3003
    ISSN 0903-1936
    DOI 10.1183/13993003.00597-2020
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Effect of continuing the use of renin-angiotensin system inhibitors on mortality in patients hospitalized for coronavirus disease 2019: a systematic review, meta-analysis, and meta-regression analysis.

    Liu, Qi / Fu, Wei / Zhu, Chang-Ju / Ding, Zi-Heng / Dong, Bin-Bin / Sun, Bao-Qing / Chen, Rong-Chang

    BMC infectious diseases

    2023  Volume 23, Issue 1, Page(s) 53

    Abstract: Background: The effect of angiotensin-converting enzyme inhibitors (ACEIs)/angiotensin receptor blockers (ARBs) on mortality was preliminarily explored through the comparison of ACEIs/ARBs with non-ACEIs/ARBs in patients with coronavirus disease 2019 ( ... ...

    Abstract Background: The effect of angiotensin-converting enzyme inhibitors (ACEIs)/angiotensin receptor blockers (ARBs) on mortality was preliminarily explored through the comparison of ACEIs/ARBs with non-ACEIs/ARBs in patients with coronavirus disease 2019 (COVID-19). Reaching a conclusion on whether previous ACEI/ARB treatment should be continued in view of the different ACE2 levels in the comparison groups was not unimpeachable. Therefore, this study aimed to further elucidate the effect of ACEI/ARB continuation on hospital mortality, intensive care unit (ICU) admission, and invasive mechanical ventilation (IMV) in the same patient population.
    Methods: We searched PubMed, the Cochrane Library, Ovid, and Embase for relevant articles published between December 1, 2019 and April 30, 2022. Continuation of ACEI/ARB use after hospitalization due to COVID-19 was considered as an exposure and discontinuation of ACEI/ARB considered as a control. The primary outcome was hospital mortality, and the secondary outcomes included 30-day mortality, rate of ICU admission, IMV, and other clinical outcomes.
    Results: Seven observational studies and four randomized controlled trials involving 2823 patients were included. The pooled hospital mortality in the continuation group (13.04%, 158/1212) was significantly lower than that (22.15%, 278/1255) in the discontinuation group (risk ratio [RR] = 0.45; 95% confidence interval [CI], 0.28-0.72; P = 0.001). Continuation of ACEI/ARB use was associated with lower rates of ICU admission (10.5% versus 16.2%, RR = 0.63; 95% CI 0.5-0.79; P < 0.0001) and IMV (8.2% versus 12.5%, RR = 0.62; 95% CI 0.46-0.83, P = 0.001). Nevertheless, the effect was mainly demonstrated in the observational study subgroup (P < 0.05). Continuing ACEI/ARB had no significant effect on 30-day mortality (P = 0.34), acute myocardial infarction (P = 0.08), heart failure (P = 0.82), and acute kidney injury after hospitalization (P = 0.98).
    Conclusion: Previous ACEI/ARB treatment could be continued since it was associated with lower hospital deaths, ICU admission, and IMV in patients with COVID-19, although the benefits of continuing use were mainly shown in observational studies. More evidence from multicenter RCTs are still needed to increase the robustness of the data. Trial registration PROSPERO (CRD42022341169). Registered 27 June 2022.
    MeSH term(s) Humans ; Angiotensin-Converting Enzyme Inhibitors/therapeutic use ; COVID-19 ; Angiotensin Receptor Antagonists/therapeutic use ; Renin-Angiotensin System ; Antihypertensive Agents/therapeutic use ; Regression Analysis ; Randomized Controlled Trials as Topic ; Observational Studies as Topic ; Multicenter Studies as Topic
    Chemical Substances Angiotensin-Converting Enzyme Inhibitors ; Angiotensin Receptor Antagonists ; Antihypertensive Agents
    Language English
    Publishing date 2023-01-24
    Publishing country England
    Document type Systematic Review ; Meta-Analysis ; Journal Article
    ZDB-ID 2041550-3
    ISSN 1471-2334 ; 1471-2334
    ISSN (online) 1471-2334
    ISSN 1471-2334
    DOI 10.1186/s12879-023-07994-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Strategies for the prevention and management of coronavirus disease 2019

    Guan, Wei-Jie / Chen, Rong-Chang / Zhong, Nan-Shan

    European respiratory journal, Early view

    2020  

    Abstract: Early protection, early identification, early diagnosis, and early isolation are crucial to combat with Covid-19 outbreaks. Since the outbreak in Wuhan city in December 2019, there has been a surge of newly diagnosed cases with coronavirus disease 2019 ( ... ...

    Abstract Early protection, early identification, early diagnosis, and early isolation are crucial to combat with Covid-19 outbreaks. Since the outbreak in Wuhan city in December 2019, there has been a surge of newly diagnosed cases with coronavirus disease 2019 (Covid-19) globally [1–4]. The total number has reached to 101 927 laboratory-confirmed cases as of March 8th, 2020 [5]. An increasing number of countries have issued the alert of the highest level.
    Keywords COVID-19 ; control ; Transmission ; laboratory testing ; prevention ; therapy ; covid19
    Language English
    Publishing country de
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article ; Online: Sporadic Dissemination of

    Cheng, Ying-Ying / Liu, Yang / Chen, Yong / Huang, Fu-Man / Chen, Rong-Chang / Xiao, Yong-Hong / Zhou, Kai

    Microbiology spectrum

    2021  Volume 9, Issue 3, Page(s) e0114121

    Abstract: The emergence of high-level tigecycline resistance mediated by plasmid- ... ...

    Abstract The emergence of high-level tigecycline resistance mediated by plasmid-borne
    MeSH term(s) Acinetobacter/drug effects ; Acinetobacter/genetics ; Acinetobacter/isolation & purification ; Acinetobacter Infections/drug therapy ; Acinetobacter Infections/veterinary ; Animals ; Anti-Bacterial Agents/pharmacology ; Bacterial Proteins/genetics ; Cattle ; Livestock/microbiology ; Microbial Sensitivity Tests ; Mixed Function Oxygenases/genetics ; Plasmids/genetics ; Sheep/microbiology ; Swine/microbiology ; Tetracycline Resistance/genetics ; Tigecycline/pharmacology
    Chemical Substances Anti-Bacterial Agents ; Bacterial Proteins ; Tigecycline (70JE2N95KR) ; Mixed Function Oxygenases (EC 1.-)
    Language English
    Publishing date 2021-12-01
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2807133-5
    ISSN 2165-0497 ; 2165-0497
    ISSN (online) 2165-0497
    ISSN 2165-0497
    DOI 10.1128/Spectrum.01141-21
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: The bronchiectasis severity index and FACED score for bronchiectasis.

    Guan, Wei-Jie / Chen, Rong-Chang / Zhong, Nan-Shan

    The European respiratory journal

    2016  Volume 47, Issue 2, Page(s) 382–384

    MeSH term(s) Bronchiectasis ; Forced Expiratory Volume ; Humans ; Severity of Illness Index ; Tomography, X-Ray Computed
    Language English
    Publishing date 2016-02
    Publishing country England
    Document type Comment ; Editorial ; Research Support, Non-U.S. Gov't
    ZDB-ID 639359-7
    ISSN 1399-3003 ; 0903-1936
    ISSN (online) 1399-3003
    ISSN 0903-1936
    DOI 10.1183/13993003.01717-2015
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 2322: Show issues Location:
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  9. Article: Scutellarin protects against myocardial ischemia-reperfusion injury by suppressing NLRP3 inflammasome activation

    Xu, Li-jiao / Chen, Rong-chang / Ma, Xiao-yu / Zhu, Yue / Sun, Gui-bo / Sun, Xiao-bo

    Phytomedicine. 2020 Mar., v. 68

    2020  

    Abstract: Activation of NLRP3 inflammasome plays a key role in cardiac dysfunction for acute myocardial ischemia-reperfusion injury. Scutellarin (Scu) is a flavonoid purified from Erigeron breviscapus. Whether Scu has any influence on the activation of NLRP3 ... ...

    Abstract Activation of NLRP3 inflammasome plays a key role in cardiac dysfunction for acute myocardial ischemia-reperfusion injury. Scutellarin (Scu) is a flavonoid purified from Erigeron breviscapus. Whether Scu has any influence on the activation of NLRP3 inflammasome in cardiomyocytes remains unknown.We aimed to examine the therapeutic effect of Scu on cardiomyocyte ischemia-reperfusion (I/R) injury and its effect on NLRP3 inflammasome in rats with acute myocardial I/R injury and anoxia/reoxygenation (A/R)-induced H9c2 injuries.Heart injuries were induced through 30 min of ischemia followed by 24 h of reperfusion. Scu was intraperitoneally administered 15 min before vascular ligation. Effects of Scu on cardiac injury were detected by echocardiograms, TTC staining, and histological and immunohistochemical analyses. The effects of Scu on biochemical parameters were analyzed. H9c2 cells were pretreated with different concentrations of Scu for 6 h before A/R exposure. Afterward, cell viability, LDH release, and Hoechst 33342 and peromide iodine double staining were determined. Western blot analyses of proteins, including those involved in autophagy, NLRP3, mTOR complex 1 (mTORC1), and Akt signaling, were conducted.In vivo study revealed that Scu improved diastolic dysfunction, ameliorated myocardium structure abnormality, inhibited myocyte apoptosis and inflammatory response, and promoted autophagy. Scu reduced NLRP3 inflammasome activation, inhibited mTORC1 activity, and increased Akt phosphorylation. In vitro investigation showed the same results. The Scu-mediated NLRP3 inflammasome and mTORC1 inhibition and cardioprotection were abolished through the genetic silencing of Akt by siRNA.The cardioprotective effect of Scu was achieved through its anti-inflammatory effect. It suppressed the activation of NLRP3 inflammasome. In addition, inflammasome restriction by Scu was dependent on Akt activation and mTORC1 inhibition.
    Keywords Erigeron breviscapus ; Western blotting ; anti-inflammatory activity ; apoptosis ; autophagy ; cardiomyocytes ; cardioprotective effect ; cell viability ; flavonoids ; hypoxia ; inflammasomes ; inflammation ; iodine ; ischemia ; phosphorylation ; staining ; therapeutics
    Language English
    Dates of publication 2020-03
    Publishing place Elsevier GmbH
    Document type Article
    ZDB-ID 1205240-1
    ISSN 1618-095X ; 0944-7113
    ISSN (online) 1618-095X
    ISSN 0944-7113
    DOI 10.1016/j.phymed.2020.153169
    Database NAL-Catalogue (AGRICOLA)

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  10. Article ; Online: Serum myostatin levels and skeletal muscle wasting in chronic obstructive pulmonary disease.

    Ju, Chun-Rong / Chen, Rong-Chang

    Respiratory medicine

    2012  Volume 106, Issue 1, Page(s) 102–108

    Abstract: Introduction: It is well confirmed that myostatin is a negative regulator of skeletal muscle mass and implicated in several diseases involved in muscle wasting and cachexia. Skeletal muscle wasting is an important systemic manifestation of chronic ... ...

    Abstract Introduction: It is well confirmed that myostatin is a negative regulator of skeletal muscle mass and implicated in several diseases involved in muscle wasting and cachexia. Skeletal muscle wasting is an important systemic manifestation of chronic obstructive pulmonary disease (COPD), while the expression of circulating myostatin in COPD remains unclear. The aim of this study was to investigate the expression of circulating myostatin and its relationship with skeletal muscle wasting in COPD.
    Methods: Seventy-one patients with stable COPD and sixty age-matched, healthy control subjects participated in the study. Total skeletal muscle mass (SMM) were calculated according to a validated formula by using age and anthropometric measurements. Serum levels of myostatin, tumor necrosis factor (TNF)-α and interleukin-6 were determined by ELISA.
    Results: Serum myostatin levels were significantly elevated in COPD patients when compared to controls [(11.85 ± 4.01) ng/ml vs. (7.46 ± 2.21) ng/ml, p < 0.01], while total SMM was significantly decreased in COPD patients when compared to controls [(20.81 ± 1.74) kg vs. (27.31 ± 2.18) kg for male, and (11.70 ± 0.56) kg vs. (19.89 ± 1.47) kg for female] (both p < 0.05). Regression correlation analysis on all COPD patients showed that serum myostatin levels weren't significantly correlated with SMM, but correlated with TNF-α levels (R(2) = 0.042, p = 0.048). However, when stratified for gender, serum myostatin levels were correlated inversely both with SMM (R(2) = 0.20, p = 0.000) and with BMI (R(2) = 0.084, p = 0.019) in subgroup of male patients.
    Conclusion: This study demonstrates that circulating myostatin levels are elevated in COPD and related to SMM in male patients, suggesting that myostatin contributes to skeletal muscle wasting in COPD.
    MeSH term(s) Aged ; Biomarkers/blood ; Cachexia/etiology ; Case-Control Studies ; Enzyme-Linked Immunosorbent Assay ; Female ; Humans ; Interleukin-6/blood ; Male ; Muscle, Skeletal/metabolism ; Muscle, Skeletal/pathology ; Muscular Atrophy/blood ; Muscular Atrophy/etiology ; Muscular Atrophy/metabolism ; Myostatin/blood ; Myostatin/metabolism ; Pulmonary Disease, Chronic Obstructive/blood ; Pulmonary Disease, Chronic Obstructive/complications ; Pulmonary Disease, Chronic Obstructive/metabolism ; Pulmonary Disease, Chronic Obstructive/pathology ; Respiratory Function Tests ; Tumor Necrosis Factor-alpha/blood
    Chemical Substances Biomarkers ; Interleukin-6 ; Myostatin ; Tumor Necrosis Factor-alpha
    Language English
    Publishing date 2012-01
    Publishing country England
    Document type Comparative Study ; Journal Article
    ZDB-ID 1003348-8
    ISSN 1532-3064 ; 0954-6111
    ISSN (online) 1532-3064
    ISSN 0954-6111
    DOI 10.1016/j.rmed.2011.07.016
    Database MEDical Literature Analysis and Retrieval System OnLINE

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