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  1. Article: Development and validation of risk prediction model for refeeding syndrome in neurocritical patients.

    Zhang, Wei / Zhang, Sheng-Xiang / Chen, Shu-Fan / Yu, Tao / Tang, Yun

    Frontiers in nutrition

    2023  Volume 10, Page(s) 1083483

    Abstract: Background: The incidence of refeeding syndrome (RFS) in critically ill patients is high, which is detrimental to their prognoses. However, the current status and risk factors for the occurrence of RFS in neurocritical patients remain unclear. ... ...

    Abstract Background: The incidence of refeeding syndrome (RFS) in critically ill patients is high, which is detrimental to their prognoses. However, the current status and risk factors for the occurrence of RFS in neurocritical patients remain unclear. Elucidating these aspects may provide a theoretical basis for screening populations at high risk of RFS.
    Methods: A total of 357 patients from January 2021 to May 2022 in a neurosurgery ICU of a tertiary hospital in China were included using convenience sampling. Patients were divided into RFS and non-RFS groups, based on the occurrence of refeeding-associated hypophosphatemia. Risk factors for RFS were determined using univariate and logistic regression analyses, and a risk prediction model for RFS in neurocritical patients was developed. The Hosmer-Lemeshow test was used to determine the goodness of fit of the model, and the receiver operator characteristic curve was used to examine its discriminant validity.
    Results: The incidence of RFS in neurocritical patients receiving enteral nutrition was 28.57%. Logistic regression analyses showed that history of alcoholism, fasting hours, Acute Physiology and Chronic Health Evaluation II (APACHE II) scores, Sequential Organ Failure Assessment (SOFA) scores, low serum albumin, and low baseline serum potassium were risk factors of RFS in neurocritical patients (
    Conclusion: The incidence of RFS in neurocritical patients was high, and the risk factors were diverse. The risk prediction model in this study had good predictive effects and clinical utility, which may provide a reference for assessing and screening for RFS risk in neurocritical patients.
    Language English
    Publishing date 2023-02-15
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2776676-7
    ISSN 2296-861X
    ISSN 2296-861X
    DOI 10.3389/fnut.2023.1083483
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Mask-wearing behavior during COVID-19 in China and its correlation with e-health literacy.

    Zhang, Wei / Chen, Shu-Fan / Li, Kun-Kun / Liu, Huan / Shen, Hai-Chen / Zhang, Xian-Cui

    Frontiers in public health

    2022  Volume 10, Page(s) 930653

    Abstract: Background: During the Coronavirus : Methods: We conducted a nationwide survey on the mask-wearing behavior of the public and their health literacy levels by distributing electronic questionnaires. Univariate and logistic regression analyses were ... ...

    Abstract Background: During the Coronavirus
    Methods: We conducted a nationwide survey on the mask-wearing behavior of the public and their health literacy levels by distributing electronic questionnaires. Univariate and logistic regression analyses were performed to determine the factors influencing mask-wearing behavior. Pearson's correlation was used to analyze the correlation between mask-wearing behaviors and e-health literacy.
    Results: A total of 1,972 valid questionnaires were collected; 99.8% of the public wore masks when going out and 59.2% showed good mask-wearing behavior. Most people choose to wear disposable medical masks (61.3%), followed by medical surgical masks (52.9%). All participants indicated that they had understood the information on how to use masks, and most obtained it through social media (61.8%). The average of the e-health literacy scores of those with good mask-wearing behavior was significantly higher than those with poor mask-wearing behavior (
    Conclusion: The overall compliance of the public's mask-wearing behavior in China during COVID-19 is good. However, there are shortcomings regarding the selection, use, and precautions. The differences in mask-wearing behavior are related to factors including gender, place of residence, educational level, work or living environment, marital status, presence of flu symptoms, and whether living with people in home quarantine. Higher levels of e-health literacy indicated better mask-wearing behavior. Therefore, it is necessary to strengthen the public's popularization and education regarding the prevention and control of COVID-19.
    MeSH term(s) COVID-19/epidemiology ; COVID-19/psychology ; China/epidemiology ; Health Literacy ; Humans ; Masks ; SARS-CoV-2
    Language English
    Publishing date 2022-07-22
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2711781-9
    ISSN 2296-2565 ; 2296-2565
    ISSN (online) 2296-2565
    ISSN 2296-2565
    DOI 10.3389/fpubh.2022.930653
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: The MAP3Ks DLK and LZK Direct Diverse Responses to Axon Damage in Zebrafish Peripheral Neurons.

    Adula, Kadidia Pemba / Shorey, Matthew / Chauhan, Vasudha / Nassman, Khaled / Chen, Shu-Fan / Rolls, Melissa M / Sagasti, Alvaro

    The Journal of neuroscience : the official journal of the Society for Neuroscience

    2022  Volume 42, Issue 32, Page(s) 6195–6210

    Abstract: Mitogen-activated protein kinase kinase kinases (MAP3Ks) dual leucine kinase (DLK) and leucine zipper kinase (LZK) are essential mediators of axon damage responses, but their responses are varied, complex, and incompletely understood. To characterize ... ...

    Abstract Mitogen-activated protein kinase kinase kinases (MAP3Ks) dual leucine kinase (DLK) and leucine zipper kinase (LZK) are essential mediators of axon damage responses, but their responses are varied, complex, and incompletely understood. To characterize their functions in axon injury, we generated zebrafish mutants of each gene, labeled motor neurons (MNs) and touch-sensing neurons in live zebrafish, precisely cut their axons with a laser, and assessed the ability of mutant axons to regenerate in larvae, before sex is apparent in zebrafish. DLK and LZK were required redundantly and cell autonomously for axon regeneration in MNs but not in larval Rohon-Beard (RB) or adult dorsal root ganglion (DRG) sensory neurons. Surprisingly, in
    MeSH term(s) Animals ; Axons/physiology ; Leucine/metabolism ; Leucine Zippers ; MAP Kinase Kinase Kinases/genetics ; MAP Kinase Kinase Kinases/metabolism ; Motor Neurons/metabolism ; Nerve Regeneration/genetics ; Zebrafish
    Chemical Substances MAP Kinase Kinase Kinases (EC 2.7.11.25) ; Leucine (GMW67QNF9C)
    Language English
    Publishing date 2022-07-15
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
    ZDB-ID 604637-x
    ISSN 1529-2401 ; 0270-6474
    ISSN (online) 1529-2401
    ISSN 0270-6474
    DOI 10.1523/JNEUROSCI.1395-21.2022
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1668: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  4. Article ; Online: Risk prediction models for intensive care unit-acquired weakness in intensive care unit patients: A systematic review.

    Zhang, Wei / Tang, Yun / Liu, Huan / Yuan, Li Ping / Wang, Chu Chu / Chen, Shu Fan / Huang, Jin / Xiao, Xin Yuan

    PloS one

    2021  Volume 16, Issue 9, Page(s) e0257768

    Abstract: Background and objectives: Intensive care unit-acquired weakness (ICU-AW) commonly occurs among intensive care unit (ICU) patients and seriously affects the survival rate and long-term quality of life for patients. In this systematic review, we ... ...

    Abstract Background and objectives: Intensive care unit-acquired weakness (ICU-AW) commonly occurs among intensive care unit (ICU) patients and seriously affects the survival rate and long-term quality of life for patients. In this systematic review, we synthesized the findings of previous studies in order to analyze predictors of ICU-AW and evaluate the discrimination and validity of ICU-AW risk prediction models for ICU patients.
    Methods: We searched seven databases published in English and Chinese language to identify studies regarding ICU-AW risk prediction models. Two reviewers independently screened the literature, evaluated the quality of the included literature, extracted data, and performed a systematic review.
    Results: Ultimately, 11 studies were considered for this review. For the verification of prediction models, internal verification methods had been used in three studies, and a combination of internal and external verification had been used in one study. The value for the area under the ROC curve for eight models was 0.7-0.923. The predictor most commonly included in the models were age and the administration of corticosteroids. All the models have good applicability, but most of the models are biased due to the lack of blindness, lack of reporting, insufficient sample size, missing data, and lack of performance evaluation and calibration of the models.
    Conclusions: The efficacy of most models for the risk prediction of ICU-AW among high-risk groups is good, but there was a certain bias in the development and verification of the models. Thus, ICU medical staff should select existing models based on actual clinical conditions and verify them before applying them in clinical practice. In order to provide a reliable basis for the risk prediction of ICU-AW, it is necessary that large-sample, multi-center studies be conducted in the future, in which ICU-AW risk prediction models are verified.
    MeSH term(s) Area Under Curve ; Bias ; Critical Care/methods ; Humans ; Intensive Care Units ; Models, Theoretical ; Muscle Weakness/epidemiology ; Quality of Life ; Risk Assessment/methods
    Language English
    Publishing date 2021-09-24
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Systematic Review
    ISSN 1932-6203
    ISSN (online) 1932-6203
    DOI 10.1371/journal.pone.0257768
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Increased serum levels of betatrophin in pancreatic cancer-associated diabetes.

    Susanto, Hendra / Liu, Ta-Yu / Chen, Chang-Chiang / Purnomo, Jerry D T / Chen, Shu-Fan / Wang, Chih-Hong

    Oncotarget

    2016  Volume 7, Issue 27, Page(s) 42330–42339

    Abstract: Long-standing diabetes or glucose intolerance is recognized as a crucial event in the process of pancreatic cancer. Betatrophin, a novel liver-derived hormone, promotes β-cell proliferation and improves glucose intolerance. However, the relationship ... ...

    Abstract Long-standing diabetes or glucose intolerance is recognized as a crucial event in the process of pancreatic cancer. Betatrophin, a novel liver-derived hormone, promotes β-cell proliferation and improves glucose intolerance. However, the relationship between betatrophin and PDAC-associated diabetes is not fully understood. To evaluate the serum betatrophin levels in PDAC-associated diabetes, a total 105 Taiwanese subjects including 15 healthy subjects, and 12 patients having PDAC with normal glucose tolerance (PDAC-NGT), 12 patients having PC with impaired glucose tolerance (PDAC-IGT), and 66 patients having PC with diabetes mellitus (PDAC-DM) were enrolled for this study. Serum betatrophin and carbohydrate antigen 19-9 (CA19-9) levels were analyzed by enzyme-linked immunosorbent assay (ELISA). Compared to healthy subjects, PDAC patients had higher levels of betatrophin and CA19-9. Consistently, betatrophin protein was significantly expressed in pancreatic ductal of PDAC-associated DM patients using immunohistochemistry (IHC) method. Furthermore, multivariate regression analysis showed the betatrophin was significantly and positively independent with T category (β= 0.605, P=0.010), serum albumin (β= 0. 423, P=0.021), lipase (β= 0.292, P=0.039), and blood urea nitrogen (BUN) (β= 0.303, P=0.040). Further, the betatrophin was three folds of having PDAC-associated diabetes with the highest odds ratio [OR=3.39; 95% CI (1.20-9.57); P=0.021) and receiver operating characteristic (ROC) curve analysis showed that AUC value of betarophin was 0.853 which is slightly larger than AUC value of CA19-9 (0.792) in PDAC-DM patients. Interestingly, AUC value of betarophin plus CA19-9 was 0.988 in PDAC-DM patients. Therefore, betatrophin combined CA19-9 may serve as a potential biomarker for PDAC-associated diabetes.
    Language English
    Publishing date 2016-07-05
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2560162-3
    ISSN 1949-2553 ; 1949-2553
    ISSN (online) 1949-2553
    ISSN 1949-2553
    DOI 10.18632/oncotarget.9815
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: The Polysaccharides from

    Fu, Yu-Ping / Feng, Bin / Zhu, Zhong-Kai / Feng, Xin / Chen, Shu-Fan / Li, Li-Xia / Yin, Zhong-Qiong / Huang, Chao / Chen, Xing-Fu / Zhang, Bing-Zhao / Jia, Ren-Yong / Song, Xu / Lv, Cheng / Yue, Gui-Zhou / Ye, Gang / Liang, Xiao-Xia / He, Chang-Liang / Yin, Li-Zi / Zou, Yuan-Feng

    Molecules (Basel, Switzerland)

    2018  Volume 23, Issue 7

    Abstract: Based on previous studies about microflora regulation and immunity enhancement activities of polysaccharides ... ...

    Abstract Based on previous studies about microflora regulation and immunity enhancement activities of polysaccharides from
    MeSH term(s) Animals ; Codonopsis/chemistry ; Cyclophosphamide/pharmacology ; Cytokines/blood ; Gastrointestinal Microbiome/drug effects ; Immunity/drug effects ; Immunity, Mucosal/drug effects ; Immunocompromised Host ; Immunoglobulin A, Secretory/blood ; Immunoglobulin A, Secretory/immunology ; Immunologic Factors/pharmacology ; Immunosuppressive Agents/pharmacology ; Liver/drug effects ; Liver/immunology ; Mice ; Polysaccharides/pharmacology ; Spleen/drug effects ; Spleen/immunology ; Thymus Gland/drug effects ; Thymus Gland/immunology
    Chemical Substances Cytokines ; Immunoglobulin A, Secretory ; Immunologic Factors ; Immunosuppressive Agents ; Polysaccharides ; Cyclophosphamide (8N3DW7272P)
    Language English
    Publishing date 2018-07-20
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 1413402-0
    ISSN 1420-3049 ; 1431-5165 ; 1420-3049
    ISSN (online) 1420-3049
    ISSN 1431-5165 ; 1420-3049
    DOI 10.3390/molecules23071801
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.MO 81: Show issues

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  7. Article: Oral cancer diagnosis with optical coherence tomography.

    Chen, Shu-Fan / Lu, Chih-Wei / Tsai, Meng-Tsan / Wang, Yih-Ming / Yang, C / Chiang, Chun-Ping

    Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference

    2005  Volume 2005, Page(s) 7227–7229

    Abstract: We use an optical coherence tomography system with a specially designed probe to image the structures of tissues within the oral cavity for the diagnosis of oral precancer and cancer. Various types of oral mucosa, such as gingiva and buccal mucosa, ... ...

    Abstract We use an optical coherence tomography system with a specially designed probe to image the structures of tissues within the oral cavity for the diagnosis of oral precancer and cancer. Various types of oral mucosa, such as gingiva and buccal mucosa, normal and abnormal, can be well distinguished.
    Language English
    Publishing date 2005-08-22
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2091094-0
    ISSN 1558-4615 ; 1557-170X ; 1094-687X
    ISSN (online) 1558-4615
    ISSN 1557-170X ; 1094-687X
    DOI 10.1109/IEMBS.2005.1616178
    Database MEDical Literature Analysis and Retrieval System OnLINE

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