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Article ; Online: In situ

Jiang, Xi / Luo, Fengting / Liu, Ya / Yu, Pei / Chen, Shijian

2023 Volume 34, Issue 32

Abstract: Transition metal sulfides (TMSs) for electrochemical water splitting undergo significant self-reconstruction to form actual active species favorable for high oxygen evolution reaction (OER) performance. However, the complete self-reconstruction of most ... ...

Abstract	Transition metal sulfides (TMSs) for electrochemical water splitting undergo significant self-reconstruction to form actual active species favorable for high oxygen evolution reaction (OER) performance. However, the complete self-reconstruction of most reported TMSs in alkaline media is unfrequent and the active species cannot be efficiently used. Herein, self-supported FeS
Language	English
Publishing date	2023-05-26
Publishing country	England
Document type	Journal Article
ZDB-ID	1362365-5
ISSN	1361-6528 ; 0957-4484
ISSN (online)	1361-6528
ISSN	0957-4484
DOI	10.1088/1361-6528/acd3f6
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Article: Safety and efficacy of stenting for symptomatic intracranial artery stenosis: a systematic reveiw and meta-analysis.

Shi, Ting / Chen, ShiJian / Long, YongPei / Gu, ZhongDeng

Frontiers in pharmacology

2023 Volume 14, Page(s) 1122842

Abstract: Background: ...

Abstract	Background:
Language	English
Publishing date	2023-06-08
Publishing country	Switzerland
Document type	Systematic Review
ZDB-ID	2587355-6
ISSN	1663-9812
ISSN	1663-9812
DOI	10.3389/fphar.2023.1122842
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Article ; Online: Xanthones with multiple roles against diabetes: their synthesis, structure-activity relationship, and mechanism studies.

Ke, Youhong / Xu, Qinfang / Hu, Jianling / Zhang, Jianrun / Chen, Shijian / Liu, Zhijun / Peng, Shuling / Zhang, Chao / Chen, Zhenqiang / Chen, Heru

Drug development research

2024 Volume 85, Issue 2, Page(s) e22170

Abstract: A four-step synthetic process has been developed to prepare 1,3,5,8-tetrahydroxyxanthone (2a) and its isomer 1,3,7,8-tetrahydroxyxanthone (2b). 25 more xanthones were also synthesized by a modified scheme. Xanthone 2a was identified as the most active ... ...

Abstract	A four-step synthetic process has been developed to prepare 1,3,5,8-tetrahydroxyxanthone (2a) and its isomer 1,3,7,8-tetrahydroxyxanthone (2b). 25 more xanthones were also synthesized by a modified scheme. Xanthone 2a was identified as the most active inhibitor against both α-glucosidase and aldose reductase (ALR2), with IC
MeSH term(s)	Humans ; Structure-Activity Relationship ; Hypoglycemic Agents/pharmacology ; Hypoglycemic Agents/therapeutic use ; Hypoglycemic Agents/chemistry ; alpha-Glucosidases/chemistry ; alpha-Glucosidases/metabolism ; Diabetes Complications/drug therapy ; Antioxidants/pharmacology ; Antioxidants/therapeutic use ; Xanthones/pharmacology ; Xanthones/therapeutic use ; Molecular Docking Simulation ; Diabetes Mellitus/drug therapy
Chemical Substances	Hypoglycemic Agents ; alpha-Glucosidases (EC 3.2.1.20) ; Antioxidants ; Xanthones
Language	English
Publishing date	2024-03-13
Publishing country	United States
Document type	Journal Article
ZDB-ID	604587-x
ISSN	1098-2299 ; 0272-4391
ISSN (online)	1098-2299
ISSN	0272-4391
DOI	10.1002/ddr.22170
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Article ; Online: Functional Connectivity Changes in Multiple-Frequency Bands in Acute Basal Ganglia Ischemic Stroke Patients: A Machine Learning Approach.

Li, Jie / Cheng, Lulu / Chen, Shijian / Zhang, Jian / Liu, Dongqiang / Liang, Zhijian / Li, Huayun

Neural plasticity

2022 Volume 2022, Page(s) 1560748

Abstract: Purpose: Several functional magnetic resonance imaging (fMRI) studies have investigated the resting-state functional connectivity (rs-FC) changes in the primary motor cortex (M1) in patients with acute basal ganglia ischemic stroke (BGIS). However, the ... ...

Abstract	Purpose: Several functional magnetic resonance imaging (fMRI) studies have investigated the resting-state functional connectivity (rs-FC) changes in the primary motor cortex (M1) in patients with acute basal ganglia ischemic stroke (BGIS). However, the frequency-specific FC changes of M1 in acute BGIS patients are still unclear. Our study was aimed at exploring the altered FC of M1 in three frequency bands and the potential features as biomarkers for the identification by using a support vector machine (SVM). Methods: We included 28 acute BGIS patients and 42 healthy controls (HCs). Seed-based FC of two regions of interest (ROI, bilateral M1s) were calculated in conventional, slow-5, and slow-4 frequency bands. The abnormal voxel-wise FC values were defined as the features for SVM in different frequency bands. Results: In the ipsilesional M1, the acute BGIS patients exhibited decreased FC with the right lingual gyrus in the conventional and slow-4 frequency band. Besides, the acute BGIS patients showed increased FC with the right medial superior frontal gyrus (SFGmed) in the conventional and slow-5 frequency band and decreased FC with the left lingual gyrus in the slow-5 frequency band. In the contralesional M1, the BGIS patients showed lower FC with the right SFGmed in the conventional frequency band. The higher FC values with the right lingual gyrus and left SFGmed were detected in the slow-4 frequency band. In the slow-5 frequency band, the BGIS patients showed decreased FC with the left calcarine sulcus. SVM results showed that the combined features (slow-4+slow-5) had the highest accuracy in classification prediction of acute BGIS patients, with an area under curve (AUC) of 0.86. Conclusion: Acute BGIS patients had frequency-specific alterations in FC; SVM is a promising method for exploring these frequency-dependent FC alterations. The abnormal brain regions might be potential targets for future researchers in the rehabilitation and treatment of stroke patients.
MeSH term(s)	Basal Ganglia/diagnostic imaging ; Brain Mapping/methods ; Humans ; Ischemic Stroke/diagnostic imaging ; Machine Learning ; Magnetic Resonance Imaging/methods
Language	English
Publishing date	2022-03-20
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1454938-4
ISSN	1687-5443 ; 2090-5904 ; 0792-8483
ISSN (online)	1687-5443
ISSN	2090-5904 ; 0792-8483
DOI	10.1155/2022/1560748
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Article ; Online: Weighted Gene Co-Expression Network Analysis to Identify Potential Biological Processes and Key Genes in COVID-19-Related Stroke.

Cen, Gengyu / Liu, Liuyu / Wang, Jun / Wang, Xue / Chen, Shijian / Song, Yiting / Liang, Zhijian

Oxidative medicine and cellular longevity

2022 Volume 2022, Page(s) 4526022

Abstract: The purpose of this research was to explore the underlying biological processes causing coronavirus disease 2019- (COVID-19-) related stroke. The Gene Expression Omnibus (GEO) database was utilized to obtain four COVID-19 datasets and two stroke datasets. ...

Abstract	The purpose of this research was to explore the underlying biological processes causing coronavirus disease 2019- (COVID-19-) related stroke. The Gene Expression Omnibus (GEO) database was utilized to obtain four COVID-19 datasets and two stroke datasets. Thereafter, we identified key modules via weighted gene co-expression network analysis, following which COVID-19- and stroke-related crucial modules were crossed to identify the common genes of COVID-19-related stroke. The common genes were intersected with the stroke-related hub genes screened via Cytoscape software to discover the critical genes associated with COVID-19-related stroke. Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analysis for common genes associated with COVID-19-related stroke, and the Reactome database was used to annotate and visualize the pathways involved in the key genes. Two COVID-19-related crucial modules and one stroke-related crucial module were identified. Subsequently, the top five genes were screened as hub genes after visualizing the genes of stroke-related critical module using Cytoscape. By intersecting the COVID-19- and stroke-related crucial modules, 28 common genes for COVID-19-related stroke were identified. ITGA2B and ITGB3 have been further identified as crucial genes of COVID-19-related stroke. Functional enrichment analysis indicated that both ITGA2B and ITGB3 were involved in integrin signaling and the response to elevated platelet cytosolic Ca
MeSH term(s)	COVID-19/complications ; COVID-19/genetics ; Computational Biology ; Gene Expression Profiling ; Gene Ontology ; Gene Regulatory Networks ; Humans ; Integrin alpha2/genetics ; Integrin beta3/genetics ; Stroke/genetics ; Stroke/virology
Chemical Substances	ITGA2B protein, human ; ITGB3 protein, human ; Integrin alpha2 ; Integrin beta3
Language	English
Publishing date	2022-05-09
Publishing country	United States
Document type	Journal Article
ZDB-ID	2455981-7
ISSN	1942-0994 ; 1942-0994
ISSN (online)	1942-0994
ISSN	1942-0994
DOI	10.1155/2022/4526022
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Article ; Online: FG7142 combined with restraint stress induces anxiogenic-like effects via downregulation gamma-aminobutyric acid type A receptor subunit alpha1 and 5-hydroxytryptamine 1A receptors expression in the hippocampus.

Wei, Xiaoyue / Wang, Kezhu / Gao, Jinfeng / Chen, Shijian / Zeng, Siying / Zhao, Yuhong

Neuroreport

2022 Volume 33, Issue 3, Page(s) 145–152

Abstract: Objectives: The existing anxiety animal models are susceptible to interference, and no single animal anxiety model can predict the future anxiolytic potential and profile of new putative anxiolytics. Therefore, to find a better anxiety animal model, we ... ...

Abstract	Objectives: The existing anxiety animal models are susceptible to interference, and no single animal anxiety model can predict the future anxiolytic potential and profile of new putative anxiolytics. Therefore, to find a better anxiety animal model, we used FG7142, a nonselective benzodiazepine inverse agonist. This anxiety animal model was established by intraperitoneal injection of FG7142 combined with restraint stress. Methods: Adult male C57BL/6J mice (18-20 g) were randomly classified into five groups (n = 10 per group), namely the control, restraint stress, restraint stress + 10 mg/kg FG7142, restraint stress + 20 mg/kg FG7142, restraint stress +30 mg/kg FG7142. The impact on behavior was explored by elevated plus maze, and marble burying test, followed by immunohistochemistry and quantitative real-time PCR enabled the elucidation of the possible mechanism. Results: Compared with the control group and restraint stress group, intraperitoneal injection of FG7142 combined with restraint stress model group was found to induce anxiogenic-like behavior in elevated plus maze and marble burying test. Moreover, relative to the control group, significantly increased expression of c-fos in the hippocampus and amygdala in the model group was evident, whereas the expression of gamma-aminobutyric acid type A receptor subunit alpha1 and 5-hydroxytryptamine receptor 1A mRNA was significantly decreased in the hippocampus. Conclusions: These results indicated that FG7142 combined with restraint stress is sufficient to induce anxiety, and its mechanism is associated with downregulation of hippocampal gamma-aminobutyric acid type A receptor subunit alpha1 and 5-hydroxytryptamine 1A receptors.
MeSH term(s)	Animals ; Anxiety/etiology ; Down-Regulation ; Hippocampus/metabolism ; Male ; Mice ; Mice, Inbred C57BL ; Receptor, Serotonin, 5-HT1A/metabolism ; Restraint, Physical ; gamma-Aminobutyric Acid/metabolism
Chemical Substances	Receptor, Serotonin, 5-HT1A (112692-38-3) ; gamma-Aminobutyric Acid (56-12-2)
Language	English
Publishing date	2022-02-09
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1049746-8
ISSN	1473-558X ; 0959-4965
ISSN (online)	1473-558X
ISSN	0959-4965
DOI	10.1097/WNR.0000000000001763
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Zs.A 3118: Show issues

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Jg. 1995 - 2021: Lesesall (2.OG)
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Article ; Online: Human urinary kallidinogenase may improve the prognosis of acute stroke patients with early neurological deterioration.

Xie, Yiju / Li, Shengyu / Zhang, Jian / Chen, Shijian / Deng, Xuhui / Cen, Gengyu / Liang, Zhijian

Brain and behavior

2022 Volume 12, Issue 3, Page(s) e2524

Abstract: Objectives: Some acute ischemic stroke (AIS) patients still suffer from early neurological deterioration (END) after receiving intravenous thrombolysis (IVT), and these patients often have a poor prognosis. The purpose of our study is to observe the ... ...

Abstract	Objectives: Some acute ischemic stroke (AIS) patients still suffer from early neurological deterioration (END) after receiving intravenous thrombolysis (IVT), and these patients often have a poor prognosis. The purpose of our study is to observe the efficacy and safety of human urinary kallidinogenase (HUK) treatment in patients with END. Methods: This was a retrospective analysis and 49 patients with END who met the inclusion criteria were divided into the observation group and the control group. All patients received routine treatment of AIS, while patients in the observation group were treated with HUK within 24 h after IVT and the other group without HUK. Results: There were 24 patients in the observation group and 25 patients in the control group. After treatment, favorable prognosis (mRS scores ≤2) at 3 months in the observation group with 13 cases (54.17%) was significantly better than that in the control group with four cases (16%) (p = .001), and there was no statistical difference between the two groups in any hemorrhagic complication. Conclusion: HUK is considered to be safe and may improve the prognosis of AIS patients with END after IVT. More clinical trials are needed to validate these results in the future.
MeSH term(s)	Brain Ischemia/complications ; Brain Ischemia/drug therapy ; Fibrinolytic Agents/therapeutic use ; Humans ; Ischemic Stroke ; Prognosis ; Retrospective Studies ; Stroke/complications ; Stroke/drug therapy ; Tissue Kallikreins/therapeutic use ; Treatment Outcome
Chemical Substances	Fibrinolytic Agents ; Tissue Kallikreins (EC 3.4.21.35)
Language	English
Publishing date	2022-02-13
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2623587-0
ISSN	2162-3279 ; 2162-3279
ISSN (online)	2162-3279
ISSN	2162-3279
DOI	10.1002/brb3.2524
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Article: Intracranial angioplasty with a self-expandable stent for intracranial atherosclerotic stenosis: Systematic review and meta-analysis.

Zhong, Cai / Chen, Shijian / Zhang, Jian / Luo, Shuguang / Ye, Ziming / Liu, Yayuan / Pang, Linlin / Dong, Zimei / Qin, Chao

Frontiers in neurology

2023 Volume 13, Page(s) 1074228

Abstract: Background: Intracranial angioplasty with a self-expandable stent (SES) is an important endovascular therapy for symptomatic intracranial arterial stenosis. We sought to update the evaluation of the perioperative safety and long-term outcomes of self- ... ...

Abstract	Background: Intracranial angioplasty with a self-expandable stent (SES) is an important endovascular therapy for symptomatic intracranial arterial stenosis. We sought to update the evaluation of the perioperative safety and long-term outcomes of self-expandable stent for the treatment of symptomatic intracranial arterial stenosis. Methods: We comprehensively searched the published literature from each database through Sept 16, 2022, for the PubMed, EMBASE, Web of Science, Cochrane, and Clinical Trials databases. The characteristics of the studies and patients, perioperative complications, and long-term outcomes were extracted. The pooled outcomes and 95% confidence intervals (CIs) were estimated by Stata Statistical Software 14.0. Results: A total of 4,632 patients from 58 studies were included. The pooled rate of perioperative stroke or death was 6.32% (95% CI 5.04-7.72%); ischemic stroke beyond 30 days through 1 year was 2.72% (95% CI 1.41-4.38%). Perioperative complications differed between the 2014-2022 and 2005-2013 subgroups, as did long-term outcomes between the off-label SES and Wingspan subgroups. Conclusion: The perioperative complications of intracranial angioplasty with SES have been reduced, but the risk of perioperative stroke or death is still higher than that of aggressive medical therapy, and additional studies are needed to determine whether it has better long-term outcomes than aggressive medical therapy. Perioperative complications varied between the 2014-2022 and 2005-2013 subgroups, as did long-term outcomes between the off-label SES and Wingspan subgroups. Given the high level of heterogeneity observed between the included studies, these results should be interpreted with caution and additional studies are needed. Systematic review registration: https://www.crd.york.ac.uk/prospero/, identifier: CRD42022316066.
Language	English
Publishing date	2023-01-09
Publishing country	Switzerland
Document type	Systematic Review
ZDB-ID	2564214-5
ISSN	1664-2295
ISSN	1664-2295
DOI	10.3389/fneur.2022.1074228
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Article ; Online: Ultra-high performance humidity sensor enabled by a self-assembled CuO/Ti

Wang, Lei / Yao, Xinqi / Yuan, Shuaishuai / Gao, Yang / Zhang, Ruhang / Yu, Xinhai / Tu, Shan-Tung / Chen, Shijian

RSC advances

2023 Volume 13, Issue 9, Page(s) 6264–6273

Abstract: An ultra-high performance humidity sensor based on a CuO/ ... ...

Abstract	An ultra-high performance humidity sensor based on a CuO/Ti
Language	English
Publishing date	2023-02-21
Publishing country	England
Document type	Journal Article
ISSN	2046-2069
ISSN (online)	2046-2069
DOI	10.1039/d2ra06903b
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Article ; Online: Collaborative Enhancement of Humidity Sensing Performance by KCl-Doped CuO/SnO

Wang, Lei / Huang, Feng / Yao, Xinqi / Yuan, Shuaishuai / Yu, Xinhai / Tu, Shan-Tung / Chen, Shijian

ACS omega

2023 Volume 8, Issue 5, Page(s) 4878–4888

Abstract: In this study, a high-performance humidity sensor based on KCl-doped CuO/ ... ...

Abstract	In this study, a high-performance humidity sensor based on KCl-doped CuO/SnO
Language	English
Publishing date	2023-01-26
Publishing country	United States
Document type	Journal Article
ISSN	2470-1343
ISSN (online)	2470-1343
DOI	10.1021/acsomega.2c07098
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