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Article ; Online: Bicarotid trunk and severe kinking of right common carotid artery presenting with large intracranial hemorrhage.

Chen, S J / Chang, S S / Meng, N H

2024

Language	English
Publishing date	2024-04-23
Publishing country	India
Document type	Journal Article
ZDB-ID	410691-x
ISSN	0972-2823 ; 0022-3859
ISSN (online)	0972-2823
ISSN	0022-3859
DOI	10.4103/jpgm.jpgm_891_23
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Article ; Online: Research trends of Janus Kinase inhibitors: a bibliometric and visualized study from 2012 to 2023.

Chang, H-C / Tsai, R-Y / Lee, C-Y / Kuan, Y-H / Liao, W-C / Chen, S-J / Gau, S-Y

European review for medical and pharmacological sciences

2024 Volume 27, Issue 24, Page(s) 12088–12102

Abstract: Objective: Janus Kinase (JAK) inhibitors have been extensively evaluated for their potential in the management of various diseases. Despite previous research on this topic, there is a lack of bibliometric analysis that summarizes research trends on JAK ... ...

Abstract	Objective: Janus Kinase (JAK) inhibitors have been extensively evaluated for their potential in the management of various diseases. Despite previous research on this topic, there is a lack of bibliometric analysis that summarizes research trends on JAK inhibitors. This study aims to provide a comprehensive overview of the top 100 most frequently cited studies on JAK inhibitors over the last ten years. Materials and methods: The Web of Science database was used to screen and extract relevant studies on JAK inhibitors. The top 100 studies most cited within the JAK inhibitor-related research were identified and evaluated, and various data such as the year of publication, study focus and keywords, author information, and number of citations were extracted and analyzed for further examination. Results: In the top 100 most cited studies of JAK inhibitors, more than 70% of studies focused on the role of JAK inhibitors in disease treatments, with 42% of these studies focused on using JAK inhibitors as treatment for autoimmune diseases and 19 of them focused on the treatment of neoplasms. Time trend analysis revealed that the keywords "tofacitinib", "atopic dermatitis", and "rheumatoid arthritis" were widely mentioned in 2016, while new trends emerged in 2018, with "ruxolitinib" and "baricitinib" being more commonly mentioned. Conclusions: The top 100 most frequently cited studies on JAK inhibitors focused primarily on the safety and efficacy of these inhibitors in the management of various diseases, particularly inflammatory diseases and neoplasms. The results can serve as a valuable reference for rheumatologists and immunologists interested in the development of JAK inhibitors and expanding future research fields.
MeSH term(s)	Humans ; Janus Kinase Inhibitors/therapeutic use ; Janus Kinase Inhibitors/pharmacology ; Arthritis, Rheumatoid ; Autoimmune Diseases ; Neoplasms ; Bibliometrics
Chemical Substances	Janus Kinase Inhibitors
Language	English
Publishing date	2024-01-02
Publishing country	Italy
Document type	Review ; Journal Article
ZDB-ID	605550-3
ISSN	2284-0729 ; 1128-3602 ; 0392-291X
ISSN (online)	2284-0729
ISSN	1128-3602 ; 0392-291X
DOI	10.26355/eurrev_202312_34807
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Zs.A 1887: Show issues

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Article: [Association between volatile organic compounds and mortality risk of stroke].

Yang, S R / Huang, L / Dong, H / Liu, D / Yang, Z / Chen, S J / Lin, G Z / Wang, B G / Yang, J

Zhonghua liu xing bing xue za zhi = Zhonghua liuxingbingxue zazhi

2023 Volume 44, Issue 8, Page(s) 1216–1223

Abstract: Objective: ...

Abstract	Objective:
MeSH term(s)	Female ; Humans ; Aged ; Hemorrhagic Stroke ; Volatile Organic Compounds ; Stroke ; Toluene
Chemical Substances	pentane (4FEX897A91) ; Volatile Organic Compounds ; Toluene (3FPU23BG52)
Language	Chinese
Publishing date	2023-09-01
Publishing country	China
Document type	English Abstract ; Journal Article
ZDB-ID	645026-x
ISSN	0254-6450
ISSN	0254-6450
DOI	10.3760/cma.j.cn112338-20221031-00930
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Article: [Transoral robotic thyroidectomy via vestibular approach: a retrospective study of 107 cases in a single center].

Li, X L / Chen, S J / Li, C Y / Cao, X J / Zhuang, D Y / Zhou, P / Yue, T / Wang, M / Zhu, J / He, Q Q

Zhonghua wai ke za zhi [Chinese journal of surgery

2024 Volume 62, Issue 5, Page(s) 419–423

Abstract: Objective: ...

Abstract	Objective:
Language	Chinese
Publishing date	2024-03-27
Publishing country	China
Document type	English Abstract ; Journal Article
ZDB-ID	604573-x
ISSN	0529-5815
ISSN	0529-5815
DOI	10.3760/cma.j.cn112139-20230915-00123
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Zs.B 2469: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)
Zs.MO 218: Show issues

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Article: Efficacy of light therapy on nonseasonal depression among elderly adults: a systematic review and meta-analysis [Corrigendum].

Chang, C H / Liu, C Y / Chen, S J / Tsai, H C

Neuropsychiatric disease and treatment

2019 Volume 15, Page(s) 1427

Language	English
Publishing date	2019-05-27
Publishing country	New Zealand
Document type	Journal Article ; Published Erratum
ZDB-ID	2186503-6
ISSN	1178-2021 ; 1176-6328
ISSN (online)	1178-2021
ISSN	1176-6328
DOI	10.2147/NDT.S214219
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Article ; Online: Ligature-Induced Periodontitis Drives Colorectal Cancer: An Experimental Model in Mice.

Shi, Y T / He, J M / Tong, Z A / Qian, Y J / Wang, Q W / Jia, D J C / Zhu, W J / Zhao, Y X / Cai, B B / Chen, S J / Si, M S

Journal of dental research

2023 Volume 102, Issue 6, Page(s) 689–698

Abstract: Periodontitis is a prevalent inflammatory oral disease associated with an increased risk of colorectal cancer. Experimental animal models are critical tools to investigate the effects and mechanisms of periodontitis on colorectal cancer. Several murine ... ...

Abstract	Periodontitis is a prevalent inflammatory oral disease associated with an increased risk of colorectal cancer. Experimental animal models are critical tools to investigate the effects and mechanisms of periodontitis on colorectal cancer. Several murine periodontitis models have been used in research, including oral gavage, periodontal pathogen injection, and ligature models. The role of experimental periodontitis caused by silk ligation in colorectal cancer remains unclear. In this study, we used an experimental periodontitis model on a colitis-associated colorectal cancer model and a spontaneous model, respectively. We observed the promotion of colorectal cancer in ligature-induced periodontitis mice compared to those control mice in 2 different models, as assessed by tumor number, tumor size, and tumor load. Since bacterial dysbiosis is an important feature of periodontitis, we next analyzed the oral and gut microbiomes using 16S ribosomal RNA gene sequencing. We found that the experimental periodontitis model reshaped the microbial community in the oral cavity and gut. In addition, we found a higher extent of programmed death 1 (PD-1)-positive CD8
MeSH term(s)	Mice ; Animals ; Periodontitis/microbiology ; Bacteria/genetics ; Gastrointestinal Microbiome ; Colorectal Neoplasms/complications ; Disease Models, Animal ; Mice, Inbred C57BL ; RNA, Ribosomal, 16S/genetics
Chemical Substances	RNA, Ribosomal, 16S
Language	English
Publishing date	2023-03-21
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	80207-4
ISSN	1544-0591 ; 0022-0345
ISSN (online)	1544-0591
ISSN	0022-0345
DOI	10.1177/00220345231158269
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Ul III Zs.75: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)
Zs.MO 262: Show issues

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Article ; Online: Excretory/secretory proteins of adult Toxocara canis induce changes in the expression of proteins involved in the NOD1-RIP2-NF-κB pathway and modulate cytokine production in mouse macrophages.

Li, F / Li, X L / Chen, S J / Tan, C / Mei, S P / Jia, H G / Song, Z H / Zhou, R Q

Experimental parasitology

2021 Volume 229, Page(s) 108152

Abstract: Dog roundworm (Toxocara canis) is the major causative agent of toxocarosis, a parasitic disease of both veterinary and medical importance. Knowledge gaps in fundamental and applied aspects hinder the control of this important zoonotic disease. To have a ... ...

Abstract	Dog roundworm (Toxocara canis) is the major causative agent of toxocarosis, a parasitic disease of both veterinary and medical importance. Knowledge gaps in fundamental and applied aspects hinder the control of this important zoonotic disease. To have a better understanding of Toxocara infection and host immune responses, mouse macrophages were exposed to excretory/secretory (ES) proteins released by adult worms of T. canis in vitro. The messenger RNA transcription and protein expression of nucleotide-binding oligomerization domain-containing protein 1 (NOD1), receptor interacting protein 2 (RIP2) and nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) in macrophages were analysed using quantitative real-time PCR (qRT-PCR) and Western blot. The levels of tumour necrosis factor alpha (TNF-ɑ), interleukin-1 beta (IL-1β) and IL-6 released by the stimulated macrophages were analysed using enzyme-linked immunosorbent assay. It was found that 20 μg/mL ES proteins of adult T. canis induced the expression of NOD1, RIP2 and NF-κB in mouse macrophages at both transcriptional and translational levels after 9 h of incubation in vitro. Incubation with 20 μg/mL ES proteins also modulated the production of pro-inflammatory cytokines TNF-ɑ, IL-1β and IL-6 by the macrophages. Taken together, ES proteins of adult T. canis appeared to be able to affect the macrophage NOD1-RIP2-NF-κB signalling pathway, which might play a role in regulating the production of proinflammatory cytokines. Further investigation of these aspects should lead to a better understanding of immune recognition of and modulation by Toxocara canis in host animals.
MeSH term(s)	Animals ; Blotting, Western ; Cell Survival ; Cytokines/biosynthesis ; Cytokines/metabolism ; Dogs ; Electrophoresis, Polyacrylamide Gel ; Enzyme-Linked Immunosorbent Assay ; Female ; Helminth Proteins/metabolism ; Helminth Proteins/pharmacology ; Interleukin-1beta/biosynthesis ; Interleukin-1beta/metabolism ; Interleukin-6/biosynthesis ; Interleukin-6/metabolism ; Macrophages, Peritoneal/drug effects ; Macrophages, Peritoneal/metabolism ; Macrophages, Peritoneal/parasitology ; Mice ; Mice, Inbred C57BL ; NF-kappa B/metabolism ; Nod1 Signaling Adaptor Protein/metabolism ; Receptor-Interacting Protein Serine-Threonine Kinase 2/metabolism ; Toxocara canis/chemistry ; Toxocara canis/metabolism ; Tumor Necrosis Factor-alpha/biosynthesis ; Tumor Necrosis Factor-alpha/metabolism
Chemical Substances	Cytokines ; Helminth Proteins ; Interleukin-1beta ; Interleukin-6 ; NF-kappa B ; Nod1 Signaling Adaptor Protein ; Tumor Necrosis Factor-alpha ; Receptor-Interacting Protein Serine-Threonine Kinase 2 (EC 2.7.11.1)
Language	English
Publishing date	2021-08-19
Publishing country	United States
Document type	Journal Article
ZDB-ID	391089-1
ISSN	1090-2449 ; 0014-4894
ISSN (online)	1090-2449
ISSN	0014-4894
DOI	10.1016/j.exppara.2021.108152
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Article: [Prevalence of cataract among the population aged 50 years and over at different altitudes in Gansu Province].

Yuan, X B / Zhang, D Y / Chen, S J / Wu, P C / Zhang, W F

Zhonghua yan ke za zhi] Chinese journal of ophthalmology

2019 Volume 55, Issue 8, Page(s) 589–594

Abstract: Objective: ...

Abstract	Objective:
MeSH term(s)	Aged ; Altitude ; Blindness ; Cataract/epidemiology ; China/epidemiology ; Cross-Sectional Studies ; Female ; Humans ; Male ; Middle Aged ; Prevalence ; Vision, Low
Language	Chinese
Publishing date	2019-08-17
Publishing country	China
Document type	Journal Article
ZDB-ID	604574-1
ISSN	0412-4081
ISSN	0412-4081
DOI	10.3760/cma.j.issn.0412-4081.2019.08.008
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Zs.B 2482: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)
Zs.MO 267: Show issues

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Article: Excretory/secretory proteins of adult Toxocara canis induce changes in the expression of proteins involved in the NOD1-RIP2-NF-κB pathway and modulate cytokine production in mouse macrophages

Li, F. / Li, X.L. / Chen, S.J. / Tan, C. / Mei, S.P. / Jia, H.G. / Song, Z.H. / Zhou, R.Q.

Experimental parasitology. 2021 Oct., v. 229

2021

Abstract	Dog roundworm (Toxocara canis) is the major causative agent of toxocarosis, a parasitic disease of both veterinary and medical importance. Knowledge gaps in fundamental and applied aspects hinder the control of this important zoonotic disease. To have a better understanding of Toxocara infection and host immune responses, mouse macrophages were exposed to excretory/secretory (ES) proteins released by adult worms of T. canis in vitro. The messenger RNA transcription and protein expression of nucleotide-binding oligomerization domain-containing protein 1 (NOD1), receptor interacting protein 2 (RIP2) and nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) in macrophages were analysed using quantitative real-time PCR (qRT-PCR) and Western blot. The levels of tumour necrosis factor alpha (TNF-ɑ), interleukin-1 beta (IL-1β) and IL-6 released by the stimulated macrophages were analysed using enzyme-linked immunosorbent assay. It was found that 20 μg/mL ES proteins of adult T. canis induced the expression of NOD1, RIP2 and NF-κB in mouse macrophages at both transcriptional and translational levels after 9 h of incubation in vitro. Incubation with 20 μg/mL ES proteins also modulated the production of pro-inflammatory cytokines TNF-ɑ, IL-1β and IL-6 by the macrophages. Taken together, ES proteins of adult T. canis appeared to be able to affect the macrophage NOD1-RIP2-NF-κB signalling pathway, which might play a role in regulating the production of proinflammatory cytokines. Further investigation of these aspects should lead to a better understanding of immune recognition of and modulation by Toxocara canis in host animals.
Keywords	Toxocara canis ; Western blotting ; adults ; dogs ; enzyme-linked immunosorbent assay ; etiological agents ; interleukin-1beta ; interleukin-6 ; macrophages ; messenger RNA ; mice ; oligomerization ; parasitology ; protein synthesis ; quantitative polymerase chain reaction ; toxocariasis ; transcription (genetics) ; tumor necrosis factor-alpha ; zoonoses
Language	English
Dates of publication	2021-10
Publishing place	Elsevier Inc.
Document type	Article
ZDB-ID	391089-1
ISSN	1090-2449 ; 0014-4894
ISSN (online)	1090-2449
ISSN	0014-4894
DOI	10.1016/j.exppara.2021.108152
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Galectins expressed differently in genetically susceptible C57BL/6 and resistant BALB/c mice during acute ocular Toxoplasma gondii infection.

Chen, S-J / Zhang, Y-X / Huang, S-G / Lu, F-L

Parasitology

2017 Volume 144, Issue 8, Page(s) 1064–1072

Abstract: Ocular toxoplasmosis (OT) caused by Toxoplasma gondii is a major cause of infectious uveitis, however little is known about its immunopathological mechanism. Susceptible C57BL/6 (B6) and resistant BALB/c mice were intravitreally infected with 500 ... ...

Abstract	Ocular toxoplasmosis (OT) caused by Toxoplasma gondii is a major cause of infectious uveitis, however little is known about its immunopathological mechanism. Susceptible C57BL/6 (B6) and resistant BALB/c mice were intravitreally infected with 500 tachyzoites of the RH strain of T. gondii. B6 mice showed more severe ocular pathology and higher parasite loads in the eyes. The levels of galectin (Gal)-9 and its receptors (Tim-3 and CD137), interferon (IFN)-γ, IL-6 and IL-10 were significantly higher in the eyes of B6 mice than those of BALB/c mice; however, the levels of IFN-α and -β were significantly decreased in the eyes and CLNs of B6 mice but significantly increased in BALB/c mice after infection. After blockage of galectin-receptor interactions by α-lactose, neither ocular immunopathology nor parasite loads were different from those of infected BALB/c mice without α-lactose treatment. Although the expressions of Gal-9/receptor were significantly increased in B6 mice and Gal-1 and -3 were upregulated in both strains of mice upon ocular T. gondii infection, blockage of galectins did not change the ocular pathogenesis of genetic resistant BALB/c mice. However, IFN-α and -β were differently expressed in B6 and BALB/c mice, suggesting that type I IFNs may play a protective role in experimental OT.
Language	English
Publishing date	2017-07
Publishing country	England
Document type	Journal Article
ZDB-ID	207627-5
ISSN	1469-8161 ; 0031-1820
ISSN (online)	1469-8161
ISSN	0031-1820
DOI	10.1017/S0031182017000270
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